Psychiatric manifestations of sporadic Creutzfeldt-Jakob disease simulate depressive disorder with psychotic symptoms

Creutzfeldt–Jakob disease (CJD) is a rare and fatal neurodegenerative disorder with a broad spectrum of early clinical manifestations, comprising neurological and psychiatric symptoms. The authors report the case of a patient admitted with a diagnosis of depressive disorder with psychotic symptoms, with post-mortem confirmation of CJD and discuss how CJD’s clinical heterogeneity can lead to misdiagnosis of the disease. Despite CJD’s unique pathogenesis, its kaleidoscopic presentation justifies the integrated investigation of patients with psychiatric symptoms, avoiding restrictive diagnosis.

Spectral Frame Analysis and Learning through Graph Structure

This dissertation investigates the connection between spectral analysis and frame theory. When considering the spectral properties of a frame, we present a few novel results relating to the spectral decomposition. We first show that scalable frames have the property that the inner product of the scaling coefficients and the eigenvectors must equal the inverse eigenvalues. From this, we prove a similar result when an approximate scaling is obtained. We then focus on the optimization problems inherent to the scalable frames by first showing that there is an equivalence between scaling a frame and optimization problems with a non-restrictive objective function. Various objective functions are considered, and an analysis of the solution type is presented. For linear objectives, we can encourage sparse scalings, and with barrier objective functions, we force dense solutions. We further consider frames in high dimensions, and derive various solution techniques. From here, we restrict ourselves to various frame classes, to add more specificity to the results. Using frames generated from distributions allows for the placement of probabilistic bounds on scalability. For discrete distributions (Bernoulli and Rademacher), we bound the probability of encountering an ONB, and for continuous symmetric distributions (Uniform and Gaussian), we show that symmetry is retained in the transformed domain. We also prove several hyperplane-separation results. With the theory developed, we discuss graph applications of the scalability framework. We make a connection with graph conditioning, and show the in-feasibility of the problem in the general case. After a modification, we show that any complete graph can be conditioned. We then present a modification of standard PCA (robust PCA) developed by Cand\`es, and give some background into Electron Energy-Loss Spectroscopy (EELS). We design a novel scheme for the processing of EELS through robust PCA and least-squares regression, and test this scheme on biological samples. Finally, we take the idea of robust PCA and apply the technique of kernel PCA to perform robust manifold learning. We derive the problem and present an algorithm for its solution. There is also discussion of the differences with RPCA that make theoretical guarantees difficult.

Performing masculinity, performing the self: Rudolfo Anaya's Bless me, Ultima and Heart of Aztlan

This article explores how Bless Me, Ultima and Heart of Aztlan, the two earliest novels by acclaimed Chicano writer Rudolfo Anaya, problematise and negotiate Chicano masculinity issues. I will focus on the main characters of the novels, who, at different vital moments of their lives, question the meaning of manhood amidst important socio-economic changes and conflicting cultural traditions. Anaya reveals the complexity of being “mestizo” in American society, and exposes how hegemonic standards of masculinity are Manichean, restrictive and reliant on gender inequality. I will finally examine whether the novels challenge hegemonic gender orders, successfully negotiate non-heterosexist ideals of manhood, and ultimately contribute to the advancement of egalitarian gender relations for the Chicana/o community

Surveillance in Cyberspace: Applying Natural and Place Manager Surveillance to System Trespassing

Research on the criminological side of system trespassing (i.e. unlawfully gaining access to a computer system) is relatively rare and has yet to examine the effect of the presence of other users on the system during the trespassing event (i.e. the time of communication between a trespasser’s system and the infiltrated system). This thesis seeks to analyze this relationship drawing on principles of Situational Crime Prevention, Routine Activities Theory, and restrictive deterrence. Data were collected from a randomized control trial of target computers deployed on the Internet network of a large U.S. university. This study examined whether the number (one or multiple) and type (administrative or non-administrative) of computer users present on a system reduced the seriousness and frequency of trespassing. Results indicated that the type of user (administrative) produced a restrictive deterrent effect and significantly reduced the frequency and duration of trespassing events.

Previsão da Classificação da qualidade dos efluentes da indústria petrolífera com recurso a sistemas inteligentes

O presente trabalho realizou-se na Refinaria de Sines e teve como principal objectivo a utilização de ferramentas oriundas da Área Científica da Inteligência Artificial no desenvolvimento de modelos de previsão da classificação da Água Residual Industrial de acordo com a Legislação em vigor, com vista à minimização dos impactes ambientais e das tarifas aplicadas pela Concessionária (Águas de Santo André) à Refinaria. Actualmente a avaliação da qualidade do efluente é realizada através de métodos analíticos após colheita de uma amostra do efluente final. Esta abordagem é muito restritiva já que não permite actuar sobre o efluente em questão pois apenas pode evitar que, no futuro, uma mistura semelhante volte a ser refinada. Devido a estas limitações, o desenvolvimento de modelos de previsão baseados em Data Mining mostrou ser uma alternativa para uma questão pró-activa da qualidade dos efluentes que pode contribuir decisivamente para o cumprimento das metas definidas pela Empresa. No decurso do trabalho, foram desenvolvidos dois modelos de previsão da qualidade do efluente industrial com desempenhos muito semelhantes. Um deles utiliza a composição das misturas processadas e o outro, utiliza informações relativas ao crude predominante na mistura. ABSTRACT; This study has taken place at the Sines Refinery and its main objective is the use of Artificial Intelligence tools for the development of predictive models to classify industrial residual waters according with the Portuguese Law, based on the characteristics of the mixtures of crude oil that arrive into the Refinery to be processed, to minimize the Environmental impacts and the application of taxes. Currently, the evaluation of the quality of effluent is performed by analytical methods after harvesting a sample of the final effluent. This approach is very restrictive since it does not act on the intended effluent; it can only avoid that in the future a similar mixture is refined. Duet these limitations, the development of forecasting models based on Data Mining has proved to be an alternative on the important issue which is the quality of effluent, which may contribute to the achievement of targets set by the Company. During this study, two models were developed to predict the quality of industrial effluents with very similar performances. One uses the composition of processed mixtures and the other uses information regarding the predominant oil in the mixture.

Fatores críticos de sucesso das empresas familiares: uma abordagem competitiva

The present objective study to inside identify the critical factors of success of the local family companies of a competitive boarding. For in such a way the same it understands the culture and the management of the family companies of success, identifies the essential areas of performance, it establishes the restrictive factors of the success, and analyzes the level of influence of the critical factors of success in the competitiveness of this type of company. In function of the subject little to be explored, and of this study to provide a general vision concerning the factors that take the family companies to get success, this research is explorer. On the other hand, for describing characteristic of the familiar companies in prominence in the local scene and for being worried about the practical performance, the same one also is descriptive. The sample in turn is the not-probabilist one of the intentional type, for accessibility. For operacionalization of the collection of data, the direct contact was used, being the composed instrument of research for variable as management, culture, critical factors of success and competitiveness. The study it evidences that in regards to the management and the culture of the family companies of success, some variable are turned aside from the standard of the conventional family companies cited by literature. Of general form in the familiar companies of success it has a bigger level of professionalization of the management. As for the value given to the knowledge, the study sample that the conventional family companies give little importance to it, in contrast of the family companies in prominence, who value of significant form the search for the knowledge. He is demonstrated despite the family companies of success, even so total are not professionalized, possess a bigger level of professionalization of the management, ratifying of certain forms the reason for which the majority develops the Strategical Planning formal periodically. In short, the results point 17 critical factors of success with respect to the family companies, in special factors as the product quality and services, and the use of the technology

Le principe ex injuria jus non oritur en droit international

Le principe ex injuria jus non oritur selon lequel le droit ne naît pas de l’illégalité existe en droit international comme un principe qui permet d’expliquer une série de règles qui excluent, de différentes manières, qu’un fait illicite ne produise des droits dans le chef de l’auteur de ce fait. Ce principe se caractérise surtout par la tension entre le droit et le fait qui permet de comprendre les ambiguïtés dont son statut est pétri, le principe n’étant admis en droit positif que moyennant une définition restrictive de ses termes qui permet une certaine souplesse quant à son application. Cette tension est également palpable dans le discours des Etats comme dans celui des auteurs de doctrine lorsque les uns et les autres sont confrontés à des situations illicites effectives. Le principe ex injuria jus non oritur révèle bien plus qu’il ne résout les difficultés de concilier les exigences idéalistes du respect du droit avec les impératifs réalistes de prendre en compte la force du fait. Cette tension renvoie à la question de l’existence même du droit international, lequel peut être présenté comme une forme sophistiquée de discours, et non comme un corps de règles régissant effectivement la réalité sociale. Dans cette perspective, on constate que, au-delà des stratégies par lesquelles les Etats tentent de justifier certains faits accomplis sans remettre en cause le principe de légalité, il est des cas où les Etats restent tout simplement silencieux. L’analyse du principe ex injuria jus non oritur à l’épreuve de la pratique internationale tendrait peut-être à montrer qu’au-delà d’un certain seuil de tension, le discours juridique semble impropre à justifier certaines situations factuelles aux origines douteuses, ce qui expliquerait que les Etats préfèrent parfois dans ces cas s’abstenir de prendre position à leur sujet.

Finding the set of k-additive dominating measures viewed as a flow problem

n this paper we deal with the problem of obtaining the set of k-additive measures dominating a fuzzy measure. This problem extends the problem of deriving the set of probabilities dominating a fuzzy measure, an important problem appearing in Decision Making and Game Theory. The solution proposed in the paper follows the line developed by Chateauneuf and Jaffray for dominating probabilities and continued by Miranda et al. for dominating k-additive belief functions. Here, we address the general case transforming the problem into a similar one such that the involved set functions have non-negative Möbius transform; this simplifies the problem and allows a result similar to the one developed for belief functions. Although the set obtained is very large, we show that the conditions cannot be sharpened. On the other hand, we also show that it is possible to define a more restrictive subset, providing a more natural extension of the result for probabilities, such that it is possible to derive any k-additive dominating measure from it.

CHARACTERISTICS OF PRIVATE HIGH SCHOOLS FOR STUDENTS WITH EMOTIONAL DISABILITIES AND PERCEPTIONS OF THEIR PUBLIC SCHOOL CASE MANAGERS

Placement of students with disabilities in private special-education schools remains costly and controversial. This is particularly concerning, given the lack of research on the characteristics and quality of these restrictive settings. The purpose of this study was to identify the academic and vocational course offerings and behavioral supports provided in private special-education schools the serve high school students with emotional disabilities (ED). Second, the research examined the perceptions of the quality of services in these setting from the perspectives of public school case managers. Using a mixed-method design to collect data, 9 administrative heads of private special-education schools were surveyed, and 7 public school case managers were interviewed. Results indicated that (a) private special-education schools offer the basic academic core courses needed to meet graduation requirements, (b) vocational options for students enrolled in these schools are quite limited, (c) these schools provide a variety of behavioral interventions and supports, and (d) case managers are concerned with the lack of academic rigor and inconsistent programming at these schools but applauded the notion that students with ED are exiting with a high school diploma. Findings from this study may have policy implications for improving and developing programming options for high school students with ED.

Modelo de ebook multimédia para divulgação cultural investigação e desenvolvimento de um protótipo no formato EPUB

Esta investigação teve por objetivo investigar as possibilidades de criação de um modelo de ebook interativo, com o título “A Lagoa de Óbidos”, no formato EPUB3, e a compreensão das vantagens e desvantagens da sua utilização sustentada num painel com 21 participantes. O formato EPUB (electronic publication) define um conjunto de características específicas para a criação e a distribuição de publicações digitais. Estas especificações têm sido desenvolvidas e implementadas pelo International Digital Publishing Forum (IDPF) que, em 2011, aprovou a versão 3, designada como EPUB3. A inclusão de novas tecnologias - HTML5, CSS3, JavaScript - numa publicação digital deu origem a esta investigação, um estudo de caso que pretendia conhecer as potencialidades dessa integração em ebooks interativos e a sua possível utilização em diferentes áreas do saber. O trabalho da recolha de textos e a sua análise permitiram a criação de um protótipo de ebook interativo, cujo objetivo era a estruturação das especificações que compõem a versão EPUB3. As opiniões sobre as possibilidades que este modelo apresenta, ao nível da usabilidade e dos recursos utilizados, foram colhidas através de um “Questionário de Opinião”, onde participaram 21 voluntários. O tema escolhido para o ebook foi “A Lagoa de Óbidos” por considerarmos um lugar de memória cultural, com características paisagísticas, históricas, sociais e ambientais reconhecidas e que lhe dão uma identidade própria merecedora de ser divulgada, através de textos, imagens, vídeos, animações e jogos. A análise dos resultados obtidos no “Questionário de Opinião”, leva-nos a concluir que a maioria da amostra sentiu que a leitura do ebook foi uma experiência variada, interessante e ativa. A totalidade achou que a interatividade trouxe benefícios à compreensão dos assuntos. Em síntese, a opinião dos sujeitos em relação ao ebook “A Lagoa de Óbidos foi considerada bastante positiva. No entanto, a opinião quase uniforme dificulta a análise da relação entre as variáveis do “Questionário de Opinião” levando à necessidade de aprofundar este estudo.

Associação entre a apresentação fenotípica e os indicadores de prognóstico em gatos com cardiomiopatia hipertrófica

Dissertação de Mestrado Integrado em Medicina Veterinária

Determinization of timed Petri nets behaviors

International audience

Rastreio neonatal da galactosémia custo/beneficio da introdução no programa nacional de diagnóstico precoce

Trabalho Final do Curso de Mestrado Integrado em Medicina, Faculdade de Medicina, Universidade de Lisboa, 2014

Compostos bioativos de microalgas com interesse no tratamento da diabetes

Dissertação de Mestrado, Biologia Molecular e Microbiana, Faculdade de Ciências e Tecnologia, Universidade do Algarve, 2016

O domínio das orações adjectivas em português europeu: desenvolvimento da linguagem (típico e atípico) e efeitos da escolarização

Esta dissertação investiga os efeitos do desenvolvimento da linguagem ‒ típico (DTL) e atípico (ADL) ‒ e da escolarização na forma como as crianças compreendem e produzem as orações adjectivas restritivas de SU e de OD (ao centro e à direita), de Ind e de Loc (Ind e Loc apenas testadas na tarefa de repetição). A amostra foi constituída por 3 grupos de crianças – dos quais16 têm DTL do Pré-escolar; 13 são do 2.º ano básico com DTL e 7 têm ADL ‒ e por 1 grupo de adultos (o grupo de controlo) com 10 indivíduos. Através da aplicação das tarefas de representação e de repetição de Vasconcelos (1991) e da narrativa ‘A história do gato’, de Hickmann (1982), os resultados mostram a maior acessibilidade das adjectivas SU e OD à direita; elucidam-nos também sobre a importância que o processo de desenvolvimento linguístico e a escolarização têm para a temática. /ABSTRACT: This dissertation research the effects of typical (DTL) and atypical language development (LI), and the formal education system itself on the manner in which children understand and produce restrictive relative clauses of subject (SU) and direct object (DO) (center and right embedded), indirect object (Ind) and locative (Loc); Ind and Loc atested merely on construction tasks. The complete sample includes 3 groups of children - 16 pre-school with DTL; 13 in 2nd grade with DTL and 7 children diagnosed with LI - and 1 group of adults (control group)10 individuals. The results of representation and repetition exercises by Vasconcelos (1991) and the narrative of Hickmann’s ‘Cat story’ (1982) revealed that the majority of the participating children master more easily SU and OD clauses relative clauses with right association; and also important role of the language development process and of School for the matter.