Sensitization to indoor aeroallergens in children who attended the Allergy Service of the “Dr. José Eleuterio González” University Hospital of Monterrey, Mexico

Background: Indoor aeroallergens are the main cause of sensitization in children and represent a risk factor for the development of allergic diseases. Objective: Identify the major indoor aeroallergens most often sensitized to pediatric patients treated at the Allergy Service at the “Dr. José Eleuterio González” University Hospital of Monterrey Methods: We performed an observational and descriptive study where we reviewed reports of positive skin tests to the following common indoor aeroallergens: Dermatophagoides farinae (D. farinae), Dermatophagoides pteronyssinus (D. pteronyssinus), Canis familiaris (C. familiaris), Felis domesticus (F. domesticus), Blattella germanica (B. germanica) and Periplaneta americana (P. americana), found in patients under 16 years with symptoms of allergy, during the period of 2011-2012. Results: We performed 439 skin tests to aeroallergens in pediatric patients. Of these, 57.6% were male and 42.4% were female. Mean age was 6.3 years. The age groups were under 3 years: 17.8%, 3-5 years: 35%, 6-12 years: 36%, and 13-16 years: 11.2%. The main diagnoses were: allergic rhinitis (71.8%), asthma (16.6%), and atopic dermatitis (4.3%). In 57.9% of the cases, they had at least one positive skin test to any aeroallergen. The rate of sensitization to speciic aeroallergens was: D. Pteronyssinus 49.0%, D. farinae 44.6%, B. germanica 13.9%, P. Americana 10.9%, F. domesticus 10.7%, and C. familiaris 5.9%. Conclusion: Indoor aeroallergen sensitization can occur early in life, although it was more frequent in the preschooler and elementary school group. Dust house mites were the most commom cause of allergic sensitization.

Perceived benefits, motivations and preferences for foreign language learning by older adults. Insights from an initiative in Cuenca, Ecuador

El presente estudio analiza las percepciones y actitudes que tienen los adultos mayores de la ciudad de Cuenca, Ecuador hacia el aprendizaje del inglés. Un total de 151 adultos mayores (con edad promedio de 70.3 años) respondió a un cuestionario con 50 ítems. Se llevó a cabo análisis factoriales, de regresión múltiple y cluster con el propósito de definir las dimensiones subyacentes en las percepciones, motivaciones y ambiciones de los adultos mayores para aprender un idioma extranjero, y su relación con las características sociodemográficas de los participantes. Los resultados señalan que el interés por estudiar un idioma extranjero está basado en la percepción de que aquello mejora la interacción social de las personas, su desarrollo personal, el funcionamiento y mantenimiento de la mente y memoria, y que activa y vuelve su vida más dinámica. Los resultados además revelaron que la principal motivación de los participantes para tomar un curso de inglés está relacionada con el potencial de usar este idioma en la vida diaria y el de leer profusamente en esa lengua extranjera. La duración del curso y la obtención de un certificado fueron factores determinantes que permitieron agrupar a los participantes en función de sus preferencias en lo que respecta al diseño práctico de un curso de inglés. Adicionalmente, la edad y el nivel de instrucción fueron variables determinantes de motivación que influyeron en la mayor parte de las respuestas dadas por los participantes.

Florescimento psicológico e sentido navida: que relações: Validação preliminar da escala MHC-SF

Dissertação de Mestrado apresentada no ISPA – Instituto Universitário para obtenção do grau de Mestre em Psicologia especialidade em Psicologia da Saúde.

Undergraduate Social Education Student’s Perspectives about the Profession

Higher education institutions, responsible for training social educators, should ensure the construction of a profile marked by their technical versatility and whose socio-educational intervention is directed at all people, regardless of their situations in life. Reflection on the construction of this profile is fundamental given the difficulties of identity that the profession faces. In this context, we sought to develop a study which would allow us to identify how the students of a degree course in Social Education characterise this professional, in order to reflect on the contribution of training provided by the institution concerned and, if necessary, make the adjustments arising from the results. This is a qualitative, exploratory study, using an unstructured questionnaire applied to a convenience sample of 140 Portuguese students of the three years of a degree course in Social Education. Its emerging categorical content analysis was performed using the NVivo software, version 11. The main results point to a broad vision of the profession and are not limited to the work geared to specific populations or issues, valuing the relevance of the professional in the field of non-assistance socio-educational intervention. The main area of overlap between training objectives and students’ perceptions about practice allows the impact of training to be positively assessed, despite possible curricular adjustments resulting from further analysis, including the need to reinforce community intervention, undervalued by students, even though it plays a key role for social educators.

Partner relationship in couples living with atrial fibrillation

The aim of this thesis was to describe and explore how the partner relationship of patient–partner dyads isaffected following cardiac disease and, in particular, atrial fibrillation (AF) in one of the spouses. The thesis is based on four individual studies with different designs: descriptive (I), explorative (II, IV), and cross-sectional (III). Applied methods comprised a systematic review (I) and qualitative (II, IV) and quantitative methods (III). Participants in the studies were couples in which one of the spouses was afflicted with AF. Coherent with a systemic perspective, the research focused on the dyad as the unit of analysis. To identify and describe the current research position and knowledge base, the data for the systematic review were analyzed using an integrative approach. To explore couples’ main concern, interview data (n=12 couples) in study II were analyzed using classical grounded theory. Associations between patients and partners (n=91 couples) where analyzed through the Actor–Partner Interdependence Model using structural equation modelling (III). To explore couples’ illness beliefs, interview data (n=9 couples) in study IV were analyzed using Gadamerian hermeneutics. Study I revealed five themes of how the partner relationship is affected following cardiac disease: overprotection, communication deficiency, sexual concerns, changes in domestic roles, and adjustment to illness. Study II showed that couples living with AF experienced uncertainty as the common main concern, rooted in causation of AF and apprehension about AF episodes. The theory of Managing Uncertainty revealed the strategies of explicit sharing (mutual collaboration and finding resemblance) and implicit sharing (keeping distance and tacit understanding). Patients and spouses showed significant differences in terms of self-reported physical and mental health where patients rated themselves lower than spouses did (III). Several actor effects were identified, suggesting that emotional distress affects and is associated with perceived health. Patient partner effects and spouse partner effects were observed for vitality, indicating that higher levels of symptoms of depression in patients and spouses were associated with lower vitality in their partners. In study IV, couples’ core and secondary illness beliefs were revealed. From the core illness belief that “the heart is a representation of life,” two secondary illness beliefs were derived: AF is a threat to life, and AF can and must be explained. From the core illness belief that “change is an integral part of life,” two secondary illness beliefs were derived: AF is a disruption in our lives, and AF will not interfere with our lives. Finally, from the core illness belief that “adaptation is fundamental in life,” two secondary illness beliefs were derived: AF entails adjustment in daily life, and AF entails confidence in and adherence to professional care. In conclusion, the thesis result suggests that illness, in terms of cardiac disease and AF, affected and influenced the couple on aspects such as making sense of AF, responding to AF, and mutually incorporating and dealing with AF in their daily lives. In the light of this, the thesis results suggest that clinicians working with persons with AF and their partners should employ a systemic view with consideration of couple’s reciprocity and interdependence, but also have knowledge regarding AF, in terms of pathophysiology, the nature of AF (i.e., cause, consequences, and trajectory), and treatments. A possible approach to achieve this is a clinical utilization of an FSN based framework, such as the FamHC. Even if a formalized FSN framework is not utilized, partners should not be neglected but, rather, be considered a resource and be a part of clinical caring activities. This could be met by inviting partners to take part in rounds, treatment decisions, discharge calls or follow-up visits or other clinical caring activities. Likewise, interventional studies should include the couple as a unit of analysis as well as the target of interventions.

A literary approach to teaching english language in a multicultural classroom

Literature is not generally considered as a coherent branch of the curriculum in relation to language development in either native or foreign language teaching. As teachers of English in multicultural Indian classrooms, we come across students with varying degrees of competence in English language learning. Although language learning is a natural process for natives, students of other languages put in colossal efforts to learn it. Despite their sincere efforts, they face challenges regarding pronunciation, spelling, and vocabulary. Indian classrooms are a microcosm of the larger society, so teaching English language in a manner that equips the students to face the cutthroat competition has become a necessity and a challenge for English language teachers. English today has become the key determinant for being successful in their careers. The hackneyed and stereotypical methods of teaching are not acceptable now. Teachers are no longer arbitrary dispensers of knowledge, but they are playing the role of a guide and facilitator for the students. Teachers of English are using innovative ideas to make English language teaching and learning interesting and simple. Teachers have started using literary texts and their analyses to explore and ignite the imagination and creative skills of the students. One needs to think and rethink the contribution of literature to intelligent thinking as well as its role in the process of teaching/learning. This article is, therefore, an attempt at exploring the nature of the literary experience in the present-day classrooms and the broader role of literature in life.

Genomics to elucidate the molecular basis of calcific aortic valve disease

Le rétrécissement valvulaire aortique (RVA) est causé par une calcification et une fibrose progressive de la valve aortique. Le risque de développer la maladie augmente avec l’âge. À cause de l’augmentation de l’espérance de vie, le RVA est devenu un problème de santé publique. Le RVA est fatal en absence de traitement médical. Actuellement, la chirurgie est le seul traitement pour le stade sévère de la maladie, mais près de 50% des individus avec RVA n’y sont pas éligibles, principalement due à la présence de comorbidités. Plusieurs processus biologiques ont été associés à la maladie, mais les voies moléculaires spécifiques et les gènes impliqués dans le développement et la progression du RVA ne sont pas connus. Il est donc urgent de découvrir les gènes de susceptibilité pour le RVA afin d’identifier les personnes à risque ainsi que les biomarqueurs et les cibles thérapeutiques pouvant mener au développement de médicaments pour inverser ou limiter la progression de la maladie. L’objectif de cette thèse de doctorat était d’identifier la base moléculaire du RVA. Des approches modernes en génomique, incluant l’étude de gènes candidats et le criblage génomique par association (GWAS), ont été réalisées à l’aide de collections d’ADN provenant d’un grand nombre de patients bien caractérisés pour le RVA. Des études complémentaires en transciptomique ont comparé le profil d’expression global des gènes entre des valves calcifiées et non-calcifiées à l’aide de biopuces à ADN et de séquençage de l’ARN. Une première étude a identifié des variations dans le gène NOTCH1 et suggère pour la première fois la présence d’un polymorphisme commun dans ce gène conférant une susceptibilité au RVA. La deuxième étude a combiné par méta-analyse deux GWAS de patients provenant de la ville de Québec et Paris (France) aux données transcriptomiques. Cette étude de génomique intégrative a confirmé le rôle de RUNX2 dans le RVA et a permis l’identification d’un nouveau gène de susceptibilité, CACNA1C. Les troisième et quatrième études sur l’expression des gènes ont permis de mieux comprendre les bases moléculaires de la calcification des valves aortiques bicuspides et ainsi d’identifier de nouvelles cibles thérapeutiques pour le RVA. Les données générées par ce projet sont la base de futures découvertes importantes qui permettront d’améliorer les options de traitement et la qualité de vie des patients atteints du RVA.

A conservation trade-off? Interspecific differences in seahorse responses to experimental changes in fishing effort

1. A 2-year experimental seining programme and underwater visual censuses were undertaken to quantify the direct effects of active demersal fishing on the population structure and relative abundance of two sympatric seahorse species of conservation concern: the European long-snouted seahorse, Hippocampus guttulatus Cuvier 1829 and the short-snouted seahorse, Hippocampus hippocampus L. The influence of habitat preference on population-level responses to changes in habitat structure following a reduction in fishing effort was also investigated. 2. It was predicted that the benthic habitat would be more structurally complex after fishing ceased and that seahorse densities would increase in response to reduced fishing mortality. Furthermore, it was predicted that the magnitude of the increase in density would be greater for H. guttulatus than for H. hippocampus, because the former species prefers complex vegetated habitats while the latter species uses sparsely vegetated habitats. 3. As predicted, the amount of habitat cover increased significantly when seining ceased, primarily through increases in the abundance of drifting macroalgae and unattached invertebrates. Despite similarities in life histories, the two seahorse species responded differently in terms of magnitude and direction to reduced fishing effort: the abundance of H. guttulatus increased significantly while H. hippocampus decreased in abundance. 4. Results suggest that active demersal fishing may influence the magnitude and direction of the responses of benthic marine fishes to exploitation through its impacts on habitat structure. An increase in habitat cover appeared to favour higher densities of H. guttulatus when seining effort was reduced. By contrast, repeated seining, which maintained less complex habitats, appeared to favour greater abundances of H. hippocampus. 5. Given differences in habitat preference among benthic marine fishes subject to incidental capture in fisheries, simultaneous attempts to manage populations of sympatric species may require complementary strategies that support the persistence of diverse habitat types. Copyright (c) 2006 John Wiley & Sons, Ltd.

Epidemiological studies of Johne’s Disease in cattle from Scottish farms, with a focus on slaughterhouse investigations

The PARABAN project has been a Scotland-wide initiative to develop and deliver farm-specific ‘best practice’ for the control of Mycobacterium avium ssp. paratuberculosis (MAP) in cattle using ‘Knowledge Exchange’. A range of partners have been involved, including nine ‘Champion Farms’. With input from the farmer, his/her vet and PARABAN advisors, a tailored monitoring and control programme was devised for each ‘Champion Farm’, taking into account the history of the disease on the farm, the physical facilities available and farmer objectives. Culling decisions based on live animal test results were incorporated into each farm-specific programme to complement the management programme already in place to maintain each herd. Results were analysed and discussed with all the partners throughout the project and then offered for wider scrutiny at farm open days. Feedback and questions from these open days have been used to complete the ‘Knowledge Exchange’ cycle. As a major component of the PARABAN project the author collected samples from all adult animals culled from ‘Champion Farms’ at slaughter or as fallen stock, irrespective of in-life MAP test status. These were then subjected to histopathological examination by experienced veterinary pathologists and the results compared with the results from in-life MAP testing. This was intended to evaluate the contribution slaughterhouse sampling could make towards decision making for disease control on farm and formed the main aim of this thesis. In total, samples of terminal ileum and draining lymph node were collected from three-hundred and fifty-two animals. A positive result on histopathology was defined as the presence of lesions typical of MAP and also the presence of acid-fast bacteria within the sections. There was found to be fair agreement between the overall results from histopathology and serum ELISA (Kappa = 0.33), though there appeared to be some variation in agreement between the tests on the individual ‘Champion Farms’. The presence of MAP was confirmed in seven of the eight farms which contributed animals to this study, despite sometimes prolonged efforts at controlling the disease. A separate study was undertaken to make use of the archives of the Scottish Centre for Production Animal Health and Food Safety at the Veterinary School, University of Glasgow. The archive contained records of cases from across southern Scotland and northern England. Analysis of the data generated from examination of these records suggested that MAP is widespread within the Scottish cattle herd and may well be increasing

Estereotipos sobre el envejecimiento según el periodo del desarrollo y el género

Teniendo en cuenta el drástico aumento en Colombia y el mundo de la población adulta mayor la pirámide poblacional se ha invertido. Lo que ha generado que cada vez haya más adultos mayores y la esperanza de vida sea mayor. Motivo por el cual surge la importancia de conocer diversos aspectos del envejecimiento, entre ellos los estereotipos. Adicionalmente hay muy poca investigación relacionada con los estereotipos sobre el envejecimiento según el género y el periodo de desarrollo. Levy (2009) encontró que son los jóvenes quienes tienen más estereotipos negativos sobre el envejecimiento pues estos sienten que la vejez está muy lejos de su realidad actual y no es en una amenaza personal. Por otro lado Bodner, Bergman y Cohen (2012), encontraron que son los hombres quienes tienen más estereotipos negativos sobre el envejecimiento. La presente investigación tuvo como objetivo describir el efecto del periodo del desarrollo y el género en los estereotipos sobre el envejecimiento en 860 adultos colombianos. Se midió la variable de estereotipos sobre el envejecimiento a través del cuestionario de Ramírez y Palacios (2015) y el periodo del desarrollo y el género a través de un cuestionario de datos sociodemograficos. Contrario a lo esperado, los resultados mostraron que no existe relación entre los estereotipos negativos con el género, el periodo del desarrollo, ni en la interacción de estos. En cambio, se encontraron diferencias entre los estereotipos positivos el género y el periodo de desarrollo. Se considera importante continuar realizando investigaciones relacionadas con esta temática pues cada vez son más los adultos mayores y la manera en que nos relacionemos con ellos, va a determinar un mejor proceso de envejecimiento para ellos.

Life Design Counseling: A study on client's operations for meaning construction

This study evaluates the adequacy of the micro-theory of client operations to explain meaning construction in Life Design Counseling. Four adolescents were interviewed on their second counseling session. Their recollections were stimulated through the replay of counseling videotapes and the resulting transcribed interviews were qualitatively analyzed. Results confirmed a sequence of client operations evolving from the symbolic representation of experience and reflexive self-examination towards making new realizations and revisioning self. Moreover, clients reported negative and positive session moments evidencing that clients’ attention and activity during the session was not restricted to meaning construction operations. Practical implications for life design counseling are derived from the results and discussed.

Learning Process in Teaching and Bio-pedagogical Knowledge Building

Bio-pedagogy is built on praxis, i.e. the interrelationship between reflection and innovative action where these two merge in the construction of senses to generate knowledge. Then, the following question arises: How is teaching understood? How can practice be renovated from the action-reflection-action in a recurring manner and in life itself? A way to search for those answers is the systematization of experiences –a modality of qualitative research. It promotes the transformation of a common practice, based on knowledge building by holistic approaches to the educational process complexity. The systematization of bio-pedagogical experiences involves self-organization, joy, uncertainty and passion; it respects freedom and autonomy, and generates relational spaces, which promote creative processes in learning.

A single nucleotide polymorphism in NEUROD1 is associated with production traits in nelore beef cattle.

Feed efficiency and carcass characteristics are late-measured traits. The detection of molecular markers associated with them can help breeding programs to select animals early in life, and to predict breeding values with high accuracy. The objective of this study was to identify polymorphisms in the functional and positional candidate gene NEUROD1 (neurogenic differentiation 1), and investigate their associations with production traits in reference families of Nelore cattle. A total of 585 steers were used, from 34 sires chosen to represent the variability of this breed. By sequencing 14 animals with extreme residual feed intake (RFI) values, seven single nucleotide polymorphisms (SNPs) in NEUROD1 were identified. The investigation of marker effects on the target traits RFI, backfat thickness (BFT), ribeye area (REA), average body weight (ABW), and metabolic body weight (MBW) was performed with a mixed model using the restricted maximum likelihood method. SNP1062, which changes cytosine for guanine, had no significant association with RFI or REA. However, we found an additive effect on ABW (P ≤ 0.05) and MBW (P ≤ 0.05), with an estimated allele substitution effect of -1.59 and -0.93 kg0.75, respectively. A dominant effect of this SNP for BFT was also found (P ≤ 0.010). Our results are the first that identify NEUROD1 as a candidate that affects BFT, ABW, and MBW. Once confirmed, the inclusion of this SNP in dense panels may improve the accuracy of genomic selection for these traits in Nelore beef cattle as this SNP is not currently represented on SNP chips.

REVISTING A CHIMBOTE – TRANSLATION CULTURAL IN ARGUEDAS

José María Arguedas was a privileged peruvian writer for knowing two worlds, two cultures. His book El Zorro de arriba y el Zorro de abajo is one of the most unique and emblematic of Latin American literature. As a cultural mediator, Arguedas chronicles the changes in Chimbote. This microcosm is recognized by the reader through the polyphony of voices and records of their marginal characters. His cultural translation excels revealing their heterogeneity. In the book of Arguedas, as in life, is exposed the impossibility of harmonious coexistence between the two cultures. Through the position of Arguedas and opinions Moreiras, question the Rama theory of transculturation. Through an ethical stance, Arguedas is considered one of the most representative writers of the Andean context and Latin América.

THE DOUBLE AND THE OTHERNESS IN “O CÍRCULO”, BY RUTH LAUS

This article aims to approach the issue of deployment of the self in the short story "O círculo", by Ruth Laus, through the figure of the character Paula and the pursuit of her double. The study of the female character, while literary representation, and related to the duplicity, is associated with issues related to identity and the construction of the self, from an internal scission, allowing therefore to examine the representation of the double, permeated by issues related to otherness, especially regarding to the maintenance of subjectivity in the search of the Other as an extension of the self. The double, in turn, is established as the phenomenon able to settle an active connection with the world, the dialectic condition of the creature, as a way of affirmation from the conception of (re)cognition of the Other as a link between past-present-future in the (re)construction of the unit and establishment of the balance. For the character Paula the element that indicates the division of her personality is the aborted fetus and thenceforth begins the maintenance of the inner Self of the protagonist: find what from her was split.