Cuba, 1835 (Image 2 of 6) (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Carta geogro. topográfica de la isla de Cuba : dedicanla a la Reyna Nuestra Señora Doñ a Isabel II, El Teniente General Conde de Cuba y la Comisión de Gefes y Oficiales Militares y de Agrimensores Públicos que la levantó y formó de su orden en los años de 1824 á 1831/Do. Estruch lo grabó en Barcelona 1835 ; Carlos Roca lo dibujó. It was published in 1835. Scale [ca. 1:325,000]. This layer is image 2 of 6 total images of the six sheet source map. Map in Spanish.The image inside the map neatline is georeferenced to the surface of the earth and fit to the World Mercator project coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as drainage, cities and other human settlements, roads, shoreline features, and more. Relief shown by hachures, depths by soundings. Includes also indexes, table of distances, statistical tables, and insets: "Plano de la ciudad y puerto de La Habana" [ca. 1:16.000]. -- "Plano de la ciudad y bahía de Sn. Carlos de Matanzas" [ca. 1:14.500]. -- "Ciudad de Sta. María del Puerto Principe" [ca. 1:16.000]. -- "Plano de la ciudad de Santiago de Cuba" [ca. 1:16.000] -- "Plano de la bahía de Cuba" [ca. 1:48.000]. -- "Plano de la ciudad de Trinidad" [ca. 1:16.000]. -- "Puerto de Casilda" [ca. 1:43.000].This layer is part of a selection of digitally scanned and georeferenced historic maps from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of originators, ground condition dates, scales, and map purposes.

Cuba, 1835 (Image 3 of 6) (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Carta geogro. topográfica de la isla de Cuba : dedicanla a la Reyna Nuestra Señora Doñ a Isabel II, El Teniente General Conde de Cuba y la Comisión de Gefes y Oficiales Militares y de Agrimensores Públicos que la levantó y formó de su orden en los años de 1824 á 1831/Do. Estruch lo grabó en Barcelona 1835 ; Carlos Roca lo dibujó. It was published in 1835. Scale [ca. 1:325,000]. This layer is image 3 of 6 total images of the six sheet source map. Map in Spanish.The image inside the map neatline is georeferenced to the surface of the earth and fit to the World Mercator project coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as drainage, cities and other human settlements, roads, shoreline features, and more. Relief shown by hachures, depths by soundings. Includes also indexes, table of distances, statistical tables, and insets: "Plano de la ciudad y puerto de La Habana" [ca. 1:16.000]. -- "Plano de la ciudad y bahía de Sn. Carlos de Matanzas" [ca. 1:14.500]. -- "Ciudad de Sta. María del Puerto Principe" [ca. 1:16.000]. -- "Plano de la ciudad de Santiago de Cuba" [ca. 1:16.000] -- "Plano de la bahía de Cuba" [ca. 1:48.000]. -- "Plano de la ciudad de Trinidad" [ca. 1:16.000]. -- "Puerto de Casilda" [ca. 1:43.000].This layer is part of a selection of digitally scanned and georeferenced historic maps from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of originators, ground condition dates, scales, and map purposes.

Cuba, 1835 (Image 4 of 6) (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Carta geogro. topográfica de la isla de Cuba : dedicanla a la Reyna Nuestra Señora Doñ a Isabel II, El Teniente General Conde de Cuba y la Comisión de Gefes y Oficiales Militares y de Agrimensores Públicos que la levantó y formó de su orden en los años de 1824 á 1831/Do. Estruch lo grabó en Barcelona 1835 ; Carlos Roca lo dibujó. It was published in 1835. Scale [ca. 1:325,000]. This layer is image 4 of 6 total images of the six sheet source map. Map in Spanish.The image inside the map neatline is georeferenced to the surface of the earth and fit to the World Mercator project coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as drainage, cities and other human settlements, roads, shoreline features, and more. Relief shown by hachures, depths by soundings. Includes also indexes, table of distances, statistical tables, and insets: "Plano de la ciudad y puerto de La Habana" [ca. 1:16.000]. -- "Plano de la ciudad y bahía de Sn. Carlos de Matanzas" [ca. 1:14.500]. -- "Ciudad de Sta. María del Puerto Principe" [ca. 1:16.000]. -- "Plano de la ciudad de Santiago de Cuba" [ca. 1:16.000] -- "Plano de la bahía de Cuba" [ca. 1:48.000]. -- "Plano de la ciudad de Trinidad" [ca. 1:16.000]. -- "Puerto de Casilda" [ca. 1:43.000].This layer is part of a selection of digitally scanned and georeferenced historic maps from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of originators, ground condition dates, scales, and map purposes.

Cuba, 1835 (Image 5 of 6) (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Carta geogro. topográfica de la isla de Cuba : dedicanla a la Reyna Nuestra Señora Doñ a Isabel II, El Teniente General Conde de Cuba y la Comisión de Gefes y Oficiales Militares y de Agrimensores Públicos que la levantó y formó de su orden en los años de 1824 á 1831/Do. Estruch lo grabó en Barcelona 1835 ; Carlos Roca lo dibujó. It was published in 1835. Scale [ca. 1:325,000]. This layer is image 5 of 6 total images of the six sheet source map. Map in Spanish.The image inside the map neatline is georeferenced to the surface of the earth and fit to the World Mercator project coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as drainage, cities and other human settlements, roads, shoreline features, and more. Relief shown by hachures, depths by soundings. Includes also indexes, table of distances, statistical tables, and insets: "Plano de la ciudad y puerto de La Habana" [ca. 1:16.000]. -- "Plano de la ciudad y bahía de Sn. Carlos de Matanzas" [ca. 1:14.500]. -- "Ciudad de Sta. María del Puerto Principe" [ca. 1:16.000]. -- "Plano de la ciudad de Santiago de Cuba" [ca. 1:16.000] -- "Plano de la bahía de Cuba" [ca. 1:48.000]. -- "Plano de la ciudad de Trinidad" [ca. 1:16.000]. -- "Puerto de Casilda" [ca. 1:43.000].This layer is part of a selection of digitally scanned and georeferenced historic maps from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of originators, ground condition dates, scales, and map purposes.

Cuba, 1835 (Image 6 of 6) (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Carta geogro. topográfica de la isla de Cuba : dedicanla a la Reyna Nuestra Señora Doñ a Isabel II, El Teniente General Conde de Cuba y la Comisión de Gefes y Oficiales Militares y de Agrimensores Públicos que la levantó y formó de su orden en los años de 1824 á 1831/Do. Estruch lo grabó en Barcelona 1835 ; Carlos Roca lo dibujó. It was published in 1835. Scale [ca. 1:325,000]. This layer is image 6 of 6 total images of the six sheet source map. Map in Spanish.The image inside the map neatline is georeferenced to the surface of the earth and fit to the World Mercator project coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as drainage, cities and other human settlements, roads, shoreline features, and more. Relief shown by hachures, depths by soundings. Includes also indexes, table of distances, statistical tables, and insets: "Plano de la ciudad y puerto de La Habana" [ca. 1:16.000]. -- "Plano de la ciudad y bahía de Sn. Carlos de Matanzas" [ca. 1:14.500]. -- "Ciudad de Sta. María del Puerto Principe" [ca. 1:16.000]. -- "Plano de la ciudad de Santiago de Cuba" [ca. 1:16.000] -- "Plano de la bahía de Cuba" [ca. 1:48.000]. -- "Plano de la ciudad de Trinidad" [ca. 1:16.000]. -- "Puerto de Casilda" [ca. 1:43.000].This layer is part of a selection of digitally scanned and georeferenced historic maps from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of originators, ground condition dates, scales, and map purposes.

Análise do regime de produção distribuída fotovoltaica para autoconsumo

Tese de mestrado integrado em Engenharia da Energia e do Ambiente, apresentada à Universidade de Lisboa, através da Faculdade de Ciências, 2016

Violência conjugal: dados sócio-demográficos, comportamentos e crenças associados: fragmentos de um amor menor

A violência doméstica tornou-se um fenómeno social de grande complexidade, que não pode ser tratado de forma superficial, seja por parte daqueles que intervêm tecnicamente, seja por parte das vítimas e agressores, pois trata-se da vida real de muitos indivíduos ou sujeitos. Deste modo, tornou-se necessário analisar a violência doméstica, procurando perceber o papel dos agentes, em especial dos técnicos, que acompanham as vítimas de violência doméstica na construção do seu projecto de vida. Para a realização deste estudo, fiz uma abordagem dos diferentes conceitos de violência doméstica, fundamental neste trabalho, em virtude da complexidade e controvérsia que a sua definição implica para diferentes autores e abordagens teóricas. Naturalmente que, se o tema da violência doméstica atravessa todo o trabalho, era indispensável ouvir as vítimas desta problemática quanto ao seu sofrimento, coragem e resiliência, ou abandono do lar e acompanhamento recebido. Assim sendo, e porque pretendi fazer uma análise à forma como é realizado o acompanhamento e intervenção por parte dos técnicos, este trabalho apresenta ainda uma investigação empírica realizada através da aplicação de inquéritos por questionário vítimas e não vítimas de violência doméstica, bem como a caracterização dos dados sociodemográficos do distrito de Portalegre. O tratamento e análise dos dados permitiram confirmar, em larga medida, a fundamentação teórica apresentada na primeira parte do estudo onde se verificou haver a divergência no conceito de violência doméstica, as vítimas serem predominantemente do sexo feminino e os agressores do sexo masculino, os vários motivos que levam as vítimas a permanecer na relação e a importância do papel dos técnicos de acompanhamento na definição de projectos de vida alternativos.

Therapeutic Streetscapes: A New Bell Street Designed to Accommodate Those on the Autism Spectrum

Thesis (Master's)--University of Washington, 2016-06

The measurement of nicotine in human plasma by high-performance liquid chromatography-electrospray-tandem mass spectrometry

The authors describe a reverse-phase high-performance liquid chromatography-electrospray-tandem mass spectrometry method for the measurement of nicotine in human plasma. Samples (500 muL) with added deuterium-labeled d(3)-nicotine as an internal standard (IS) were treated with a 2-step process of ether extraction (6 mL) followed by back-extraction into 0.1% formic acid (50 muL). Chromatography was performed on a phenyl Novapak column with a mobile phase consisting of 50% 10 mM ammonium fortriate (pH 3.3) and acetonitrile (50:50, vol/vol). A flow rate of 0.2 mL/min resulted in a total analysis time of 5 minutes per sample. Mass spectrometric detection was by selected reactant monitoring (nicotine m/z 163.2 --> 130.2; IS m/z 166.2 --> 87.2). The assay was linear from 0.5 to 100 mug/L (r > 0.993, n = 9). The accuracy and imprecision of the method for quality control sampleswere 87.5% to 113% and < 10.2%, respectively. Interday accuracy and imprecision at the limit of quantification (0.5 mug/L) was 113% and 7.2% (n = 4). The process efficiency for nicotine in plasma was > 75%. The method described has good process efficiency, stabilized nicotine, avoided concentration steps, and most importantly minimized potential contamination. Further, we have established that water-based standards and controls are interchangeable with plasma-based samples. This method was used successfully to measure the pharmacokinetic profiles of subjects involved in the development of an aerosol inhalation drug delivery system.

A low-profile dual-band antenna for a wireless LAN access point

The design of dual-band 2.45/5.2 GHz antenna for an acces point of a Wireless Local Area Network (LAN) is presented. The proposed antenna is formed by a Radial Line Slot Array (RLSA) operating at 2.4 GHz and a Microstrip patch working at 5.2 GHz, both featuring circular polarization. The design of this antenna system is accomplished using commercially available Finite Element software. High Frequency Structure Simulator (HFSS) of Ansoft and an in-house developed iteration procedure. The performance of the designed antenna is assessed in terms of return loss (RL), radiation pattern and polarization purity in the two frequency bands.

Super-fast scanning technique for phased array weather radar aplications

The authors present a super-fast scanning (SFS) technique for phased array weather radar applications. The fast scanning feature of the SFS technique is described and its drawbacks identified. Techniques which combat these drawbacks are also presented. A concept design phased array radar system (CDPAR) is used as a benchmark to compare the performance of a conventional scanning phased array radar system with the SFS technique. It is shown that the SFS technique, in association with suitable waveform processing, can realise four times the scanning speed and achieve similar accuracy compared to the conventional phased array benchmark.

Increased adjuvant activity of minimal CD8 T cell peptides incorporated into lipid-core-peptides

A problem facing the use of subunit peptide and protein vaccines is their inability to stimulate protective immune responses. Many different approaches have been utilized to overcome this inefficient immune activation. The approach we have taken is to modify the vaccine antigen so that it now has adjuvant properties. To do this, multiple copies of minimal CD8 T cell epitopes were attached to a poly lysine lipid core. These constructs are known as lipid-core-peptides (LCP). The research presented here examines the adjuvant activity of LCP. Using mouse models, we were able to show that LCP were indeed able to activate antigen-presenting cells in vitro and to activate cytotoxic T-cell responses in vivo. More importantly, LCP were able to stimulate the development of a protective antitumour immune response.

Activation of dendritic cells by human papillomavirus-like particles through TLR4 and NF-B-mediated signalling, moderated by TGF-beta

Human papillomavirus-like particles (HPV-VLP) are a candidate vaccine for prevention of HPV infection, and also are a candidate for an immunogenic delivery system for incorporated antigen. VLP activate in vitro generated dendritic cells (DC) but not Langerhans cells (LC); however, the mechanism of this activation is unknown. We have shown that uptake and activation of DC by VLP involves proteoglycan receptors and can be inhibited by heparin. Heparin has been shown to activate DC by signalling through Toll-like receptor 4 (TLR4) and nuclear factor (NF)-kappaB. The pathway of DC activation by VLP was further investigated in the present study. Exposure to VLP induced costimulatory molecule expression, RelB translocation and IL-10 production by DC but not by LC. The lack of LC activation was reversible when TGF-beta was removed from the LC medium. VLP-induced induction of costimulatory molecule expression, RelB activation and cytokine secretion by DC was blocked by inhibition of NF-kappaB activation, heparin or TLR4 mAb. The data provide evidence that HPV-VLP signal DC through a pathway involving proteoglycan receptors, TLR4 and NF-kappaB, and shed light on the mechanism by which VLP stimulate immunity in the absence of adjuvants in vivo. LC may resist activation in normal epithelium abundant in TGF-beta, but not in situations in which TGF-beta concentrations are reduced.

Synthesis of a highly pure lipid core peptide based self-adjuvanting triepitopic group A Streptococcal vaccine, and subsequent immunological evaluation

We have developed a highly pure, self-adjuvanting, triepitopic Group A Streptococcal vaccine based on the lipid core peptide system, a vaccine delivery system incorporating lipidic adjuvant, carrier, and peptide epitopes into a single molecular entity. Vaccine synthesis was performed using native chemical ligation. Due to the attachment of a highly lipophilic adjuvant, addition of 1% (w/v) sodium dodecyl sulfate was necessary to enhance peptide solubility in order to enable ligation. The vaccine was synthesized in three steps to yield a highly pure product (97.7% purity) with an excellent overall yield. Subcutaneous immunization of B10. BR (H-2(k)) mice with the synthesized vaccine, with or without the addition of complete Freund's adjuvant, elicited high serum IgG antibody titers against each of the incorporated peptide epitopes.

Investigations into a dual band 2.4/5.2GHz antenna for WLAN applications

The design of a dual-band 2.45/5.2 GHz antenna for an access point of a wireless local area network (WLAN) is presented. The proposed antenna is formed by an assembly of a radial line slot array (RLSA) operating at 2.4 GHz and a microstrip patch working at 5.2 GHz. The design of this antenna system is accomplished using commercially available finite element software, high frequency structure simulator (HFSS), of Ansoft. The performance of the designed antenna is assessed in terms of return loss (RL), radiation pattern and polarization purity in the two investigated frequency bands.