Towards tailored radiopeptide therapy.

PURPOSE Somatostatin receptor-targeted radiopeptide therapy is commonly performed using single radioisotopes. We evaluated the benefits and harms of combining radioisotopes in radiopeptide therapy in patients with neuroendocrine tumor. METHODS Using multivariable-adjusted survival analyses and competing risk analyses we evaluated outcomes in patients with neuroendocrine tumor receiving (90)Y-DOTATOC, (177)Lu-DOTATOC or their combination. RESULTS (90)Y-DOTATOC plus (177)Lu-DOTATOC treatment was associated with longer survival than (90)Y-DOTATOC (66.1 vs. 47.5 months; n = 1,358; p < 0.001) or (177)Lu-DOTATOC alone (66.1 vs. 45.5 months; n = 390; p < 0.001). (177)Lu-DOTATOC was associated with longer survival than (90)Y-DOTATOC in patients with solitary lesions (HR 0.3, range 0.1 - 0.7; n = 153; p = 0.005), extrahepatic metastases (HR 0.5, range 0.3 - 0.9; n = 256; p = 0.029) and metastases with low uptake (HR 0.1, range 0.05 - 0.4; n = 113; p = 0.001). (90)Y-DOTATOC induced higher hematotoxicity rates than combined treatment (9.5% vs. 4.0%, p = 0.005) or (177)Lu-DOTATOC (9.5 vs. 1.4%, p = 0.002). Renal toxicity was similar among the treatments. CONCLUSIONS Using (90)Y and (177)Lu might facilitate tailoring radiopeptide therapy and improve survival in patients with neuroendocrine tumors.

A systematic review of glomerular hyperfiltration assessment and definition in the medical literature.

BACKGROUND AND OBJECTIVES Evaluation of glomerular hyperfiltration (GH) is difficult; the variable reported definitions impede comparisons between studies. A clear and universal definition of GH would help in comparing results of trials aimed at reducing GH. This study assessed how GH is measured and defined in the literature. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS Three databases (Embase, MEDLINE, CINAHL) were systematically searched using the terms "hyperfiltration" or "glomerular hyperfiltration". All studies reporting a GH threshold or studying the effect of a high GFR in a continuous manner against another outcome of interest were included. RESULTS The literature search was performed from November 2012 to February 2013 and updated in August 2014. From 2013 retrieved studies, 405 studies were included. Threshold use to define GH was reported in 55.6% of studies. Of these, 88.4% used a single threshold and 11.6% used numerous thresholds adapted to participant sex or age. In 29.8% of the studies, the choice of a GH threshold was not based on a control group or literature references. After 2004, the use of GH threshold use increased (P<0.001), but the use of a control group to precisely define that GH threshold decreased significantly (P<0.001); the threshold did not differ among pediatric, adult, or mixed-age studies. The GH threshold ranged from 90.7 to 175 ml/min per 1.73 m(2) (median, 135 ml/min per 1.73 m(2)). CONCLUSION Thirty percent of studies did not justify the choice of threshold values. The decrease of GFR in the elderly was rarely considered in defining GH. From a methodologic point of view, an age- and sex-matched control group should be used to define a GH threshold.

Arrigo Minerbi

Guido Lodovico Luzzatto

Ein schön Catholisch Gebett : Zu dem H. Bischoff S. Erhardo. Zu Ehren der Hochwürdigen in Gott Frawen, Frawen ANNE MARIE, Aebbtissin deß ... Stiffts unnd Klosters Niderminster in Regenspurg

Durch Johan Sigismund Brechtel

Warhafftige Abbildung deß Flecken Plurs, in Grawen Bündten gelegen : wie solcher noch in Flor gewesen, Und auch, wie solcher nach seinem schröcklichen Untergang anzusehen

Auf der zweiten Ill. war wohl der Zustand nach dem Bergrutsch dargestellt

Bericht auff dis neben gestelt bilde : von wegen des Aderlassens, welche Ader, vnd wo man die selben, in Zeit der Pestilentz ... zulassen pflegt, vnd lassen soll

Bibliogr. Nachweis: Strauss SLW 1550-1600, S. 826

Bethlen Gabors Blutfahnen : Welchen derselbige zu Newsol von rohtem Damaschket machen ; mit gegenwertigen Figuren vnd Worten mahlen ; vnd dem Emerico Turczo als Landfenderichen solenniter überlieffern lassen

Betr. auch Graf Emmerich Thurzo, gest. um 1620

Echo Christiana : Zu Lob vnd Ehren dem frölichen Geburtstag, vnsers Einigen Erlösers vnnd Seligmachers Jesu Christi, Gottes vnd Marien Sohn

Bibliograph. Nachweis: Harms, Dt. Illustr. Flugbl., III, 10 (Ausg. 1619); Straus, German single-leaf woodcut 1600-1700, p. 202 (Ausg. 1607)

Wie der Durchleuchtigste vnd Hochgeborne Fürst vnd Herr, Herr Friderich, dieses Namens der V. Pfaltzgraff bey Rhein, Hertzog in Ober vnd Nider Beyern ... zum König in Böheimb zu Prag gesalbet, confirmirt, vnd gecrönet worden

Bibliograph. Nachweis: VD 17 39:124403C ; Paas P-439

Duabus, Tribus, Quatuor, Quinque, Sex, et Octo, Una cum Psalmo Miserere Mei Deus, Octo vocibus continens : cum basso continuo & generali, organi applicato ; opus secundum

Digitalisat des Exemplars Mus W 47 Nr. 2

Ms. lat. oct. 72 - Philosophia peripatetica qua praecipua Aristotelis Stagiritae dogmata summarie continentur, Tractatus I - VI

Vorbesitzer: Peter Schick

Duabus, Tribus, Quatuor, Quinque, Sex, et Octo, Una cum Psalmo Miserere Mei Deus, Octo vocibus continens : cum basso continuo & generali, organi applicato ; opus secundum

Enth.: S, A, T, B, org