Towards tailored radiopeptide therapy.
Data(s) |
01/07/2015
|
---|---|
Resumo |
PURPOSE Somatostatin receptor-targeted radiopeptide therapy is commonly performed using single radioisotopes. We evaluated the benefits and harms of combining radioisotopes in radiopeptide therapy in patients with neuroendocrine tumor. METHODS Using multivariable-adjusted survival analyses and competing risk analyses we evaluated outcomes in patients with neuroendocrine tumor receiving (90)Y-DOTATOC, (177)Lu-DOTATOC or their combination. RESULTS (90)Y-DOTATOC plus (177)Lu-DOTATOC treatment was associated with longer survival than (90)Y-DOTATOC (66.1 vs. 47.5 months; n = 1,358; p < 0.001) or (177)Lu-DOTATOC alone (66.1 vs. 45.5 months; n = 390; p < 0.001). (177)Lu-DOTATOC was associated with longer survival than (90)Y-DOTATOC in patients with solitary lesions (HR 0.3, range 0.1 - 0.7; n = 153; p = 0.005), extrahepatic metastases (HR 0.5, range 0.3 - 0.9; n = 256; p = 0.029) and metastases with low uptake (HR 0.1, range 0.05 - 0.4; n = 113; p = 0.001). (90)Y-DOTATOC induced higher hematotoxicity rates than combined treatment (9.5% vs. 4.0%, p = 0.005) or (177)Lu-DOTATOC (9.5 vs. 1.4%, p = 0.002). Renal toxicity was similar among the treatments. CONCLUSIONS Using (90)Y and (177)Lu might facilitate tailoring radiopeptide therapy and improve survival in patients with neuroendocrine tumors. |
Formato |
application/pdf |
Identificador |
http://boris.unibe.ch/76677/1/Towards%20Tailored%20Radiopeptide%20Therapy.pdf Radojewski, Piotr; Dumont, Rebecca; Marincek, Nicolas; Brunner, Philippe; Mäcke, Helmut R; Müller-Brand, Jan; Briel, Matthias; Walter, Martin Alexander (2015). Towards tailored radiopeptide therapy. European journal of nuclear medicine and molecular imaging, 42(8), pp. 1231-1237. Springer 10.1007/s00259-015-3030-9 <http://dx.doi.org/10.1007/s00259-015-3030-9> doi:10.7892/boris.76677 info:doi:10.1007/s00259-015-3030-9 info:pmid:25792454 urn:issn:1619-7070 |
Idioma(s) |
eng |
Publicador |
Springer |
Relação |
http://boris.unibe.ch/76677/ |
Direitos |
info:eu-repo/semantics/restrictedAccess |
Fonte |
Radojewski, Piotr; Dumont, Rebecca; Marincek, Nicolas; Brunner, Philippe; Mäcke, Helmut R; Müller-Brand, Jan; Briel, Matthias; Walter, Martin Alexander (2015). Towards tailored radiopeptide therapy. European journal of nuclear medicine and molecular imaging, 42(8), pp. 1231-1237. Springer 10.1007/s00259-015-3030-9 <http://dx.doi.org/10.1007/s00259-015-3030-9> |
Palavras-Chave | #610 Medicine & health |
Tipo |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion PeerReviewed |