The Bell System technical journal

Mode of access: Internet.

Report of the Commission on the Foreign Service Personnel System /

"June 1989."

Lessons from European schools and the American centennial.

"The metric system," p. [21]-58.

An improved personnel system for the conduct of foreign affairs; a report to the Secretary of State.

Mode of access: Internet.

The American commonwealth,

I. The national government. II. The state governments. The party system. The party system (contin.) III. Public opinion. Illustrations and reflections. Social institutions.

An American text-book of physiology,

Vol. 2 has imprint: Philadelphia and London ...

Introduction to philosophy : an inquiry after a rational system of scientific principles in their relation to ultimate reality /

Mode of access: Internet.

The American Nation: a history from original sources by associated scholars;

Vols. 1, 3-12, 14-16, 18-20, 22, 25-27 have no date on t. p.

Wildlife and America : contributions to an understanding of American wildlife and its conservation /

Cosponsored by U.S. Fish and Wildlife Service, Forest Service, and the National Oceanic and Atmospheric Administration.

The Federal role in the federal system : the dynamics of growth.

"A-77 - A-87."

Is Crimea Kosovo? Fundamental Misunderstandings and Failed Diplomacy Between Russia and the West in the Post-Cold War International System

Thesis (Master's)--University of Washington, 2016-06

Mental Health Experiences within the Hmong American LGBTQ Community: A Qualitative Research Project

Thesis (Master's)--University of Washington, 2016-06

Spin squeezing as a measure of entanglement in a two-qubit system

We show that the two definitions of spin squeezing extensively used in the literature [M. Kitagawa and M. Ueda, Phys. Rev. A 47, 5138 (1993) and D.J. Wineland , Phys. Rev. A 50, 67 (1994)] give different predictions of entanglement in the two-atom Dicke system. We analyze differences between the definitions and show that the spin squeezing parameter of Kitagawa and Ueda is a better measure of entanglement than the commonly used spectroscopic spin squeezing parameter. We illustrate this relation by examining different examples of a driven two-atom Dicke system in which spin squeezing and entanglement arise dynamically. We give an explanation of the source of the difference using the negativity criterion for entanglement.

Potential of lipid core peptide technology as a novel self-adjuvanting vaccine delivery system for multiple different synthetic peptide immunogens

This study demonstrates the effectiveness of a novel self-adjuvanting vaccine delivery system for multiple different synthetic peptide immunogens by use of lipid core peptide (LCP) technology. An LCP formulation incorporating two different protective epitopes of the surface antiphagocytic M protein of group A streptococci (GAS)-the causative agents of rheumatic fever and subsequent rheumatic heart disease-was tested in a murine parenteral immunization and GAS challenge model. Mice were immunized with the LCP-GAS formulation, which contains an M protein amino-terminal type-specific peptide sequence (8830) in combination with a conserved non-host-cross-reactive carboxy-terminal C-region peptide sequence (J8) of the M protein. Our data demonstrated immunogenicity of the LCP-8830-J8 formulation in B10.BR mice when coadministered in complete Freund's adjuvant and in the absence of a conventional adjuvant. In both cases, immunization led to induction of high-titer GAS peptide-specific serum immunoglobulin G antibody responses and induction of highly opsonic antibodies that did not cross-react with human heart tissue proteins. Moreover, mice were completely protected from GAS infection when immunized with LCP-8830-J8 in the presence or absence of a conventional adjuvant. Mice were not protected, however, following immunization with an LCP formulation containing a control peptide from a Schistosoma sp. These data support the potential of LCP technology in the development of novel self-adjuvanting multi-antigen component vaccines and point to the potential application of this system in the development of human vaccines against infectious diseases.

Effector ExoU from the type III secretion system is an important modulator of gene expression in lung epithelial cells in response to Pseudomonas aeruginosa infection

Pseudomonas aeruginosa is an important pathogen in immunocompromised patients and secretes a diverse set of virulence factors that aid colonization and influence host cell defenses. An important early step in the establishment of infection is the production of type III-secreted effectors translocated into host cells by the bacteria. We used cDNA microarrays to compare the transcriptomic response of lung epithelial cells to P. aeruginosa mutants defective in type IV pili, the type III secretion apparatus, or in the production of specific type III-secreted effectors. Of the 18,000 cDNA clones analyzed, 55 were induced or repressed after 4 It of infection and could be classified into four different expression patterns. These include (i) host genes that are induced or repressed in a type III secretion-independent manner (32 clones), (ii) host genes induced specifically by ExoU (20 clones), and (iii) host genes induced in an ExoU-independent but type III secretion dependent manner (3 clones). In particular, ExoU was essential for the expression of immediate-early response genes, including the transcription factor c-Fos. ExoU-dependent gene expression was mediated in part by early and transient activation of the AN transcription factor complex. In conclusion, the present study provides a detailed insight into the response of epithelial cells to infection and indicates the significant role played by the type III virulence mechanism in the initial host response.