Epistola di D. Emanuele re di Portogallo al papa Leone X, annunziandogli l'entrata solenne dell'Ambasciata Portoghese in Abissini;

Bibliographical footnotes.

Presentazione e proposta di traduzione in italiano commentata di alcuni capitoli del libro “Proibido!” dello scrittore portoghese António Costa Santos

Presentazione del libro “Proibido!” (2007) dell’autore portoghese António Costa Santos (Lisbona: Guerra&Paz), con proposta di traduzione commentata di tre capitoli e intervista finale all’autore. Spiegazione del contesto storico del libro: Salazar e la dittatura dell’Estado Novo.

Letras, Nº 69-70, 2014

Contenido: Viel, así en el cieslo como en el canon : un lugar en el corpus de la poesía argentina / María Amelia Arancet Ruda -- Hacia un canon poético místico en clave estético teológica : vigencia de la figura del centro como expectación del Otro / Cecilia I. Avenatti de Palumbo -- La traducción como "instrumento poético" : Raúl Gustavo Aguirre, entre Rimbaud y Char / Magdalena Cámpora -- Giuseppe Ungaretti : un itinerario lírico / Daniel Alejandro Capano -- Teoría y práctica de la poesía cinética en Composición de lugar (1976) de Amanda Berenguer / María Lucía Puppo -- Poesía, subjetividad y memoria en la escritura de Alicia Genovese / Alicia Salomone -- "No nos legaron cartas, ni alianzas, ni retratos" : Olga Orozco o la autofiguración desde la muerte / Sebastián Urli -- Poesía lírica y teoría crítica del siglo XX : entrevista a Miguel Ángel Garrido Gallardo / Sofía M. Carrizo Rueda -- Reseñas bibliográficas

A mulher como representação do bem e do mal n A Demanda do Santo Graal e n A Divina Comédia

Esta dissertação tem como objetivo trabalhar com a forte significação que o feminino apresenta nas narrativas medievais, em especial nA Demanda do Santo Graal e nA Divina Comédia, dois dos mais importantes textos medievais. Pode-se observar um padrão na caracterização dessas mulheres, pois elas são modelos do Bem ou do Mal. Pode-se perceber esse modelo em ambas as obras citadas. NA Demanda do Santo Graal, encontram-se mulheres que desviam o caminho do homem rumo ao Graal que representa o máximo da ascese espiritual. São as mulheres pecadoras, filhas de Eva, que trouxe a morte ao mundo. Também, na Demanda, encontram-se mulheres santas e plenas de virtude que se equiparam à mãe de todas as santas da literatura medieval: Beatriz, dA Divina Comédia. Beatriz é um guia espiritual e não um obstáculo a ser ultrapassado. Daí vai a comparação com as mulheres plenas de virtude da Demanda. Aqui as mulheres santas das duas obras se equiparam. São todas elas símbolos de crescimento na vida dos personagens masculinos. No entanto, tentaremos comprovar que Beatriz é a maior de todas e será utilizada neste trabalho porque na Demanda não podemos encontrar o modelo de mulher perfeita. Chega-se então ao principal objetivo desse trabalho que é observar, na literatura medieval, os vários tipos de mulheres existentes, e as semelhanças e diferenças entre elas, especialmente nA Divina Comédia e nA Demanda do Santo Graal. Tenta-se com isso traçar um elo entre essas duas importantes literaturas (portuguesa e italiana) através de dois textos que apresentam o misterioso papel das mulheres na literatura

CNV analysis in a large schizophrenia sample implicates deletions at 16p12.1 and SLC1A1 and duplications at 1p36.33 and CGNL1

Large and rare copy number variants (CNVs) at several loci have been shown to increase risk for schizophrenia. Aiming to discover novel susceptibility CNV loci, we analysed 6,882 cases and 11,255 controls genotyped on Illumina arrays, most of which have not been used for this purpose before. We identified genes enriched for rare exonic CNVs among cases, and then attempted to replicate the findings in an additional 14,568 cases and 15,274 controls. In a combined analysis of all samples, 12 distinct loci were enriched among cases with nominal levels of significance (P500kb), rare CNVs showed a 1.2% excess in cases after excluding known schizophrenia-associated loci, suggesting that additional susceptibility loci exist. However, even larger samples are required for their discovery.

Evidence that duplications of 22q11.2 protect against schizophrenia

A number of large, rare copy number variants (CNVs) are deleterious for neurodevelopmental disorders, but large, rare, protective CNVs have not been reported for such phenotypes. Here we show in a CNV analysis of 47?005 individuals, the largest CNV analysis of schizophrenia to date, that large duplications (1.5-3.0?Mb) at 22q11.2-the reciprocal of the well-known, risk-inducing deletion of this locus-are substantially less common in schizophrenia cases than in the general population (0.014% vs 0.085%, OR=0.17, P=0.00086). 22q11.2 duplications represent the first putative protective mutation for schizophrenia.

Inactivating mutations in an SH2 domain-encoding gene in X-linked lymphoproliferative syndrome

X-linked lymphoproliferative syndrome (XLP) is an inherited immunodeficiency characterized by increased susceptibility to Epstein-Barr virus (EBV). In affected males, primary EBV infection leads to the uncontrolled proliferation of virus-containing B cells and reactive cytotoxic T cells, often culminating in the development of high-grade lymphoma. The XLP gene has been mapped to chromosome band Xq25 through linkage analysis and the discovery of patients harboring large constitutional genomic deletions. We describe here the presence of small deletions and intragenic mutations that specifically disrupt a gene named DSHP in 6 of 10 unrelated patients with XLP. This gene encodes a predicted protein of 128 amino acids composing a single SH2 domain with extensive homology to the SH2 domain of SHIP, an inositol polyphosphate 5-phosphatase that functions as a negative regulator of lymphocyte activation. DSHP is expressed in transformed T cell lines and is induced following in vitro activation of peripheral blood T lymphocytes. Expression of DSHP is restricted in vivo to lymphoid tissues, and RNA in situ hybridization demonstrates DSHP expression in activated T and B cell regions of reactive lymph nodes and in both T and B cell neoplasms. These observations confirm the identity of DSHP as the gene responsible for XLP, and suggest a role in the regulation of lymphocyte activation and proliferation. Induction of DSHP may sustain the immune response by interfering with SHIP-mediated inhibition of lymphocyte activation, while its inactivation in XLP patients results in a selective immunodeficiency to EBV.

Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores

Polygenic risk scores have shown great promise in predicting complex disease risk and will become more accurate as training sample sizes increase. The standard approach for calculating risk scores involves linkage disequilibrium (LD)-based marker pruning and applying a p value threshold to association statistics, but this discards information and can reduce predictive accuracy. We introduce LDpred, a method that infers the posterior mean effect size of each marker by using a prior on effect sizes and LD information from an external reference panel. Theory and simulations show that LDpred outperforms the approach of pruning followed by thresholding, particularly at large sample sizes. Accordingly, predicted R(2) increased from 20.1% to 25.3% in a large schizophrenia dataset and from 9.8% to 12.0% in a large multiple sclerosis dataset. A similar relative improvement in accuracy was observed for three additional large disease datasets and for non-European schizophrenia samples. The advantage of LDpred over existing methods will grow as sample sizes increase.

Schizophrenia risk from complex variation of complement component 4

Schizophrenia is a heritable brain illness with unknown pathogenic mechanisms. Schizophrenia's strongest genetic association at a population level involves variation in the major histocompatibility complex (MHC) locus, but the genes and molecular mechanisms accounting for this have been challenging to identify. Here we show that this association arises in part from many structurally diverse alleles of the complement component 4 (C4) genes. We found that these alleles generated widely varying levels of C4A and C4B expression in the brain, with each common C4 allele associating with schizophrenia in proportion to its tendency to generate greater expression of C4A. Human C4 protein localized to neuronal synapses, dendrites, axons, and cell bodies. In mice, C4 mediated synapse elimination during postnatal development. These results implicate excessive complement activity in the development of schizophrenia and may help explain the reduced numbers of synapses in the brains of individuals with schizophrenia.

Dalla questione della lingua all’aggressione linguistica: le idee sulla lingua nei giornali italiani dell’ultimo decennio

Riassunto: L’articolo è suddiviso in tre parti. Nella prima, dall’esame di brani dalla Repubblica e dal Corriere della sera si osserva in che modo i giornali trattano questioni linguistiche. Nella seconda, si esemplifica il fenomeno della discriminazione mediante l’analisi di alcuni etnonimi (siciliano, calabrese, milanese, torinese, ecc.). Nella terza parte, si analizza un interessante strumento lessicografico del settimanale L’Espresso: Slangopedia, sui gerghi giovanili. A tenere insieme questi tre temi è il rapporto tra media e ideologia linguistica, nell’intento di stimolare la ricerca futura a investigare sull’identità linguistica degli italiani, attraverso la stampa periodica, come riflesso dell’identità culturale. Se ne ricava che la società italiana non sembra più in grado di riflettere criticamente sulla propria lingua: in molti articoli, infatti, spicca il tono aggressivo e forse discriminatorio nei confronti di chi si allontana da uno standard spesso male interpretato.

O homem novo do fascismo italiano e do estado novo português

Tese de doutoramento, História (Dinâmicas do Mundo Contemporâneo), Universidade de Lisboa, ISCTE - Instituto Universitário de Lisboa, Universidade Católica Portuguesa, Universidade de Évora, 2014

Uma só palavra: experiência de narrativa dramática: trabalho de projecto

Trabalho de Projecto submetido à Escola Superior de Teatro e Cinema para cumprimento dos requisitos necessários à obtenção do grau de Mestre em Teatro - especialização em Artes Performativas (Escritas de Cena).

Populismo in Portogallo? Dall'Estrema Destra a Madeira

Dall'inizio della crisi economica del 2008 il populismo ha assunto una dimensione europea presentandosi in contesti fino ad allora considerati insospettabili come il Regno Unito. Questa diffusione non ha toccato però la Terra Lusitana. Lo scopo di questa tesi è quello di riflettere sulle cause che determinano l'immunità al populismo del Portogallo. Dopo una rassegna generale con i principali contributi sull'argomento abbiamo individuato nella letteratura le variabili in grado di spiegare il successo e l'insuccesso dei fenomeni di populismo. Invece di applicarle direttamente al solo caso portoghese abbiamo preferito testarle su quattro nazioni europee caratterizzate dalla presenza del populismo e soggette ad una crisi economico-politica: Spagna, Francia, Italia, Grecia. Il risultato di questa comparazione ci ha portato a scartare tutte le variabili tranne quella della Leadership permettendoci di proporre l'ipotesi che il mancato successo populista in Portogallo derivi dall'assenza di imprenditori politici capaci di sfruttare la struttura di opportunità apertasi con la crisi economico-politica. Abbiamo testato questa nostra ipotesi andando ad analizzare due dei casi di populismo riscontrabili: Alberto João Jardim, governatore di Madeira, ed il Partido Nacional Renovador, partito ascrivibile alla destra radicale populista. Entrambi i casi da noi analizzati sembrano dimostrare la nostra teoria.

Clinical presentation, etiology, and outcome of infective endocarditis in the 21st century: the International Collaboration on Endocarditis-Prospective Cohort Study.

We sought to provide a contemporary picture of the presentation, etiology, and outcome of infective endocarditis (IE) in a large patient cohort from multiple locations worldwide. Prospective cohort study of 2781 adults with definite IE who were admitted to 58 hospitals in 25 countries from June 1, 2000, through September 1, 2005. The median age of the cohort was 57.9 (interquartile range, 43.2-71.8) years, and 72.1% had native valve IE. Most patients (77.0%) presented early in the disease (<30 days) with few of the classic clinical hallmarks of IE. Recent health care exposure was found in one-quarter of patients. Staphylococcus aureus was the most common pathogen (31.2%). The mitral (41.1%) and aortic (37.6%) valves were infected most commonly. The following complications were common: stroke (16.9%), embolization other than stroke (22.6%), heart failure (32.3%), and intracardiac abscess (14.4%). Surgical therapy was common (48.2%), and in-hospital mortality remained high (17.7%). Prosthetic valve involvement (odds ratio, 1.47; 95% confidence interval, 1.13-1.90), increasing age (1.30; 1.17-1.46 per 10-year interval), pulmonary edema (1.79; 1.39-2.30), S aureus infection (1.54; 1.14-2.08), coagulase-negative staphylococcal infection (1.50; 1.07-2.10), mitral valve vegetation (1.34; 1.06-1.68), and paravalvular complications (2.25; 1.64-3.09) were associated with an increased risk of in-hospital death, whereas viridans streptococcal infection (0.52; 0.33-0.81) and surgery (0.61; 0.44-0.83) were associated with a decreased risk. In the early 21st century, IE is more often an acute disease, characterized by a high rate of S aureus infection. Mortality remains relatively high.