Kokemuksia salmonellasaneerauksesta nautakarjassa

Summary: Practical experience in the elimination of salmonellosis in cattle

Tervehdys gerontologeille

Tervehdyssanat III Gerontologian päivien avaustilaisuudessa Tampereella 30.1.1998

Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders.

Elevated resting heart rate is associated with greater risk of cardiovascular disease and mortality. In a 2-stage meta-analysis of genome-wide association studies in up to 181,171 individuals, we identified 14 new loci associated with heart rate and confirmed associations with all 7 previously established loci. Experimental downregulation of gene expression in Drosophila melanogaster and Danio rerio identified 20 genes at 11 loci that are relevant for heart rate regulation and highlight a role for genes involved in signal transmission, embryonic cardiac development and the pathophysiology of dilated cardiomyopathy, congenital heart failure and/or sudden cardiac death. In addition, genetic susceptibility to increased heart rate is associated with altered cardiac conduction and reduced risk of sick sinus syndrome, and both heart rate-increasing and heart rate-decreasing variants associate with risk of atrial fibrillation. Our findings provide fresh insights into the mechanisms regulating heart rate and identify new therapeutic targets.

Vanha yrityskulttuuri muutosten este ja ehto, mutta ydintyövoiman osuutta voitaisiin tuntuvasti kasvattaa

Artikkelissa haastatellaan Kimmo Kevätsaloa, joka on tutkinut työorganisaatioita väitöskirjassaan Jäykät joustot ja tuhlatut resurssit

Hajautuvat politiikan paikat - yhtäläistyvät kaupunkipolitiikat : kaupunkisuunnittelu politiikkojen toteuttajana Berliinissä

Abstract: Fragmenting places of politics - uniforming urban policies : urban planning implementing policies in Berlin