Report to the director, National Cancer Institute, from the Occupational Cancer Task Force.

Mode of access: Internet.

Employment opportunities at the National Cancer Institute.

Mode of access: Internet.

Cancer among blacks and other minorities : statistical profiles /

"National Cancer Institute, Division of Cancer Prevention and Control."

Breast Cancer Task Force program and related projects /

Item 507-G-2

Cancer mortality in the United States, 1950-1977 /

Item 507-L

The virus cancer program:

Mode of access: Internet.

Cancer chemotherapy reports.

Mode of access: Internet.

Cancer chemotherapy reports.

Issue for Dec. 1968 has subtitle: Program information.

Clinical anatomy of the European hamster Cricetus cricetus, L. /

Mode of access: Internet.

National Cancer Program research objective : working group report, National Cancer Program Planning Conference. --

Mode of access: Internet.

DES exposure in utero : vaginal and cervical cancers and other abnormalities associated with exposure in utero to diethylstilbestrol and related synthetic hormones.

Mode of access: Internet.

National longitudinal study of the high school class of 1972 : sample design efficiency study: effects of stratification, clustering, and unequal weighting on the variances of NLS statistics /

Project officer: William B. Fetters.

Annual report of the Division of Risk Assessment, National Center for Devices and Radiological Health /

Mode of access: Internet.

Drugs and heart disease; a review of research grants supported by the National Heart Institute July 1, 1949 to June 30, 1962.

Includes bibliographies.

Mechanisms of tumour invasion and metastasis : emerging targets for therapy

The progression of a tumour from one of benign and delimited growth to one that is invasive and metastatic is the major cause of poor clinical outcome in cancer patients. The invasion and metastasis of tumours is a highly complex and multistep process that requires a tumour cell to modulate its ability to adhere, degrade the surrounding extracellular matrix, migrate, proliferate at a secondary site and stimulate angiogenesis. Knowledge of the process has greatly increased and this has resulted in the identification of a number of molecules that are fundamental to the process. The involvement of these molecules has been shown to relate not only to the survival and proliferation of the tumour cell but, also to the processes of tumour cell adhesion, migration, and the tumour cells ability to degrade and escape the primary site as well as play a role in angiogenesis. These molecules may provide important therapeutic targets that represent the ability to target specific steps in the process of invasion and metastasis and provide additional therapies. The review focuses on representative key targets in each of these processes and summarises the state of play in each case.