Atmospheric conservation properties in ERA-Interim

We study the global atmospheric budgets of mass, moisture, energy and angular momentum in the latest reanalysis from the European Centre for Medium-Range Weather Forecasts (ECMWF), ERA-Interim, for the period 1989–2008 and compare with ERA-40. Most of the measures we use indicate that the ERA-Interim reanalysis is superior in quality to ERA-40. In ERA-Interim the standard deviation of the monthly mean global dry mass of 0.7 kg m−2 (0.007%) is slightly worse than in ERA-40, and long time-scale variations in dry mass originate predominately in the surface pressure field. The divergent winds are improved in ERA-Interim: the global standard deviation of the time-averaged dry mass budget residual is 10 kg m−2 day−1 and the quality of the cross-equatorial mass fluxes is improved. The temporal variations in the global evaporation minus precipitation (E − P) are too large but the global moisture budget residual is 0.003 kg m−2 day−1 with a spatial standard deviation of 0.3 kg m−2 day−1. Both the E − P over ocean and P − E over land are about 15% larger than the 1.1 Tg s−1 transport of water from ocean to land. The top of atmosphere (TOA) net energy losses are improved, with a value of 1 W m−2, but the meridional gradient of the TOA net energy flux is smaller than that from the Clouds and the Earth's Radiant Energy System (CERES) data. At the surface the global energy losses are worse, with a value of 7 W m−2. Over land however, the energy loss is only 0.5 W m−2. The downwelling thermal radiation at the surface in ERA-Interim of 341 W m−2 is towards the higher end of previous estimates. The global mass-adjusted energy budget residual is 8 W m−2 with a spatial standard deviation of 11 W m−2, and the mass-adjusted atmospheric energy transport from low to high latitudes (the sum for the two hemispheres) is 9.5 PW

Observational tracking of the 2D structure of coronal mass ejections between the sun and 1 AU

The Solar TErrestrial RElations Observatory (STEREO) provides high cadence and high resolution images of the structure and morphology of coronal mass ejections (CMEs) in the inner heliosphere. CME directions and propagation speeds have often been estimated through the use of time-elongation maps obtained from the STEREO Heliospheric Imager (HI) data. Many of these CMEs have been identified by citizen scientists working within the SolarStormWatch project ( www.solarstormwatch.com ) as they work towards providing robust real-time identification of Earth-directed CMEs. The wide field of view of HI allows scientists to directly observe the two-dimensional (2D) structures, while the relative simplicity of time-elongation analysis means that it can be easily applied to many such events, thereby enabling a much deeper understanding of how CMEs evolve between the Sun and the Earth. For events with certain orientations, both the rear and front edges of the CME can be monitored at varying heliocentric distances (R) between the Sun and 1 AU. Here we take four example events with measurable position angle widths and identified by the citizen scientists. These events were chosen for the clarity of their structure within the HI cameras and their long track lengths in the time-elongation maps. We show a linear dependency with R for the growth of the radial width (W) and the 2D aspect ratio (χ) of these CMEs, which are measured out to ≈ 0.7 AU. We estimated the radial width from a linear best fit for the average of the four CMEs. We obtained the relationships W=0.14R+0.04 for the width and χ=2.5R+0.86 for the aspect ratio (W and R in units of AU).

The water quality of the River Enborne, UK: observations from high-frequency Monitoring in a rural, lowland river system

This paper reports the results of a 2-year study of water quality in the River Enborne, a rural river in lowland England. Concentrations of nitrogen and phosphorus species and other chemical determinands were monitored both at high-frequency (hourly), using automated in situ instrumentation, and by manual weekly sampling and laboratory analysis. The catchment land use is largely agricultural, with a population density of 123 persons km−2. The river water is largely derived from calcareous groundwater, and there are high nitrogen and phosphorus concentrations. Agricultural fertiliser is the dominant source of annual loads of both nitrogen and phosphorus. However, the data show that sewage effluent discharges have a disproportionate effect on the river nitrogen and phosphorus dynamics. At least 38% of the catchment population use septic tank systems, but the effects are hard to quantify as only 6% are officially registered, and the characteristics of the others are unknown. Only 4% of the phosphorus input and 9% of the nitrogen input is exported from the catchment by the river, highlighting the importance of catchment process understanding in predicting nutrient concentrations. High-frequency monitoring will be a key to developing this vital process understanding.

Acumulação de capacidades tecnológicas e mecanismos de aprendizagem: um estudo comparativo em duas subsidiárias de empresas multinacionais do setor de tecnologias da informação e comunicação no Brasil

Esta dissertação examina o relacionamento entre o acúmulo de capacidades tecnológicas e os mecanismos de aprendizagem tecnológica em subsidiárias de empresas multinacionais inseridas em economias em desenvolvimento. Este relacionamento é analisado por meio de estudo de caso comparativo de duas subsidiárias do setor de tecnologia da informação e comunicação brasileiro, de diferente países de origem, para as tecnologias associadas ao acesso à internet em alta velocidade, no período de 2004 a 2009. A literatura referente ao desenvolvimento de capacidades tecnológicas em organizações inseridas em economias emergentes evoluiu consideravelmente nos últimos anos, descrevendo vários exemplos da evolução destas capacidades tecnológicas. Porém, ainda são raros os estudos que examinam este processo em subsidiárias de empresas multinacionais presentes em economias emergentes e,mais raros ainda, os estudos que examinam os relacionamentos entre estas trajetórias de acumulação e os seus mecanismos de aprendizado em duas subsidiárias. Com o objetivo de contribuir para o preenchimento dessa lacuna, esta pesquisa buscou enriquecer este debate baseando-se em evidências empíricas primárias e secundárias, para explorar este relacionamento com bastante profundidade e pôde verificar que: 1. Em ambas as subsidiárias pesquisadas houve acumulação de capacidades tecnológicas. Porém, houve uma forte distinção entre estas empresas estudadas em termos da natureza e velocidade de acumulação de capacidades tecnológicas. 2. Também pôde-se identificar um intenso uso de mecanismos intra-organizacionais de fontes internas e de interorganizacionais de fontes externas de aprendizagem tecnológica. Porém, esta característica também apresentou uma grande variabilidade de diversidade e intensidade do uso destes mecanismos, para acumulação de capacidades tecnológicas ao nível da subsidiária. E, a partir destas evidências, pode-se concluir que os diferentes mecanismos de aprendizado tecnológico utilizados pelas organizações inseridas em economias em desenvolvimento desempenham um papel de fundamental relevância não somente para a natureza das capacidades tecnológicas acumuladas, mas também para a intensidade de acumulação. Assim, desta conclusão pode-se interpretar que a Alcatel-Lucent, através de seus esforços de aprendizado tecnológico, está melhor preparada para um contexto competitivo caracterizado por inovações tecnológicas que a ZTE Corporation. Mas este contexto competitivo muitas vezes não se forma em economias emergentes, como a brasileira, que devido à baixa competição e uma crescente necessidade de resultados econômicos de curto prazo faz com que a opção por empresas com o enfoque de custos (ou capacidades operacionais) seja mais valorizada do que empresas com o enfoque de desenvolvimento de capacidades inovadoras capazes de produzir tecnologias. Logo, os resultados desta dissertação sugerem aos gestores destas empresas: (1) a necessidade de um contínuo engajamento em busca de novas fontes de aprendizado tecnológico interno e externo às suas respectivas organizações, de forma a sustentar e acumular novas capacidades tecnológicas operacionais e inovadoras, (2) a importância da qualidade e intensidade dos diversos tipos de relacionamentos e interações internos e externos a estas organizações, de forma a intensificar estes relacionamentos de aprendizado em tecnologias inexistentes nestas organizações. Os resultados desta dissertação também permitem apontar sugestões para gestores governamentais, visto que, no “Plano Nacional de Banda larga”, em desenvolvimento pelo governo federal brasileiro, (1) deve-se incentivar o fortalecimento das parcerias e interações entre as diversas organizações do setor, como as subsidiárias de EMN, as operadoras e centros tecnológicos e universidades locais, de forma a criar projetos mútuos de pesquisa e desenvolvimento de novas tecnologias no setor e, por conseqüência, um maior desenvolvimento tecnológico setorial e (2) buscar através da regulação do setor, que as empresas sejam incentivadas a buscar novos e melhores mecanismos de aprendizagem de forma a consolidar e evoluir as suas capacidades tecnológicas, visando o desenvolvimento tecnológico setorial.

Evaluation testicular fine needle aspiration cytology and serum testosterone levels in dogs

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Polymorphisms in FGFBP1 and FGFBP2 genes associated with carcass and meat quality traits in chickens

In the past, the focus of broiler breeding programs on yield and carcass traits improvement led to problems related to meat quality. Awareness of public concern for quality resulted in inclusion of meat quality traits in the evaluation process. Nevertheless, few genes associated with meat quality attributes are known. Previous studies mapped quantitative trait loci for weight at 35 and 42 days in a region of GGA4 flanked by the microsatellite markers, MCW0240 and LEI0063. In this region, there are 2 fibroblast growth factor binding protein (FGFBP) genes that play an important role in embryogenesis, cellulardifferentiation, and proliferation in chickens. The objective of this study was to identify and associate single nucleotide polymorphisms (SNPs) in FGFBP1 and FGFBP2 with performance, carcass, and meat quality in experimental and commercial chicken populations. In the commercial population, SNP g.2014G>A in FGFBP1 was associated with decreased carcass weight (P < 0.05), and SNP g.651G>A in FGFBP2 was associated with thawing loss and meat redness content (P < 0.05). Four haplotypes were constructed based on 2 SNPs and were associated with breast weight, thawing loss, and meat redness content. The diplotypes were associated with thawing loss, lightness, and redness content. The SNPs evaluated in the present study may be used as markers in poultry breeding programs to aid in improving growth and meat quality traits. © FUNPEC-RP.

Enzyme replacement therapy for Anderson-Fabry disease.

Anderson-Fabry disease is an X-linked defect of glycosphingolipid metabolism. Progressive renal insufficiency is a major source of morbidity, additional complications result from cardio- and cerebro-vascular involvement. Survival is reduced among affected males and symptomatic female carriers. To evaluate the effectiveness and safety of enzyme replacement therapy compared to other interventions, placebo or no interventions, for treating Anderson-Fabry disease. We searched 'Clinical Trials' on The Cochrane Library, MEDLINE, EMBASE, LILACS and the Cystic Fibrosis and Genetic Disorders Group's Inborn Errors of Metabolism Trials Register (date of the most recent search: 11 September 2012). The original search was performed in September 2008.Date of the most recent search of the Cystic Fibrosis and Genetic Disorders Group's Inborn Errors of Metabolism Trials Register: 11 September 2012. Randomized controlled trials of agalsidase alfa or beta in participants diagnosed with Anderson-Fabry disease. Two authors selected relevant trials, assessed methodological quality and extracted data. Six trials comparing either agalsidase alfa or beta in 223 participants fulfilled the selection criteria.Both trials comparing agalsidase alfa to placebo reported on globotriaosylceramide concentration in plasma and tissue; aggregate results were non-significant. One trial reported pain scores, there was a statistically significant improvement for participants receiving treatment at up to three months, mean difference -2.10 (95% confidence interval (CI) -3.79 to -0.41); at up to five months, mean difference -1.90 (95% CI -3.65 to -0.15); and at up to six months, mean difference -2.00 (95% CI -3.66 to -0.34). There was a significant difference in pain-related quality of life at over five months and up to six months, mean difference -2.10 (95% CI -3.92 to -0.28) but not at other time-points. Neither trial reported deaths.One of the three trials comparing agalsidase beta to placebo reported on globotriaosylceramide concentration in plasma and tissue and showed significant improvement: kidney, mean difference -1.70 (95% CI -2.09 to -1.31); heart, mean difference -0.90 (95% CI -1.18 to -0.62); and composite results (renal, cardiac, and cerebrovascular complications and death), mean difference -4.80 (95% CI -5.45 to -4.15). There was no significant difference between groups for death; no trials reported on pain.Only one trial compared agalsidase alfa to agalsidase beta. There was no significant difference between the groups for any adverse events, risk ratio 0.36 (95% CI 0.08 to 1.59), or any serious adverse events; risk ratio 0.30; 95% CI 0.03 to 2.57). Six small, poor quality randomised controlled trials provide no robust evidence for use of either agalsidase alfa and beta to treat Anderson-Fabry disease.

A bayesian analysis for the parameters of the exponential-logarithmic distribution

The exponential-logarithmic is a new lifetime distribution with decreasing failure rate and interesting applications in the biological and engineering sciences. Thus, a Bayesian analysis of the parameters would be desirable. Bayesian estimation requires the selection of prior distributions for all parameters of the model. In this case, researchers usually seek to choose a prior that has little information on the parameters, allowing the data to be very informative relative to the prior information. Assuming some noninformative prior distributions, we present a Bayesian analysis using Markov Chain Monte Carlo (MCMC) methods. Jeffreys prior is derived for the parameters of exponential-logarithmic distribution and compared with other common priors such as beta, gamma, and uniform distributions. In this article, we show through a simulation study that the maximum likelihood estimate may not exist except under restrictive conditions. In addition, the posterior density is sometimes bimodal when an improper prior density is used. © 2013 Copyright Taylor and Francis Group, LLC.

Proposal for a code of good practice in statistics in Latin America and the Caribbean and implementation plan for 2012-2013

Incluye Bibliografía

Tecnologia para produção de extrato aquoso de amendoim e elaboração de produto fermentado

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Fatores que afetam a viabilidade e a proporção do sexo de embriões bovinos produzidos in vitro em programa de sexagem comercial

Pós-graduação em Ciência Animal - FMVA

Localização da proteína fosfolipase C zeta em extratos esppermáticos de gatos domésticos normospérmicos

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Geostatistics and remote sensing methods in the classification of images of areas cultivated with citrus

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Qualidade de vida e satisfação das gestantes portadoras de diabete em uso de insulina em hospital universitário do interior de São Paulo

Pós-graduação em Ginecologia, Obstetrícia e Mastologia - FMB