A web-based system for visualizing upper limb motor performance of Parkinson’s disease patients

Objective To design, develop and set up a web-based system for enabling graphical visualization of upper limb motor performance (ULMP) of Parkinson’s disease (PD) patients to clinicians. Background Sixty-five patients diagnosed with advanced PD have used a test battery, implemented in a touch-screen handheld computer, in their home environment settings over the course of a 3-year clinical study. The test items consisted of objective measures of ULMP through a set of upper limb motor tests (finger to tapping and spiral drawings). For the tapping tests, patients were asked to perform alternate tapping of two buttons as fast and accurate as possible, first using the right hand and then the left hand. The test duration was 20 seconds. For the spiral drawing test, patients traced a pre-drawn Archimedes spiral using the dominant hand, and the test was repeated 3 times per test occasion. In total, the study database consisted of symptom assessments during 10079 test occasions. Methods Visualization of ULMP The web-based system is used by two neurologists for assessing the performance of PD patients during motor tests collected over the course of the said study. The system employs animations, scatter plots and time series graphs to visualize the ULMP of patients to the neurologists. The performance during spiral tests is depicted by animating the three spiral drawings, allowing the neurologists to observe real-time accelerations or hesitations and sharp changes during the actual drawing process. The tapping performance is visualized by displaying different types of graphs. Information presented included distribution of taps over the two buttons, horizontal tap distance vs. time, vertical tap distance vs. time, and tapping reaction time over the test length. Assessments Different scales are utilized by the neurologists to assess the observed impairments. For the spiral drawing performance, the neurologists rated firstly the ‘impairment’ using a 0 (no impairment) – 10 (extremely severe) scale, secondly three kinematic properties: ‘drawing speed’, ‘irregularity’ and ‘hesitation’ using a 0 (normal) – 4 (extremely severe) scale, and thirdly the probable ‘cause’ for the said impairment using 3 choices including Tremor, Bradykinesia/Rigidity and Dyskinesia. For the tapping performance, a 0 (normal) – 4 (extremely severe) scale is used for first rating four tapping properties: ‘tapping speed’, ‘accuracy’, ‘fatigue’, ‘arrhythmia’, and then the ‘global tapping severity’ (GTS). To achieve a common basis for assessment, initially one neurologist (DN) performed preliminary ratings by browsing through the database to collect and rate at least 20 samples of each GTS level and at least 33 samples of each ‘cause’ category. These preliminary ratings were then observed by the two neurologists (DN and PG) to be used as templates for rating of tests afterwards. In another track, the system randomly selected one test occasion per patient and visualized its items, that is tapping and spiral drawings, to the two neurologists. Statistical methods Inter-rater agreements were assessed using weighted Kappa coefficient. The internal consistency of properties of tapping and spiral drawing tests were assessed using Cronbach’s α test. One-way ANOVA test followed by Tukey multiple comparisons test was used to test if mean scores of properties of tapping and spiral drawing tests were different among GTS and ‘cause’ categories, respectively. Results When rating tapping graphs, inter-rater agreements (Kappa) were as follows: GTS (0.61), ‘tapping speed’ (0.89), ‘accuracy’ (0.66), ‘fatigue’ (0.57) and ‘arrhythmia’ (0.33). The poor inter-rater agreement when assessing “arrhythmia” may be as a result of observation of different things in the graphs, among the two raters. When rating animated spirals, both raters had very good agreement when assessing severity of spiral drawings, that is, ‘impairment’ (0.85) and irregularity (0.72). However, there were poor agreements between the two raters when assessing ‘cause’ (0.38) and time-information properties like ‘drawing speed’ (0.25) and ‘hesitation’ (0.21). Tapping properties, that is ‘tapping speed’, ‘accuracy’, ‘fatigue’ and ‘arrhythmia’ had satisfactory internal consistency with a Cronbach’s α coefficient of 0.77. In general, the trends of mean scores of tapping properties worsened with increasing levels of GTS. The mean scores of the four properties were significantly different to each other, only at different levels. In contrast from tapping properties, kinematic properties of spirals, that is ‘drawing speed’, ‘irregularity’ and ‘hesitation’ had a questionable consistency among them with a coefficient of 0.66. Bradykinetic spirals were associated with more impaired speed (mean = 83.7 % worse, P < 0.001) and hesitation (mean = 77.8% worse, P < 0.001), compared to dyskinetic spirals. Both these ‘cause’ categories had similar mean scores of ‘impairment’ and ‘irregularity’. Conclusions In contrast from current approaches used in clinical setting for the assessment of PD symptoms, this system enables clinicians to animate easily and realistically the ULMP of patients who at the same time are at their homes. Dynamic access of visualized motor tests may also be useful when observing and evaluating therapy-related complications such as under- and over-medications. In future, we foresee to utilize these manual ratings for developing and validating computer methods for automating the process of assessing ULMP of PD patients.

Valuation and reporting of native fauna in monetary terms: compatibility between a market-Based system and natural resources?

A change in community values and priorities has introduced ethical,
environmental and social issues into the way in which business conducts
its activities. There are an increasing number of managed investment funds focusing on socially responsible investment (SRI) by concentrating on firms that operate according to predetermined criteria for environmental, social and ethical issues. For investors in these funds environmental stewardship issues are integrated with concern over financial resources and performance. In this paper the accounting and reporting by business activities concerned with conservation of wildlife are examined. The world of accounting has functioned for many years with relatively few accounting standards devoted to specialised industry needs. In 1998 the Australian Accounting Standards Board and in 2001 the International Accounting Standards Board issued standards devoted to agriculture. Both standards deal with the reporting of managed biological assets and require application of essentially the same approaches despite the Australian standard requiring net market value while the International standard requires fair value. In this paper we analyse how one conservation firm Earth Sanctuaries Ltd. (ESL) has applied AASB 1037 and then we explore the implications for conservation firms operating in geographical locations outside Australia. It is suggested that AASB 1037 and indeed lAS 41 may not provide value appropriate information for investor decisions relating to accounting profits for such firms. Our examination shows that it is appropriate to reconsider accounting guidelines provided by these standards in order to link the information relating to economic and environmental performance. Transparency may be improved by a move closer to Elkington 's (1997) triple bottom line reporting. We therefore contend that the issues arising from the use ofAASB 1037 and lAS 41 need to be widely considered by all standard setters, particularly given the increasing attention to SRI.

A contract-based system for aerospace aftercare

The logistics of the aerospace aftermarket raises a number of very interesting challenges from the perspective of electronic contracting. This is a highly dynamic domain, where contracts are established between airlines and engine manufacturers, as well as between engine manufacturers all the way down the supply lines, providing a particularly illustrative showcase for the technologies developed in the CONTRACT project. In this paper, we describe such a domain, as well as our modelling of it as a multiagent simulator where the CONTRACT framework has been used to monitor for compliance with norms.

Location based power control for energy critical sensors in a disconnected network

This paper provides a location based power control strategy for disconnected sensory nodes deployed for long term service. Power conservation is of importance particularly when sensors communicate with a mobile robot used for data collection. The proposed algorithm uses estimations from a Robust Extended Kalman Filter (REKF) with RSSI measurements, in implementing a sigmoid function based power control algorithm which essentially approaches a desired power emission trajectory based on carrier-to-interference ratios(CIR) to ensure interferenceless reception. The more realistic modelling we use incorporates physical dynamics between the mobile robot and the sensors together with the wireless propagation parameters between the transmitter and receiver to formulate a sophisticated and effective power control strategy for the exclusive usage of energy critical disconnected nodes in a sensory network increasing their life span.

A ring-based architectural model for middle agents in agent-based system

In agent-based systems, the performance of middle agents not only relies on the matchmaking algorithms employed by them, but also the architecture that organizes them with suitable organizational structure and coordination mechanism. In this paper, we contribute a framework and develop a couple of middle agents with logical ring organizational structure to match requester agents with service provider agents. The middle agent is of the features of proliferation and self-cancellation according to the sensory input from its environment. The token-based coordination mechanism of middle agents is designed. Two kinds of middle agents, namely, host and duplicate, are designed for promoting the scalability and robustness of agent-based systems. We demonstrate the potentials of the architecture by case study.

The application of a fuzzy rule based system in an exposition of the antecedents of sedge warbler song flight

The utilization of a fuzzy aspect within data analysis attempts to move from a quantitative to a more qualitative investigative environment. As such, this may allow the more non-quantitative researchers results they can use, based on sets of linguistic terms. In this paper an inductive fuzzy decision tree approach is utilized to construct a fuzzy-rule-based system for the first time in a biological setting. The specific biological problem considered attempts to identify the antecedents (conditions in the fuzzy decision rules) which characterize the length of song flight of the male sedge warbler when attempting to attract a mate. Hence, for a non-quantitative investigator the resultant set of fuzzy rules allows an insight into the linguistic interpretation on the relationship between associated characteristics and the respective song flight duration.

Student construction of a knowledge-based system as an actor network

The study contributes to the educational computing discourse in two ways. It extends our understandings of the way students use and understand the building of small knowledge-based systems, and provides a novel and holistic way of investigating the use of information technology in classrooms.

A hybrid graphical password based system

In this age of electronic connectivity, where we all face viruses, hackers, eavesdropping and electronic fraud, there is indeed no time when security is not critical. Passwords provide security mechanism for authentication and protection services against unwanted access to resources. A graphical based password is one promising alternatives of textual passwords. According to human psychology, humans are able to remember pictures easily. In this paper, we have proposed a new hybrid graphical password based system, which is a combination of recognition and recall based techniques that offers many advantages over the existing systems and may be more convenient for the user. Our scheme is resistant to shoulder surfing attack and many other attacks on graphical passwords. This resistant scheme is proposed for small mobile devices (like smart phones i.e. ipod, iphone, PDAs etc) which are more handy and convenient to use than traditional desktop computer systems.

The hidden permutation model and location-based activity recognition

Permutation modeling is challenging because of the combinatorial nature of the problem. However, such modeling is often required in many real-world applications, including activity recognition where subactivities are often permuted and partially ordered. This paper introduces a novel Hidden Permutation Model (HPM) that can learn the partial ordering constraints in permuted state sequences. The HPM is parameterized as an exponential family distribution and is flexible so that it can encode constraints via different feature functions. A chain-flipping Metropolis-Hastings Markov chain Monte Carlo (MCMC) is employed for inference to overcome the O(n!) complexity. Gradient-based maximum likelihood parameter learning is presented for two cases when the permutation is known and when it is hidden. The HPM is evaluated using both simulated and real data from a location-based activity recognition domain. Experimental results indicate that the HPM performs far better than other baseline models, including the naive Bayes classifier, the HMM classifier, and Kirshner's multinomial permutation model. Our presented HPM is generic and can potentially be utilized in any problem where the modeling of permuted states from noisy data is needed.