990 resultados para Lönnqvist, Jan-Erik
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In multibeam echosounder and subbottom profiler data acquired during R/V Polarstern cruise ARK-VII/3a from the Hovgaard Ridge (Fram Strait), we found evidence for very deep (>1200 m) iceberg scouring. Five elongated seafloor features have been detected that are interpreted to be iceberg scours. The scours are oriented in north-south/south-north direction and are about 15 m deep, 300 m wide, and 4 km long crossing the entire width of the ridge. They are attributed to multiple giant paleo-icebergs that most probably left the Arctic Ocean southward through Fram Strait. The huge keel depths are indicative of ice sheets extending into the Arctic Ocean being at least 1200 m thick at the calving front during glacial maxima. The deep St. Anna Trough or grounded ice observed at the East Siberian Continental Margin are likely source regions of these icebergs that delivered freshwater to the Nordic Seas.
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Viestinnän merkitys yrityksen menestymisessä on noussut 2000-luvulla yhä suurempaan osaan ja pelkästään ulkoiseen viestintään panostamisen sijaan on alettu yhä enemmän kiinnittää huomiota yrityksen omaan sisäiseen viestintään. Tutkimuksessa haluttiin selvittää mitkä osa-alueet ja viestintäkanavat ovat tärkeimmät pk-yrityksen sisäisessä viestinnässä, sekä haasteet joita mahdollisesti kohdataan. Tutkimus on tapaustutkimus, jossa tutkittiin muovimateriaalien valmistajan sisäisen viestinnän nykytilaa ja sen toteutumista käytännön tasolla. Teoria osiossa käsitellään viestinnän perusteita ja sisäistä viestintää ja sen eri aspekteja. Empiirisen osion data kerättiin teemahaastattelulla, jossa haastateltiin niin johtoa kuin henkilöstöä case-yrityksen eri organisaatiotasoilta. Case-yrityksen avulla tutkittiin, kuinka sisäinen viestintä on järjestetty Aikolon Oy:ssä. Näitä saatuja tuloksia analysoimalla annettiin kehitysehdotuksia ja saatiin parempi ymmärrys siitä mitä pk-yrityksen sisäisessä viestinnässä tapahtuu ja miten sitä voidaan parantaa.
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Signatur des Originals: S 36/F07300
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Signatur des Originals: S 36/F07302
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Signatur des Originals: S 36/F07311
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Mode of access: Internet.
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Universidade Estadual de Campinas . Faculdade de Educação Física
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Tyrosine hydroxylase deficiency is an autosomal recessive disorder resulting from cerebral catecholamine deficiency. Tyrosine hydroxylase deficiency has been reported in fewer than 40 patients worldwide. To recapitulate all available evidence on clinical phenotypes and rational diagnostic and therapeutic approaches for this devastating, but treatable, neurometabolic disorder, we studied 36 patients with tyrosine hydroxylase deficiency and reviewed the literature. Based on the presenting neurological features, tyrosine hydroxylase deficiency can be divided in two phenotypes: an infantile onset, progressive, hypokinetic-rigid syndrome with dystonia (type A), and a complex encephalopathy with neonatal onset (type B). Decreased cerebrospinal fluid concentrations of homovanillic acid and 3-methoxy-4-hydroxyphenylethylene glycol, with normal 5-hydroxyindoleacetic acid cerebrospinal fluid concentrations, are the biochemical hallmark of tyrosine hydroxylase deficiency. The homovanillic acid concentrations and homovanillic acid/5-hydroxyindoleacetic acid ratio in cerebrospinal fluid correlate with the severity of the phenotype. Tyrosine hydroxylase deficiency is almost exclusively caused by missense mutations in the TH gene and its promoter region, suggesting that mutations with more deleterious effects on the protein are incompatible with life. Genotype-phenotype correlations do not exist for the common c.698G > A and c.707T > C mutations. Carriership of at least one promotor mutation, however, apparently predicts type A tyrosine hydroxylase deficiency. Most patients with tyrosine hydroxylase deficiency can be successfully treated with l-dopa.
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Foram avaliados todos os internamentos no Serviço de Ginecologia da MAC de 2 de Janeiro a 19 de Setembro de 1991. O critério de selecção baseou-se no registo de morbilidade intra-operatória e no prolongamento de tempo de internamento. Foram estudados os dados relativos à idade, factores de risco associados, risco anestésico, tipo de intervenção cirúrgica, tempo operatório, tipo de complicações e média de tempo de internamento. Verificou-se uma morbilidade global de 5,6%, tendo-se constatado uma maior incidência de complicações no grupo das histerectomias abdominais (16,8%). Nos casos com morbilidade 72% apresentavam um ou mais factores de risco associados. Ocorreram 5 lesões de órgão (0,73%), 33 complicações pós-operatórias (4,8%) e 7 reintervenções (1%). A média de internamento neste grupo de doentes foi de 11 dias.
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v.4:no.4(1925)