Non-alcoholic fatty liver disease associated with hypobetalipoproteinemia: report of three cases and a novel mutation in APOB gene

Background: Non-alcoholic fatty liver disease, the leading cause of chronic liver disease in children, is defined by hepatic fat infiltration >5% of hepatocytes, in the absence of excessive alcohol intake, evidence of viral, autoimmune or drug-induced liver disease. Conditions like rare genetic disorders must be considered in the differential diagnosis. Case Report: Two male brothers, and a non-related girl, all overweight, had liver steatosis. One of the brothers and the girl had elevated transaminases; all three presented with low total cholesterol, low density lipoproteins and very low density lipoproteins cholesterol levels, hypotriglyceridemia and low apolipoprotein B. A liver biopsy performed in the brother with citolysis confirmed steatohepatitis and the molecular study of apolipoprotein B gene showed a novel homozygous mutation (c.9353dup p.Asn3118Lysfs17). Patients with cytolysis lost weight, however liver steatosis persists. Conclusion: Fatty liver disease might be a consequence of hypobetalipoproteinemia. Evidence is scarce due to low number of reported cases.

Nutrição na fisiopatologia e tratamento do fígado gordo não-alcoólico

Trabalho Final do Curso de Mestrado Integrado em Medicina, Faculdade de Medicina, Universidade de Lisboa, 2014

Fígado gordo não-alcoólico : uma entidade emergente com potencial oncogénico

Trabalho Final do Curso de Mestrado Integrado em Medicina, Faculdade de Medicina, Universidade de Lisboa, 2014

Data pertinent to a review of minimum wage rates established under the Fair labor standards act for newly covered employment in the alcoholic beverage and industrial alcohol industry in Puerto Rico /

"WH65-69."

The Hitch case - saving ampoules for a defendant from a chemical test for alcoholic intoxication. Final report.

National Highway Traffic Safety Administration, Office of Driver and Pedestrian Programs, Washington, D.C.

Comparison of recovered alcoholic and non-alcoholic communicator in alcohol education. Final report.

National Highway Traffic Safety Administration, Washington, D.C.

On the use and abuse of alcoholic liquors : in health and disease /

Mode of access: Internet.

Rehabilitation of the alcoholic; a report from the Study Group on Rehabilitation of the Alcoholic and Public Offender.

Report presented at the Sixth Institute on Rehabilitation Services, held May 20-22, 1968, at University Park, Pa.

Memoria presentada por el Ilmo. Sr. D. Cipriano Segundo Montesino, como indivíduo de la comisión encargada del estudio de la Exposición Internacional de Londres de 1862 : clase V, material de ferro-carriles : publicada en virtud de lo dispuesto por Real Orden de 26 de abril del mismo año.

Mode of access: Internet.

Alcoholism. The subcommittee to study the problems of effective implementation of a comprehensive program of care and treatment for alcoholic individuals and public inebriates of the state of Illinois.

Cover title.

Salvage warehouses and salvage warehouse stores for foods, alcoholic liquors, drugs and cosmetics /

Includes the Act and rules and regulations relating to the Act.

An essay on alcoholic & narcotic substances, as articles of common use : addressed particularly to students /

Second edition issued in 1830 under title: An essay on temperance, addressed particularly to students ...

Home made beverages, the manufacture of non-alcoholic and alcoholic drinks in the household,

Mode of access: Internet.

To prohibit the advertising of alcoholic beverages by radio. Hearings before a subcommittee of the Committee on Interstate Commerce, United States Senate, Seventy-sixth Congress, first session, on an amendment in the nature of a substitute to S. 517, a bill to amend the Communications Act of 1934 to prohibit the advertising of alcholic beverages by radio, March 29, 31, 1939.

Mode of access: Internet.

On the use and abuse of alcoholic liquors, in health and disease,

At head of title: Prize essay.