Altered emotional and locomotor responses in mice deficient in the transcription factor CREM

Various transcription factors act as nuclear effectors of the cAMP-dependent signaling pathway. These are the products of three genes in the mouse, CREB, CRE modulator (CREM), and ATF-1. CREM proteins are thought to play important roles within the hypothalamic–pituitary axis and in the control of rhythmic functions in the pineal gland. We have generated CREM-mutant mice and investigated their response in a variety of behavioral tests. CREM-null mice show a drastic increase in locomotion. In contrast to normal mice, the CREM-deficient mice show equal locomotor activity during the circadian cycle. The anatomy of the hypothalamic suprachiasmatic nuclei, the center of the endogenous pacemaker, is normal in mutant mice. Remarkably, CREM mutant mice also elicit a different emotional state, revealed by a lower anxiety in two different behavioral models, but they preserve the conditioned reactiveness to stress. These results demonstrate the high degree of functional specificity of each cAMP-responsive transcription factor in behavioral control.

Post T Tauri stars in the solar neighborhood: isolated or members of young associations and moving groups

Post T Tauri stars (PTTS) are late-type stars in the age range between 10 and 100 Myr filling the gap between T Tauri (TTs) and zero-age: main sequence phases. This period of evolution remains ambiguous and until now different studies of young stars have failed to find the numbers of PTTS that are expected. In the last years, some PTTS have been identified among the X-ray detected pre-main sequence stars in some star-forming regions. More recently, additional PTTS have been identified in young associations and moving groups (β Pic, TW Hya, Tucana/Horologium, and the AB Dor). However, many isolated PTTS still remain undiscovered. In this contribution, we compiled the PTTS previously identified in the literature, and identified new candidates using the information provided by the high resolution spectra obtained during our surveys of late-type stars possible members to young moving groups, FGK stars in the solar neighborhood, and RasTyc sample. To identify PTTS we applied an age-oriented definition using relative age indicators (Li abundance, chromospheric and coronal emission and the kinematics) as well as color-magnitude diagrams and pre-main sequence isochrones.

Youth Sports: Implementing Findings and Moving Forward with Research

This paper reviews the literature, outlines practical implications, and discusses future studies in youth sport researc h. The literature is discussed in light of three potential benefits of youth sport participation 1) physic al health, 2) psycho- social development, and 3) motor skills acquisition. The ultimate objective of youth sport programs is to consider all the benefits of youth sport participation rather than focusing on one or two at the cost of the other(s). It is suggested that researchers, s port administrators, coaches, and parents work together to promote sporting activities and programs that are more likely to enhance children’s physical health, psychosocia l development and lifelong recreational or elite sport participation.

Forensic laboratories : handbook for facility planning, design, construction, and moving /

"NCJ 168106."

The Julius Cahn-Gus Hill theatrical guide and moving picture directory.

Mode of access: Internet.

Statements, calculations and hints, relative to rail-roads and moving power locomotive engines to be used thereon : embellished with a fine copperplate engraving /

Mode of access: Internet.

Established hemlock dune (Tsuge Canadensis) and moving dune.; Sawyer, Michigan

[Xsh 53.3]

The camp counselor; responsibilities and opportunities in promoting physical, mental, emotional, and social well-being of campers,

Bouve collection.