918 resultados para Edward W. Said


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Vol. 1, pt. 1-3 have imprint: Richmond, Va., Whittet & Shepperson printers.

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Includes bibliographical references (p. 32-33).

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On verso: L to R: Mill, E.W. - in charge of training program; Dr. Jose F. Imperial; Mr. Tiburcio C. Baja; Mr. Manuael A. Adeva. Standing: Mr. Vincente I. Singian; Mr. Candido T. Elbo

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Irving Kane and Allen B. Pond, architects. Plans for the Union were on a scale unknown at the time for "club houses" in American colleges and universities: 250 feet long and 200 feet wide. Construction began in 1916 and owing to war time difficulties was not ready to be used by students until 1919. Two new wings to the south were completed in 1936 and 1938. Library was completed in 1925 following a gift from Mrs. Edward W. Pendleton of Detroit in memory of her husband. His library was also donated. Swain's index to this image reads "Michigan Union Library." Verso: G.R.Swain, 713 East University Ave, Ann Arbor, Michigan.

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Front Row: Charles C. Bates, James H. Walters, John Narcy.

Back Row diving coach Bruce Harlan, Edward W. Cole, John W. Murphy, David Markstone, Andrew White.

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Front Row: John C. Smith, Theodore C. Reissing, Richard D. Hanley, Cyrus C. Hopkins, Anthony Tashnick, Carl T. Woolley, Peter H. Fries

Middle Row: Thomas W. Prunk, M. Allen Maten, Jr., Myril Kaplan, Brian L. Browne, Edward R. Pongracz, Jim Tanner, E. Lee Fitzhugh.

Back Row: diving coach Bruce Harlan, head coach Gus Stager, manager Ray Haselby, Tony A. Turner, Edward W. Cole, Richard J. Kimball, Alvaro Gaxiola, Theodore Pong.

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Signed: United States section, Harley B. Ferguson, Edward W. Markham, Eugene Raybold ; Canadian section, Duncan W. McLachlan, Oliver O. Lefebvre, Charles H. Mitchell.

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Mode of access: Internet.

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"Bibliographical Essay": p. [319]-332.

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Mode of access: Internet.

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Nesfatin-1 is a recently identified anorexigenic peptide derived from its precursor protein, nonesterified fatty acid/nucleobindin 2 (NUCB2). Although the hypothalamus is pivotal for the maintenance of energy homeostasis, adipose tissue plays an important role in the integration of metabolic activity and energy balance by communicating with peripheral organs and the brain via adipokines. Currently no data exist on nesfatin-1 expression, regulation, and secretion in adipose tissue. We therefore investigated NUCB2/nesfatin-1 gene and protein expression in human and murine adipose tissue depots. Additionally, the effects of insulin, dexamethasone, and inflammatory cytokines and the impact of food deprivation and obesity on nesfatin-1 expression were studied by quantitative RT-PCR and Western blotting. We present data showing NUCB2 mRNA (P < 0.001), nesfatin-1 intracellular protein (P < 0.001), and secretion (P < 0.01) were significantly higher in sc adipose tissue compared with other depots. Also, nesfatin-1 protein expression was significantly increased in high-fat-fed mice (P < 0.01) and reduced under food deprivation (P < 0.01) compared with controls. Stimulation of sc adipose tissue explants with inflammatory cytokines (TNFa and IL-6), insulin, and dexamethasone resulted in a marked increase in intracellular nesfatin-1 levels. Furthermore, we present evidence that the secretion of nesfatin-1 into the culture media was dramatically increased during the differentiation of 3T3-L1 preadipocytes into adipocytes (P < 0.001) and after treatments with TNF-a, IL-6, insulin, and dexamethasone (P < 0.01). In addition, circulating nesfatin-1 levels were higher in high-fat-fed mice (P < 0.05) and showed positive correlation with body mass index in human. We report that nesfatin-1 is a novel depot specific adipokine preferentially produced by sc tissue, with obesity- and food deprivation-regulated expression.

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Certificate that Joseph Kingsmill, sheriff, has sold 6 acres in Lot no. 9 in the 4th Concession of Caistor to W.H. Dickson [originally said S.D. Woodruff, but this was crossed out], May 23, 1857.