Structural and vibrational study of 8-hydroxyquinoline-2-carboxaldehyde isonicotinoyl hydrazone: a potential metal-protein attenuating compound (MPAC) for the treatment of Alzheimer's disease

A comprehensive structural and vibrational study of the potential metal-protein attenuating compound 8-hydroxyquinoline-2-carboxaldehyde isonicotinoyl hydrazone is reported. X-ray diffraction data, as well as FT-IR and Raman frequencies, were compared with the respective theoretical values obtained from DFT calculations. Theory agrees well with experiment. In this context, an attempt of total assignment concerning the FT-IR and Raman spectra of the title compound was performed, shedding new light on previous partial assignments published elsewhere.

The Acropolitan - v. 8, no. 2

in this issue...Annie Anderson, Hecla MIne, F. A. Thomson, Anaconda Copper Mining Company, Sigma RHO, Mines football, Montana State University

The Amplifier - v. 8, no. 2

In this issue...United Nations meeting, Newman Club, Sylvia White, Veteran's Day, Glee Club, Montana Power Company, Harvest Festival Dance, Joe Knuckey's Melody Makers

The Amplifier - v. 8,(a-2) no. 2

In this issue...Anaconda Scholarships, homecoming, David Rovig, Berkeley Pit, National Reactor Testing Station, Anaconda Company, Wesley Club, Star Lanes Bowling

Baylis-Hillman reaction assisted synthesis of substituted 5,8-dihydro-isoxazolo[4,5-c]azepin-4-one: A novel isoxazole-annulated heterocycle

The novel synthesis of a new isoxazole-annulated heterocycle namely 5,8-dihydro-isoxazolo[4,5-c]azepin-4-one described herein is based on the reaction of benzyl amine with acetates of Baylis-Hillman adducts generated from 3-aryl-5-formyl-isoxazole-4-carboxylate

The Olive Tree, Vol. 8 Number 2, 2000

The Winter 2000 issue of The Olive Tree features articles about library projects, collections, technological innovations, and events at Fogler Library, University of Maine.

TNF receptors regulate vascular homeostasis in zebrafish through a caspase-8, caspase-2 and P53 apoptotic program that bypasses caspase-3

Although it is known that tumor necrosis factor receptor (TNFR) signaling plays a crucial role in vascular integrity and homeostasis, the contribution of each receptor to these processes and the signaling pathway involved are still largely unknown. Here, we show that targeted gene knockdown of TNFRSF1B in zebrafish embryos results in the induction of a caspase-8, caspase-2 and P53-dependent apoptotic program in endothelial cells that bypasses caspase-3. Furthermore, the simultaneous depletion of TNFRSF1A or the activation of NF-κB rescue endothelial cell apoptosis, indicating that a signaling balance between both TNFRs is required for endothelial cell integrity. In endothelial cells, TNFRSF1A signals apoptosis through caspase-8, whereas TNFRSF1B signals survival via NF-κB. Similarly, TNFα promotes the apoptosis of human endothelial cells through TNFRSF1A and triggers caspase-2 and P53 activation. We have identified an evolutionarily conserved apoptotic pathway involved in vascular homeostasis that provides new therapeutic targets for the control of inflammation- and tumor-driven angiogenesis.

Fragm. lat. I 8 - Elucidarium 2,13 - 16; 37 - 45

Trägerband: "Registrum Summae Missae 1560"; Vorbesitzer: Stadtarchiv Frankfurt am Main