Partial gene deletion of endothelial nitric oxide synthase predisposes to exaggerated high-fat diet-induced insulin resistance and arterial hypertension.

Nitric oxide (NO) plays a major role in the regulation of cardiovascular and metabolic homeostasis, as evidenced by insulin resistance and arterial hypertension in endothelial NO synthase (eNOS) null mice. Extrapolation of these findings to humans is difficult, however, because eNOS gene deficiency has not been reported. eNOS gene polymorphism and impaired NO synthesis, however, have been reported in several cardiovascular disease states and could predispose to insulin resistance. High-fat diet induces insulin resistance and arterial hypertension in normal mice. To test whether partial eNOS deficiency facilitates the development of insulin resistance and arterial hypertension during metabolic stress, we examined effects of an 8-week high-fat diet on insulin sensitivity (euglycemic clamp) and arterial pressure in eNOS(+/-) mice. When fed a normal diet, these mice had normal insulin sensitivity and were normotensive. When fed a high-fat diet, however, eNOS(+/-) mice developed exaggerated arterial hypertension and had fasting hyperinsulinemia and a 35% lower insulin-stimulated glucose utilization than control mice. The partial deletion of the eNOS gene does not alter insulin sensitivity or blood pressure in mice. When challenged with nutritional stress, however, partial eNOS deficiency facilitates the development of insulin resistance and arterial hypertension, providing further evidence for the importance of this gene in linking metabolic and cardiovascular disease.

VOLUMES RELIES du Cabinet des titres : recherches de noblesse, armoriaux, preuves, histoires généalogiques. Recueil sur la noblesse de Normandie, copié en partie sur le recueil précédent. IV.

Contient : I « Recherche des nobles de la Généralité de Caen, par M. de Chamillart, intendant » ; II « État de la recherche de la noblesse de la Généralité d'Alençon, faite par M. de Marle. » (1666.) — XX-pages 258-???396

Induced sputum versus exhaled nitric oxide for the evaluation of airway inflammation in allergic paediatric asthma patients treated with omalizumab

Our purpose is to determine the inflammatory changes in the airways of allergic paediatric asthma patients treated with omalizumab, measured by the percentage of eosinophils in induced sputum and exhaled nitric oxide (FENO). We observed a progressive and statistically significant decrease of eosinophil count in the induced sputum meanwhile FENO, although very sensible, was a less reproducible and thus a less reliable method to evaluate chronic airway inflammation in this population. Induced sputum seems to be a better method to monitor chronic inflammation and thus the response to chronic omalizumab treatment while FENO measurement would be more useful to monitor acute events preceding exacerbations.

Cerambycidae (Coleoptera) da Colômbia: IV. Cerambycinae com olhos grosseiramente granulados

New records for Colombian Cerambycidae - Achrysonini: Achryson immaculipenne Gounelle, 1909, A. lineolatum Erichson, 1847, A. quadrimaculatum (Fabricius, 1792); Ectenessini: Ectenessa lurida Martins, 1973; Cerambycini: Jupoata rufipennnis (Gory, 1831), Poeciloxestia carlyslei Fragoso, 1978, P. paraensis Lane, 1965; Elaphidionini: Ambonus electus (Gahan & Arrow, 1903), Paramallocera cribripennis (Bates, 1885), Periboeum pubescens (Olivier, 1790), Stizocera plicicollis (Germar, 1824), S. poeyi (Guérin-Méneville, 1838), Pantonyssus glabricollis Fuchs, 1961; Piezocerini: Haruspex lineolatus Bates, 1870; Eligmodermini: Eligmoderma spinicolle Aurivillius, 1923, E. ziczac Nonfried, 1895. New species described: Pantonyssus suturale sp. nov. (Santander); Anelaphus colombianus sp. nov. (Santander); A. sparsus sp. nov. (Magdalena).

Aventures d'amour et d'épée sous Henri IV ; 1-4. Le capitaine Bel-Coeur. Vol. 3 / Georges Spitzmuller

Collection : Le livre national ; n° 321-324

Aventures d'amour et d'épée sous Henri IV ; 1-4. Le capitaine Bel-Coeur. Vol. 4 / Georges Spitzmuller

Collection : Le livre national ; n° 321-324