On some classes of exactly-solvable Klein-Gordon equations

In this work we discuss some exactly solvable Klein-Gordon equations. We basically discuss the existence of classes of potentials with different nonrelativistic limits, but which shares the intermediate effective Schroedinger differential equation. We comment about the possible use of relativistic exact solutions as approximations for nonrelativistic inexact potentials. (c) 2005 Elsevier B.V. All rights reserved.

Documenting the advantages and limitations of different classes of molecular markers in a well-established phylogeographic context: lessons from the Iberian endemic Golden-striped salamander, Chioglossa lusitanica (Caudata: Salamandridae)

Previous analyses of mitochondrial (mt)DNA and allozymes covering the range of the Iberian endemic golden-striped salamander, Chioglossa lusitanica, suggested a Pleistocene split of the historical species distribution into two population units (north and south of the Mondego river), postglacial expansion into the northernmost extant range, and secondary contact with neutral diffusion of genes close to the Mondego river. We extended analysis of molecular variation over the species range using seven microsatellite loci and the nuclear P-fibrinogen intron 7 (beta-fibint7). Both microsatellites and beta-fibint7 showed moderate to high levels of population structure, concordant with patterns detected with mtDNA and allozymes; and a general pattern of isolation-by-distance, contrasting the marked differentiation of two population groups suggested by mtDNA and allozymes. Bayesian multilocus analyses showed contrasting results as populations north and south of the Douro river were clearly differentiated based on microsatellites, whereas allozymes revealed differentiation north and south of the Mondego river. Additionally, decreased microsatellite variability in the north supported the hypothesis of postglacial colonization of this region. The well-documented evolutionary history of C. lusitanica, provides an excellent framework within which the advantages and limitations of different classes of markers can be evaluated in defining patterns of population substructure and inferring evolutionary processes across distinct spatio-temporal scales. The present study serves as a cautionary note for investigations that rely on a single type of molecular marker, especially when the organism under study exhibits a widespread distribution and complex natural history. (C) 2008 The Linnean Society of London, Biological Journal of the Linnean Society, 2008, 95, 371-387.

Classes of exact wave functions for general time-dependent Dirac Hamiltonians in 1+1 dimensions

The construction of two classes of exact solutions for the most general time-dependent Dirac Hamiltonian in 1+1 dimensions was discussed. The extension of solutions by introduction of a time-dependent mass was elaborated. The possibility of existence of a generalized Lewis-Riesenfeld invariant connected with such solutions was also analyzed.

Efeito da cadência de pedalada sobre as respostas metabólica e cardiovascular durante o exercício incremental e de carga constante em indivíduos ativos

The main purpose of this study was to analyze the effect of the pedaling cadence (500 × 100 rpm) on the heart rate (HR) and the blood lactate response during incremental and constant workload exercises in active individuals. Nine active male individuals (20.9 ± 2.9 years old; 73.9 ± 6.5 kg; 1.79 ± 0.9 m) were submitted to two incremental tests, and to 6-8 constant workload tests to determine the intensity corresponding to the maximal steady state lactate (MLSSintens) in both cadences. The maximal power (Pmax) attained during the incremental test, and the MLSSintens were significantly lower at 100 rpm (240.9 ± 12.6 W; 148.1 ± 154.W) compared to 50 rpm (263.9 ± 18.6 W; 186.1 ± 21.2 W), respectively. The HRmax did not change between cadences (50 rpm = 191.1 ± 8.8 bpm; 100 rpm = 192.6 ± 9.9 bpm). Regardless the cadence, the HRmax percentage (70, 80, 90, and 100%) determined the same lactate concentrations during the incremental test. However, when the intensity was expressed in Pmax percentage or in absolute power, the lactate and the HR values were always higher at highest cadences. The HR corresponding to MLSSintens was similar between cadences (50 rpm = 162.5 ± 9.1 bpm; 100 rpm = 160.4 ± 9.2 bpm). Based on these results, it can be conclude that regardless the cadence employed (50 × 100 rpm), the use of the HR to individualize the exercise intensity indicates similar blood lactate responses, and this relationship is also kept in the exercise of constant intensity performed at MLSSintens. On the other hand, the use of the Pmax percentages depend on the cadence used, indicating different physiological responses to a same percentage.

Consumo de medicamentos por idosos segundo prescrição médica em Jaú-SP

This study was carried out in order to identify the interactions that occur most often between prescribed drugs as they are taken by elderly patients attending municipal public health centers in the city of Jaú, São Paulo State, Brazil. It is known that older people frequently have to live with chronic health problems, which oblige them to use the health service a great deal and to consume large quantities of medicines. When concomitant diseases are present, and polytherapy is being applied, the likelihood of adverse reactions and interactions between drugs increases. The population under study consisted of 148 persons aged 65 or more who frequented the pharmacy at the Núcleo de Gestão Assistencial (Municipal Health Centre, NGA25) in Jaú, between August and December 2004. Data were collected from medical prescriptions, the independent variables being the age and sex of the patient. For each patient, the pharmacological classes of drugs taken and drug-drug interactions were recorded. It was found that the mean numbers of drugs consumed were 3.8 among women and 3.9 among men. In terms of age, the highest number of drugs (4.2) was used in the group aged 75 to 84 years. The most frequently prescribed classes, in decreasing order, were: antihypertensives, 25.0%, heart drugs, 15.5%, diuretics, and anti-diabetic drugs, 10.7%. It was concluded that the classes most involved in drug-drug interactions were heart drugs, diuretics and antihypertensives. The most problematic active constituents were digoxin, amiodarone, frusemide, captopril, propranolol and nifedipine.

Quantum propagator for some classes of three-dimensional three-body systems

In this work we solve exactly a class of three-body propagators for the most general quadratic interactions in the coordinates, for arbitrary masses and couplings. This is done both for the constant as the time-dependent couplings and masses, by using the Feynman path integral formalism. Finally, the energy spectrum and the eigenfunctions are recovered from the propagators. © 2005 Elsevier Inc. All rights reserved.

Análise da incerteza na representação de classes de cobertura do solo urbano resultantes da aplicação de uma rede neural artificial

The great diversity of materials that characterizes the urban environment determines a structure of mixed classes in a classification of multiespectral images. In that sense, it is important to define an appropriate classification system using a non parametric classifier, that allows incorporating non spectral (such as texture) data to the process. They also allow analyzing the uncertainty associated to each class from the output alues of the network calculated in relation to each class. Considering these properties, an experiment was carried out. This experiment consisted in the application of an Artificial Neural Network aiming at the classification of the urban land cover of Presidente Prudente and the analysis of the uncertainty in the representation of the mapped thematic classes. The results showed that it is possible to discriminate the variations in the urban land cover through the application of an Artificial Neural Network. It was also possible to visualize the spatial variation of the uncertainty in the attribution of classes of urban land cover from the generated representations. The class characterized by a defined pattern as intermediary related to the impermeability of the urban soil presented larger ambiguity degree and, therefore, larger mixture.

Destroying horseshoes via heterodimensional cycles: Generating bifurcations inside homoclinic classes

In this paper, we propose a model for the destruction of three-dimensional horseshoes via heterodimensional cycles. This model yields some new dynamical features. Among other things, it provides examples of homoclinic classes properly contained in other classes and it is a model of a new sort of heteroclinic bifurcations we call generating. © 2008 Cambridge University Press.

Retalho de rotação para defeitos da asa nasal

Surgical defects of the alar lobule can be difficult to repair with functional and aesthetically desirable results. Skin grafts are smoother and paler than the nasal skin. Flaps from the cheek and proximal nose can bridge the alar crease, resulting in obstruction. The authors describe a technique to repair nasal ala defects, with maintenance of the cosmetic unit, without airflow disturbance.

Dependência estrutural da capacidade de rotação plástic em vigas de concreto armado

Summary In this work the structural dependence of plastic rotation capacity in RC beams is evaluated using the Finite Element Method. The objective is to achieve a better understanding of the non-linear behavior of reinforced concrete members and perform extensive parameter studies, using a rational model developed by Bigaj [1] to analyze the phenomenon of plastic rotation capacity in reinforced concrete members. It is assumed that only bending failure is relevant due to sufficient member resistance against shear and torsion. The paper begins with the physical and theoretical background of the phenomenon of plastic hinge development in RC structures. Special emphasis is laid on the issue of structural dependence of deformation capacity of plastic hinges in RC members. Member size dependence and influence of properties of construction materials were emphasized as well. The essential components of the Bigajs model for calculating the plastic rotation capacity are discussed. The behaviour of the plastic hinge is analysed taking into account the strain localisation in the damage zones of the hinge region. The Fictitious Crack Model (FCM) and the Compressive Damage Zone Model (CDZ) are adopted in a Fracture Mechanics approach to model the behaviour of concrete in tension and compression, respectively. The approach is implemented in FEMOOP, a FEM in-house solver under development, and applied to evaluate ductility in 2D beams. The models were generated with GiD, a pre-processor and post-processor developed by CIMNE, and analyzed with the capabilities implemented in FEMOOP. © Universitat Politècnica de Catalunya, Barcelona, España 2010.

Planejamento, síntese e avaliação farmacológica de compostos híbridos potencialmente ativos para o tratamento da anemia falciforme

Sickle cell disease (SCD) is a hereditary hemolytic anemia caused by the inheritance of one S hemoglobin gene from each ancestor. Patients with SCD present increased circulating levels of cytokines, including TNF-alpha (TNF-α). Hydroxyurea (HU) is the available therapeutically strategy for treatment; it acts as a source of nitric oxide and benefits patients by increasing the levels of fetal hemoglobin (HbF). Thus, within one research line that aims at finding new drugs, a series of compounds with TNF-α inhibition and nitric oxide donation properties have been synthesized in order to explore possible synergism of actions beneficial in the treatment of the disease. Six compounds were synthesized: five derivatives of organic nitrates and one of sulfonamide. The compounds, (1,3-dioxo-1,3-dihydro-2Hisoindol-2-yl) methyl nitrate (compound I); (1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl) ethyl nitrate (compound II); 3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl) benzyl nitrate (compound III);4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-hydroxybenzenesulfonamide (compound IV); 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl) benzyl nitrate (compound V) and 2-[4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl) phenyl]ethyl nitrate (compound VI), were synthesized using linear synthetic methodology, with excellent overall yields. All compounds showed anti-inflammatory and analgesic effects with a reduction in 43%-65% of ear edema in mice and a reduction of 25%-42% of writhing induced by acetic acid. All compounds showed comparable reductions in the leukocyte infiltration capacity and ability to generate nitric oxide. The aryl compounds (III, IV and V) presented less mutagenic activity compared to compounds I, II and VI according to the salmonella mutagenicity assay (Ames test). Compounds IV and VI showed activity in K562 culture cells, with increases in gamma globin gene expression to levels higher than with hydroxyurea suggesting a potential to increase fetal hemoglobin. This data set characterizes new potentially useful drug candidates for the treatment of symptoms of sickle cell anemia.

Consórcio de milho com Urochloa ruziziensis e os efeitos na cultura da soja em rotação

This work aimed to study the intercropping of corn and Urochloa ruziziensis cv. Common, regarding to vegetative growth and corn yield, capacity of production of forage dry matter, the infestation of weeds and the effect of this system of production in the soybean crop in rotation. Two forms of sowing (hand-sowing and on-line sowing) of U. ruziziensis, four amounts of seeds (200, 400, 600 e 800 points of cultural value, PCV = quantities of seeds x cultural value) and one treatment additional with the single corn were studied. The intercropping did not affect negatively the vegetative growth and corn yield when compared to the single corn. The sowing of 200 PCV of U. ruziziensis seeds, hand-sowed and on-line sowed to 22 days after of sowing of the corn was enough for the maintenance of adequate amount of straw on the soil. At the moment of the harvest of the corn, the dry matter of weed reduced with the increase of the amount of U. ruziziensis seeds and was bigger when the forager was hand-sowed. In the soybean crop in rotation, the density and dry matter of weed reduced linearly with the increase of the amount of U. ruziziensis seeds used in the first year of the research. The intercropping of corn and U. ruziziensis in the first year of the experiment benefited the plants population, plants height and yield of soybean when compared to the monoculture of corn in the same period.

Lê cycles and Milnor classes

The purpose of this work is to establish a link between the theory of Chern classes for singular varieties and the geometry of the varieties in question. Namely, we show that if Z is a hypersurface in a compact complex manifold, defined by the complex analytic space of zeroes of a reduced non-zero holomorphic section of a very ample line bundle, then its Milnor classes, regarded as elements in the Chow group of Z, determine the global Lê cycles of Z; and vice versa: The Lê cycles determine the Milnor classes. Morally this implies, among other things, that the Milnor classes determine the topology of the local Milnor fibres at each point of Z, and the geometry of the local Milnor fibres determines the corresponding Milnor classes. © 2013 Springer-Verlag Berlin Heidelberg.