The politics of suffering: Progress, modernity and the adolescent crisis

A concern for progress is central to the public agendas of modern societies. Political actors compete with one another mainly with regard to their respective claims to bring about a better future, particularly in the economic and technological spheres. The focus on progress has, however, deeper roots which date back to the aspirations of the Enlightenment. Around that time, the belief arose that systematic improvements are made possible by the structural features of modern society and culture, improvements that will gradually release humanity from much of the suffering characterising its historical past. This article argues the persistence of a culture of progress, rather than easing suffering, in fact enhances and mobilises it for the pursuit of superficial forms of gain. It is also claimed the attempt by Habermas' critical theory to develop a broader and more satisfactory conception of progress fails to address this problem. The article suggests an alternative and more fundamental critique of progressive ideas is required. It reflects upon these abstract theoretical questions in connection with the concrete example of the 'adolescent crisis' and the role ideas of progress play within it.

Mass transfer correlations for rotating drum bioreactors

Evaporative cooling is extremely important for large-scale operation of rotating drum bioreactors (RDBs). Outlet water vapour concentrations were measured for a RDB containing wet wheat bran with the aim of determining the mass transfer coefficient for evaporation from the bran bed to the headspace. Mass transfer was expressed as the mass transfer coefficient times the area for transfer per unit volume of void space in the drum. Values of ka' were determined under combinations of aeration superficial velocities ranging from 0.006 to 0.017 ms(-1) and rotation rates ranging from 0 to 9 rpm. Mass transfer coefficients were evaluated using a variety of residence time distributions (RTDs) for flow in the gas phase including plug flow and well-mixed and a Central Jet RTD based on RTD studies. If plug flow is assumed, the degree of holdup at low effective Peclet (Pe(eff)) numbers gives an apparent under-estimate of ka' compared with empirical correlations. Values of ka' calculated using the Central Jet RTD agree well with values of ka' from literature correlations. There was a linear relationship between ka' and effective Peclet number: ka' = 2.32 x 10(-3) Pe(eff). (C) 2002 Elsevier Science B.V. All rights reserved.

Intraorbital anatomy of the koala (Phascolarctos cinereus)

This is the first documented study of the anatomical details of the contents of the normal koala orbit, excluding the bulbus oculi. Baseline data were established which are necessary for understanding and treating ocular disease in the koala (Phascolarctos cinereus). The anatomy of the orbital contents of the koala were examined and described from animals that presented dead or were euthanized for humane reasons. Dissections of the orbital cavity were performed under magnification. Polymethyl methacrylate (PMMA) casts of the nasolacrimal system and the vascular supply of the orbit were also made in order to study these systems. The superficial lymphatic drainage of the conjunctival tissues was studied by subcutaneous injection of Evan's Blue into the palpebral conjunctiva of a freshly deceased animal, and by Microfil casts of the efferent lymphatics. In general, the orbital contents of the koala are consistent with those of other carnivorous polyprotodont and herbivorous diprotodont marsupials.

The embryonic development of the bodywall and nervous system of the cestode flatworm Hymenolepis diminuta

Cestodes (tapeworms) are a derived, parasitic clade of the phylum Platyhelminthes (flatworms). The cestode body wall represents an adaptation to its endoparasitic lifestyle. The epidermis forms a nonciliated syncytium, and both muscular and nervous system are reduced. Morphological differences between cestodes and free-living flatworms become apparent already during early embryogenesis. Cestodes have a complex life cycle that begins with an infectious larva, called the oncosphere. In regard to cell number, cestode oncospheres are among the simplest multicellular organisms, containing in the order of 50-100 cells. As part of our continuing effort to analyze embryonic development in flatworms, we describe here the staining pattern obtained with acTub in embryos and larvae of the cestode Hymenolepis diminuta and, briefly, the monogenean Neoheterocotyle rhinobatidis. In addition, we labeled the embryonic musculature of Hymenolepis with phalloidin. In Hymenolepis embryos, two different cell types that we interpret as neurons and epidermal gland cells express acTub. There exist only two neurons that develop close to the midline at the anterior pole of the embryo. The axons of these two neurons project posteriorly into the center of the oncosphere, where they innervate the complex of muscles that is attached to the booklets. In addition to neurons, acTub labels a small and invariant set of epidermal gland cells that develop at superficial positions, anteriorly adjacent to the neurons, in the dorsal midline, and around the posteriorly located hooklets. During late stages of embryogenesis they spread and form a complete covering of the embryo. We discuss these data in the broader context of platyhelminth embryology.

Th1 cytokines in oral lichen planus

Background: Cell-mediated immune responses in oral lichen planus (OLP) may be regulated by cytokines and their receptors. Methods: In situ cytokine expression and in vitro cytokine secretion in OLP were determined by immunohistochemistry and ELISA. Resulults: The majority of subepithelial and intraepithelial mononuclear cells in OLP were CD8(+) . In some cases, intraepithelial CD8(+) cells were adjacent to degenerating keratinocytes. CD4(+) cells were observed mainly in the deep lamina propria with occasional CD4(+) cells close to basal keratinocytes. Mononuclear cells expressed IFN-gamma in the superficial lamina propria and TNF-alpha adjacent to basal keratinocytes. Basal keratinocytes expressed TNF-alpha as a continuous band. TNF R1 was expressed by mononuclear cells and basal and suprabasal keratinocytes. There was variable expression of TGF-beta1 in the subepithelial infiltrate while all intraepithelial mononuclear cells were TGF-beta1(-) . Keratinocytes in OLP stained weakly for TGF-beta1. Unstimulated OLP lesional T cells secreted IFN-gammain vitro . TNF-alpha stimulation down-regulated IFN-gamma secretion and up-regulated TNF-alpha secretion. IL-4, IL-10 and TGF-beta1 secretion were not detected. Conclusions: These data suggest the development of a T helper 1 immune response that may promote CD8(+) cytotoxic T-cell activity in OLP.

Development of motor system dysfunction following whiplash injury

Dysfunction in the motor system is a feature of persistent whiplash associated disorders. Little is known about motor dysfunction in the early stages following injury and of its progress in those persons who recover and those who develop persistent symptoms. This study measured prospectively, motor system function (cervical range of movement (ROM), joint position error (JPE) and activity of the superficial neck flexors (EMG) during a test of cranio-cervical flexion) as well as a measure of fear of re-injury (TAMPA) in 66 whiplash subjects within 1 month of injury and then 2 and 3 months post injury. Subjects were classified at 3 months post injury using scores on the neck disability index: recovered (30). Motor system function was also measured in 20 control subjects. All whiplash groups demonstrated decreased ROM and increased EMG (compared to controls) at 1 month post injury. This deficit persisted in the group with moderate/severe symptoms but returned to within normal limits in those who had recovered or reported persistent mild pain at 3 months. Increased EMG persisted for 3 months in all whiplash groups. Only the moderate/severe group showed greater JPE, within 1 month of injury, which remained unchanged at 3 months. TAMPA scores of the moderate/severe group were higher than those of the other two groups. The differences in TAMPA did not impact on ROM, EMG or JPE. This study identifies, for the first time, deficits in the motor system, as early as 1 month post whiplash injury, that persisted not only in those reporting moderate/severe symptoms at 3 months but also in subjects who recovered and those with persistent mild symptoms. (C) 2002 International Association for the Study of Pain. Published by Elsevier Science B.V. All rights reserved.

Myoelectric manifestations of sternocleidomastoid and anterior scalene muscle fatigue in chronic neck pain patients

Objective: This study compares myoelectric manifestations of fatigue of the sternocleidomastoid (SCM) and anterior scalene (AS) muscles between 10 chronic neck pain subjects and 10 normal matched controls. Methods: Surface electromyography (sEMG) signals were recorded from the sternal bead of SCM and AS muscles bilaterally during submaximal isometric cervical flexion contractions at 25 and 50% of the maximum voluntary contraction (MVC). The mean frequency, average rectified value and conduction velocity of the sEMG signal were calculated to quantify myoelectric manifestations of muscle fatigue. Results: For both the SCM and AS muscles, the Mann-Whitney U test indicated that the initial value and slope of the mean frequency in neck pain patients were greater than in healthy subjects (P < 0.05). This was significant both at 25 and 50% of MVC. Conclusions: These results suggest: (a) a predominance of type-II fibres in the neck pain patients and/or (b) greater fatigability of the superficial cervical flexors in neck pain patients. These results are in agreement with previous muscle biopsy studies in subjects with neck pain, which identified transformation of slow-twitch type-I fibres to fast-twitch type-IIB fibres, as well as the clinical observation of reduced endurance in the cervical flexors in neck pain patients. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.

Prognostic use of growth characteristics of early gastric cancer and expression patterns of apoptotic, cell proliferation, and cell adhesion proteins

Background and Objectives: Selection of suitable treatment for early gastric cancers, such as endoscopic mucosal resection or the major surgical option of resection of the cancer together with a radical lymph node dissection, may be assisted by comparing the growth characteristics of the cancer with selected molecular characteristics. The results could be used to predict those cases that have a higher risk of developing secondary metastases. Methods: A total of 1,196 Japanese patients with early gastric cancers (648 mucosal cancers and 548 submucosal) were included in the selection of two groups: a metastatic group made up 57 cancers with lymph node metastasis (9 mucosal, 48 submucosal), and a nonmetastatic group of 61 cases (6 mucosal, 55 submucosal) without lymph node metastasis. Growth characteristics of the cancers (superficially spreading, penetrating or invasive, lymph node metastasis) were compared with immunohistochemical expression of single-stranded DNA (ssDNA) protein (apoptosis indicator), bcl-2 and p53 (apoptosis-associated), Ki-67 (cell proliferation), and E-cadherin (cell adhesion) proteins. Results: The lesions in the nonmetastatic group had higher levels of apoptosis and lower expression of bcl-2 than in the metastatic group, indicating an inhibitory role for apoptosis in malignant progression. Apoptosis was also higher in the superficial compared with the invasive lesions of both groups. The lesions in the metastatic group had higher p53 expression than that of the nonmetastatic group, whereas apoptosis in the metastatic group was lower than in the nonmetastatic group. An unproved explanation for this finding may be that, although increased, p53 was mutated and ineffective in promoting apoptotic control of metastatic progression. E-cadherin was decreased in the invasive lesions of both groups, indicating a greater ability of these cells to lose adhesion, to invade the submucosa, and to metastasize. Cell proliferation was highest in the superficial lesions of both metastatic and nonmetastatic groups. Conclusions: Early gastric cancers with low levels of apoptosis, increased bcl-2, and high levels of p53 expression are more likely to invade and metastasize. (C) 2003 Wiley-Liss, Inc.

Melanocytic nevi, solar keratoses, and divergent pathways to cutaneous melanoma

Background: Some melanomas form on sun-exposed body sites, whereas others do not. We previously proposed that melanomas at different body sites arise through different pathways that have different associations with melanocytic nevi and solar keratoses. We tested this hypothesis in a case-case comparative study of melanoma patients in Queensland, Australia. Methods: We randomly selected patients from among three prespecified groups reported to the population-based Queensland Cancer Registry: those with superficial spreading or nodular melanomas of the trunk (n = 154, the reference group), those with such melanomas of the head and neck (n = 77, the main comparison group), and those with lentigo maligna melanoma (LMM) (n = 75, the chronic sun-exposed group). Each participant completed a questionnaire, and a research nurse counted melanocytic nevi and solar keratoses. We calculated exposure odds ratios (ORs) and 95% confidence intervals (CIs) to quantify the association between factors of interest and each melanoma group. Results: Patients with head and neck melanomas, compared with patients with melanomas of the trunk, were statistically significantly less likely to have more than 60 nevi (OR = 0.34, 95% CI = 0.15 to 0.79) but were statistically significantly more likely to have more than 20 solar keratoses (OR = 3.61, 95% CI = 1.42 to 9.17) and also tended to have a past history of excised solar skin lesions (OR = 1.87, 95% CI = 0.89 to 3.92). Patients with LMM were also less likely than patients with truncal melanomas to have more than 60 nevi (OR = 0.32, 95% CI = 0.14 to 0.75) and tended toward more solar keratoses (OR = 2.14, 95% CI = 0.88 to 5.16). Conclusions: Prevalences of nevi and solar keratoses differ markedly between patients with head and neck melanomas or LMM and patients with melanomas of the trunk. Cutaneous melanomas may arise through two pathways, one associated with melanocyte proliferation and the other with chronic exposure to sunlight.

Censo previdenci??rio: solu????es inovadoras para a atualiza????o cadastral

Este trabalho apresenta as pr??ticas bem-sucedidas de uma pol??tica p??blica implementada e gerenciada por equipe de servidores no ??mbito do INSS e que apresentou solu????es inovadoras para a atualiza????o do cadastro e comprova????o de vida de 17,2 milh??es de benefici??rios. As inconsist??ncias prejudicavam o controle da correta manuten????o dos pagamentos de benef??cios. O projeto possibilitou atualizar a base de dados e representou grande economia para a institui????o, devendo seu sucesso a uma ampla rede de atendimento, ??s parcerias, ?? valoriza????o dos servidores e, acima de tudo, ?? preocupa????o com a qualidade do atendimento, construindo um processo que se ajuste ??s necessidades dos benefici??rios e n??o o contr??rio. Esse esfor??o pode, ainda, ser adaptado a outras institui????es que desejem realizar atualiza????es cadastrais, com qualidade de atendimento e integridade das informa????es coletadas

Fortalecer o servi??o p??blico e valorizar a cidadania: a op????o australiana

O artigo analisa o processo de reforma administrativa empreendida na Austr??lia ao longo das d??cadas de 70-80, destacando duas de suas principais tend??ncias: o fortalecimento da ???Fun????o Executiva Superior???e a valoriza????o da cidadania. Nele s??o descritos os princ??pios b??sicos norteadores da reforma ao longo dos anos 70, bem como, os objetivos visados com a segunda fase das reformas executadas a partir da d??cada de 80, implementadas por governos trabalhistas. Destaca-se a organiza????o e o funcionamento do sistema das Ag??ncias de Ombudsmen e dos Comiss??rios de Contas respons??veis pela fiscaliza????o e gest??o or??ament??ria. A seguir, s??o descritas algumas das a????es encaminhadas pela Public Service Commission (PSC) no sentido de aperfei??oar o gerenciamento e o melhor desempenho dos recursos humanos, destacando a introdu????o do importante conceito de Novo Profissionalismo, assentado em valores como responsabilidade para com o governo, foco nos resultados, m??rito como valor b??sico, altos n??veis de integridade e probidade na conduta, desempenho com accountability e melhoramento cont??nuo do desempenho das equipes e indiv??duos. Outro importante instrumento analisado ?? o Human Resource Management, atrav??s do qual as autoridades australianas introduziram novas pr??ticas como negocia????o no local de trabalho, plano de oportunidades igualit??rias no local de trabalho e o plano de treinamento e especializa????o. Para finalizar, o artigo enfoca a pol??tica de contratualiza????o de servi??os p??blicos adotada na Austr??lia ??? os Competitive Tendering and Contracting, evidenciando os fatores indutores da ado????o desta nova pr??tica de gest??o.

Teoria da estrutura em organiza????o

Dentro de uma conceitua????o geral, pode-se dizer que organiza????o ?? sinergia: unidade de a????o. E que a unidade de a????o tem seu fundamento na singularidade de prop??sito. Assim, um team de foot-ball, que ?? um conjunto de elementos operando com o mesmo prop??sito, ?? uma organiza????o. Esta caracteriza????o din??mica subentende a exist??ncia de uma base f??sica em cada organiza????o. A base f??sica, ou o corpo da organiza????o, ?? o grupo social. A ci??ncia organiza????o se preocupa com os fen??menos da natureza relacional, ocorridos entre os elementos do grupo social , e que repercutem na consecu????o do fim a que se prop??e o grupo. P??sto assim o problema, percebe-se, de imediato, que em organiza????o todos os fatos s??o moldados por um valor constante: o fim a que se prop??e o grupo; e que a natureza d??sses fatos ?? ???relacional???, do que resulta serem insepar??veis, inatomiz??veis. Uma an??lise, mesmo superficial de um grupo organizado ??? voltemos ao exemplo do team de foot-ball ??? revela que ??le ?? constitu??do de: a) elementos materiais e humanos (a bola, o campo e os homens); b) tarefas a executar (as fun????es de keeper, de back, etc); c) rela????es estruturais f??sicas e psicol??gicas entre os elementos para realiza????o das tarefas.

Resolu????o n?? 12, de 31 de outubro de 2014: estabelece a Pol??tica de Seguran??a da Informa????o e Comunica????es - PoSIC no ??mbito da ENAP

A Escola Nacional de Administra????o P??blica (Enap) publicou, no dia 31 de outubro de 2014, a Resolu????o n?? 12, que estabelece a Pol??tica de Seguran??a da Informa????o e Comunica????es (PoSIC). A PoSIC institui diretrizes estrat??gicas, responsabilidades e compet??ncias, visando assegurar a disponibilidade, integridade, confidencialidade e autenticidade das informa????es produzidas ou custodiadas pela Enap, de modo a preservar os seus ativos e sua imagem institucional. A Pol??tica trata do uso e compartilhamento do conte??do de dados, informa????es e documentos no ??mbito da Enap, em todo o seu ciclo de vida - cria????o, manuseio, divulga????o, armazenamento, transporte e descarte. O objetivo ?? garantir a continuidade de seus processos cr??ticos, em conformidade com a legisla????o vigente, normas pertinentes, requisitos regulamentares e contratuais, valores ??ticos e as melhores pr??ticas de seguran??a da informa????o e comunica????es.

??tica na pesquisa agropecu??ria: percep????o dos pesquisadores da Embrapa

Esse trabalho apresenta os resultados de um estudo sobre a percep????o dos pesquisadores da Empresa Brasileira de Pesquisa Agropecu??ria (Embrapa) a respeito da ??tica na pesquisa agropecu??ria. O estudo foi explorat??rio e adotou abordagens qualitativa e quantitativa. A pesquisa qualitativa utilizou entrevistas individuais semiestruturadas com 21 formadores de opini??o (dirigentes, ex-dirigentes e ocupantes ou ex-ocupantes de cargos estrat??gicos) e serviu de base para a constru????o do question??rio para a pesquisa quantitativa. Da popula????o estudada, 1.846 pesquisadores, houve um retorno de 26,65% dos question??rios. Os resultados da pesquisa revelaram grande interesse entre os pesquisadores ouvidos pelo tema objeto do estudo e ao mesmo tempo uma falta de clareza de parte deles sobre o que seria ??tica na pesquisa agropecu??ria. O estudo recomenda uma ampla discuss??o na Empresa sobre o tema, culminando na implanta????o de ???gest??o da ??tica??? na pesquisa.

Os sentidos da escola no contexto de crise de sentido : uma análise a partir do programa educação em valores humanos/projeto escola sustentável em Serra-ES

À luz dos autores Berger e Luckmann (2005); De Bastiani (2008); Ferreira (2009); Peruzzo (2010) e Maia (2011), esta pesquisa aborda o que os autores chamam de crise de sentido, contexto em que se percebe uma radical mudança das condições básicas da vida humana e uma crescente transformação dos valores sociais. Esse cenário revela a condição de estar em um mundo onde o que é valorizado é o fugaz, o aparente, o superficial, o sem sentido. Desse modo, propõe uma análise sobre a educação como processo de formação humana, afirmando a instituição escolar como espaço privilegiado de possibilidades emancipatórias de existência. Tendo como contexto de investigação o Programa Educação em Valores Humanos (PEVH) / Projeto Escola Sustentável (PES) desenvolvido em uma das escolas do município de Serra-ES, as questões orientadoras tiveram como objetivo investigar como essa experiência se articula aos enunciados da crise de sentido e como tem favorecido o desenvolvimento da ideia de formação humana no âmbito escolar. A metodologia privilegiada foi o estudo de caso tendo como instrumentos de pesquisa a observação participante, a análise documental e as entrevistas. A partir da perspectiva qualitativa, a pesquisa em campo evidenciou que, embora os sentidos pretendidos pelo desenvolvimento do PEVH / PES nas escolas tenham despertado atenção a questões atuais e relevantes, circunscreveram-se alheios a um debate mais amplo e profundo acerca da escola na atualidade distanciando-se de uma perspectiva crítica. Logo, pela via da responsabilização individual, desconsiderou as contradições históricas.