Behavioural and histopathological alterations in mice with cerebral malaria.

Different features of sensorimotor function and behaviour were studied in murine cerebral malaria (CM) and malaria without cerebral involvement (non-CM) applying the primary screen of the SHIRPA protocol. Histopathological analysis of distinct brain regions was performed and the relative size of haemorrhages and plugging of blood cells to brain vasculature was analysed. Animals suffering from CM develop a wide range of behavioural and functional alterations in the progressive course of the disease with a statistically significant impairment in all functional categories assessed 36 h prior to death when compared with control animals. Early functional indicators of cerebral phenotype are impairments in reflex and sensory system and in neuropsychiatric state. Deterioration in function is paralleled by the degree of histopathological changes with a statistically significant correlation between the SHIRPA score of CM animals and the mean size of brain haemorrhage. Furthermore, image analysis yielded that the relative area of the brain lesions was significantly larger in the forebrain and brainstem compared with the other regions of interest. Our results indicate that assessment of sensory and motor tasks by the SHIRPA primary screen is appropriate for the early in vivo discrimination of cerebral involvement in experimental murine malaria. Our findings also suggest a correlation between the degree of functional impairment and the size of the brain lesions as indicated by parenchymal haemorrhage. Applying the SHIRPA protocol in the functional characterization of animals suffering from CM might prove useful in the preclinical assessment of new antimalarial and potential neuroprotective therapies.

The economics of reducing the county road system: three case studies in Iowa. Final report.

Transportation Department, Office of University Research, Washington, D.C.

Accident investigation studies in conjunction with FMVSS 301 compliance testing (1981 model year). Final report.

National Highway Traffic Safety Administration, Office of Vehicle Safety Compliance, Washington, D.C.

Studies in the packing industry /

[no. 1] The chain store and the packing industry, by E. L. Rhoades.--[no. 2] The management of chain meat markets, by E. L. Rhoades.--[no. 3] Chain stores and the independent meat retailer, by E. L. Rhoades.--[no. 4] Advertising of meats by chain grocery companies, by E. L. Rhoades.--[no. 5] Consumption of meat and meat products, with particular reference fo price, by J. H. Cover.

Winds of doctrine : studies in contemporary opinion /

Title page in red and black.

Humanism and tyranny, studies in the Italian trecento,

The text of each document, with an introduction.

Studies in Japanese folklore.

Mode of access: Internet.

Studies in plains Indian folklore,

Mode of access: Internet.

Studies in Chaucer: his life and writings.

Mode of access: Internet.

Hamline studies in musicology.

Errata slips inserted.

Texts and studies in Jewish history and literature,

Errata slip inserted between p. [vii] and viii of v. 1 and p. [iv] and v of v. 2.

The Manly anniversary studies in language and literature.

"Presented to John Matthews Manly by his students and associates on the completion of his twenty-fifth year as head of the Department of English in the University of Chicago."