A new short and simple health-related quality of life measurement for paediatric rheumatic diseases: initial validation in juvenile idiopathic arthritis

Objective. To develop and validate a new short and simple measure of health-related quality of life (HRQL) in children with juvenile idiopathic arthritis (JIA).Methods. The Paediatric Rheumatology Quality of Life Scale (PRQL) is a 10-item questionnaire that explores HRQL in two domains: physical health (PhH) and psychosocial health (PsH). Validation of the parent proxy report and child self-report versions of the instrument was accomplished by evaluating 472 JIA patients and similar to 800 healthy children. Validation analyses included assessment of feasibility, face and content validity; construct and discriminative ability; internal structure and consistency; test-retest reliability; responsiveness to clinical change; and minimal clinically important difference.Results. The PRQL was found to be feasible and to possess both face and content validity. The PRQL score correlated in the predicted range with most of the other JIA outcome measures, thereby demonstrating good construct validity, and discriminated well between different levels of disease severity. Assessment of internal structure (factor analysis) revealed that the PhH and PsH subscales identify two unambiguously separated domains. The internal consistency (Cronbach's alpha) was 0.86. The intraclass correlation coefficient for test-retest reliability was 0.91. The PRQL revealed fair responsiveness, with a standardized response mean of 0.67 in improved patients. Overall, the PRQL appeared to be more able to capture physical HRQL than psychosocial HRQL.Conclusion. The PRQL was found to possess good measurement properties and is, therefore, a valid instrument for the assessment of HRQL in children with JIA. This tool is primarily proposed for use in standard clinical care.

Seleção de espermatozoides para ICSI

The application of assisted reproduction techniques has provided help to many men seeking to father a child, although the current success of these procedures remains suboptimal. Today some protocols allow sperm to be selected according to their ultrastructural morphology or surface molecular characteristics. On the other hand, successful human reproduction relies partly on the inherent integrity of sperm DNA. Therefore, it is now necessary to improve the safety of the sperm selection method. It is urgent to optimize procedures to isolate spermatozoa for ICSI with low risk of DNA damage. In recent years, two technologies have attracted the attention of specialists as methods capable of identifying a spermatozoon with low risk of DNA damage: Ultrastructural morphology sperm selection at high magnification and sperm head birefringence selection. This review analyses these two technologies. © Todos os direitos reservados a SBRA - Sociedade Brasileira de Reprodução Assistida.

The millennium development goals and the challenges facing Latin America and the Caribbean in making progress towards higher levels of well-being, better human capital and more equal opportunities

Includes bibliography

Entre os discursos, as representações e as práticas: crianças e jovens empregadas domésticas na cidade de Marília

Pós-graduação em Ciências Sociais - FFC

Paternidad responsable en el Istmo Centroamericano

Incluye Bibliografía

An evaluative study of the implementation of domestic violence legislation: Antigua and Barbuda, St. Kitss

Includes bibliography

Crianças brincando de casinha numa brinquedoteca: um olhar psicanalítico

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Child abuse: a painful reality behind closed doors

Child abuse violates the most basic rights of children and adolescents. As documented in the main article of this issue of Challenges, child abuse is a massive, daily and underreported problem that affects the population of Latin America and the Caribbean. It manifests itself in different forms, including physical and psychological aggression, rape and sexual abuse, and takes place in the home, in neighbourhoods, at school, at work and in legal and child protection institutions. Abuse tends to be transmitted from one generation to the next, and the individuals most often responsible are parents or other adult members of the household

Concepções maternas e paternas sobre desenvolvimento infantil e relações afetivas

Pós-graduação em Psicologia do Desenvolvimento e Aprendizagem - FC

Hermenêutica gestáltica do abuso sexual para uma adolescente

Esta pesquisa qualitativa de orientação fenomenológica existencial gestáltica, procura desvelar alguns significados atribuídos ao fenômeno do abuso sexual intrafamiliar, por meio de um estudo de caso em que a informante, dos 9 aos 11 anos, foi vitimizada pelo pai e ainda hoje, no seu campo existencial, é influenciada pela vivência dessa experiência. A violência contra a criança, em suas diversas modalidades, é um problema de saúde pública e de relações interpessoais entre família ou cuidador e a criança. Em se tratando do abuso sexual, em que o agressor é o responsável pelos cuidados primários, geralmente, há negação pela vítima, agressor e a família, e quase sempre, ocorre, envolvendo mais de uma modalidade de violência. Mesmo não havendo um consenso entre os autores, a maioria destaca os efeitos nocivos desses acontecimentos sobre a saúde psíquica, ocupacional, física e desenvolvimental das vítimas. Os dados foram coletados na ONG República de Emaús abrangendo leitura de documentos, relatos informais, observação participante e entrevista com a adolescente, sendo esta última, a principal fonte de apreciação. A análise da entrevista conjugou, na medida do possível, a teoria da interpretação de Ricoeur, alguns conceitos da gestalt-terapia como o de contato, figura-fundo, e nutrição psicológica; e da Terapia Ocupacional, como áreas, componentes e os contextos de desempenho. Da entrevista foram criadas unidades de significação que nortearam as reflexões acerca dos significados do discurso da adolescente. Alguns resultados são: apresentação do peso da vivência do abuso sexual ora como figura ora como fundo; repercussões disfuncionais de auto-contato e contato com o outro; na auto-imagem, auto-estima e em algumas áreas de desempenho: aprendizagem e socialização. O ajustamento criativo pode ser identificado na abertura em revelar a experiência, o que sugere expansão de suas fronteiras de contato. Uma conclusão que o estudo apontou foi sobre a relação da adolescente com o pai que, ainda, destaca-se enquanto uma gestalt aberta.

Molecular evidence of mother-to-child transmission of HTLV-IIc in the Kararao Village (Kayapo) in the Amazon Region of Brazil

Amostras de sangue de índios nativos na aldeia Kararao (Kayapó) foram analisadas, usando-se métodos sorológico e molecular, para caracterizar a infecção e analisar a transmissão do HTLV-II. Observou-se reatividade específica em 3/26 indivíduos, dos quais duas amostras eram de uma mãe e de seu filho. A análise pela RFLP de regiões pX e env confirmou a infecção pelo HTLV-II. A seqüência de nucleotídios do segmento 5'LTR e a análise filogenética mostraram alta similaridade (98%) entre as três amostras e o protótipo HTLV-IIa (mot) e confirmaram a ocorrência do subtipo HTLV-IIc. Houve uma alta similaridade genética (99,9%) entre as amostras da mãe e do filho e a única diferença foi uma deleção de dois nucleotídios (TC) na seqüência materna. Estudos epidemiológicos anteriores entre índios nativos do Brasil forneceram prova da transmissão intrafamilial e vertical do HTLV-IIc. O presente estudo fornece evidência molecular da transmissão do HTLV-IIc de mãe para filho, um mecanismo que em grande parte é responsável pela endemicidade do HTLV nessas populações epidemiologicamente fechadas. Embora a verdadeira via de transmissão seja desconhecida, a amamentação materna poderia ser a mais provável.

Evaluation of nutritional indicators and body composition in patients with advanced liver disease enrolled for liver transplantation

PURPOSE: Malnutrition is prevalent in patients with advanced liver disease (LD) related to multifactorial causes. Fluid retention can underestimate the nutritional status based on anthropometric measures. We evaluated nutritional indicators and body composition (BC) in patients with liver cirrhosis and correlated them with LD severity. METHODS: Forty three patients with LD enrolled for liver transplantation were evaluated by Anthropometric measures, subjective evaluation (Global Assessment of Nutritional Status - SGA) and biochemical indicators. Single-frequency electrical bioimpedance (SFE-BIA) was used to evaluate body composition (BC). It measured resistance (R), reactance (Xc) and the phase angle (PA). LD severity was estimated by Child-Pugh and Meld criteria (Model for End-Stage Liver Disease). RESULTS: Child-Pugh index between patients was 7.11±1.70 and Meld was 12.23±4.22. Arm Circumference, Arm Muscle Circumference and Arm Muscle Area, SGA, hemoglobin, hematocrit and albumin showed better correlation with disease severity. Xc and PA showed correlation both with Meld and Child-Pugh score when BC were evaluated. PA was depleted in 55.8% of the patients. CONCLUSIONS: Diagnosis of malnutrition varied according to the method. Global assessment of nutritional status showed better correlation with disease severity than with objective methods. Single-frequency electrical bioimpedance for body composition analysis in cirrhotic patients must be cautiously used; however, primary vectors seems to be valid and promising in clinical practice.

Social aspects of dental caries in the context of mother-child pairs

The relationship between mother and child in the context of oral health has traditionally been exposed by the scientific literature in microbiology, which lacks a broad and necessary discussion of health and illness seen as processes, both biological and social. Objective: Investigate the family social determinants associated with the caries history of children and the need for dental treatment (NDT) among their mothers was the objective of this study. Material and Methods: This research employed a cross-sectional study of mother-child pairs living in southern Brazil. Data collection occurred in public institutions of early childhood education. The instruments included a structured questionnaire administered to mothers and clinical oral examinations of the mothers and children. The social variables considered were marital status, maternal education, number of children, income, employment status, and frequency of visits to a dental professional. The measured outcomes were the maternal NDT and child caries history. Data were analyzed by the chi-square test (chi 2) and by discriminant analysis. Results: The final sample consisted of 272 mother-child pairs and it was found that the greatest need for treatment was among mothers with low educational level and low family income who rarely or never visited a dentist. Tooth decay was less frequent in only child, and most frequent in children of mothers with low educational attainment, and in children in lower income households who rarely or never visited the dentist. The social determinants of caries in children and of the maternal NDT were similar. It follows that the maternal NDT and caries history among children were strongly associated with maternal education (p<0.0001), household income (p<0.0001), and frequency of visits to a dental professional (0.0018). Caries history among children was also associated with number of children in the household (p<0.0001). Conclusions: The results suggest that the caries experience in children depended less on the family social variables than on the maternal NDT.

Body mass index, dental caries and sugar intake in 2-5 year-old preschoolers

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)