979 resultados para Delaware Bay Region (Del. and N.J.)--Maps, Tourist.
Resumo:
Expansins are unusual proteins discovered by virtue of their ability to mediate cell wall extension in plants. We identified cDNA clones for two cucumber expansins on the basis of peptide sequences of proteins purified from cucumber hypocotyls. The expansin cDNAs encode related proteins with signal peptides predicted to direct protein secretion to the cell wall. Northern blot analysis showed moderate transcript abundance in the growing region of the hypocotyl and no detectable transcripts in the nongrowing region. Rice and Arabidopsis expansin cDNAs were identified from collections of anonymous cDNAs (expressed sequence tags). Sequence comparisons indicate at least four distinct expansin cDNAs in rice and at least six in Arabidopsis. Expansins are highly conserved in size and sequence (60-87% amino acid sequence identity and 75-95% similarity between any pairwise comparison), and phylogenetic trees indicate that this multigene family formed before the evolutionary divergence of monocotyledons and dicotyledons. Sequence and motif analyses show no similarities to known functional domains that might account for expansin action on wall extension. A series of highly conserved tryptophans may function in expansin binding to cellulose or other glycans. The high conservation of this multigene family indicates that the mechanism by which expansins promote wall extensin tolerates little variation in protein structure.
Resumo:
Glycoproteins expressing the Lutheran blood group antigens were isolated from human erythrocyte membranes and from human fetal liver. Amino acid sequence analyses allowed the design of redundant oligonucleotides that were used to generate a 459-bp, sequence-specific probe by PCR. A cDNA clone of 2400 bp was isolated from a human placental lambda gt 11 library and sequenced, and the deduced amino acid sequence was studied. The predicted mature protein is a type I membrane protein of 597 amino acids with five potential N-glycosylation sites. There are five disulfide-bonded, extracellular, immunoglobulin superfamily domains (two variable-region set and three constant-region set), a single hydrophobic, membrane-spanning domain, and a cytoplasmic domain of 59 residues. The overall structure is similar to that of the human tumor marker MUC 18 and the chicken neural adhesion molecule SC1. The extracellular domains and cytoplasmic domain contain consensus motifs for the binding of integrin and Src homology 3 domains, respectively, suggesting possible receptor and signal-transduction function. Immunostaining of human tissues demonstrated a wide distribution and provided evidence that the glycoprotein is under developmental control in liver and may also be regulated during differentiation in other tissues.
Resumo:
WT1, the Wilms tumor-suppressor gene, maps to the human chromosomal region 11p13 and encodes a transcriptional repressor, WT1, implicated in controlling normal urogenital development. Microinjection of the WT1 cDNA into quiescent cells or cells in early to mid G1 phase blocked serum-induced cell cycle progression into S phase. The activity of WT1 varied significantly depending on the presence or absence of an alternatively spliced region located upstream of the zinc finger domain. The inhibitory activity of WT1 was abrogated by the overexpression of cyclin E/CDK2 as well as cyclin D1/CDK4. Furthermore, both CDK4- and CDK2-associated kinase activities were downregulated in cells overexpressing WT1, whereas the levels of CDK4, CDK2, and cyclin D1 expression were unchanged. These findings suggest that inhibition of the activity of cyclin/CDK complexes may be involved in mediating the WT1-induced cell cycle block.
Resumo:
We present optical integral field spectroscopy (IFS) observations of the Mice, a major merger between two massive (≳10^11 M_⊙) gas-rich spirals NGC 4676A and B, observed between first passage and final coalescence. The spectra provide stellar and gas kinematics, ionised gas properties, and stellar population diagnostics, over the full optical extent of both galaxies with ~1.6 kpc spatial resolution. The Mice galaxies provide a perfect case study that highlights the importance of IFS data for improving our understanding of local galaxies. The impact of first passage on the kinematics of the stars and gas has been significant, with strong bars most likely induced in both galaxies. The barred spiral NGC 4676B exhibits a strong twist in both its stellar and ionised gas disk. The edge-on disk galaxy NGC 4676A appears to be bulge free, with a strong bar causing its “boxy” light profile. On the other hand, the impact of the merger on the stellar populations has been minimal thus far. By combining the IFS data with archival multiwavelength observations we show that star formation induced by the recent close passage has not contributed significantly to the total star formation rate or stellar mass of the galaxies. Both galaxies show bicones of high ionisation gas extending along their minor axes. In NGC 4676A the high gas velocity dispersion and Seyfert-like line ratios at large scaleheight indicate a powerful outflow. Fast shocks (vs ~ 350 km s^-1) extend to ~6.6 kpc above the disk plane. The measured ram pressure (P/k = 4.8 × 10^6 K cm^-3) and mass outflow rate (~8−20 M_⊙ yr^-1) are similar to superwinds from local ultra-luminous infrared galaxies, although NGC 4676A only has a moderate infrared luminosity of 3 × 10^10 L_⊙. Energy beyond what is provided by the mechanical energy of the starburst appears to be required to drive the outflow. Finally, we compare the observations to mock kinematic and stellar population maps extracted from a hydrodynamical merger simulation. The models show little enhancement in star formation during and following first passage, in agreement with the observations. We highlight areas where IFS data could help further constrain the models.
Resumo:
The use of solitary confinement in U.S. prisons and jails has come under increasing scrutiny. Over the past few months, Supreme Court Justice Anthony Kennedy all but invited constitutional challenges to the use of solitary confinement, while President Obama asked, “Do we really think it makes sense to lock so many people alone in tiny cells for 23 hours a day for months, sometime for years at a time?” Even some of the most notorious prisons and jails, including California’s Pelican Bay State Prison and New York’s Rikers Island, are reforming their use of solitary confinement because of successful litigation and public outcry. Rovner suggests that in light of these developments and “the Supreme Court’s increasing reliance on human dignity as a substantive value underlying and animating constitutional rights,” there is a strong case to make that long-term solitary confinement violates the constitutional right to freedom from cruel and unusual punishment.
Resumo:
Objetivo: Comparar la prevalencia de la violencia de género entre mujeres inmigrantes y españolas. Describir sus respuestas ante esta situación y posibles diferencias entre ellas. Identificar intervenciones ya existentes en España sobre prevención y atención sociosanitaria de violencia de género dirigidas a inmigrantes. Métodos: Estudio transversal mediante encuesta autoadministrada en 10.202 mujeres que acudieron a centros de atención primaria en España (2006-2007). Análisis de contenido del informe de seguimiento de la ley 1/2004 de medidas de protección integral contra la violencia de género remitido por las comunidades autónomas (CC.AA.) (2005) y las leyes y planes autonómicos más recientes. Resultados: La prevalencia de violencia de género en las españolas es del 14,3% y en las inmigrantes del 27,3%. La probabilidad de violencia de género en las inmigrantes es mayor (odds ratio ajustada: 2,06; intervalo de confianza del 95%: 1,61–2,64). Las inmigrantes dijeron haber denunciado a su pareja con más frecuencia, así como que no sabían resolver su situación. Algunas CC.AA. ya han emprendido intervenciones para superar las barreras de acceso a los servicios sociosanitarios, pero sólo tres facilitan el número de mujeres inmigrantes beneficiarias de ayudas económicas y laborales hasta 2005. Conclusiones: Existe una desigual distribución en la prevalencia de la violencia de género según el país de origen, afectando en mayor medida a las mujeres inmigrantes. Éstas denuncian con más frecuencia que las españolas, pero tal actuación no supone una garantía de resultados efectivos. Aunque se han identificado otras intervenciones específicas en algunas CC.AA., sería necesario evaluarlas para asegurar que las mujeres inmigrantes se están beneficiando.
Resumo:
El propósito de la presente aportación se centra en la consideración de los riesgos de origen natural en la actividad turística, desde una doble vertiente: el efecto de los riesgos naturales, sobre todo los de carácter excepcional, en el desarrollo de las prácticas turísticas, y la consideración del papel que corresponde al turismo en la configuración de modelos territoriales sobre territorios en riesgo. Como enmarque general, el tema de estudio es analizado como una de las dimensiones dentro de las interacciones entre medio ambiente y sistemas de ocupación del territorio, bien entendido que el desarrollo del turismo, como manifestación de las intervenciones del grupo humano en un territorio, implica y genera nuevos modelos de organización y gestión del suelo. En definitiva, formas de afectar a la relación del hombre con su entorno.
Resumo:
Comunicación presentada en la VI Conferencia de la Asociación Española para la Inteligencia Artificial (CAEPIA'95), Alicante, 15-17 noviembre 1995.
Resumo:
El turismo, objeto de diversas disciplinas, es uno de los sectores más relevantes de la economía mundial, siendo en España la primera industria nacional. En los últimos años el turismo cultural se ha revelado como un motor esencial de desarrollo para bastantes territorios. Un caso sobresaliente es el conocido como «efecto Guggenheim» que desde su creación en 1997 se ha configurado como un icono arquitectónico que ha remodelado la ciudad de Bilbao. El objeto del presente estudio ha sido reflexionar sobre las ventajas e inconvenientes desde el ámbito económico, social y medioambiental que ha tenido lugar en Bilbao desde la construcción de dicho museo.
Resumo:
Introducción: En este estudio se investigan los efectos de la crisis económica en los flujos migratorios internacionales. Específicamente, se realiza un análisis comparado sobre los comportamientos en la movilidad residencial de los principales grupos de residentes a partir de las Estadísticas de Variaciones Residenciales (EVR) de 2005 a 2010 en Alicante. Método: Se analizan los microdatos de las EVR para comparar las entradas y salidas de inmigrantes procedentes de los países que aglutinan a las personas que se trasladan orientadas por motivos más cercanos a la esfera del ocio que a la del trabajo, con el grupo de nacionalidades que concentra a la mayoría de los inmigrantes laborales que llegaron atraídos por las ofertas de empleo generadas con la expansión del sector inmobiliario. Resultados: Entre los años 2007 y 2009 se redujeron mucho las variaciones residenciales de entrada en la provincia Alicante desde el extranjero, mientras que se incrementaron las variaciones relacionadas con las salidas. Aunque existen diferencias en el balance de entradas y salidas según la zona de la provincia, la nacionalidad y la edad de los migrantes, la crisis parece asociarse con una tendencia a la reducción del número de residentes extranjeros en general. Discusión o Conclusión: Se concluye que la crisis no sólo ha generado un éxodo de los ciudadanos con menos recursos económicos, también ha provocado la salida masiva de aquellos otros inmigrantes cuya presencia en España se asocia con el consumo.
Resumo:
Los estudios sobre la vulnerabilidad social han ampliado la gestión de los riesgos naturales tradicionalmente direccionada a la amenaza natural y soluciones tecnológicas. Sin embargo la visión dominante se mantiene hegemónica sin un análisis adecuado de las causas que originan vulnerabilidad social. Este artículo propone un nuevo argumento, organizado en torno al concepto de la incuestionabilidad del riesgo, entendido como la incapacidad cultural y política de objetar el modelo socioeconómico imperante en donde residen las causas de fondo productoras de riesgo. Para concretar el concepto, a modo de ejemplo, se analizan el Plan de Actuación Municipal frente al Riesgo Sísmico de la ciudad de Torrevieja.
Resumo:
Objective: Few evaluations have assessed the factors triggering an adequate health care response to intimate partner violence. This article aimed to: 1) describe a realist evaluation carried out in Spain to ascertain why, how and under what circumstances primary health care teams respond to intimate partner violence, and 2) discuss the strengths and challenges of its application. Methods: We carried out a series of case studies in four steps. First, we developed an initial programme theory (PT1), based on interviews with managers. Second, we refined PT1 into PT2 by testing it in a primary healthcare team that was actively responding to violence. Third, we tested the refined PT2 by incorporating three other cases located in the same region. Qualitative and quantitative data were collected and thick descriptions were produced and analysed using a retroduction approach. Fourth, we analysed a total of 15 cases, and identified combinations of contextual factors and mechanisms that triggered an adequate response to violence by using qualitative comparative analysis. Results: There were several key mechanisms —the teams’ self-efficacy, perceived preparation, women-centred care—, and contextual factors —an enabling team environment and managerial style, the presence of motivated professionals, the use of the protocol and accumulated experience in primary health care—that should be considered to develop adequate primary health-care responses to violence. Conclusion: The full application of this realist evaluation was demanding, but also well suited to explore a complex intervention reflecting the situation in natural settings.
Resumo:
La importancia de la actividad turística para las economías locales es un hecho constatado en las últimas décadas desde diferentes organismos oficiales, tanto nacionales como internacionales. A su vez, el mayor acceso y mejora de la tecnología permite desarrollar metodologías que establezcan modelos locales de turismo más eficientes e innovadores, acordes tanto con el valor y los recursos endógenos, como con la realidad del destino turístico en cuestión. El objetivo de este artículo ha sido desarrollar y aplicar una metodología que ha permitido; por un lado, la selección y georeferenciación de los principales atractivos culturales de la ciudad de Murcia de acuerdo a la opinión de sus habitantes; y por otro, desarrollar una ruta turística a partir de la ubicación de esos puntos, haciendo uso de la extensión de análisis de redes de un SIG.
Resumo:
Contains a variety of material relating to cases before the courts of common pleas in Kent, New Castle, and Sussex counties. One file deals exclusively with cases regarding slaves. Most likely kept by Rodney but some materials attributed to Wilson's Red Book.
Resumo:
This layer is a georeferenced raster image of the historic paper map entitled: Blachford & Co.'s new chart of the coast of Brazil : from the Equator to Rio Janeiro, drawn from the surveys made by order of the Portuguese government, including those of Jose Patriceo, Manoe Pimental & several other officers in the Royal Navy. It was published by R. Blachford & Co., chart sellers to the Admiralty, and East India Compny, etc., 115 Minories in 1830. Scale [ca. 1:1,700,000]. Covers a portion of coastal Brazil.The image inside the map neatline is georeferenced to the surface of the earth and fit to the South America Lambert Conformal Conic projected coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows coastal features such as rocks, channels, points, ports, coves, islands, flats, bottom types, anchorage points, and more. Includes also selected land features such as towns, drainage, and more. Relief shown by hachures. Depths shown by soundings. Includes notes and insets: Harbor of Cape Frio, Rio de Janeiro, Harbor of Bahia, or St. Salvador, Fernand de Noronha, Bay of Maranham and Pernambuco. Decorated with 10 views of harbor entrances to Rio de Janeiro, Cape Frio, Bahia, etc.This layer is part of a selection of digitally scanned and georeferenced historic maps from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of originators, ground condition dates, scales, and map purposes.