Production of Referring Expressions for an Unknown Audience : a Computational Model of Communal Common Ground

The research reported in this article is based on the Ph.D. project of Dr. RK, which was funded by the Scottish Informatics and Computer Science Alliance (SICSA). KvD acknowledges support from the EPSRC under the RefNet grant (EP/J019615/1).

Beat that Word : How Listeners Integrate Beat Gesture and Focus in Multimodal Speech Discourse

Peer reviewed

Coordination and collective performance : Cooperative goals boost interpersonal synchrony and task outcomes

Peer reviewed

Coordination and collective performance : Cooperative goals boost interpersonal synchrony and task outcomes

Peer reviewed

Increased cognitive demands boost the spatial interference effect in bimanual pointing

Peer reviewed

Use of NeuroEyeCoach™ to Improve Eye Movement Efficacy in Patients with Homonymous Visual Field Loss

Acknowledgements: We would like to thank Sigrid Kenkel, Susanne Muller, Valentina Varalta, Cristina Fonte, Venecia Alb and Cristina Racasan who have contributed to data collection. Declaration of Interest: AS is Chief Science Officer of NovaVision Inc. NS has no conflict of interest. JZ is a member of the Scientific Advisory Board of NovaVision Inc. This study was supported by a NovaVision Inc. research grant to AS.

Coordination and Collective Performance : Cooperative Goals Boost Interpersonal Synchrony and Task Outcomes

Peer reviewed

A Therapeutic Antibody for Cancer, Derived from Single Human B Cells.

Some patients with cancer never develop metastasis, and their host response might provide cues for innovative treatment strategies. We previously reported an association between autoantibodies against complement factor H (CFH) and early-stage lung cancer. CFH prevents complement-mediated cytotoxicity (CDC) by inhibiting formation of cell-lytic membrane attack complexes on self-surfaces. In an effort to translate these findings into a biologic therapy for cancer, we isolated and expressed DNA sequences encoding high-affinity human CFH antibodies directly from single, sorted B cells obtained from patients with the antibody. The co-crystal structure of a CFH antibody-target complex shows a conformational change in the target relative to the native structure. This recombinant CFH antibody causes complement activation and release of anaphylatoxins, promotes CDC of tumor cell lines, and inhibits tumor growth in vivo. The isolation of anti-tumor antibodies derived from single human B cells represents an alternative paradigm in antibody drug discovery.

Maternal HIV-1 envelope-specific antibody responses and reduced risk of perinatal transmission.

Despite the wide availability of antiretroviral drugs, more than 250,000 infants are vertically infected with HIV-1 annually, emphasizing the need for additional interventions to eliminate pediatric HIV-1 infections. Here, we aimed to define humoral immune correlates of risk of mother-to-child transmission (MTCT) of HIV-1, including responses associated with protection in the RV144 vaccine trial. Eighty-three untreated, HIV-1-transmitting mothers and 165 propensity score-matched nontransmitting mothers were selected from the Women and Infants Transmission Study (WITS) of US nonbreastfeeding, HIV-1-infected mothers. In a multivariable logistic regression model, the magnitude of the maternal IgG responses specific for the third variable loop (V3) of the HIV-1 envelope was predictive of a reduced risk of MTCT. Neutralizing Ab responses against easy-to-neutralize (tier 1) HIV-1 strains also predicted a reduced risk of peripartum transmission in secondary analyses. Moreover, recombinant maternal V3-specific IgG mAbs mediated neutralization of autologous HIV-1 isolates. Thus, common V3-specific Ab responses in maternal plasma predicted a reduced risk of MTCT and mediated autologous virus neutralization, suggesting that boosting these maternal Ab responses may further reduce HIV-1 MTCT.

Making a difference? Public service broadcasting, distinctiveness and children’s provision in Italy and Spain

This article evaluates the performance of public service broadcasters in the area of children’s television in Italy and Spain. It asks: how distinctive is the output of public service children’s channels? As core area of public service provision, children’s television represents an important testing ground for wider debates about the distinctiveness of public service broadcasting in a digital age. Public broadcasters in Southern Europe have historically been more vulnerable to market pressure than their counterparts in continental and Northern Europe, and this is believed to have impacted negatively on their ability to maintain a distinctive public service profile. After engaging with debates on distinctiveness in order to develop a framework for the analysis, the article presents the results of a two-week analysis of the TV schedules of the main children’s channels operating in the two countries. It finds evidence that in both countries the output of public service children’s channels is distinctive to a degree, but also that there are important gaps in public service provision as well as some significant differences between the public service children’s channels analysed.

Defining ‘Community’ for Community Translation

Unlike community interpreting, community translation engages with the members of the community both at individual and group levels. This duality of the process makes the identification of the community as a socio-cultural entity and of its individual members all the more important. There have been several attempts to define the concept of ‘community’ in different professional and academic contexts. Mindful of the difficulty of defining community, the paper proposes three methods that can help community translators in visualizing the characteristics of the intended audience and in making informed translation decisions. The three methods, derived from user-centred translation, are scrutinized using a case study based on a real-life National Health Service (NHS) text.

El Norte de Africa y el Sahel y la Estrategia Global de Seguridad de la Unión Europea

El objetivo del artículo es exponer una adecuada y necesaria redefinición de la política de la UE hacia el Norte de África y el Sahel, tanto en términos geográficos como en términos estratégicos de acuerdo con lo expuesto en la nueva Estrategia Global Europea. En este sentido, se revisarán los postulados y la evolución de la antigua Estrategia Europea de Seguridad (EES) y su consiguiente Política de Vecindad (ENP), en comparación con la recién lanzada Estrategia. La nueva Estrategia es concebida como una guía para el desarrollo de la política exterior y de seguridad que la UE ha de llevar a cabo, inter alia, en su periferia. Lamentablemente su concepción de esta zona regional resulta anclada en el pasado.

Beamforming and interference cancellation in D2D communication underlaying cellular networks

This paper presents an analytical performance investigation of both beamforming (BF) and interference cancellation (IC) strategies for a device-to-device (D2D) communication system underlaying a cellular network with an M-antenna base station (BS). We first derive new closed-form expressions for the ergodic achievable rate for BF and IC precoding strategies with quantized channel state information (CSI), as well as, perfect CSI. Then, novel lower and upper bounds are derived which apply for an arbitrary number of antennas and are shown to be sufficiently tight to the Monte-Carlo results. Based on these results, we examine in detail three important special cases including: high signal-to-noise ratio (SNR), weak interference between cellular link and D2D link, and BS equipped with a large number of antennas. We also derive asymptotic expressions for the ergodic achievable rate for these scenarios. Based on these results, we obtain valuable insights into the impact of the system parameters, such as the number of antennas, SNR and the interference for each link. In particular, we show that an irreducible saturation point exists in the high SNR regime, while the ergodic rate under IC strategy is verified to be always better than that under BF strategy. We also reveal that the ergodic achievable rate under perfect CSI scales as log2M, whilst it reaches a ceiling with quantized CSI.

Beamforming and interference cancellation schemes for D2D communications

We investigate device-to-device (D2D) communication underlaying cellular networks with M-antenna base stations. We consider both beamforming (BF) and interference cancellation (IC) strategies under quantized channel state information (CSI), as well as, perfect CSI. We derive tight closed-form approximations of the ergodic achievable rate which hold for arbitrary transmit power, location of users and number of antennas. Based on these approximations, we derive insightful asymptotic expressions for three special cases namely high signal-to-noise (SNR), weak interference, and large M. In particular, we show that in the high SNR regime a ceiling effect exists which depends on the received signal-to-interference ratio and the number of antennas. Moreover, the achievable rate scales logarithmically with M. The ergodic achievable rate is shown to scale logarithmically with SNR and the antenna number in the weak interference case. When the BS is equipped with large number of antennas, we find that the ergodic achievable rate under quantized CSI reaches a saturated value, whilst it scales as log2M under perfect CSI.