932 resultados para Transdermal Penetration, Steroids


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研究了连续波Nd:YAG激光焊接功率、速度、离焦量和侧吹保护气流量对激光深熔焊接K418与42CrMo异种金属焊缝形貌、焊缝熔深的影响,讨论了焊缝区热裂纹产生机制.结果表明,额定功率为3 kW的Nd:YAG激光深熔焊接K418与42CrMo异种金属,由于它们的物理化学性质的差异,焊缝靠近42CrMo侧易出现未熔合;激光光斑向42CrMo侧偏移可以减少焊缝靠近42CrMo侧未熔合量;通过优化侧吹保护气流量和离焦量可以增加熔深.由于K418液态金属的流动性差,导致焊缝靠近K418侧对流传热不充分,使焊缝靠近K418侧熔合线呈现锯齿形.焊缝区热裂纹的产生主要是由于焊缝区元素偏析形成的低熔物导致.

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吸力式沉箱是广泛应用于离岸结构物中的新型基础形式,贯入分析方法的研究是很重要的课题.分析了砂性土地基吸力贯入过程中的渗流状况,得出了筒内壁的压降比率与贯入深径比的关系公式,分析评估了抽吸作用对筒内壁压降比率的影响,提出了砂土地基中吸力贯入阻力和地基极限吸力的简便计算方法,给出了砂土地基中极限贯入深径比的计算公式,分析了各种砂土地基中的吸力贯入极限深径比.不计简体自重和抽吸效应影响时,这一比值介于2.1~2.5之间.

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[ES] Las Pymes colombianas, al igual que las de América Latina, afrontan una serie de barreras para la exportación asociadas a la carencia de recursos y capacidades organizacionales y directivas, las cuales hacen que su permanencia en los mercados internacionales sea cuestionable. Al no superar tales barreras y mostrar una posición competitiva más fuerte difícilmente éstas podrán penetrar y sobrevivir en los mercados internacionales y aprovechar las grandes oportunidades que ofrece el mercado mundial. Especialmente, aquéllas que surgen como resultado de los acuerdos de integración y de los sistemas de preferencia suscritos y otorgados a Colombia.

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在化学氧碘激光的混合喷管内发生的是一个气体动力学、化学反应动力学以及光学等相互耦合的复杂过程,每个过程都对COIL性能有着至关重要的影响.利用三维CFD技术,通过求解层流Navier-Stokes方程与组分输运方程,对简化后的化学氧碘激光RADICL模型进行数值模拟与分析,对COIL的气动和增益特性进行探讨.在不同的射流穿透条件下,计算COIL混合喷管中的混合与化学反应过程,发现穿透深度决定了增益的分布特性以及过度穿透条件下的非定常结构,

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[ES] La marca de distribuidor está experimentando un proceso de crecimiento notable en nuestro país, especialmente en los mercados de productos de gran consumo. Sobre este particular, este trabajo tiene por objeto analizar la situación actual así como las tendencias futuras en la comercialización de marcas de distribuidor en la industria de productos de gran consumo. Para ello, se tendrá en cuenta la penetración de las marcas de distribuidor en distintas categorías de productos de gran consumo, exponiéndose una serie de argumentos con objeto de explicar las tendencias observadas.

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[ES] China ha irrumpido como actor principal del escenario global al haber protagonizado, durante las tres últimas décadas, un proceso de transformación económica y social de gran magnitud. Ahora bien, vender productos –sobre todo, del sector de alimentación– de origen occidental en China es, con diferencia, el reto más complicado al que deben enfrentarse las compañías de deciden entrar a operar en este mercado.

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The Argentine Republic is situated in the southernmost portion of the American continent, occupying over 2,785,600 km2 not including the Antarctic territory. The country ranges from subtropical areas (21º46’S) to subantarctic regions (55º03’S), extending latitudinally over about 4,000 km. It possesses significant latitudinal and altitudinal variation (33º of latitudinal range, and heights from Bajo de San Julián in Santa Cruz province at 105 m below sea level, up to Mt. Aconcagua, 6,959 m over sea level), as well as two gradients of physical variability, extending in north-south and east-west directions. Owing to these features, the country presents a wide range of climates and soil types, being one of the countries with greatest diversity of biogeographical units (Lean et al., 1990, In: Bertonatti & Corcuera, 2000). There are four main hydrographic systems: Río de la Plata basin, the Atlantic and Pacific drainages, and several endorrheic systems. Within these basins, the ichthyofaunistic assemblage is well represented, with different magnitude in accordance with the different taxonomic groupings and regions considered. From an ichthyogeographic standpoint, and according to the works of Ringuelet (1975) and Arratia et al. (1983), Argentina is included in the Brasilic and Austral Subregions. The first of these is represented by two domains: the Andean Domain, comprising the southernmost portion of Titicaca Province, and the Paranensean Domain, including part of Alto Paraná and Paranoplatensean Provinces. The Austral Subregion is represented in Argentina by the Subandean-Cuyan and Patagonian Provinces. The present survey indicates that there are about 441 fish species in Argentina, distributed throughout the country; this number represents less than 10% of the total fish species occurring in the Neotropical Region. There is a recognizable trend of faunal impoverishment, both in North-South and East-West direction, reaching its maximum expression in the provinces of Tierra del Fuego (situated at approximately 52º30’S to 55ºS, and 65ºS to 68º50’W) and San Juan (approximately 28º50’S and 67ºW to 70º45’W), which have 4 and 5 fish species respectively. In north-south direction, one of the regional indicators of this phenomenon is the Salado river basin in Buenos Aires province, which constitutes the southern distributional boundary for the majority of the paranoplatensean ichthyofauna; 12 of the families occurring in the Paraná-Plata system are absent from this pauperized paranensean ichthyofaunal assemblage. Most of the continental fish fauna of Argentina belongs to the primary division of Myers (1949), while some elements are included in the secondary division and others in an amphibiotic or ‘marine penetration’ category. This ichthyofaunistic scope encompasses a wide range of morphological, biological, ecological and ethological types (benthic and pelagic, migrating and sedentary, haematophagous or parasites, annual species, inhabitants of plains or heights, estivation-adapted, etc.) inhabiting different regions within the national territory.

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Characteristics of vaporized aviation kerosene injection in a supersonic model combustor were preliminarily investigated. The electrically storage type heater has a volume capacity of heating kerosene of 0.8 kg up to 670 K at a pressure of 5.5 Mpa. The temperature to cause pressurized kerosene jet being fully vaporized in Quiescent atmosphere was found to be 550 K at 4 Mpa however the pressurized hot kerosene remains in liquid state within the tube. The correspondent jet spray in Mach 2.5 vitiated air cross-flow were visualized by using stop schlieren photograph.It was found the penetration depth of the hot pressurized kerosene jet is approximately same with the temperature varied from 290 K to 550 k. at pressure of 4 Mpa. This results showed that the atomization process of hot kerosene jet spray in supersonic combustor could be bypassed and directly transferred to be gas state at temperature 550 K and pressure of 4 Mpa.

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Characteristics of supersonic combustion by injecting kerosene vapor into a Mach 2.5 crossflow at various preheat temperatures and pressures were investigated experimentally. A two-stage heating system has been designed and tested, which can prepare heated kerosene of 0.8 kg up to 820 K at pressure of 5.5 Mpa with minimum/negligible fuel coking. In order to simulate the thermophysical properties of kerosene over a wide range of thermodynamic conditions, a three-component surrogate that matches the compound class of the parent fuel was employed. The flow rate of kerosene vapor was calibrated using a sonic nozzle. Computed flow rates using the surrogate fuel are in agreement with the experimental data. Kerosene jets at various preheat temperatures injecting into both quiescent environment and Mach 2.5 crossflow were visualized. It was found that at injection pressure of 4 Mpa and preheat temperature of 550 K the kerosene jet was completely in vapor phase, while keeping almost the same penetration depth as compared to the liquid kerosene injection. Supersonic combustion tests were also carried out to compare the combustor performance for the cases of vaporized kerosene injection, liquid kerosene injection, and effervescent atomization with hydrogen barbotage, under the similar stagnation conditions. Experimental results demonstrated that the use of vaporized kerosene injection leads to better combustor performance. Further parametric study on vaporized kerosene injection in a supersonic model combustor is needed to assess the combustion efficiency as well as to identify the controlling mechanism for the overall combustion enhancement.

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Algal blooms, worsening marine ecosystems and causing great economic loss, have been paid much attention to for a long time. Such environmental factors as light penetration, water temperature, and nutrient concentration are crucial in blooms processes. Among them, only nutrients can be controlled. Therefore, the threshold of nutrients for algal blooms is of great concern. To begin with, a dynamic eutrophication model has been constructed to simulate the algal growth and phosphorus cycling. The model encapsulates the essential biological processes of algal growth and decay, and phosphorus regeneration due to algal decay. The nutrient limitation is based upon commonly used Monod's kinetics. The effects of temperature and phosphorus limitation are particularly addressed. Then, we have endeavored to elucidate the threshold of phosphorus at different temperature for algal blooms. Based on the numerical simulation, the isoquant contours of change rate of alga as shown in the figure are obtained, which obviously demonstrate the threshold of nutrient at an arbitrary reasonable temperature. The larger the change rate is, the more rapidly the alga grows. If the phosphorus concentration at a given temperature remains larger than the threshold the algal biomass may increase monotonically, leading to the algal blooming. With the rising of temperature, the threshold is apparently reduced, which may explain why likely red tide disasters occur in a fine summer day. So, high temperature and sufficient phosphorus supply are the major factors which result in algal growth and blowout of red tide.

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Adiabatic shear localization is a mode of failure that occurs in dynamic loading. It is characterized by thermal softening occurring over a very narrow region of a material and is usually a precursor to ductile fracture and catastrophic failure. This reference source is the first detailed study of the mechanics and modes of adiabatic shear localization in solids, and provides a systematic description of a number of aspects of adiabatic shear banding. The inclusion of the appendices which provide a quick reference section and a comprehensive collection of thermomechanical data allows rapid access and understanding of the subject and its phenomena. The concepts and techniques described in this work can usefully be applied to solve a multitude of problems encountered by those investigating fracture and damage in materials, impact dynamics, metal working and other areas. This reference book has come about in response to the pressing demand of mechanical and metallurgical engineers for a high quality summary of the knowledge gained over the last twenty years. While fulfilling this requirement, the book is also of great interest to academics and researchers into materials performance.

Table of Contents

1Introduction1
1.1What is an Adiabatic Shear Band?1
1.2The Importance of Adiabatic Shear Bands6
1.3Where Adiabatic Shear Bands Occur10
1.4Historical Aspects of Shear Bands11
1.5Adiabatic Shear Bands and Fracture Maps14
1.6Scope of the Book20
2Characteristic Aspects of Adiabatic Shear Bands24
2.1General Features24
2.2Deformed Bands27
2.3Transformed Bands28
2.4Variables Relevant to Adiabatic Shear Banding35
2.5Adiabatic Shear Bands in Non-Metals44
3Fracture and Damage Related to Adiabatic Shear Bands54
3.1Adiabatic Shear Band Induced Fracture54
3.2Microscopic Damage in Adiabatic Shear Bands57
3.3Metallurgical Implications69
3.4Effects of Stress State73
4Testing Methods76
4.1General Requirements and Remarks76
4.2Dynamic Torsion Tests80
4.3Dynamic Compression Tests91
4.4Contained Cylinder Tests95
4.5Transient Measurements98
5Constitutive Equations104
5.1Effect of Strain Rate on Stress-Strain Behaviour104
5.2Strain-Rate History Effects110
5.3Effect of Temperature on Stress-Strain Behaviour114
5.4Constitutive Equations for Non-Metals124
6Occurrence of Adiabatic Shear Bands125
6.1Empirical Criteria125
6.2One-Dimensional Equations and Linear Instability Analysis134
6.3Localization Analysis140
6.4Experimental Verification146
7Formation and Evolution of Shear Bands155
7.1Post-Instability Phenomena156
7.2Scaling and Approximations162
7.3Wave Trapping and Viscous Dissipation167
7.4The Intermediate Stage and the Formation of Adiabatic Shear Bands171
7.5Late Stage Behaviour and Post-Mortem Morphology179
7.6Adiabatic Shear Bands in Multi-Dimensional Stress States187
8Numerical Studies of Adiabatic Shear Bands194
8.1Objects, Problems and Techniques Involved in Numerical Simulations194
8.2One-Dimensional Simulation of Adiabatic Shear Banding199
8.3Simulation with Adaptive Finite Element Methods213
8.4Adiabatic Shear Bands in the Plane Strain Stress State218
9Selected Topics in Impact Dynamics229
9.1Planar Impact230
9.2Fragmentation237
9.3Penetration244
9.4Erosion255
9.5Ignition of Explosives261
9.6Explosive Welding268
10Selected Topics in Metalworking273
10.1Classification of Processes273
10.2Upsetting276
10.3Metalcutting286
10.4Blanking293
 Appendices297
AQuick Reference298
BSpecific Heat and Thermal Conductivity301
CThermal Softening and Related Temperature Dependence312
DMaterials Showing Adiabatic Shear Bands335
ESpecification of Selected Materials Showing Adiabatic Shear Bands341
FConversion Factors357
 References358
 Author Index369
 Subject Index375

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海底管线的稳定性是保证油气输送管道正常运行的关键。本文通过研制开发计算管土相互作用的有限元程序,对管土相互作用进行数值模拟,分析管道在自重和环境荷载作用下在砂质海床中的沉降发展,分析影响土体对管道的侧向阻力的各种因素,以便为管道稳定性设计提供参考。采用二维非线性有限元计算技术,计算管道在自重、静水压力和环境荷载的作用下土体的静态响应,以土的临界破坏状态作为管土系统的稳定性的极限状态,分析管道-土体这一对类似挡土结构-土体力学系统在临界状态时的相互作用。通过对计算结果的分析和有关文献试验结果的比较,证明了该程序基本上能够正确地完成关于土的非线性特征、管道自沉降的发展过程和管土系统的相互作用等数值模拟任务,从而为深入研究管土的非线性相互作用和管土相互作用对管道的在位稳定性的影响提供了思路和有力的分析工具。

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Background: Budesonide has a long history as intranasal drug, with many marketed products. Efforts should be made to demonstrate the therapeutic equivalence and safety comparability between them. Given that systemic availability significantly varies from formulations, the clinical comparability of diverse products comes to be of clinical interest and a regulatory requirement. The aim of the present study was to compare the systemic availability, pharmacodynamic effect, and safety of two intranasal budesonide formulations for the treatment of rhinitis. Methods: Eighteen healthy volunteers participated in this randomised, controlled, crossover, clinical trial. On two separated days, subjects received a single dose of 512 mu g budesonide (4 puffs per nostril) from each of the assayed devices (Budesonida nasal 64 (R), Aldo-Union, Spain and Rhinocort 64 (R), AstraZeneca, Spain). Budesonide availability was determined by the measurement of budesonide plasma concentration. The pharmacodynamic effect on the hypothalamic-adrenal axis was evaluated as both plasma and urine cortisol levels. Adverse events were tabulated and described. Budesonide availability between formulations was compared by the calculation of 90% CI intervals of the ratios of the main pharmacokinetic parameters describing budesonide bioavailability. Plasma cortisol concentration-time curves were compared by means of a GLM for Repeated Measures. Urine cortisol excretion between formulations was compared through the Wilcoxon's test. Results: All the enroled volunteers successfully completed the study. Pharmacokinetic parameters were comparable in terms of AUC(t) (2.6 +/- 1.5 vs 2.2 +/- 0.7), AUCi (2.9 +/- 1.5 vs 2.4 +/- 0.7), t(max) (0.4 +/- 0.1 vs 0.4 +/- 0.2), C(max)/AUC(i) (0.3 +/- 0.1 vs 0.3 +/- 0.0), and MRT (5.0 +/- 1.4 vs 4.5 +/- 0.6), but not in the case of C(max) (0.9 +/- 0.3 vs 0.7 +/- 0.2) and t(1/2) (3.7 +/- 1.8 vs 2.9 +/- 0.4). The pharmacodynamic effects, measured as the effect over plasma and urine cortisol, were also comparables between both formulations. No severe adverse events were reported and tolerance was comparable between formulations. Conclusion: The systemic availability of intranasal budesonide was comparable for both formulations in terms of most pharmacokinetic parameters. The pharmacodynamic effect on hypothalamic-pituitary-adrenal axis was also similar. Side effects were scarce and equivalent between the two products. This methodology to compare different budesonide-containing devices is reliable and easy to perform, and should be recommended for similar products intented to be marketed or already on the market.

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The magnitude evolution of ettringite and gypsum in hydrated Portland cement mortars due to sulfate attack was detected by X-ray powder diffraction. The influences of sulfate concentration and water-to-cement ratio on the evolution of ettringite and gypsum were investigated. Experimental results show that the magnitude of ettringite formation in sodium sulfate solution follows a three-stage process, namely, the 'penetration period', 'enhance period of strength', and 'macro-crack period'. The cracking of concrete materials is mainly attributed to the effect of ettringite. The gypsum formations occurred in two stages, the 'latent period' and the 'accelerated period'. The gypsum formation including ettringite formation was relative to the linear expansion of mortars to some extend. Both water-to-cement ratio and sulfate concentration play important roles in the evolution of ettringite and gypsum. (C) 2008 Elsevier Ltd. All rights reserved.

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In this paper, a new definition of SE and CE, which is based on the hexahedron mesh and simpler than Chang's original CE/SE method (the space-time Conservation Element and Solution Element method), is proposed and an improved CE/SE scheme is constructed. Furthermore, the improved CE/SE scheme is extended in order to solve the elastic-plastic flow problems. The hybrid particle level set method is used for tracing the interfaces of materials. Proper boundary conditions are presented in interface tracking. Two high-velocity impact problems are simulated numerically and the computational results are carefully compared with the experimental data, as well as the results from other literature and LS-DYNA software. The comparisons show that the computational scheme developed currently is clear in physical concept, easy to be implemented and high accurate and efficient for the problems considered. (C) 2008 Elsevier Ltd. All rights reserved.