Anatomical Laboratory

On verso: Interior of ... Anatomical Laboratory which stood just south of old Medical Bldg. About where ... old Engineering building stands now

Taken in Flint Buick, No.1

signed: Henry Helwig Fenton, Interior of Buick Motor Company, plant no. 1

Nazm-ı Dilârâ, [1231, i.e. 1815 or 1816].

Elegant autograph copy of the versified Persian-Turkish glossary of the müderris Osman Şakir (whose name appears in Īḍāḥ al-maknūn as ʻUthmān Shukrī, d.1818?). Apparently inspired by the popular Tuhfe-yi Vehbî (used for many years in Ottoman schools) of Sünbülzâde Vehbi Mehmet Efendi (d.1809), see opening matter on p.5-15.

Thomas Mitchell and the Wellington caves: The relationship among science, religion, and aesthetics in early-nineteenth-century Australia

THOMAS MITCHELL (1792–1855), explorer and Surveyor-General in New South Wales between 1828 and 1855, was a talented and competent draughtsman who was responsible for the original sketches and even some of the lithographs he used to illustrate his two journals of exploration, published in 1838 and 1848. In this paper, I will be concerned with the 1838 journal, entitled Three Expeditions into the Interior of Eastern Australia; with descriptions of the recently explored region of Australia Felix, and of the Present Colony of New South Wales. On the whole, it is a detailed and lavishly illustrated account of the land Mitchell encountered, along with its inhabitants and natural history. My particular interest is in offering an explanation for differences between a sepia sketch depicting a cave at Wellington, NSW, that Mitchell prepared as one of the illustrations for geological material included in this journal, and the final lithograph.

A mulher Evangélica Congregacional em Angola Análise do processo da formação pastoral da mulher no período de 1965-1975

Esta dissertação tem por objetivo analisar a mulher congregacional, sua formação pastoral no período de 1965-1975, considerado de grande desenvolvimento da Igreja. Fez-se analise dos contextos social, político, econômico e religioso para ter idéia do contexto geral do espaço em que a Igreja Evangélica Congregacional em Angola foi implantada. Falou-se da viagem dos primeiros missionários norte-americanos para o interior do país, assim como do episódio acontecido durante a implantação da Igreja no Bailundo, sede do reino na época, liderado pelo rei Ekuikui II nos primeiros anos de vida da Igreja. O desenvolvimento da igreja mereceu um olhar especial, assim como os modelos pastorais, a cooperação dos nativos na expansão do evangelho, as instituições da Igreja e sua mudança de nome. Destacaram-se as relações de gênero, a formação na cultura, o processo da formação pastoral das mulheres e os principais cursos ministrados nos centros, nas estações missionárias e no Dôndi. Os cursos eram: economia doméstica, alfabetização, educação cristã, formação feminina, formação das parteiras. A contribuição das mulheres para o desenvo lvimento da Igreja e da sociedade era diversificada, o que acontece até hoje, entretanto, destacam-se as contribuições das mulheres leigas, diaconisas, esposas dos pastores e o programa do Fogo Cristão implementado por elas. Apontei as dificuldades que as mulheres encontraram no processo da formação. Analisei a situação geral e a necessidade da formação pastoral das mulheres nos dias de hoje no Huambo e em toda Angola. O trabalho faz propostas de formação pastoral das mulheres que podem servir de ponte entre a nova e a velha geração.

ADOLESCÊNCIA, ESCOLA DOMINICAL E EDUCAÇÃO: PERSPECTIVAS DE UM NOVO PROCESSO

Este estudo tem como objetivo identificar alguns fatores que têm contribuído para a evasão de adolescentes da Escola Dominical. O trabalho limita-se ao âmbito da Igreja Metodista, em cidades do interior do Estado de São Paulo. Entender a atual condição da adolescência é requisito para desenvolver ações capazes de prepará-la para o exercício da fé. O primeiro capítulo enfoca o desenvolvimento da adolescência.. Desde o início da Revolução Industrial pesquisadores, médicos, psicólogos, educadores entre outros têm se voltado à pesquisa desta fase de vida. O segundo capítulo propõe uma análise da Escola Dominical. O objetivo deste capítulo é compreender suas origens, seu relacionamento com a adolescência, sua estrutura e funcionamento, pois, ela é um dos melhores espaços para a formação do adolescente. Este precisa de um modelo educativo que ajude seu desenvolvimento e a Escola Dominical pode ser a agência educativa para garantir uma educação apropriada à época atual. O terceiro capítulo aprofunda o conceito de educação de modo geral e educação cristã de modo específico distinguindo-as de ensino. O modelo de educação necessário para o desenvolvimento do adolescente deve ser aquele que o ajude a elaborar seu próprio desenvolvimento numa prática contínua de elaboração e re-elaboração de sua educação, propiciando experiências de vida numa perspectiva cristã. Por fim, o quarto capítulo analisa o resultado da pesquisa de campo, a opinião do adolescente sobre a Escola Dominical e a partir desta compreensão identificar os fatores que contribuem para a evasão.

Adolescência, Escola Dominical e Educação:perspectivas de um novo processo.

Este estudo tem como objetivo identificar alguns fatores que têm contribuído para a evasão de adolescentes da Escola Dominical. O trabalho limita-se ao âmbito da Igreja Metodista, em cidades do interior do Estado de São Paulo. Entender a atual condição da adolescência é requisito para desenvolver ações capazes de prepará-la para o exercício da fé. O primeiro capítulo enfoca o desenvolvimento da adolescência.. Desde o início da Revolução Industrial pesquisadores, médicos, psicólogos, educadores entre outros têm se voltado à pesquisa desta fase de vida. O segundo capítulo propõe uma análise da Escola Dominical. O objetivo deste capítulo é compreender suas origens, seu relacionamento com a adolescência, sua estrutura e funcionamento, pois, ela é um dos melhores espaços para a formação do adolescente. Este precisa de um modelo educativo que ajude seu desenvolvimento e a Escola Dominical pode ser a agência educativa para garantir uma educação apropriada à época atual. O terceiro capítulo aprofunda o conceito de educação de modo geral e educação cristã de modo específico distinguindo-as de ensino. O modelo de educação necessário para o desenvolvimento do adolescente deve ser aquele que o ajude a elaborar seu próprio desenvolvimento numa prática contínua de elaboração e re-elaboração de sua educação, propiciando experiências de vida numa perspectiva cristã. Por fim, o quarto capítulo analisa o resultado da pesquisa de campo, a opinião do adolescente sobre a Escola Dominical e a partir desta compreensão identificar os fatores que contribuem para a evasão.

Parceria ou mera relação social? Estudo de Caso das relações entre a BASF SA e a comunidade do seu entorno em Guaratinguetá/SP

Estudo sobre as relações comunicacionais entre a multinacional BASF e a comunidade no seu entorno na cidade de Guaratinguetá, no interior de São Paulo. O objetivo geral é analisar em que condições uma empresa multinacional e uma comunidade ao seu redor podem concretizar na prática uma parceria em busca de uma gestão socialmente mais responsável, bem como verificar qual o poder de interferência dessa comunidade em seus processos de comunicação. A metodologia utilizada foi estudo de caso por meio de análise de documentos, observação participante em reunião do Conselho Comunitário, grupo de discussão e entrevistas semiestruturadas, além de pesquisa bibliográfica. Procuramos compreender a percepção de membros do Conselho, de moradores da cidade, da mídia local e também dos profissionais de comunicação da multinacional. A principal conclusão é que o quepoderia se constituir em uma parceria de sucesso para ambos os lados, acaba se restringindo a uma mera relação social, onde os dois lados parecem se sentir bem e estão convictos de que realizam seus trabalhos da melhor maneira possível.

Second Order Optimality Conditions in Nonsmooth Unconstrained Optimization

AMS subject classification: 49J52, 90C30.

Blurring the lines between public and private spaces in residential design

This thesis explores the role of public space as an integral part of residential design to promote a sense of community, where neighbors can congregate and children can play in safety. ^ Through research and analysis of successful public spaces, I evaluated relationships between dwellings and public spaces that offer progressive levels of privacy, and between indoor and outdoor spaces. Further research of published studies on child development, human behavior and relationships with nature identified a human preference for natural environments, a need for adequate recreation space for children's development and the potential of open spaces to build a strong sense of community. ^ My project develops multiple transitional spaces between the street and the interior of dwellings that provide varying degrees of privacy closely related to the community's green spaces. The result is a community-oriented pedestrian environment that encourages family and community values and contributes to the healthy living of its residents without depriving them of their privacy. ^

Structural flexibility and oxygen diffusion pathways in monomeric fluorescent proteins

Fluorescent proteins are valuable tools as biochemical markers for studying cellular processes. Red fluorescent proteins (RFPs) are highly desirable for in vivo applications because they absorb and emit light in the red region of the spectrum where cellular autofluorescence is low. The naturally occurring fluorescent proteins with emission peaks in this region of the spectrum occur in dimeric or tetrameric forms. The development of mutant monomeric variants of RFPs has resulted in several novel FPs known as mFruits. Though oxygen is required for maturation of the chromophore, it is known that photobleaching of FPs is oxygen sensitive, and oxygen-free conditions result in improved photostabilities. Therefore, understanding oxygen diffusion pathways in FPs is important for both photostabilites and maturation of the chromophores. We used molecular dynamics calculations to investigate the protein barrel fluctuations in mCherry, which is one of the most useful monomeric mFruit variants, and its GFP homolog citrine. We employed implicit ligand sampling and locally enhanced sampling to determine oxygen pathways from the bulk solvent into the mCherry chromophore in the interior of the protein. The pathway contains several oxygen hosting pockets, which were identified by the amino acid residues that form the pocket. We calculated the free-energy of an oxygen molecule at points along the path. We also investigated an RFP variant known to be significantly less photostable than mCherry and find much easier oxygen access in this variant. We showed that oxygen pathways can be blocked or altered, and barrel fluctuations can be reduced by strategic amino acid substitutions. The results provide a better understanding of the mechanism of molecular oxygen access into the fully folded mCherry protein barrel and provide insight into the photobleaching process in these proteins.

Entre salinas e maledicências: uma leitura do romance Macau e sua aplicabilidade ao ensino de literatura

The objective of this research is to present a reading of the novel Macau (1934), authoring of Aurélio Pinheiro, situated in the context of Brazilian literature produced in the 30s of the last century and analyze the settings of language that reveal individual and social conflicts related to tensions arising of the modernization of a city in the interior of Rio Grande do Norte, in view of the applicability of this knowledge in the educational context. The discussions on the teaching of literature led to an internship experience in the higher education, with the guiding literary reading of the novel Macau. In this sense, this research, bibliographic, analytical and empirical, is in discussions between literature and education that allow us, in addition to a critical reading about Macau romance, a look both in basic education and in teacher training, which justifies linking this thesis in the research line “Reading of the literary text and teaching”. The objectives were met from literary readings of the text, brief study of the author, analysis of the tensions expressed by language, literature defense as a universal right, panoramic review of research on the teaching of literature, reading official documents governing the Brazilian education, discussion of teacher training, training in higher education with application of a didactic sequence, receipt of that novel by teachers in training directed to the applicability in basic education. For this, the research was the theoretical framework primarily the studies of Antonio Candido (1976; 1995), Luís Bueno (2006), Walter Benjamin (1985), Mikhail Bakhtin (2010), Hans Robert Jauss (1994), Theodor Adorno (2006), Antoine Compagnon (2009), and Rildo Cosson (2009).

A democracia participativa na jurisdição constitucional brasileira: o amicus curiae enquanto mediador democrático no controle concentrado de constitucionalidade no Supremo Tribunal Federal

This master thesis aims to research the tension established between the judicial review and democratic theory which was always present in the constitutional doctrine of separation of powers. In this regard, the expansion of the Brazilian constitutional jurisdiction checked after the occurrence of the Federal Constitution of 1988 and the inertia of the Legislature in disciplinary relevant legal aspects of Brazilian society contributed to a hyperactivity of the Supreme Court. However, in a complex society of context, as is the Brazilian society, there are contained demands and political controversies that hardly would be well represented or resolved through the action of the Court of ministers at the expense of other government bodies. Among the supremacy of Parliament and the legitimacy deficit of these magistrates, is the constitutional text and the social fabric that makes this legal status of the political. Participatory democracy established by the guidelines of the Federal Constitution requires this perspective when the Supreme Court acting in place of concentrated constitutionality control. In a plural society, there is no reason to get rid of state decision moments popular participation. Lack the Supreme Court, this time, the democratizing perception that the institute brings to the interior of the Court, as state determination of space in which to come together and meet the aspirations of society and state claims. The dissertation investigates thus the possibility of amicus curiae Institute serve as a mediator of the democratic debate, to assist the Supreme Court in the preparation of the decision is, historically, that which is of greater legitimacy, from the perspective of a theory participatory democracy. Analyzes, likewise, the unfolding of abstract judicial review in the context of Brazilian law. Proposes, incidentally, a rereading of the separation of powers, with the call for the Judiciary be careful not to become the protagonist of national political decisions. It maintains, finally, that procedural opening the interpreters of the constitution, through the amicus curiae Institute, shows up as able to decrease the legitimacy deficit in the performance of the Brazilian Supreme Court.

"Do alto da colina" - a província do Rio Grande do Norte, o comércio, os rios Potengi e Jundiaí e o complexo comercial do Guarapes 1850 - 1900

The commercial complex Guarapes was during the second half of the nineteenth century most commercial street of Rio Grande do Norte province. In that time frame, you can see its flourishing as one of the central places of trade in the province in 1850, and its subsequent abandonment in 1900. This thesis aims to investigate, in its first part, the paths that help to understand, as the context of the expansion of global markets in the second half of the nineteenth century enabled the conditions for the emergence of the commercial complex. However, trade relations established in this province through the commercial complex, even participating in this global environment, reserved particular characteristics in their social and trade relations, as if dealing with a peripheral province, we look at the uniqueness of the relationship occurred in this space. In the second part, we seek to understand the importance that the rivers Potengi and Jundiaí had to install the commercial complex Guarapes in the second half of the nineteenth century. As the geographical position in relation to rivers, enabled this space became flow zone and confluence of goods distributed to the various parts of the interior of the province. We also monitor the process that made these rivers leave the role of mobility and transport relations in this space, giving way the railways and roads shooting. In the third part, we seek to understand the commercial complex Guarapes in focus. Analyzing their spatial distribution on the landscape, and how the spatial organization held at the same time traces of the Brazilian patriarchy exposed by Gilberto Freyre, but also "modern" features, due to the increase of a new culture inserted material in the province. We also seek to understand elements of material culture that was the environment of the complex, and how these materials are important sources for understanding this society under study. We treat from the biggest to the smallest fragments without hierarchize them. Understanding that, the study associated the written sources and materials provide a gain in understanding of everyday these people who lived in that area of the complex in the second half of the nineteenth century.

Avaliação das atividades farmacológicas de fucoidans obtidos do extrato bruto de fucoidan comercial de Fucus vesiculosus

Fucoidan is a term used to define heteropolysaccharides that are composed of less than 90% L-fucose. The exception to this rule is the homofucoidan obtained from the seaweed Fucus vesiculosus. This fucoidan can be purchased from SIGMA Co. and have been used in various research for evaluation of their pharmacological activities. However, it is not a pure molecule. In fact, it is a mix of several fucoidan molecules. In this work, were obtained, from acetone precipitation, and biochemically characterized, four fucoidan molecules from SIGMA-ALDRICH Co. fucoidan to evaluate their anticoagulant, antioxidant, antiadipogenic, immunomodulatory and antiurolithiatic activities. In anticoagulant activity, evaluated by aPTT assay, fucoidans F0.9, F1.1 and F2.0 increased eightfold the coagulation time, compared to the control, when a mass of 10 μg was used. To PT test, only fucoidan F0.9 was capable of increase the coagulation time, compared to control. In the total antioxidant capacity assay (TAC), the fucoidan F2.0 showed 400 ascorbic acid equivalents, while fucoidan F0.5, the lest effective, 38 equivalents. In respect to the effect on pre-adipocyte cell lines (3T3-L1) adipogenesis, was observed that fucoidan F1.1 and F2.0 reduced the adipogenesis and this effect was associated to the reduction in the expression of regulatoy proteins C/EBPα, C/EBPβ and PPARγ. On the other hand, fucoidans F0.5 and F0.9 induced increased expression of these regulatory proteins. Furthermore, fucoidan F2.0 induced hydrolysis of triglycerides present in the interior of adipocytes. The immunomodulatory effect was evaluated and observed that the presence of fucoidans F0.5 , F1.1 and F2.0 significantly reduced the production of nitric oxide by activated macrophages with LPS specially fucoidan F2.0 that in 100 μg/mL, reduced about 55% the effect caused by LPS. Relative to the effect upon the formation of calcium oxalate crystals, fucoidan F0.5 was more effective in reduce the aggregation of the crystals and this effect it was not significantly different regarding the effect caused by the crude. Besides, fucoidan F0.5 only promoted the formation of COD type crystals, while fucoidans F1.1 and F2.0 did not influence the formation of crystals compared with the control. The results described in this study indicate that the commercial crude fucoidan of Fucus vesiculosus it’s a mix of several fucoidan which, in turn, have different chemical compositions besides having different pharmacological activities. The use of these fucoidans it´s indicated according the pharmacological activity to be evaluated.