Diabetes mellitus triggers oxidative stress in the liver of alloxan-treated rats: A mechanism for diabetic chronic liver disease

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Elucidation of carbohydrate molecular interaction mechanism of recombinant and native ArtinM

The quartz crystal microbalance (QCM) technique has been applied for monitoring the biorecognition of ArtinM lectins at low horseradish peroxidase glycoprotein (HRP) concentrations, using a simple kinetic model based on Langmuir isotherm in previous work.18 The latter approach was consistent with the data at dilute conditions but it fails to explain the small differences existing in the jArtinM and rArtinM due to ligand binding concentration limit. Here we extend this analysis to differentiate sugar-binding event of recombinant (rArtinM) and native (jArtinM) ArtinM lectins beyond dilute conditions. Equivalently, functionalized quartz crystal microbalance with dissipation monitoring (QCM-D) was used as real-time label-free technique but structural-dependent kinetic features of the interaction were detailed by using combined analysis of mass and dissipation factor variation. The stated kinetic model not only was able to predict the diluted conditions but also allowed to differentiate ArtinM avidities. For instance, it was found that rArtinM avidity is higher than jArtinM avidity whereas their conformational flexibility is lower. Additionally, it was possible to monitor the hydration shell of the binding complex with ArtinM lectins under dynamic conditions. Such information is key in understanding and differentiating protein binding avidity, biological functionality, and kinetics. © 2013 American Chemical Society.

Periodic compression of an adiabatic gas: Intermittency-enhanced Fermi acceleration

A gas of non-interacting particles diffuses in a lattice of pulsating scatterers. In the finite-horizon case with bounded distance between collisions and strongly chaotic dynamics, the velocity growth (Fermi acceleration) is well described by a master equation, leading to an asymptotic universal non-Maxwellian velocity distribution scaling as v∼t. The infinite-horizon case has intermittent dynamics which enhances the acceleration, leading to v∼t ln t and a non-universal distribution. © Copyright EPLA, 2013.

Shvo's catalyst in chemoenzymatic dynamic kinetic resolution of amines-inner or outer sphere mechanism?

Evidence is provided for the inner-sphere mechanism with actual metal coordination of the racemic amine in the crucial hydrogen transfer step promoted by Shvo's catalyst of the chemoenzymatic dynamic kinetic resolution (DKR) of amines. Key intermediates involved in this H-transfer step were intercepted and continuously monitored by electrospray ionization mass spectrometry (ESI-MS) and characterized by their dissociation chemistries via ESI-MS/MS. © 2013 The Royal Society of Chemistry.

Meeting of the Expanded Core Group for the Establishment of a Regional Coordinating Mechanism for the Implementation of the Mauritius Strategy

Includes bibliography

Survey of the needs for technical assistance and the ability to provide such: a discussion of the survey findings and of the principles and mechanism of technical co-operation among developing countries

Includes bibliography

Issues in the development of a regional mechanism

Includes bibliography

O bilhar stadium dependente do tempo: aceleração de Fermi e o fenômeno de retardo de velocidade

Pós-graduação em Física - IGCE

Ten Years of Operation of the World Trade Organization Dispute Settlement Mechanism: Outcome for Latin America and the Caribbean

Dispute settlement mechanisms help to create a fairly predictable and accurate environment in which economic agents can pursue their activities in the international arena. The World Trade Organization (WTO) Dispute Settlement Body (DSB) has now been in operation for 10 years and it is fitting, at this point to assess the progress achieved by Latin America and the Caribbean, the region that made most use of this mechanism during the period, and whose countries have made significant gains against protectionism in key export sectors. These successes constitute important precedents which will influence upcoming multilateral negotiations and future trade disputes.This article reviews the work carried out by the DSB, the role of the leading stakeholders in the system (the United States and the European Union) and progress made by countries of the region in a global context marked by the complexity of trade issues and the legal framework that regulates them. The findings presented in this article are based on the study "Una década de funcionamiento del Sistema de Solución de Diferencias de la OMC: avances y desafíos".

Meeting of the Technical Advisory Committee (TAC) of the Regional Coordinating Mechanism (RCM)

.--Introduction.-- Agenda item 1 – Opening remarks.-- Agenda item 2 - Adoption of agenda.-- Agenda item 3 - Procedural matters and organization of work.-- Agenda Item 4: Consideration of the work programme of the RCM for the period 2008-2009.-- Agenda item 5: Review of preparation for the Commission on Sustainable Development (CSD).-- Agenda item 6 – Conclusions of the TAC

Report of the second meeting of the Technical Advisory Committee (TAC) of the Regional Coordinating Mechanism (RCM)

.--Introduction.-- Agenda item 1: Opening remarks .-- Agenda Item 2: Adoption of agenda.-- Agenda item 3: Review of the work programme of the RCM for the period 2008-2009.-- Agenda Item 4: Review of preparations for the MSI Review 2010 .-- Agenda item 5: Proposals for 2010-2011 work programme.-- Agenda item 6: Close