Shvo's catalyst in chemoenzymatic dynamic kinetic resolution of amines-inner or outer sphere mechanism?


Autoria(s): Vaz, Boniek G.; Milagre, Cintia Duarte de Freitas; Eberlin, Marcos N.; Milagre, Humberto Márcio Santos
Contribuinte(s)

Universidade Estadual Paulista (UNESP)

Data(s)

27/05/2014

27/05/2014

21/10/2013

Resumo

Evidence is provided for the inner-sphere mechanism with actual metal coordination of the racemic amine in the crucial hydrogen transfer step promoted by Shvo's catalyst of the chemoenzymatic dynamic kinetic resolution (DKR) of amines. Key intermediates involved in this H-transfer step were intercepted and continuously monitored by electrospray ionization mass spectrometry (ESI-MS) and characterized by their dissociation chemistries via ESI-MS/MS. © 2013 The Royal Society of Chemistry.

Formato

6695-6698

Identificador

http://dx.doi.org/10.1039/c3ob41318g

Organic and Biomolecular Chemistry, v. 11, n. 39, p. 6695-6698, 2013.

1477-0520

http://hdl.handle.net/11449/76881

10.1039/c3ob41318g

WOS:000325119600006

2-s2.0-84884472099

Idioma(s)

eng

Relação

Organic and Biomolecular Chemistry

Direitos

closedAccess

Palavras-Chave #Dissociation chemistry #Dynamic kinetic resolution #Electrospray ionization mass spectrometry #Hydrogen transfer #Innersphere mechanism #Metal coordination #Amines #Catalysts #Mass spectrometry #Dynamics
Tipo

info:eu-repo/semantics/article