Efficacy of a Nasal Spray from Citrus limon and Cydonia oblonga for the Treatment of Hay Fever Symptoms - A Randomized, Placebo Controlled Cross-Over Study

Nasal spray from lemon and quince (LQNS) is used to treat hay fever symptoms and has been shown to inhibit histamine release from mast cells in vitro. Forty-three patients with grass pollen allergy (GPA) were randomized to be treated either with placebo or LQNS for one week, respectively, in a cross-over study. At baseline and after the respective treatments patients were provoked with grass pollen allergen. Outcome parameters were nasal flow measured with rhinomanometry (primary), a nasal symptom score, histamine in the nasal mucus and tolerability. In the per protocol population absolute inspiratory nasal flow 10 and 20 min after provocation was higher with LQNS compared to placebo (-37 ± 87 mL/s; p = 0.027 and -44 ± 85 mL/s; p = 0.022). The nasal symptom score showed a trend (3.3 ± 1.8 in the placebo and 2.8 ± 1.5 in the LQNS group; p = 0.070) in favor of LQNS; the histamine concentration was not significantly different between the groups. Tolerability of both, LQNS and placebo, was rated as very good. LQNS seems to have an anti-allergic effect in patients with GPA. Copyright © 2016 John Wiley & Sons, Ltd.

(Table 2) Physical properties at DSDP Holes 44-391 and 76-534

Laboratory measurements on sediment samples and density well logs run at DSDP Site 534 in the Blake-Bahama Basin were used to establish an in situ velocity and density structure. Synthetic seismograms were generated for comparison to reprocessed seismic reflection data in the vicinity of the Site. Uncertainties in the relative positions of the hole and seismic reflection data, velocity corrections, and the composition of the unrecovered section were evaluated. In light of the errors and compressed section, no unique correlation of the seismic reflection data to the drill hole is completely defensible either in this chapter or elsewhere. The preferred correlation resulting from this exercise is as follows, with the Site 534 report correlation shown in parentheses where different. Horizon beta', 887 m; Horizon beta, 950 m (975 m); Horizon C , 1202 m (1250 m); Horizon C, 1268 m (1340 m); Horizon D', 1342 m (1432 m); Horizon D, 1550 m (1552 m). The major differences in these correlations arise from the use of slightly different velocities and hole location relative to the seismic profiles. The Site 534 report results rely on hole placement on a basement flank, whereas in this chapter we locate it within a basement depression still within the uncertainty of the navigation. The Site 534 report also uses drilling rates, CDP velocity analyses, sonobuoy data, and previous similar drilling correlation methods used at Site 391, along with other geologic considerations in arriving at differing results. Although the correlation method used in this investigation is more objective and the hole location uncertainties better defined, in order to have confidence in any results we will require drilling in areas where reflections are either more widely spaced or where we have better vertical velocity control in the hole.

Distribution of clay minerals in surface sediments of the Eurasian Arctic Ocean

Clay-mineral distributions in the Arctic Ocean and the adjacent Eurasian shelf areas are discussed to identify source areas and transport pathways of terrigenous material in the Arctic Ocean. The main clay minerals in Eurasian Arctic Ocean sediments are illite and chlorite. Smectite and kaolinite occur in minor amounts in these sediments, but show strong variations in the shelf areas. These two minerals are therefore reliable in reconstructions of source areas of sediments from the Eurasian Arctic. The Kara Sea and the western part of the Laptev Sea are enriched in smectite, with highest values of up to 70% in the deltas of the Ob and Yenisey rivers. Illite is the dominant clay mineral in all the investigated sediments except for parts of the Kara Sea. The highest concentrations with more than 70% illite occur in the East Siberian Sea and around Svalbard. Chlorite represents the clay mineral with lowest concentration changes in the Eastern Arctic, ranging between 10 and 25%. The main source areas for kaolinite in the Eurasian Arctic are Mesozoic sedimentary rocks on Franz-Josef Land islands. Based on clay-mineral data, transport of the clay fraction via sea ice is of minor importance for the modern sedimentary budget in the Arctic basins.