Efficacy of a Nasal Spray from Citrus limon and Cydonia oblonga for the Treatment of Hay Fever Symptoms - A Randomized, Placebo Controlled Cross-Over Study


Autoria(s): Hoffmann, A; Klein, Sabine; Gründemann, C; Garcia-Käufer, M; Wolf, Ursula; Huber, R
Data(s)

10/06/2016

Resumo

Nasal spray from lemon and quince (LQNS) is used to treat hay fever symptoms and has been shown to inhibit histamine release from mast cells in vitro. Forty-three patients with grass pollen allergy (GPA) were randomized to be treated either with placebo or LQNS for one week, respectively, in a cross-over study. At baseline and after the respective treatments patients were provoked with grass pollen allergen. Outcome parameters were nasal flow measured with rhinomanometry (primary), a nasal symptom score, histamine in the nasal mucus and tolerability. In the per protocol population absolute inspiratory nasal flow 10 and 20 min after provocation was higher with LQNS compared to placebo (-37 ± 87 mL/s; p = 0.027 and -44 ± 85 mL/s; p = 0.022). The nasal symptom score showed a trend (3.3 ± 1.8 in the placebo and 2.8 ± 1.5 in the LQNS group; p = 0.070) in favor of LQNS; the histamine concentration was not significantly different between the groups. Tolerability of both, LQNS and placebo, was rated as very good. LQNS seems to have an anti-allergic effect in patients with GPA. Copyright © 2016 John Wiley & Sons, Ltd.

Formato

application/pdf

Identificador

http://boris.unibe.ch/83725/1/ptr5649.pdf

Hoffmann, A; Klein, Sabine; Gründemann, C; Garcia-Käufer, M; Wolf, Ursula; Huber, R (2016). Efficacy of a Nasal Spray from Citrus limon and Cydonia oblonga for the Treatment of Hay Fever Symptoms - A Randomized, Placebo Controlled Cross-Over Study. Phytotherapy research, 30(9), pp. 1481-1486. Wiley 10.1002/ptr.5649 <http://dx.doi.org/10.1002/ptr.5649>

doi:10.7892/boris.83725

info:doi:10.1002/ptr.5649

info:pmid:27282490

urn:issn:1099-1573

Idioma(s)

eng

Publicador

Wiley

Relação

http://boris.unibe.ch/83725/

Direitos

info:eu-repo/semantics/restrictedAccess

Fonte

Hoffmann, A; Klein, Sabine; Gründemann, C; Garcia-Käufer, M; Wolf, Ursula; Huber, R (2016). Efficacy of a Nasal Spray from Citrus limon and Cydonia oblonga for the Treatment of Hay Fever Symptoms - A Randomized, Placebo Controlled Cross-Over Study. Phytotherapy research, 30(9), pp. 1481-1486. Wiley 10.1002/ptr.5649 <http://dx.doi.org/10.1002/ptr.5649>

Palavras-Chave #580 Plants (Botany) #610 Medicine & health
Tipo

info:eu-repo/semantics/article

info:eu-repo/semantics/publishedVersion

PeerReviewed