Assessing the efficiency of a pharmacokinetic-based algorithm for target-controlled infusion of ketamine in ponies

The objective of this study was to assess a pharmacokinetic algorithm to predict ketamine plasma concentration and drive a target-controlled infusion (TCI) in ponies. Firstly, the algorithm was used to simulate the course of ketamine enantiomers plasma concentrations after the administration of an intravenous bolus in six ponies based on individual pharmacokinetic parameters obtained from a previous experiment. Using the same pharmacokinetic parameters, a TCI of S-ketamine was then performed over 120 min to maintain a concentration of 1 microg/mL in plasma. The actual plasma concentrations of S-ketamine were measured from arterial samples using capillary electrophoresis. The performance of the simulation for the administration of a single bolus was very good. During the TCI, the S-ketamine plasma concentrations were maintained within the limit of acceptance (wobble and divergence <20%) at a median of 79% (IQR, 71-90) of the peak concentration reached after the initial bolus. However, in three ponies the steady concentrations were significantly higher than targeted. It is hypothesized that an inaccurate estimation of the volume of the central compartment is partly responsible for that difference. The algorithm allowed good predictions for the single bolus administration and an appropriate maintenance of constant plasma concentrations.

Scientific Institutions in a Society of Transition: Strategies of Modernisation

Kristina Petkova (Group Leader), Tzocho Boyadgiev, Galin Gornev, Ivan Tcholakov (Bulgaria), Martin Bauer (Switzerland). Scientific Institutions in a Society of Transition: Strategies of Modernisation. Ms. Petkova is involved in teaching and research in the Institute of Sociology of the Bulgarian Academy of Science and led this project, which was carried out between July 1995 and June 1997. The aims of this project were a) to outline the main adaptive strategies of scientific institutions in a situation of social transition, and b) to analyse the opportunities for mobilising public opinion in support scientific work. The group began from the assumption that the social representation of science reflects the historical development of society as a whole. They developed a theoretical model describing the position of science in the three main types of society in the world today (modern, post-modern, totalitarian) and carried out three types of investigation: a representative survey of the public understanding of scientific institutions in Bulgaria; an in-depth cross-national investigation (Bulgarian - Great Britain); and a content analysis of how science is represented in two national newspapers, the "Rabotnichesko Delo" and the "Daily Telegraph". The results showed that Bulgarian public opinion has a more standard view of science and a more optimistic vision of scientific development than do the British, but that there is a certain insensitivity to the risks of scientific results, etc. The group conclude that in order to survive, scientific institutions in Bulgaria should change their passive attitude and adopt active strategies in both their relationships with the state, and in their contacts with private business and with the institutions of civil society.

Why Cherry-Picking Never Leads to Harmonisation: The Case of the Limitations on Copyright under Directive 2001/29/EC

The article examines whether the norms laid down in the Directive in relation to the exceptions and limitations on copyright and related rights can be conducive to a sensible degree of harmonisation across the European Union. Before discussing the degree of harmonisation achieved so far by the Directive, the first part gives a short overview of the main characteristics of the list of exceptions and limitations contained in Article 5 of the Directive. A comprehensive review of the implementation of each limitation by the Member States is beyond the scope of this article. The following section takes a closer look at three examples of limitations that have led to legislative changes at the Member State level as express measures towards the implementation of the Information Society Directive, that is, the limitations for the benefit of libraries, for teaching and research, and for persons with a disability. These exceptions and limitations were later on also identified by the European Commission as key elements in the deployment of a digital knowledge economy. The analysis will show that the implementation of the provisions on limitations in the Information Society Directive did not, and probably cannot, yield the expected level of harmonisation across the European Union and that, as a consequence, there still exists a significant degree of uncertainty for the stakeholders regarding the extent of permissible acts with respect to copyright protected works.

Bovine Staphylococcus aureus: diagnostic properties of specific media

As accurate discrimination between Staphylococcus (S.) aureus and NSA (non-S. aureus staphylococci) involved in bovine mastitis is essential in terms of clinical prognosis and outcome, the aim of this study was to reevaluate the classical bacteriological procedures to identify these agents. Various media and the coagulase tube test were investigated using 116 strains of S. aureus and 115 of NSA, all isolated from cows with spontaneous intramammary infections (IMI). Furthermore, 25 NSA reference strains were analyzed. The study demonstrated that a few media were appropriate for differentiating S. aureus from NSA, provided that the staphylococci were isolated from bovine IMI. Evaluation of hemolysis further revealed that double or incomplete hemolysis are specific for S. aureus and are, therefore, a decisive diagnostic criterion. For strains showing complete hemolysis, maximal discrimination between S. aureus and NSA was observed by subculturing them on CHROMagar Staph. aureus.

Short communication: Transmission of border disease virus to seronegative cows inseminated with infected semen.

The goal of this study was to investigate the transmissibility of border disease (BD) virus to seronegative cows via artificial insemination with cryopreserved semen from a bull persistently infected with BD virus. Five pestivirus naive cows were inseminated with BD virus-infected semen. Blood was collected for detection of pestivirus antibody by means of an ELISA on day 0 (day of insemination) and then every 7 days until day 56, at which time a serum neutralisation test (SNT) for differentiation of BD and BVD virus was carried out. Seroconversion was first noticed in two cows on day 14, in two cows on day 21 and in one cow on day 28. In the SNT, all cows had distinctly positive titres against BD virus. Therefore, BD virus is readily transmitted by infected semen, but none of the cows conceived, most likely because of poor semen quality.

Entrevista a Carlos Parenti. La visión del Profesorado en Educación Física de la Universidad Nacional de La Plata : Pasado, presente y futuro

Luego de cumplirse 45 años de haber ingresado como alumno al Profesorado en Educación Física de la Universidad Nacional de La Plata, el profesor Carlos Parenti es consultado sobre diferentes temas que hacen al pasado, presente y futuro de la institución en cuestión. Así, se lo indaga sobre su trayectoria como alumno y como docente, sobre su labor en la docencia y la investigación de la mano de Alejandro Amavet, su gestión al frente del Departamento de Educación Física, y los principales hechos en relación a los diferentes contextos sociales, económicos y políticos de la Argentina. Asimismo, se le pregunta sobre su visión de los alumnos en la actualidad y sobre cómo se imagina el futuro de la enseñanza, la investigación y la extensión en el Departamento

Entrevista a Carlos Parenti. La visión del Profesorado en Educación Física de la Universidad Nacional de La Plata : Pasado, presente y futuro

Luego de cumplirse 45 años de haber ingresado como alumno al Profesorado en Educación Física de la Universidad Nacional de La Plata, el profesor Carlos Parenti es consultado sobre diferentes temas que hacen al pasado, presente y futuro de la institución en cuestión. Así, se lo indaga sobre su trayectoria como alumno y como docente, sobre su labor en la docencia y la investigación de la mano de Alejandro Amavet, su gestión al frente del Departamento de Educación Física, y los principales hechos en relación a los diferentes contextos sociales, económicos y políticos de la Argentina. Asimismo, se le pregunta sobre su visión de los alumnos en la actualidad y sobre cómo se imagina el futuro de la enseñanza, la investigación y la extensión en el Departamento

Timed mind maps using MINDMANAGER & MS-PROJECT for educational innovation

The adaptation to the European Higher Education Area (EHEA) is becoming a great challenge for the University Community, especially for its teaching and research staff, which is involved actively in the teaching-learning process. It is also inducing a paradigm change for lecturers and students. Among the methodologies used for processes of teaching innovation, system thinking plays an important role when working mainly with mind maps, and is focused to highlighting the essence of the knowledge, allowing its visual representation. In this paper, a method for using these mind maps for organizing a particular subject is explained. This organization is completed with the definition of duration, precedence relationships and resources for each of these activities, as well as with their corresponding monitoring. Mind maps are generated by means of the MINDMANAGER package whilst Ms-PROJECT is used for establishing tasks relationships, durations, resources, and monitoring. Summarizing, a procedure and the necessary set of applications for self organizing and managing (timed) scheduled teaching tasks has been described in this paper.

Timed mind maps using mindmanager & msproject for educational innovation

The adaptation to the European Higher Education Area (EHEA) is becoming a great challenge for the University Community, especially for its teaching and research staff, which is involved actively in the teaching-learning process. It is also inducing a paradigm change for lecturers and students. Among the methodologies used for processes of teaching innovation, system thinking plays an important role when working mainly with mind maps, and is focused to highlighting the essence of the knowledge, allowing its visual representation. In this paper, a method for using these mind maps for organizing a particular subject is explained. This organization is completed with the definition of duration, precedence relationships and resources for each of these activities, as well as with their corresponding monitoring. Mind maps are generated by means of the MINDMANAGER package whilst Ms-PROJECT is used for establishing tasks relationships, durations, resources, and monitoring. Summarizing, a procedure and the necessary set of applications for self organizing and managing (timed) scheduled teaching tasks has been described in this paper

An Inexpensive Method for Kinematic Calibration of a Parallel Robot by Using One Hand-Held Camera as Main Sensor

This paper presents a novel method for the calibration of a parallel robot, which allows a more accurate configuration instead of a configuration based on nominal parameters. It is used, as the main sensor with one camera installed in the robot hand that determines the relative position of the robot with respect to a spherical object fixed in the working area of the robot. The positions of the end effector are related to the incremental positions of resolvers of the robot motors. A kinematic model of the robot is used to find a new group of parameters, which minimizes errors in the kinematic equations. Additionally, properties of the spherical object and intrinsic camera parameters are utilized to model the projection of the object in the image and thereby improve spatial measurements. Finally, several working tests, static and tracking tests are executed in order to verify how the robotic system behaviour improves by using calibrated parameters against nominal parameters. In order to emphasize that, this proposed new method uses neither external nor expensive sensor. That is why new robots are useful in teaching and research activities.

Diseño y simulación térmica de HB-LEDs con Autodesk y PCB para ensayos

Este PFC es un trabajo muy práctico, los objetivos fueron impuestos por el tutor, como parte del desarrollo de herramientas (software y hardware) que serán utilizados posteriormente a nivel de docencia e investigación. El PFC tiene dos áreas de trabajo, la principal y primera que se expone es la utilización de una herramienta de simulación térmica para caracterizar dispositivos semiconductores con disipador, la segunda es la expansión de una tarjeta de adquisición de datos con unas PCBs diseñadas, que no estaban disponibles comercialmente. Se ha probado y configurado “Autodesk 2013 Inventor Fusion” y “Autodesk 2013 Simulation and Multiphysics” para simulación térmica de dispositivos de alta potencia. Estas aplicaciones son respectivamente de diseño mecánico y simulación térmica, y la UPM dispone actualmente de licencia. En esta parte del proyecto se realizará un manual de utilización, para que se continúe con esta línea de trabajo en otros PFC. Además se han diseñado mecánicamente y simulado térmicamente diodos LED de alta potencia luminosa (High Brightness Lights Emitting Diodes, HB-LEDs), tanto blancos como del ultravioleta cercano (UVA). Las simulaciones térmicas son de varios tipos de LEDs que actualmente se están empleando y caracterizando térmicamente en Proyectos Fin de Carrera y una Tesis doctoral. En la segunda parte del PFC se diseñan y realizan unas placas de circuito impreso (PCB) cuya función es formar parte de sistemas de instrumentación de adquisición automática de datos basados en LabVIEW. Con esta instrumentación se pueden realizar ensayos de fiabilidad y de otro tipo a dispositivos y sistemas electrónicos. ABSTRACT. The PFC is a very practical work, the objectives were set by the tutor, as part of the development of tools (software and hardware) that will be used later at level of teaching and research. The PFC has two parts, the first one explains the use of a software tool about thermal simulation to characterize devices semiconductors with heatsink, and second one is the expansion of card data acquisition with a PCBs designed, which were not available commercially. It has been tested and configured "Autodesk 2013 Inventor Fusion" and "Autodesk 2013 Simulation Multiphysics” for thermal simulation of high power devices. These applications are respectively of mechanical design and thermal simulation, and the UPM has at present license. In this part of the project a manual of use will be realized, so that it is continued by this line of work in other PFC. Also they have been designed mechanically and simulated thermally LEDs light (High Brightness Lights Emitting Diodes , HB- LEDs) both white and ultraviolet. Thermal simulations are several types of LEDs are now being used in thermally characterizing in Thesis and PhD. In the second part of the PFC there are designed and realized circuit board (PCB) whose function is to be a part of instrumentation systems of automatic acquisition based on LabVIEW data. With this instrumentation can perform reliability testing and other electronic devices and systems.

Construction History in Spain: the Discipline's Foundation

In the past two decades the History of Construction has started to become an independent discipline. On one hand, the number of articles, theses and books that could be assigned to this field has grown exponentially. Furthermore, there have been numerous and remarkably successful Congresses: 12 National (Spain 8; France 2; United Kingdom 1; Germany 1) and 4 International Congresses (Madrid 2003, Cambridge 2006, Cottbus 2009, Paris 2012), see Table 1 below. However, the situation is far from that corresponding to an already recognized discipline, such as the History of Art or the History of Science. There are no University chairs and departments, and in the reference databases “Construction History” is not listed as a common descriptor. This is not surprising; it reflects the inertia of academia to accept new disciplines. In what follows we will discuss the current state of discipline in Spain. Previous articles have tackled the matter. We will try to avoid unnecessary repetitions and concentrate on: 1) The activities of the Spanish Society of Construction History; 2) Its consequences on teaching and research, taken as a case study the experience in the School of Architecture of Madrid, and 3) We will give a provisional List of dissertations on Construction History read in Spain in the last forty years. First, we will try to define with the least possible ambiguity its field and its objectives. The intention is not to enter into the actual debate on the "definition" of Construction History, but to expose, in as detached as possible way, the ideas behind the actions made.

Imaginar : dibujar y escribir : recorridos pedagógicos alrededor del proyectar junto a Javier Seguí

En la enseñanza de la arquitectura, el dibujo es tradicionalmente una materia propedéutica que requiere años de entrenamiento hasta conseguir la destreza necesaria para convertirse en herramienta de configuración y en lenguaje de comunicación del proyecto. El requerimiento de un dominio del dibujo eminentemente instrumental es el que encuentra en el año 1957 Javier Seguí, cuando entra en la Escuela Técnica Superior de Arquitectura de Madrid, y también en 1974, al obtener la cátedra de la asignatura de Análisis de Formas Arquitectónicas tras intentar, sin éxito, la cátedra de la asignatura Proyectos Arquitectónicos. Desde entonces, y durante treinta y nueve años como catedrático, ejerce de profesor en el ahora denominado Departamento de Ideación Gráfica Arquitectónica -agrupamiento de asignaturas encuadradas en un área de conocimiento- trabajando junto a un grupo de compañeros y alumnos que intentan desarrollar un proceso de cambio fundamental en la docencia del dibujo para abandonar la pura representación y convertirla en el dibujar para proyectar. Javier Seguí se jubila en el año 2010. Separado de la docencia y la investigación oficial, continúa dibujando y escribiendo, con el objeto de sistematizar y fundamentar todas aquellas prácticas desarrolladas y reivindicar el funcionamiento de la imaginación. Esta actividad de investigación, desde un extrañamiento extremo, permite elaborar tanto un listado de técnicas operativo-imaginarias de arranque de los procesos de proyectar, como reflexionar y recuperar algunas prácticas desarrolladas desde el grado cero y la radicalidad. Esta investigación aborda la práctica docente de Javier Seguí, ligándola a su producción investigadora desde sus propios dibujos, escritos y conversaciones realizadas en un momento en el que la crisis de la asignatura de dibujo es evidente en un contexto universitario desorientado, que constata el fracaso del cambio que Seguí soñara hace medio siglo. ABSTRACT In the teaching of architecture, drawing has traditionally been a propaedeutic subject requiring years of training to achieve the necessary skill to become a language and communication tool for project configuration. The requirement of a drawing domain aseminently instrumental is what Javier Seguí found in 1957 when he entered the Superior Technical School of Architecture of Madrid (Escuela Técnica Superior de Arquitectura de Madrid), and also in 1974, when he was awarded the position of Chair of Analysis of Architectural Forms after trying, unsuccessfully, the Chair of Architectural Projects. Since then, and for thirty-nine years as a Professor, he has taught at what now is called the Department of Architectural Graphic Ideation – group of subjects framed as an knowledge area -, in collaboration with a group of colleagues and students who try to develop a process of fundamental change in the teaching of drawing, through the abandonment of pure representation to transform drawing into a project. Javier Seguí retired in 2010. Separated from official teaching and research, he maintains a consistent practice of drawing and writing, in order to systematize and substantiate all practices developed and claim the use of the imagination. This research activity, from a one end distance, allows both a list of imaginary operational techniques to the start-up project processes, as much as recovering some practices developed from scratch and of a radical technical degree. This research addresses the teaching practice of Javier Segui, linking its research output of their own drawings, writings and conversations in a moment in which the crisis of the drawing subject is evident in a disoriented university context, demonstrating the failure of the exchange that Seguí has dreamed of since half a century ago.

A presença do homo academicus na contabilidade: um olhar bourdieusiano sobre o contexto social do desenvolvimento da produção científica contábil brasileira

Esta pesquisa investiga o contexto social do desenvolvimento da produção científica contábil brasileira, defendendo a tese de que os agentes, no decorrer do processo de divulgação de suas investigações, estão priorizando aspectos produtivistas e quantitativos e, consequentemente, deixando em segundo plano a preocupação qualitativa e epistemológica [vigilância crítica] de tal produção. Fundamentado na Teoria de Campos de Pierre Bourdieu, este estudo busca relacionar a socialização acadêmica, o habitus dos agentes imbricados no campo, a distribuição do capital científico na área contábil e as características epistemológicas das publicações científicas da área, para obtenção das evidências sobre a problemática levantada. Trata-se de um levantamento operacionalizado por meio de entrevista semiestruturada, com uma amostra de 9 respondentes e estudo documental, com uma amostra de 43 artigos. Os dados foram analisados com emprego da técnica de análise de conteúdo. Apoiando-se em Bourdieu (2004, 2008, 2009, 2011, 2013) foram encontradas evidências de que as teorias, conceitos, metodologias, técnicas e demais escolhas realizadas pelos pesquisadores da área contábil, na maioria das vezes, não passam de manobras estratégicas que visam conquistar, reforçar, assegurar ou derrubar o monopólio da autoridade científica, visando a obtenção de maior poder simbólico no campo. Com relação ao habitus dos agentes pertencentes ao campo científico contábil, constatou-se uma tendência ao produtivismo em consequência das determinações dos órgãos reguladores da pesquisa em contabilidade (CAPES) e das lutas simbólicas travadas no campo para obtenção da autoridade científica. No tocante à socialização acadêmica, reforçou-se a presença de condutas produtivistas, por meio dos programas de pós-graduação stricto sensu, que repassam aos agentes as regras do jogo científico, doutrinando-os na maneira de publicar grande quantidade de comunicações em pouco tempo e com menos custos. As análises epistemológicas puderam triangular os dois últimos constructos, a fim de lhes dar validade, e evidenciaram uma preferência por temáticas que envolvem a contabilidade destinada aos usuários externos e procedimentos contábeis destinados ao mercado financeiro, privilegiando a utilização de dados secundários, por meio de pesquisas documentais. Em termos metodológicos, constatou-se a presença unânime de estudos positivistas, com alguns aspectos empiristas, mostrando uma ausência de inovação em termos de pesquisas norteadas por abordagens metodológicas alternativas e utilização de modelos econométricos para explicar a realidade observada sem teoria para embasar e explicar esses modelos. Por fim, a distribuição do capital simbólico no campo, mostrou que individualmente nenhum agente desponta com maior capital científico, mas, institucionalmente, a FEA/USP ocupa essa posição de destaque. Por conseguinte, pôde-se concluir que o campo científico contábil permanece estagnado e sem grandes modificações teóricas, pelo fato do produtivismo e das lutas simbólicas no interior do campo; fatos esses que, de certa maneira, motivaram a criação de uma espécie de \"receita mágica para publicar\" ou \"formato ideal\" legitimado, institucionalizado e difícil de ser modificado, a não ser que ocorra uma revolução científica que mude o paradigma existente

La historia de la química: Pequeña guía para navegantes. Parte II: Libros, revistas, sociedades, centros de investigación y enseñanza

Este trabajo pretende ser una guía de las investigaciones en historia de la química. Consta de dos partes muy relacionadas entre sí. En la primera parte se ha descrito el desarrollo de la historia de la química como área de investigación, desde sus orígenes hasta el siglo XX. En esta segunda parte se ofrece una lista ordenada de fuentes de información indispensables para trabajar en historia de la química. También se describen las características de las principales instituciones europeas dedicadas a la historia de la química, a partir de una encuesta recientemente realizada por la sociedad europea de sociedades químicas. Información bibliográfica adicional se ofrece en .