Sinalização endógena do sistema Nociceptina/Orfanina FQ - receptor NOP: envolvimento na modulação da depressão experimental induzida por lipopolissacarídeo

During the last decades, it has been established that there is a relationship between major depression and activation of immune system. Nociceptin/orphanin FQ (N/OFQ) is the natural ligand of a Gi-protein coupled receptor named NOP, both compose the peptidergic system wich is involved in the regulation of mood states and inflammatory responses. Considering these actions, the present thesis aimed to investigate the consequences of blocking NOP signaling in lipopolysaccharide (LPS)-induced sickness and depressive-like behaviors in mice. Systemic administration of LPS doses, that do not cause sepsis in mice, induce changes in their behaviors related with activity of pro-inflammatory cytokines tumor necrosis factor-α (TNF-α) and interleukins 6 (IL-6) and 1β (IL-1 β). At the time points of 2 to 6 h and 24 h after intraperitoneal injection, mice treated with LPS displayed, respectively, sickness and depressive-like behaviors. In the present work the administration of LPS 0.8 mg/kg (ip) significantly induced sickness signs in Swiss and CD-1 mice, such as weight loss, transient reduction in rectal temperature and decrease of food and water intake. Moreover at 24 h after LPS injection these same mice strains displayed significantly increased immobility time on the tail suspension test (TST) when compared with control mice, this alteration was not related with possible locomotion impairments as verified on the open field test. Treatment with Nortriptyline 30 mg/kg (ip, 60 min prior the TST) reduced the immobility time of control and LPS-treated mice and was used as standard antidepressant. The NOP receptor antagonist SB-612111 (10 mg/kg, ip), 30 min prior LPS, did not modify LPS-induced sickness signs and depressive-like behavior. However, when injected 24 h after LPS treatment, SB-612111 (ip, 30 min prior the TST) as well as the peptidergic NOP receptor antagonist UFP-101 (10 nmol/2μL, icv, 5 min prior the TST) significantly reversed the toxin effects. The protocol of LPS-induced depressive-like states was also tested in NOP receptor knockout mice (NOP(-/-)) and their respective wild types (NOP(+/+)). LPS evoked transient rectal temperature reduction in NOP(-/-) mice and loss of body weight, food and water intake reduction in both NOP(+/+) and NOP(-/-) mice. The consumption of water was significantly different due to the genotype. LPS injection induced transient changes in pro-inflammatory cytokines. At 6 h after LPS injection, serum levels of TNF-α were significantly increased in NOP(+/+) and NOP(-/-) mice, as the IL-6 levels were significantly increased just in NOP(+/+) serum. At 24 h after LPS treatment the pro-inflammatory cytokines had returned to the baseline levels in both genotypes. LPS treatment elicited depressive-like effects in NOP(+/+) but not in NOP(-/-) mice. The data obtained during the execution of this doctoral thesis reveal that pharmacological and genetic blockade of NOP signaling does not affect LPS evoked sickness signs while reversing depressive-like behavior. In conclusion, these results highlight the involvement of the peptidergic system N/OFQ - NOP receptor in the modulation of behaviors related to mood and activation of the immune system.

“Num só crio pra vender, não” : etnicidade, gênero e saberes domésticos em Moita Verde (Parnamirim, RN)

O presente trabalho consiste em etnografia realizada na comunidade quilombola de Moita Verde, Parnamirim (RN). Pensada a partir do processo de emergência étnica, tendo como campo de analise o espaço doméstico para pensar a relação entre as mulheres e as distintas arenas políticas, das relações entre famílias, com o entorno e agentes de Estado. Em especial, o envolvimento das mulheres com a criação de porcos vinculada a um sistema que se relaciona com outros saberes do sítio que vão para além da dimensão técnica, levando em consideração os saberes e práticas do grupo. Além disso, este saber, associado com outros saberes políticos, em contexto de relações étnico-raciais, pode ser usado dos debates sobre identidade e especificidade de direitos.

A linguagem audiovisual do cinema como elemento integrador da arte e ciência na formação cultural dos professores de ciências e matemática

This work aims to study about the importance of cinema for cultural and professional training of teachers of Natural Sciences and Mathematics. The educational potential of cinema is emphasizing by different authors, which also reveal the teachers' training gap in this issue (media). In this study, we defend the audiovisual language of cinema as an integrating element of Arts and Science for cultural and professional training of teachers. This subject has been developed by different authors, in which the emphasis has been the importance of intelligent dialogue with the world. Specifically, the training of science teachers and mathematics, by the approach of Cinema in its formation, It envisions the possibility of minimizing the dichotomy between humanistic and scientific training, already much discussed by some researchers. Educational products contribute to an effective experience and reflection on the cultural and educational role of the Seventh Art. Considering the Cinema as a possible "bridge" between the two cultures (scientific culture and humanistic culture) and promoting ownership of audiovisual language in teacher training It was accomplished the I Exhibition - Cultural Spring: Cinema and Science Education in UFRN. The production of the booklet "Topics of History, Language and Art of Cinema for Science and Mathematics Teachers," and its application in a short course in the XXI National Symposium on Physics Teaching also aimed to contribute to the approximation of Science and Art in training teachers.

O turismo de base comunitária como vetor de etnodesenvolvimento: a comunidade Mebêngôkre-Kayapó na Terra Indígena Las Casas - PA

This study aims to analyze the contribution that the future implementation of community-based tourism can provide to Mebengokre-Kayapo, people of the village Tekrejarôti, they re-inhabiting the indigenous land Las Casas, located in southern of Pará, taking into consideration that tourism is as vector of ethnodevelopment, and it can also contribute to the conservation of Sociobiodiversity and local culture through experiences that will enable the realization of acquaintanceship, where there will be sharing of the daily activities of the customs of the local people, and cultural changes, which is the aim between visitors and the community, where these ones can promote the knowledge of non-indigenous people, and to consolidate the ethnic and cultural identity thereof too. Thus, this study guided by the participatory action research, it was used data obtained in 2012, that were results from the application of interviews with the community to make the diagnosis of tourism potential. It is an exploratory and descriptive research about the topic. The field research combined with participant observation, workshops and interviews contributed to it was possible to conduct a depth analysis about the environment studied. This research has the intention to obtain concrete results in the implementation and/or promotion of a cultural practice and environmentally sustainable ruled in organizational processes that permeates the guidelines of community-based tourism, however this depends on the conditions of human and forest resources, and infrastructure conditions in the community, providing in the short and medium terms, social activities and culturally positive for the culture of this people, and providing to long term, environmental and economic landmarks. As result, it was possible to identify that the community with its cultural events, parties and ceremonies being allied to their way of life and taken from their criteria, it is able to work with the tourism within their land and it can makes the tourism, a cultural affirmation opportunity and income generation. But, it concludes that for tourism to become ,in fact, there are required to be carried out some measures, that meets the new Regulatory Instruction IN 3/2015, this IN states that for the community to work with tourism in their land, it is necessary to be prepared a visitation plan that fits the established requirements. This research is constituted as an important tool in building this visitation plan, given that it was done from the community demand and it was conducted in a participatory manner, valuing the horizontal dialogue and the autonomy of this people.

O turismo de base comunitária como vetor de etnodesenvolvimento: a comunidade Mebêngôkre-Kayapó na Terra Indígena Las Casas - PA

This study aims to analyze the contribution that the future implementation of community-based tourism can provide to Mebengokre-Kayapo, people of the village Tekrejarôti, they re-inhabiting the indigenous land Las Casas, located in southern of Pará, taking into consideration that tourism is as vector of ethnodevelopment, and it can also contribute to the conservation of Sociobiodiversity and local culture through experiences that will enable the realization of acquaintanceship, where there will be sharing of the daily activities of the customs of the local people, and cultural changes, which is the aim between visitors and the community, where these ones can promote the knowledge of non-indigenous people, and to consolidate the ethnic and cultural identity thereof too. Thus, this study guided by the participatory action research, it was used data obtained in 2012, that were results from the application of interviews with the community to make the diagnosis of tourism potential. It is an exploratory and descriptive research about the topic. The field research combined with participant observation, workshops and interviews contributed to it was possible to conduct a depth analysis about the environment studied. This research has the intention to obtain concrete results in the implementation and/or promotion of a cultural practice and environmentally sustainable ruled in organizational processes that permeates the guidelines of community-based tourism, however this depends on the conditions of human and forest resources, and infrastructure conditions in the community, providing in the short and medium terms, social activities and culturally positive for the culture of this people, and providing to long term, environmental and economic landmarks. As result, it was possible to identify that the community with its cultural events, parties and ceremonies being allied to their way of life and taken from their criteria, it is able to work with the tourism within their land and it can makes the tourism, a cultural affirmation opportunity and income generation. But, it concludes that for tourism to become ,in fact, there are required to be carried out some measures, that meets the new Regulatory Instruction IN 3/2015, this IN states that for the community to work with tourism in their land, it is necessary to be prepared a visitation plan that fits the established requirements. This research is constituted as an important tool in building this visitation plan, given that it was done from the community demand and it was conducted in a participatory manner, valuing the horizontal dialogue and the autonomy of this people.

A SENSIBILIDADE CULTURAL DO ADVENTISMO COMO MODELO MISSIOLÓGICO EM GRANDES CENTROS URBANOS: UMA ANÁLISE DE IGREJAS ADVENTISTAS ÉTNICAS NA CIDADE DE SÃO PAULO

Esta pesquisa objetiva analisar o desenvolvimento da missão adventista na cidade de São Paulo em busca de um modelo missiológico para centros urbanos. São Paulo, uma das maiores metrópoles do mundo tem uma formação cultural plural, não apenas pelas forças atuantes da modernização, secularização, globalização e pós-modernidade. A composição da população da cidade possui uma gênese étnica plural. Além da matriz autóctone indígena, do colonizador branco europeu e dos escravos africanos, desde o início do século XIX chegaram outros imigrantes, europeus e asiáticos. Nas primeiras décadas do século XX, o Brasil foi o país que mais recebeu imigrantes em todo o mundo. Estima-se que nos anos de 1920, apenas um terço da população na cidade de São Paulo fosse de brasileiros, o restante era composto por imigrantes. A inserção do adventismo em São Paulo se deu por missionários imigrantes que trabalharam primeiro com outros imigrantes antes de evangelizar e desenvolver a missão adventista com os brasileiros nacionais. De alguma forma, esse início deixou marcas na missão adventista paulistana. São Paulo é hoje a cidade com o maior número total de adventistas no mundo e a única com Igrejas Adventistas étnicas que atendem cinco grupos étnicos distintos: japoneses, coreanos, judeus, árabes e bolivianos/peruanos. Esta pesquisa busca investigar a formação de uma sensibilidade cultural no adventismo paulistano que lhe permitiu dialogar com a pluralidade cultural da metrópole paulistana

As vogais médias tônicas: um estudo contrastivo da metafonia com base em corpus

This research analyzes the average previous stressed vowels [ε] and [e] and later [ɔ] and [o] in nominal and verbal forms in the 1st person singular and 3rd person singular and plural in the present tense, specifically the umlaut process of mid vowels /e/ and /o/, which assimilate in /ε/ and /ᴐ/ in stressed position. The general objective of this research is to describe and quantify the occurrence of umlaut and subsequently analyze in which words there is regularity or not. As specific objectives we have: i) to compile and to label an oral, spontaneous, synchronic and regional corpus, from radio programs produced in the city of Ituiutaba, Minas Gerais; ii) to describe the characteristics of the corpus to be compiled; iii) to investigate the alternating timbre of mid vowels in stressed position; iv) to identify instances of nominal and verbal umlaut of the middle vowels in stressed position; v) to describe the identified cases of nominal and verbal umlaut; vi) to analyze the probable causes for the variation of the middle vowels. To perform the proposed analysis, we have adopted as a theoretical-methodological basis multi-representational models: Phonology of Use (BYBEE, 2001) and Exemplar Theory (PIERREHUMBERT, 2001) combined with the precepts of Corpus Linguistics (BEBER SARDINHA, 2004). The corpus consisted of 16 radio programs – eight political and eight religious – from the city of Ituiutaba-MG, with recordings of about 20 to 40 minutes. We note, by means of the results generated by WordSmith Tools® software, version 6.0 (SCOTT, 2012), that the analyzed forms show little variation, which shows that the umlaut is a process already lexicalized in participants of the radio programs analyzed. We conclude that the results converge with the proposal of the Phonology of Use (BYBEE, 2001; PHILLIPS, 1984) that less frequent words that have no phonetic environment conducive to change, are changed first.

A nasalidade no dialeto quilombola do Norte de Minas: uma análise contrastiva baseada em corpus

This research investigated the nasality of vowels in the spontaneous speech of inhabitants of the quilombola communities of Brejo dos Crioulos and Poções (MG). As a theoretical framework, we based on the assumptions of Phonetics and Phonology, in renowned scholars on the investigation of nasality (CAGLIARI, 1977; CÂMARA JR., 1984, 2013; BISOL, 2013; ABAURRE; PAGOTTO, 1996; SILVA, 2015), with subsidies of the Corpus Linguistics. Its general goal was to investigate the occurrence of nasality, in the dialect of these quilombola communities, and their linguistic behavior, considering the linguistic factors that can interfere in the phenomenon. Specifically it was aimed to a) detect the occurrence of nasalized vowels with the help of the resources that the Corpus Linguistics provides (Praat and WorldSmith Tolls); b) discriminate the different types of occurring contexts of nasalized vowels; c) make quantitative and qualitative analyzes of the nasalized vowels in the study corpus; d) describe and analyze the behavior of nasalized vowels and; e) contrast the values of F1 and F2 of the oral and nasalized vowels. It was hypothesized that the nasality happens because it is conditioned by the nasal segment following the nasalized vowel - phonological process of “assimilation” - its position as the primary stress and grammatical category. It was believed that the quilombolas communities of Brejo dos Crioulos and Poções produce nasalized vowels in their speech and this linguistic phenomenon is favored by the adjacent presence of consonants or nasal vowels. Furthermore, it was hypothesized that the values of F1 and F2 of oral and nasalized vowels in these communities are distinct. The following research questions were elaborated: (i) is the presence of nasalized vowels in the speech of these quilombola communities conditioned to the presence of a nasal sound segment? (ii) does the nasal sound segment following the nasalized vowel favor the occurrence of the nasality phenomenon? is there a difference between the values of F1 and F2 of the oral and nasalized vowels in both quilombola communities considered? To compose our corpus, 24 interviews recordings were used (12 female speakers and 12 male speakers), a total of 24 participants. It was found that the following nasal sound segment tends to condition the nasalized vowel. In general, it assimilates the lowering of the soft palate of nasal consonant segment immediately following, but there are cases of nasal vowel segment - regressive assimilation; the stressed syllable tends to favor the nasality, but it occurs in pretonic and postonic position as well; F1 and F2 values of oral and nasalized vowels in the quilombola communities of Poções and Brejo dos Crioulos are distinct: the group of Brejo dos Crioulos tends to produce the F1 of oral and nasalized vowels more lowered than the group of Poções and the F2, in a more anterior position. The nasality tends to occur in verbs and nouns, although it is not specific to a grammatical category. This research found cases of spurious nasalization, confirming previous studies. In turn, it revealed cases of lexical items with favorable context for nasalization, but with its non-occurrence. This last case, considered as the lowering of the uniform soft palate in PB, presented pronounced vowels without the soft palate lowering. That is, it was detected variation in the phenomenon of nasalization in PB. With this work, it was promoted the discussion about nasality, in order to contribute to the linguistic studies about the functioning of Brazilian Portuguese in this geographical context.

Estrategias para el desarrollo humano y procesos alfabetizatorios múltiples

Es necesario reflexionar que al decir "nuevo", no implica pensar "mejor". No hablamos de un sujeto social que necesariamente o por "imperio del devenir histórico" ejerce su ciudadanía. No es así, hablamos del sujeto a descubrir, desmembrado de la red social que le dio origen, atravesado por múltiples variables que conforman una batería opuesta a las variables propias del Desarrollo humano. Nos interrogamos acerca del "nuevo sujeto social de las pobrezas". Y nos interesa observar cómo opera la idea madre de Desarrollo Humano en consonancia con la diversidad cultural, étnica y las crisis de alteridad. Para ello tenemos en cuenta que la pobreza no tiene la misma representación social para todas las culturas y étnias. El abordaje que proponemos se realiza desde un concepto pedagógico dialéctico y dialógico que opera con los procesos alfabetizatorios múltiples, entendidos como aquellos procesos de enseñanza-aprendizaje que en su dimensión social se manifiestan en el plano material y simbólico (discursivo) como estrategias articuladoras para el Desarrollo Humano. Esta reflexión se enmarca en el taller "Las Alfabetizaciones: ¿Estrategias para el desarrollo humano?" realizado durante el transcurso de este año. La mirada y la acción propuesta desde la doble hermenéutica atraviesan tres instancias: 1- La propia del aprendizaje del taller, plasmada en la interacción docente-alumno. 2- La propia del curso en el abordaje específico de las temáticas planteadas en la reflexión metodológica y sociológica. 3- La experiencia pedagógica y, a través de ésta, la propuesta de investigación diseñada por los cursantes

Estrategias para el desarrollo humano y procesos alfabetizatorios múltiples

Es necesario reflexionar que al decir "nuevo", no implica pensar "mejor". No hablamos de un sujeto social que necesariamente o por "imperio del devenir histórico" ejerce su ciudadanía. No es así, hablamos del sujeto a descubrir, desmembrado de la red social que le dio origen, atravesado por múltiples variables que conforman una batería opuesta a las variables propias del Desarrollo humano. Nos interrogamos acerca del "nuevo sujeto social de las pobrezas". Y nos interesa observar cómo opera la idea madre de Desarrollo Humano en consonancia con la diversidad cultural, étnica y las crisis de alteridad. Para ello tenemos en cuenta que la pobreza no tiene la misma representación social para todas las culturas y étnias. El abordaje que proponemos se realiza desde un concepto pedagógico dialéctico y dialógico que opera con los procesos alfabetizatorios múltiples, entendidos como aquellos procesos de enseñanza-aprendizaje que en su dimensión social se manifiestan en el plano material y simbólico (discursivo) como estrategias articuladoras para el Desarrollo Humano. Esta reflexión se enmarca en el taller "Las Alfabetizaciones: ¿Estrategias para el desarrollo humano?" realizado durante el transcurso de este año. La mirada y la acción propuesta desde la doble hermenéutica atraviesan tres instancias: 1- La propia del aprendizaje del taller, plasmada en la interacción docente-alumno. 2- La propia del curso en el abordaje específico de las temáticas planteadas en la reflexión metodológica y sociológica. 3- La experiencia pedagógica y, a través de ésta, la propuesta de investigación diseñada por los cursantes

Estrategias para el desarrollo humano y procesos alfabetizatorios múltiples

Es necesario reflexionar que al decir "nuevo", no implica pensar "mejor". No hablamos de un sujeto social que necesariamente o por "imperio del devenir histórico" ejerce su ciudadanía. No es así, hablamos del sujeto a descubrir, desmembrado de la red social que le dio origen, atravesado por múltiples variables que conforman una batería opuesta a las variables propias del Desarrollo humano. Nos interrogamos acerca del "nuevo sujeto social de las pobrezas". Y nos interesa observar cómo opera la idea madre de Desarrollo Humano en consonancia con la diversidad cultural, étnica y las crisis de alteridad. Para ello tenemos en cuenta que la pobreza no tiene la misma representación social para todas las culturas y étnias. El abordaje que proponemos se realiza desde un concepto pedagógico dialéctico y dialógico que opera con los procesos alfabetizatorios múltiples, entendidos como aquellos procesos de enseñanza-aprendizaje que en su dimensión social se manifiestan en el plano material y simbólico (discursivo) como estrategias articuladoras para el Desarrollo Humano. Esta reflexión se enmarca en el taller "Las Alfabetizaciones: ¿Estrategias para el desarrollo humano?" realizado durante el transcurso de este año. La mirada y la acción propuesta desde la doble hermenéutica atraviesan tres instancias: 1- La propia del aprendizaje del taller, plasmada en la interacción docente-alumno. 2- La propia del curso en el abordaje específico de las temáticas planteadas en la reflexión metodológica y sociológica. 3- La experiencia pedagógica y, a través de ésta, la propuesta de investigación diseñada por los cursantes

El Estado legislando, relevando, mapeando. Una etnografía de la implementación del Programa de Relevamiento Territorial de Comunidades Indígenas en Salta (Argentina)

Tomando como punto de partida mi colaboración en la recolección y la sistematización de datos vinculados al relevamiento territorial en distintas comunidades guaraníes del noroeste salteño, en apoyo al Programa de Relevamiento Territorial de Comunidades Indígenas (Re.Te.CI) y en el marco de la Ley de Emergencia en materia de posesión y propiedad comunitaria indígena (Ley 26.160), el presente artículo describe y analiza distintos momentos de la implementación del programa. Fundamentalmente, exploro las formas particulares que el mismo asumió en la provincia de Salta focalizándome en el Departamento General San Martín, siendo esta la región de mayor diversidad étnica de la provincia. Inspirada en la propuesta de Ferguson y Gupta (2002) de pensar al Estado como “una experiencia vivida” utilizo materiales etnográficos de tres comunidades indígenas donde se aplicó el programa de relevamiento territorial y me centro en una de ellas para pensar las formas que adopta la relación entre el Estado y los pueblos indígenas.

Migrant women’s employment in paid reproductive work through the crisis: the case of Italy (2007-2012)

Paid reproductive work, especially in the case of cleaning and home-care for elderly people, is an important sector for foreign women in Italy. For this reason, since the beginning of the current economic crisis, scholars have wondered about the impact of the recession on migrant domestic workers. They have looked particularly at possible competition with Italian women entering the sector for lack of better alternatives. Our paper takes this discussion a step further by assessing the overall changes affecting migrant women in the Italian labour market, 2007-2012. We will look at how their position has been transformed, by taking both an ethnic perspective, in relation to Italian women, and a gender perspective, in relation to migrant men. By way of a conclusion, the argument will be made that there is a substantial lack of competition between Italian and foreign women in the care and domestic sector due to differences in their earnings, hours of work and activities.

Model for integrates community tourism in Ecuador, case study Pastaza

The tourism industry globally has grown steadily in recent decades, showing a progressive interest oriented toward rural areas due to characteristics of tranquility, nature, biodiversity, traditions and culture. Therefore, such aspects should be preserved and can be leveraged through adequate strategic orientation. Within the framework of global tourism trends community tourism is among the options that arise in the tourism market, and is one that is more likely to grow in the future. In the case of Ecuador, community tourism has become more dynamic over the years since many of the natural reserves in the country are in the hands of indigenous communities. Sustainable tourism in this sense is concerned with the maintenance of ethnic, cultural and biological diversity of the country, and current projects and regulatory laws support its development. Therefore, the aim of this paper is to present a strategy for the integrated management of community tourism following the principles of cooperation and collaboration between stakeholders, this study focuses on the Amazon region of Ecuador, specifically the province of Pastaza, in respect to how community tourism contributes to local development

La estructuración del espacio urbano y productivo de Gadir durante la fase urbana clásica: Cambios y perduraciones

La reafirmación del modelo político-administrativo ciudadano tras la fase arcaica colonial abre una nueva etapa de prosperidad en la antigua fundación tiria. El esplendor de Gadir en el s. V a.C. se refleja en los textos clásicos y en los hallazgos arqueológicos y, sin embargo, nuestros conocimientos sobre el desarrollo histórico de la ciudad de época púnica son muy limitados. El horizonte arcaico comienza a esclarecerse tras los hallazgos del Teatro Cómico que han sacado a la luz los restos de la fundación tiria y, sin embargo, la ciudad posterior continúa siendo una gran incógnita. ¿A qué lugar se traslada la población una vez que se abandona el asentamiento primitivo? ¿Quiénes son los individuos enterrados en los excepcionales sarcófagos antropoides? ¿Qué relación jerárquica existe entre el asentamiento insular y los situados en tierra firme? ¿Qué papel jugó la industria y comercialización de las salazones? Los interrogantes planteados son múltiples y no hacen más que evidenciar la incapacidad del paradigma tradicional para explicar el desarrollo histórico de la Gadir postcolonial y la necesidad de buscar nuevos modelos interpretativos.