Identifying cancer subtypes in glioblastoma by combining genomic, transcriptomic and epigenomic data

We present a nonparametric Bayesian method for disease subtype discovery in multi-dimensional cancer data. Our method can simultaneously analyse a wide range of data types, allowing for both agreement and disagreement between their underlying clustering structure. It includes feature selection and infers the most likely number of disease subtypes, given the data. We apply the method to 277 glioblastoma samples from The Cancer Genome Atlas, for which there are gene expression, copy number variation, methylation and microRNA data. We identify 8 distinct consensus subtypes and study their prognostic value for death, new tumour events, progression and recurrence. The consensus subtypes are prognostic of tumour recurrence (log-rank p-value of $3.6 \times 10^{-4}$ after correction for multiple hypothesis tests). This is driven principally by the methylation data (log-rank p-value of $2.0 \times 10^{-3}$) but the effect is strengthened by the other 3 data types, demonstrating the value of integrating multiple data types. Of particular note is a subtype of 47 patients characterised by very low levels of methylation. This subtype has very low rates of tumour recurrence and no new events in 10 years of follow up. We also identify a small gene expression subtype of 6 patients that shows particularly poor survival outcomes. Additionally, we note a consensus subtype that showly a highly distinctive data signature and suggest that it is therefore a biologically distinct subtype of glioblastoma. The code is available from https://sites.google.com/site/multipledatafusion/

processline: visualizing time-series data in process industry

In modern process industry, it is often difficult to analyze a manufacture process due to its umerous time-series data. Analysts wish to not only interpret the evolution of data over time in a working procedure, but also examine the changes in the whole production process through time. To meet such analytic requirements, we have developed ProcessLine, an interactive visualization tool for a large amount of time-series data in process industry. The data are displayed in a fisheye timeline. ProcessLine provides good overviews for the whole production process and details for the focused working procedure. A preliminary user study using beer industry production data has shown that the tool is effective.

Ajax与WebGIS的集成研究

WebGIS是利用互联网来扩展和完善地理信息系统的一项应用技术,是GIS发展的一个重要方向。Ajax是异步JavaScript和XML技术的组合。本文介绍了地理空间信息网络服务,探讨了Ajax与WebGIS的集成模式,并以Google Maps为例,详细分析了Ajax与WebGIS集成的具体方法。

基于可视化分析的交互式仪表盘系统的设计与实现

面对日益激烈的市场竞争，企业需要更快更及时地了解和掌握业务运行状况，提高快速响应市场变化的能力。仪表盘（Dashboard）是反映公司状况和商业环境并辅助商务智能和绩效管理活动的有力工具。目前仪表盘的研究和应用在信息呈现方面特别是在显示关键绩效指标信息方面得到了广泛的开展，但是对于经营决策者们决策过程中信息利用活动的认知和操纵特点重视不足，决策过程中用户使用仪表盘的交互负担过重，干扰了决策思维活动的有效进行。可视化分析（Visual Analytics）以分析推理过程的研究为理论基础，将人机交互技术和信息可视化技术紧密结合，通过各种交互技术辅助用户洞察信息中隐藏的规律与模式，进而为经营决策提供有力的支持。本文拟基于可视化分析理论，以制造企业的经营决策为切入点，将笔手势和语音多通道交互技术引入到仪表盘的设计和使用过程中，全面研究了交互式仪表盘的设计及运行界面，开发了基于可视化分析的交互式仪表盘系统，提高了仪表盘设计人员的工作效率，减轻了企业决策者进行信息分析的交互操作负担。 论文的主要工作包括以下几个方面： 1.　分析了仪表盘系统的传统研发过程及应用特点，研究了可视化分析推理的过程和面向用户目标的可视化分析任务的分类方法，在此基础上建立了交互式仪表盘系统的业务流程，介绍了系统功能体系及体系结构。 2. 针对交互式仪表盘设计界面，研究了面向任务目标分析的概念图绘制工具，给出了概念网络图布局算法；阐述了数据特点及信息领域模型，并研究了数据定制的用户界面设计；从可视结构和可视化分析任务两方面分析了具有代表性的十五种可视化隐喻的特点，并提出了基于目标任务集与仪表盘所支持任务集的相似度确定符合用户目标的可视化隐喻推荐算法。 3. 针对交互式仪表盘运行界面，提出了可视化分析过程中支持交互操作的笔手势和语音的多通道交互方式，研究了多通道输入信息融合技术；实现了基于领域信息模型的多视图关联协调技术和基于直接操纵的动态过滤技术。 4. 在上述研究工作的基础上，设计并开发了面向制造企业生产经营状况分析的交互式仪表盘原型系统，并通过具体的实例介绍了系统的应用流程，应用结果表明系统具有良好的应用效果。

地理信息系统的新时代:网格地理信息系统

地理信息系统经过40多年的发展,形成了包括地理信息系统技术、地理信息科学和地理信息服务(科学)的综合体系,关注的重点已从技术软件系统转向信息服务。回顾历史可以知道:现代意义上的商业地理信息系统软件产品始于20世纪80年代初,也不过只有20多年的发展历史,然而发展速度之快,令人震惊。目前国际上的GIS软件厂商除了有ESRI、MapInfo等品牌GIS基础平台提供商之外,一些大型IT企业,如微软、Oracle、Google等也根据自己对行业的理解,或成立空间信息技术解决方案的部门,或通过并购等形式进入到

Variação da área irrigada por pivôs centrais no Brasil entre 2013 e 2014.

Foram comparadas as áreas irrigadas por pivôs centrais no Brasil em 2013 e 2014, mapeadas através da identificação visual a partir de mosaicos formados por imagens do satélite Landsat 8 ? OLI / TRS de 2013 e 2014, respectivamente, exibidas no programa Google Earth. Em 2013 foram identificados 17.878 pivôs centrais, ocupando uma área irrigada de 1.179.176 ha. Em 2014, foi observado aumento de 11% no número de pivôs centrais e de 8% na área irrigada (19.928 pivôs centrais, 1.279.072 ha irrigados). Em 2013, praticamente 90% dos pivôs concentravam-se nos Estados de Minas Gerais, São Paulo, Goiás, Bahia e Rio Grande do Sul, situação também observada para o ano de 2014. Em alguns Estados foi verificado aumento maior do que 20% no número de pivôs entre 2013 e 2014, como em Alagoas (133%), Santa Catarina (50%), Mato Grosso (20,07%). Em outros Estados, porém, o número de pivôs diminuiu em mais do que 20%, como é o caso do Sergipe (-100%), Pernambuco (-75%) e Maranhão (-46,61%). Em 2013, aproximadamente 45% dos pivôs centrais do Brasil concentrava-se na Região Hidrográfica do Rio Paraná; e quase 30%, na do Rio São Francisco. Em 2014, a Região Hidrográfica do Rio Paraná passou a concentrar cerca de 50% dos pivôs centrais do país. Apesar das adversidades climáticas verificadas nos últimos anos, principalmente nas áreas de Cerrado, com o aumento de incentivos econômicos para a produção de alimentos prevê-se a expansão futura das áreas irrigadas no país. Apesar do benefício potencial da irrigação para a produção agrícola, estratégias para promover o aumento da produção agrícola irrigada devem considerar restrições relacionadas com a disponibilidade, qualidade e conflitos de uso da água das bacias hidrográficas em que estão inseridas. Ações estimulando a melhoria da qualidade da água, conservação de nascentes e áreas de preservação permanente, bem como o gerenciamento eficiente dos recursos hídricos, contribuirão para a melhoria da qualidade e quantidade de água disponível, fundamentais para possibilitar a sustentabilidade e expansão futura da agricultura irrigada no Brasil.

Water-based exercise for adults with asthma

BackgroundAsthma is a common condition characterised by airway inflammation and airway narrowing, which can result in intermittent symptoms of wheezing, coughing and chest tightness, possibly limiting activities of daily life. Water-based exercise is believed to offer benefits for people with asthma through pollen-free air, humidity and effects of exercise on physical function.ObjectivesTo evaluate the effectiveness and safety of water-based exercise for adults with asthma.Search methodsWe searched the Cochrane Airways Group Specialised Register of Trials (CAGR), the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE, the Cumulative Index to Nursing and Allied Health Literature (CINAHL), the Allied and Complementary Medicine Database (AMED), PsycINFO, the Latin American and Caribbean Health Science Information Database (LILACS), the Physiotherapy Evidence Database (PEDro), the System for Information on Grey Literature in Europe (SIGLE) and Google Scholar on 13 May 2014. We handsearched ongoing clinical trial registers and meeting abstracts of the American Thoracic Society (ATS), the European Respiratory Society (ERS) and the British Thoracic Society (BTS).Selection criteriaWe included all randomised controlled trials (RCTs) of adults with asthma comparing a water-based exercise group versus one or more of the following groups: usual care, land-based exercise, non-exercise.Data collection and analysisTwo review authors (AJG, VS) independently extracted data fromthe primary studies using a standard form developed for this purpose, which includes methods, participants, interventions and outcomes. We contacted trial authors to request additional data. Data were input by one review author and were double-checked by a second review author.Main resultsIn this systematic review, we provide a narrative synthesis of available evidence from three small studies including 136 adult participants. the studies were at high risk of bias. No meta-analysis was possible because of methodological and interventional heterogeneity between included studies. the primary outcomes of quality of life and exacerbations leading to use of steroids were not reported by these studies. for exacerbations leading to health centre/hospital visits, uncertainty was wide because a very small number of events was reported (in a single study). Secondary outcomes symptoms, lung function, changes in medication and adverse effects, where available, described for each included study. the overall quality of the studies was very low, and no clear differences were noted between water-based exercise and comparator treatments. Therefore, we remain very uncertain about the effects of water-based exercise for adults with asthma.Authors' conclusionsThe small number of participants in the three included studies, the clinical and methodological heterogeneity observed and the high risk of bias assessed mean that we are unable to assess the place of water-based exercise in asthma. Randomised controlled trials are needed to assess the efficacy and safety of water-based exercise for adults with asthma. for future research, we suggest greater methodological rigour (participant selection, blinding of outcome assessors, reporting of all outcomes analysed and registering of the study protocol).

NHS Wales user needs study including knowledgebase tools report. Report for Informing Healthcare Strategy implementation programme.

Thomas, R., Spink, S., Durbin, J. & Urquhart, C. (2005). NHS Wales user needs study including knowledgebase tools report. Report for Informing Healthcare Strategy implementation programme. Aberystwyth: Department of Information Studies, University of Wales Aberystwyth. Sponsorship: Informing Healthcare, NHS Wales

ΑΝΑΛΥΣΙΣ ΠΕΡΙ ΤΑ ΣΧΗΜΑΤΑ. Restoring Aristotle’s Lost Diagrams of the Syllogistic Figures

The article examines the relevance of Aristotle’s analysis that concerns the syllogistic figures. On the assumption that Aristotle’s analytics was inspired by the method of geometric analysis, we show how Aristotle used the three terms (letters), when he formulated the three syllogistic figures. So far it has not been appropriately recognized that the three terms — the major, the middle and the minor one — were viewed by Aristotle syntactically and predicatively in the form of diagrams. Many scholars have misunderstood Aristotle in that in the second and third figure the middle term is outside and that in the second figure the major term is next to the middle one, whereas in the third figure it is further from it. By means of diagrams, we have elucidated how this perfectly accords with Aristotle's planar and graphic arrangement. In the light of these diagrams, one can appropriately capture the definition of syllogism as a predicative set of terms. Irrespective of the tricky question concerning the abbreviations that Aristotle himself used with reference to these types of predication, the reconstructed figures allow us better to comprehend the reductions of syllogism to the first figure. We assume that the figures of syllogism are analogous to the figures of categorical predication, i.e., they are specific syntactic and semantic models. Aristotle demanded certain logical and methodological competence within analytics, which reflects his great commitment and contribution to the field.

Cirurgia oral em hipocoagulados

Monografia apresentada à Universidade Fernando Pessoa para obtenção do grau de Licenciado em Medicina Dentária

Relação entre Sistema Estomatognático e Postura Corporal

Trabalho apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Medicina Dentária

Elevação do seio maxilar versus colocação de implantes curtos

Projeto de Pós-Graduação/Dissertação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Medicina Dentária

A importância da qualidade de vida na Saúde Oral dos idosos

Projeto de Pós-Graduação/Dissertação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Medicina Dentária

Sedação Consciente em Medicina Dentária

Projeto de Pós-Graduação/Dissertação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Medicina Dentária

Violência no namoro e consumos de substâncias em jovens estudantes universitários

Dissertação apresentada à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Criminologia