Proposta de um protocolo de terapia celular para o tratamento da doença pulmonar obstrutiva crônica

The main feature of pulmonary emphysema is airflow obstruction resulting from the destruction of the alveolar walls distal to the terminal bronchioles. Existing clinical approaches have improved and extended the quality of life of emphysema patients. However, no treatment currently exists that can change the disease course and cure the patient. The different therapeutic approaches that are available aim to increase survival and/or enhance the quality of life of emphysema patients. In this context, cell therapy is a promising therapeutic approach with great potential for degenerative pulmonary diseases. In this protocol proposition, all patients will be submitted to laboratory tests, such as evaluation of heart and lung function and routine examinations. Stem cells will be harvested by means of 10 punctures on each anterior iliac crest, collecting a total volume of 200 mL bone marrow. After preparation, separation, counting and labeling (optional) of the mononuclear cells, the patients will receive an intravenous infusion from the pool of Bone Marrow Mononuclear Cells (BMMC). This article proposes a rational and safe clinical cellular therapy protocol which has the potential for developing new projects and can serve as a methodological reference for formulating clinical application protocols related to the use of cellular therapy in COPD. This study protocol was submitted and approved by the Brazilian National Committee of Ethics in Research (CONEP - Brazil) registration number 14764. It is also registered in ClinicalTrials.gov (NCT01110252). (c) 2013 Sociedade Portuguesa de Pneumologia. Published by Elsevier Espana, S.L. All rights reserved.

DIGITAL ELEVATION MODEL VALIDATION WITH NO GROUND CONTROL: APPLICATION TO THE TOPODATA DEM IN BRAZIL

Digital Elevation Model (DEM) validation is often carried out by comparing the data with a set of ground control points. However, the quality of a DEM can also be considered in terms of shape realism. Beyond visual analysis, it can be verified that physical and statistical properties of the terrestrial relief are fulfilled. This approach is applied to an extract of Topodata, a DEM obtained by resampling the SRTM DEM over the Brazilian territory with a geostatistical approach. Several statistical indicators are computed, and they show that the quality of Topodata in terms of shape rendering is improved with regards to SRTM.

Hypusine Modification of the Ribosome-binding Protein eIF5A, a Target for New Anti-Inflammatory Drugs: Understanding the Action of the Inhibitor GC7 on a Murine Macrophage Cell Line

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Estudo prospectivo do desenvolvimento biométrico de olhos com catarata congênita e do desenvolvimento

Pós-graduação em Pesquisa e Desenvolvimento (Biotecnologia Médica) - FMB

Clinical, biochemical and haemathological effects in Rhamdia quelen exposed to cypermethrin

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Compactação de um cambissolo háplico causada pela extração florestal com trator Skidder

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Impacto da adição de caulim nas propriedades físico-mecânicas do papel formado por sequências ECF

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Caracterização física de painéis aglomerados de Eucalyptus grandis com adição de resíduos industriais madeireiros

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Opinião de profissionais da educação e da saúde sobre o uso da prancha ortostática para o aluno com paralisia cerebral

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Tendências e perspectivas da produção acadêmica sobre a temática educação de surdos: mapeamento da produção

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Semiótica do discurso científico: um estudo sobre novas perspectivas para a análise documental de conteúdo

Greimas Semiotic offers procedures for the analysis of different types of texts and discourses. For this reason, this study aimed to analyze the production of sense from scientific discourse, explained by Greimas Semiotics and Generative Sense Course, seeking to develop a new perspective on the identification of aboutness in Documentary Content Analysis and Information Science. The method used was exploratory and bibliographic review. Results show that the analysis of scientific discourse contributes to the identification of aboutness in Documentary Content Analysis, using Greimas Semiotics and Generative Sense Course.

A formação do conceito de ontologia na ciência da informação: uma análise nos periódicos Scire e Ibersid

The concept of ontoloy as a tool for knowledge organization and representation, which is not yet stable, is analyzed in two spanish journals of information science, namely “Scire: representación y organización del conocimiento” and “Ibersid: revista de sistemas de información y documentación”, both published by the University of Zaragoza. The term "ontology" and its variations were searched in the fields of title, keywords and abstract. A corpus of eighteen articles was obtained. The approaches to ontologies were classified into four categories of analysis: conceptualization, comparison, application and new applications. It was observed that the way which the concept of ontologies is treated in both periodicals is in consonance with their editorial policies. The term ontology is suffering a process of meta-terminologization, from the field of philosophy towards information science, a fact that deserves further and more vertical studies.

El ámbito temático: un análisis de dominio de las conferencias nacionales y regionales de ISKO (Brasil, España y América del Norte)

This article is the result of a domain analysis of the articles published in the congresses of ISKO in Brazil, Spain and North America, aiming at identifying the themes and scientific collaboration characteristics, as an input for future studies on research trends and promoting the growth of the participation in each community. So it was characterized as an exploratory research focused on the analysis domain. The results showed that the Brazilian, North American and Iberian ISKO Chapters have been building a large space of scientific production with some convergent subjects like the epistemological questions, but also considering the regional specific ones. In this vein, the presence of researchers in the three studied academic spaces reveals a concern on establishing dialogical basis in KO research, whose main research institutions are São Paulo State University (UNESP, Brazil), University of Wisconsin Milwaukee (UWM, United States) and University Carlos III de Madrid (UC3M, Spain), which have deeply intensified their collaboration in joint publications.

Aspecto éticos na organização do conhecimento na prática profissional arquivística: um estudo dos princípios de ética da AAB, CIA e SAA

An axiological discussion is drawn from the analysis of the three codes of ethics in archives developed by the Association of Brazilian Archivists (AAB), the International Council on Archives (ICA) and the Society of American Archivists (SAA), presenting a framework of ethical values for the activities related to the organization and representation of knowledge, thus contributing to the theoretical framework underlying the social issues in Archival science.

Bibliotecas escolares e instrumentos digitais nos espaços escolares: uma pesquisa em Marília-SP

The article reports on research conducted with fifteen teachers and forty-five students in three high schools municipal Marília - SP, with the goal of mapping relationships between school libraries, computer labs and digital devices. The investigation is linked to the other two poles: one in the Faculty of Education, Federal University of Uberlândia and another at the French Institute of Education, in Lyon, France. Responses were obtained through questions previously formulated and recorded by scholars in an interview situation. The article initially retrieves historical projects of French in the late nineteenth century with the intention of establishing linkages with the situation in 2012, in Brazil. It then presents and comments on the graphics with data. The findings indicate the absence of organicity in relations between libraries and computer labs. Handheld devices outside of school are predominantly used to play and participate in social networking sites.