O Megalitismo no Alentejo (Portugal): as intervenções de Manuel Heleno (1931-1939) e o seu contributo para a Arqueologia portuguesa

Entre a primavera de 1931 e a primavera de 1945, Manuel Heleno, Diretor do Museu Etnológico e Professor na Faculdade de Letras da Universidade de Lisboa, dedicou-se ao inventário e escavação de centenas de monumentos megalíticos no Alentejo Central. Apesar do volume de informação recolhido este investigador, acabou por não publicar os seus dados o que trouxe graves consequências para o estudo do megalitismo funerário alentejano. Para além de uma caracterização dos trabalhos realizados por Manuel Heleno, apresenta-se um conjunto de reflexões sobre questões relacionadas com a produção e divulgação de informação, em Arqueologia e a responsabilidade social do arqueólogo.

A INTEGRAÇÃO REGIONAL BRASILEIRA ATUAL NO CONTEXTO SULAMERICANO: DIRETRIZES DO BANCO MUNDIAL E A AGENDA NA OMC SOBRE EDUCAÇÃO PARA A REGIÃO

Autores de inclinação liberal têm defendido que o mundo atual está globalizado, no qual os países não mantêm mais restrições ao comércio e serviços. Todavia, as desigualdades socioeconômicas, regionais e espaciais fazem com que os países latino-americanos necessitem de aportes financeiros e produtivos das nações mais ricas. Isto irá se refletir nos campos social, econômico e educacional no sentido da necessidade de formação de uma mão de obra mais especializada e na formação de docentes. Historicamente a América Latina tem sua inserção na economia mundial de forma subordinada, derivada de diferentes fatores e sob a injunção de variados organismos internacionais. Assim, esta pesquisa objetiva a análise das relações internacionais, no âmbito dos países que compõem o Mercosul, enfocando as políticas educacionais em andamento nestes países a partir das ações do Banco Mundial e da Organização Mundial do Comércio, sob a ótica da geografia econômica e política. A investigação seguiu uma metodologia qualitativa, na forma de análise documental e indutiva. Foi imprescindível interagir teoricamente com várias ciências humanas, pois é inegável que uma única ciência possa dar conta de múltiplas complexidades. Espera-se com esta investigação poder contribuir para o debate acerca da resolução sobre os graves problemas latino-americanos, particularmente ligados ao ensino.

UMA RELEITURA DAS POLÍTICAS PÚBLICAS DE DESENVOLVIMENTO REGIONAL: AS INTERVENÇÕES NO ESPAÇO RURAL NA REGIÃO DO SUDOESTE BAHIA-BRASIL

As políticas de “Desenvolvimento Regional” promovem ações que objetivam assegurar melhorias na condição de vida do cidadão, ajustes na organização econômica, conservação e preservação do meio ambiente. Embora caracterizadas como Políticas de Desenvolvimento Regional, estas ações se apresentam voltadas para o alívio da pobreza e muitas vezes possuem data limite para serem concluídas, e não finaliza com o problema das desigualdades regionais. A pesquisa apresenta caráter investigativo, com abordagem metodológica que avalia aspectos econômicos e sócio-ambientais, numa análise crítica do conjunto do espaço geográfico em estudo. Realiza-se uma leitura da realidade para avaliação das ações voltadas para o desenvolvimento regional em áreas rurais, considerando as ações implementadas nos últimos oito anos. A partir da análise dos dados, o trabalho consta de eixos: o primeiro acerca de políticas públicas de desenvolvimento regional e inserção da região Nordeste neste contexto. O segundo aborda o Estado da Bahia no contexto da questão regional em face à atuação das diferentes políticas de desenvolvimento regional, no terceiro a discussão sobre a concepção, formulação e implementação de programas de desenvolvimento regional. Analisar-se-á as condições sócio-econômicas da população das áreas rurais do Sudoeste da Bahia, a gestão dos programas de desenvolvimento regional e seus desdobramentos.

Acolhimento às urgências e emergências na atenção básica: intervenções e propostas da unidade Santo Antônio - Coronel Ezequiel (RN)

Devido ao alto contingente de urgências demandado diariamente, esse tema acena no diagnóstico situacional epidemiológico, inspirando iniciativas da equipe, comunidade e gestão, visando aprimorar o acolhimento às urgências/emergências. Este plano objetiva firmar protocolo municipal de urgências, elaborar cartilha de urgências em consonância com promoção de eventos e capacitações internas, cobrir integralmente tal demanda, preconizar sala de estabilização na UBS, referenciar adequadamente as agudizações acolhidas e aprimorar o atendimento pré-hospitalar. Tais metas impactaram no cenário rural de acolhimento, contemplando quase todos os pontos preconizados, aprimorando o primeiro atendimento, a acessibilidade e interdisciplinaridade. A classificação de risco, o protocolo organizacional e a cartilha popular integraram o eixo norteador dessa estratégia, promovendo melhorias na humanização dos atendimentos, nos prognósticos dos usuários e nos sistemas de referência e acionamento da central de leitos e dos serviços móveis, apesar do status parcial de efetivação de alguns itens, a exemplo do estrutural e dos insumos.

Plano de intervenção do uso e abuso de benzodiazepínicos na unidade de saúde Zona D na cidade de Paula Cândido - Minas Gerais

O uso e abuso de benzodiazepínicos é um problema de saúde pública, sendo observado o uso inadequado em vários países. Os benzodiazepínicos são fármacos depressores do sistema nervoso central classificados como agentes sedativo-hipnóticos e, causam vários efeitos adversos e dependência física e psicológica quando usado por períodos prolongados. Assim, este estudo objetivou elaborar um projeto de intervenção visando conhecer o perfil dos usuários, para construção de informações e estratégias para conscientizar a comunidade sobre os riscos e benefícios do uso de benzodiazepínicos. Utilizou-se da revisão narrativa, de algumas publicações em dados da Biblioteca Virtual de Saúde, Scielo, Pubmed, Google acadêmico, publicações do Ministério da Saúde e o Banco de dados do Sistema de Informação da Atenção Básica. Definiu-se como descritores da pesquisa: "benzodiazepínicos", "uso crônico de benzodiazepínicos". Realizou-se o levantamento do número de usuários de benzodiazepínicos na Unidade de Saúde do município classificando-os de acordo com o gênero, idade e classe de benzodiazepínicos usada. Observou-se a prevalência de uso de benzodiazepínicos de meia-vida longa e com predomínio de uso pela faixa etária de 41 a 50 anos, pelo gênero feminino. Os resultados obtidos forneceram dados para subsidiarem a elaboração de um projeto de intervenção tendo como plano de ação a criação do grupo de saúde mental, visando à disseminação de informação e melhor avaliação e controle dos usuários de psicotrópicos, em especial os usuários crônicos de benzodiazepínicos. O que se busca é o planejamento de intervenções para a promoção da adequada prescrição e utilização destes medicamentos pela população do município contribuindo para a prevenção do abuso de benzodiazepínicos e promoção da saúde.

Hypothalamic Inflammation And The Central Nervous System Control Of Energy Homeostasis.

The control of energy homeostasis relies on robust neuronal circuits that regulate food intake and energy expenditure. Although the physiology of these circuits is well understood, the molecular and cellular response of this program to chronic diseases is still largely unclear. Hypothalamic inflammation has emerged as a major driver of energy homeostasis dysfunction in both obesity and anorexia. Importantly, this inflammation disrupts the action of metabolic signals promoting anabolism or supporting catabolism. In this review, we address the evidence that favors hypothalamic inflammation as a factor that resets energy homeostasis in pathological states.

Nebivolol Reduces Central Blood Pressure In Stage I Hypertensive Patients: Experimental Single Cohort Study.

Assessment of central blood pressure (BP) has grown substantially over recent years because evidence has shown that central BP is more relevant to cardiovascular outcomes than peripheral BP. Thus, different classes of antihypertensive drugs have different effects on central BP despite similar reductions in brachial BP. The aim of this study was to investigate the effect of nebivolol, a β-blocker with vasodilator properties, on the biochemical and hemodynamic parameters of hypertensive patients. Experimental single cohort study conducted in the outpatient clinic of a university hospital. Twenty-six patients were recruited. All of them underwent biochemical and hemodynamic evaluation (BP, heart rate (HR), central BP and augmentation index) before and after 3 months of using nebivolol. 88.5% of the patients were male; their mean age was 49.7 ± 9.3 years and most of them were overweight (29.6 ± 3.1 kg/m2) with large abdominal waist (102.1 ± 7.2 cm). There were significant decreases in peripheral systolic BP (P = 0.0020), diastolic BP (P = 0.0049), HR (P < 0.0001) and central BP (129.9 ± 12.3 versus 122.3 ± 10.3 mmHg; P = 0.0083) after treatment, in comparison with the baseline values. There was no statistical difference in the augmentation index or in the biochemical parameters, from before to after the treatment. Nebivolol use seems to be associated with significant reduction of central BP in stage I hypertensive patients, in addition to reductions in brachial systolic and diastolic BP.

Central Auditory Processing Outcome After Stroke In Children.

To investigate central auditory processing in children with unilateral stroke and to verify whether the hemisphere affected by the lesion influenced auditory competence. 23 children (13 male) between 7 and 16 years old were evaluated through speech-in-noise tests (auditory closure); dichotic digit test and staggered spondaic word test (selective attention); pitch pattern and duration pattern sequence tests (temporal processing) and their results were compared with control children. Auditory competence was established according to the performance in auditory analysis ability. Was verified similar performance between groups in auditory closure ability and pronounced deficits in selective attention and temporal processing abilities. Most children with stroke showed an impaired auditory ability in a moderate degree. Children with stroke showed deficits in auditory processing and the degree of impairment was not related to the hemisphere affected by the lesion.

Human Herpesvirus Infections Of The Central Nervous System: Laboratory Diagnosis Based On Dna Detection By Nested Pcr In Plasma And Cerebrospinal Fluid Samples.

Infections of the central nervous systems (CNS) present a diagnostic problem for which an accurate laboratory diagnosis is essential. Invasive practices, such as cerebral biopsy, have been replaced by obtaining a polymerase chain reaction (PCR) diagnosis using cerebral spinal fluid (CSF) as a reference method. Tests on DNA extracted from plasma are noninvasive, thus avoiding all of the collateral effects and patient risks associated with CSF collection. This study aimed to determine whether plasma can replace CSF in nested PCR analysis for the detection of CNS human herpesvirus (HHV) diseases by analysing the proportion of patients whose CSF nested PCR results were positive for CNS HHV who also had the same organism identified by plasma nested PCR. In this study, CSF DNA was used as the gold standard, and nested PCR was performed on both types of samples. Fifty-two patients with symptoms of nervous system infection were submitted to CSF and blood collection. For the eight HHV, one positive DNA result-in plasma and/or CSF nested PCR-was considered an active HHV infection, whereas the occurrence of two or more HHVs in the same sample was considered a coinfection. HHV infections were positively detected in 27/52 (51.9%) of the CSF and in 32/52 (61.5%) of the plasma, difference not significant, thus nested PCR can be performed on plasma instead of CSF. In conclusion, this findings suggest that plasma as a useful material for the diagnosis of cases where there is any difficulty to perform a CSF puncture.

Altered Urinary Sodium Excretion Response After Central Cholinergic And Adrenergic Stimulation Of Adult Spontaneously Hypertensive Rats.

In this study, we hypothesized that blunting of the natriuresis response to intracerebroventricularly (i.c.v.) microinjected cholinergic and adrenergic agonists is involved in the development of hypertension in spontaneously hypertensive rats (SHR). We evaluated the effect of i.c.v. injection of cholinergic and noradrenergic agonists, at increasing concentrations, and of muscarinic cholinergic and α1 and α2-adrenoceptor antagonists on blood pressure and urinary sodium handling in SHR, compared with age-matched Wistar Kyoto rats (WR). We confirmed that CCh and NE microinjected into the lateral ventricle (LV) of conscious rats leads to enhanced natriuresis. This response was associated with increased proximal and post-proximal sodium excretion accompanied by an unchanged rate of glomerular filtration. We showed that cholinergic-induced natriuresis in WR and SHR was attenuated by previous i.c.v. administration of atropine and was significantly lower in the hypertensive strain than in WR. In both groups the natriuretic effect of injection of noradrenaline into the LV was abolished by previous local injection of an α1-adrenoceptor antagonist (prazosin). Conversely, LV α2-adrenoceptor antagonist (yohimbine) administration potentiated the action of noradrenaline. The LV yohimbine pretreatment normalized urinary sodium excretion in SHR compared with age-matched WR. In conclusion, these are, as far as we are aware, the first results showing the importance of interaction of central cholinergic and/or noradrenergic receptors in the pathogenesis of spontaneous hypertension. These experiments also provide good evidence of the existence of a central adrenergic mechanism consisting of α1 and α2-adrenoceptors which works antagonistically on regulation of renal sodium excretion.

Triatominae Survey (hemiptera: Heteroptera: Reduviidae) In The South-central Region Of The State Of Bahia, Brazil Between 2008 And 2013.

Triatomine surveillance in rural areas, artificial ecotypes, and natural ecotopes of the cities of Caturama, Ibipitanga, Macaúbas, and Seabra in the south-central region of the Brazilian state of Bahia was carried out between 2008 and 2013. Natural infection by Trypanosoma cruzi was evaluated in the specimens collected to monitor vectors of Chagas disease. A total of 1,357 specimens were collected, and four species were identified: Triatoma sordida (83%), Triatoma lenti (16.4%), Triatoma pseudomaculata (0.5%), and Panstrongylus geniculatus (0.1%). Triatoma sordida was found in four cities, only 0.7% in intradomiciliary environments. Triatoma lenti was found only in Macaúbas; 8.5% were found in intradomiciliary environments, 88.3% in peridomiciliary environments, and 3.1% in sylvatic environments. Natural infection by T. cruzi was 0.5% for T. sordida and 3.1% T. lenti. All of these cases were found in peridomiciliary environments of Macaúbas. As the results show, triatomines were found in intradomiciliary environments in three cities that were surveyed in the south-central region of the state of Bahia. Thus, an epidemiologic survey should be performed to avoid the risk of transmission to the population.

Semiologia neurológica numa população de escolares da primeira série do ensino fundamental

We evaluated children in the first grade of a elementary school using neurological examination. With no previous knowledgement of their educational performance, were invited all children attending five classes of the first grade of an elementary public school chosen randomly, in Itatiba / Sao Paulo / Brazil, whose parents assigned a Commitment Term for participation in this research. Children who missed three evaluations in different days or whose parents did not assigned the Commitment Term were excluded. The Traditional Neurological Examination (ENT) (Lefevre, 1972) was applied. It was considered for normal the measurement of the skull circumference, proposed by Diament & Rodrigues (1976), and the application of all ENT items. The data were stored in a database of the Epi6 Program (Epidemiologic Information), and analyzed by percentage calculation and by the c2 test. The significance level was 0.05. Children evaluated were 124. The ENT results were normal in 87 (70.16%) and altered in 37 (29.83%). Among the alterations, there were observed: light tremor, light muscular hypotonia, speech acquisition delay, macrocephaly, microcephaly, hyperactivity, cranial nerve syndrome, central facial paralysis. One child presented corticospinal tract impairment syndrome of the distal lower extremities.

Behaviour of oligodendrocytes and Schwann cells in an experimental model of toxic demyelination of the central nervous system

Oligodendrocytes and Schwann cells are engaged in myelin production, maintenance and repairing respectively in the central nervous system (CNS) and the peripheral nervous system (PNS). Whereas oligodendrocytes act only within the CNS, Schwann cells are able to invade the CNS in order to make new myelin sheaths around demyelinated axons. Both cells have some limitations in their activities, i.e. oligodendrocytes are post-mitotic cells and Schwann cells only get into the CNS in the absence of astrocytes. Ethidium bromide (EB) is a gliotoxic chemical that when injected locally within the CNS, induce demyelination. In the EB model of demyelination, glial cells are destroyed early after intoxication and Schwann cells are free to approach the naked central axons. In normal Wistar rats, regeneration of lost myelin sheaths can be achieved as early as thirteen days after intoxication; in Wistar rats immunosuppressed with cyclophosphamide the process is delayed and in rats administered cyclosporine it may be accelerated. Aiming the enlightening of those complex processes, all events concerning the myelinating cells in an experimental model are herein presented and discussed.

Reproductive biology of Davilla kunthii A. St-Hil. (Dilleniaceae) in Central Amazonia

This survey aimed at describing the interactions of floral visitors and Davilla kunthii A. St.-Hil. as well as characteristics of its reproductive biology in Itacoatiara, state of Amazonas, Brazil. Tests of the breeding system were performed. The guild of visitors was described according to richness, abundance, relative frequency and constancy. The breeding system tests indicated that D. kunthii is self-compatible. The pollination system was characterized as generalist, with 39 visitor species, from three different orders. Bees were the main group of pollinators, thus some behavioural aspects were described. Th e period of highest foraging activity was between 7 and 10 am. Some species presented agonistic and monopolistic behaviour. Given the behaviour and destructive potential, the Curculionidae seem to have a greater impact as seed predators than pollinators.

Central retinal vein thrombosis as an initial manifestation of heterozygous protein C deficiency: case report

The purpose of this paper is to report a case of central retinal vein thrombosis associated with isolated heterozygous protein C deficiency. Acute occlusion of the central retinal vein presents as one of the most dramatic pictures in ophthalmology. It is often a result of both local and systemic causes. A rare systemic cause is heterozygous protein C deficiency, and it usually occurs in combination with other thrombophilic conditions. This case highlights that isolated heterozygous protein C deficiency may be the cause of central retinal vein thrombosis and underscores the importance of its screening in young patients with this ophthalmologic disease.