Seventeen years in the Yoruba country : memorials of Anna Hinderer, wife of the Rev. David Hinderer, C.M.S. missionary in Western Africa /

Mode of access: Internet.

Méditations et pratiques de piété : pour aider les fideles à reflechir sur la vie et les mysteres de N.S.J.C ... : avec Des Litanies conformes à ces Exercices de piété, & les sentimens d'une Ame pénitente, tirés des Pseaumes de David, qu'on appelle Pénitentiaux : tome sixieme ...

Mode of access: Internet.

Orangeism exposed, with a refutation of the charges, &c. &c. : brought against the Irish nation, by lawyer David Graham, of New York, in his defence of the Orangemen, tried in this city, on the 13th and 14th days of September, 1824, for assault and battery on a poor Irishman, on the twelfth day of July, 1824 /

Mode of access: Internet.

Report of the d'Hauteville case: The commonwealth of Pennsylvania, at the suggestion of Paul Daniel Gonsalve Grand d'Hauteville, versus David Sears, Miriam C. Sears, and Ellen Sears Grand d'Hauteville. Habeas corpus for the custody of an infant child.

In the Court of general sessions for the city and county of Philadelphia. Habeas corpus for the custody of Frederick Sears Grand d'Hauteville.

Short reply to David Thom's pamphlet, entitled "Remarks on a series of charges, &c." accompanied with all the papers laid before the presbytery of Glasgow, in the reference between Mr. Thom and the trustees of St. Andrew's church, Liverpool.

Mode of access: Internet.

Nominations before the Senate Armed Services Committee, second session, 105th Congress : hearings before the Committee on Armed Services, United States Senate, One Hundred Fifth Congress, second session, on nominations of Gen. Joseph W. Ralston, David R. Oliver; Dr. Sue Bailey; Paul J. Hoeper; Dr. Hans Mark; Dr. Joseph W. Westphal; Mahlon Apgar IV; Louis E. Caldera; Daryl L. Jones; Gen. Richard B. Myers; Vice Adm. Richard W. Mies; Lt. Gen. Charles T. Butler DeMesme; James M. Bodner; Dennis C. Blair; Richard J. Danzig; Bernard D. Rostker; Stephen W. Preston; Herbert L. Buchanan III; Jeh C. Johnson, February 4, 5; March 17; June 2, 16, 23; July 16, 22, 23; September 15, 22, 1998.

Shipping list no.: 99-0207-P.

Memoirs of the life of David Rittenhouse, LLD. F.R.S. : late president of the American philosophical society, &c. interspersed with various notices of many distinguished men: with an appendix, containing sundry philosophical and other papers, most of which have not hitherto been published.

Mode of access: Internet.

Description of a very beautiful Book of hours; illuminated probably by Hans Memling and Gérard David; now in the possesion of George C. Thomas; with reproductions in photogravure of 11 representative miniatures.

The illuminated manuscript has title: Horae Beatae Virginis Mariae secundum usum romanum, cum calendario.

Life and letters of James David Forbes, F.R.S., D.C.L., LL. D., late principal of the United college in the University of St. Andrews ...

"List of Principal Forbes' scientific writings": p. [567]-577.

The C-terminal Region Of The Human P23 Chaperone Modulates Its Structure And Function.

The p23 protein is a chaperone widely involved in protein homeostasis, well known as an Hsp90 co-chaperone since it also controls the Hsp90 chaperone cycle. Human p23 includes a β-sheet domain, responsible for interacting with Hsp90; and a charged C-terminal region whose function is not clear, but seems to be natively unfolded. p23 can undergo caspase-dependent proteolytic cleavage to form p19 (p231-142), which is involved in apoptosis, while p23 has anti-apoptotic activity. To better elucidate the function of the human p23 C-terminal region, we studied comparatively the full-length human p23 and three C-terminal truncation mutants: p23₁₋₁₁₇; p23₁₋₁₃₁ and p23₁₋₁₄₂. Our data indicate that p23 and p19 have distinct characteristics, whereas the other two truncations behave similarly, with some differences to p23 and p19. We found that part of the C-terminal region can fold in an α-helix conformation and slightly contributes to p23 thermal-stability, suggesting that the C-terminal interacts with the β-sheet domain. As a whole, our results suggest that the C-terminal region of p23 is critical for its structure-function relationship. A mechanism where the human p23 C-terminal region behaves as an activation/inhibition module for different p23 activities is proposed.

Reaching C-Reactive Protein and Low-Density Lipoprotein Cholesterol Goals in Dyslipidemic Patients (from the Lipid Treatment Assessment Project [L-TAP] 2)

The purpose of the present substudy of the Lipid Treatment Assessment Project 2 was to assess dual C-reactive protein (CRP) and low-density lipoprotein (LDL) cholesterol goal attainment across a spectrum of low-, moderate-, and high-risk patients with dyslipidemia in 8 countries in North America, Latin America, Europe, and Asia. Of the 9,518 patients studied overall, 45% were women, 64% had hypertension, 31% had diabetes, 14% were current smokers, 60% were high risk, and 79% were taking a statin. The median CRP level was 1.5 mg/L (interquartile range 0.2 to 2.8). On multivariate analysis, higher CRP levels were associated with older age, female gender, hypertension, current smoking, greater body mass index, larger waist circumference, LDL cholesterol level, and triglyceride/high-density lipoprotein cholesterol ratio. In contrast, being from Asia or taking a statin was associated with lower levels. Across all risk groups, 59% of patients attained the CRP target of <2 mg/L, and 33% had <1 mg/L. Overall, 44% of patients attained both their National Cholesterol Education Program Adult Treatment Panel III LDL cholesterol target and a CRP level of <2 mg/L, but only 26% attained their LDL cholesterol target and a CRP level of <1 mg/L. In the very high-risk group with coronary heart disease and >= 2 risk factors, only 19% attained both their LDL cholesterol goal and a CRP level of <2 mg/L and 12% their LDL cholesterol goal and a CRP level of <1 mg/L. In conclusion, with current treatment, most dyslipidemic patients do not reach the dual CRP and LDL cholesterol goals. Smoking cessation, weight reduction, and the greater use of more potent statins at higher doses might be able to improve these outcomes. (C) 2011 Elsevier Inc. All rights reserved. (Am J Cardiol 2011;107:1639-1643)

Influence of Single-Nucleotide Polymorphisms on C-Reactive Protein Levels in Chronic Kidney Disease Before and After Kidney Transplantation

Introduction. We sought to evaluate 2 sing] e-nucleotide polymorphisms (SNPs) in the C-reactive protein (CRP) gene promoter region for their effects on CRP levels in chronic kidney disease (CKD) patients before and after a successful kidney transplantation. Methods. Fifty CKD patients were evaluated before and at the first and second years after the graft. Two SNPs were studied, a bi-allelic (G -> A) at the -409 and a tri-allelic (C -> T -> A) variation at the -390 position in the CRP gene. Results. All patients presented the -409GG genotype. At the -390 position, the ""A"" allele was not found; there were 15 ""CC"" patients, 11 ""TT"" patients, and 24 ""CT"" patients. CRP levels were different among patients with various genotypes (P < .019). Also the presence of the allele ""T"" was sufficient to determine differences in CRP levels both in pretransplantation (P = .045) and at 1 year posttransplantation (P = .011), but not at the second year (P = .448). Conclusion. SNPs at the -390 position of the CRP gene promoter region influence CRP basal levels in such a way that the ""C"" allele correlated with the lowest and the ""T"" with the highest. We did not observe this influence in our patients at the second year posttransplantation.

Effects of Caffeoylquinic Acid Derivatives and C-Flavonoid from Lychnophora ericoides on in vitro Inflammatory Mediator Production

In this study we aimed at evaluating the effect of the major polar constituents of the medicinal plant Lychnophora ericoides on the production of inflammatory mediators produced by LPS-stimulated U-937 cells. The 6,8-di-C-beta-glucosylapigenin (vicenin-2) presented no effect on tumor necrosis factor (TNF)-alpha production, but inhibited, in a dose-dependent manner, the production of prostaglandin (PG) E(2) without altering the expression of cyclooxygenase (COX) -2 protein. 3,5-Dicaffeoylquinic acid and 4,5-dicaffeoylquinic acid, at lower concentrations, had small but significant effects on reducing PG E, levels; at higher doses these compounds stimulated PGE(2) and also TNF-alpha production by the cells. All the caffeoylquinic acid derivatives, in a dose-dependent fashion, were able to inhibit monocyte chemoattractant protein-3 synthesis/release, with 4,5-DCQ being the most potent at the highest tested concentration. These results add important information on the effects of plant natural polyphenols, namely vicenin-2 and caffeoylquinic acid derivatives, on the production of inflammatory mediators by cultured cells.