944 resultados para Euphorion, of Chalcis, b. ca. 276 B.C.


Relevância:

100.00% 100.00%

Publicador:

Resumo:

Three-page draft of a report presented to the "executive government" of Harvard College by the "committee appointed to prepare a plan for the suppression of certain disorders during the public services in the chapel & in the meeting house."

Relevância:

100.00% 100.00%

Publicador:

Resumo:

Artist unknown.

Relevância:

100.00% 100.00%

Publicador:

Resumo:

bk.I. The making of England; the making of empire; the establishment of empire, B.C., 55 to A.D. 1815.--bk.II. The expansion and consolidation of the British Empire, A.D. 1800 to present day.

Relevância:

100.00% 100.00%

Publicador:

Resumo:

No more published.

Relevância:

100.00% 100.00%

Publicador:

Resumo:

"Books more particularly cited": p. 30.

Relevância:

100.00% 100.00%

Publicador:

Resumo:

∗ Research partially supported by INTAS grant 97-1644

Relevância:

100.00% 100.00%

Publicador:

Resumo:

Objective: Loss of skeletal muscle is the most debilitating feature of cancer cachexia, and there are few treatments available. The aim of this study was to compare the anticatabolic efficacy of L-leucine and the leucine metabolite β-hydroxy-β-methylbutyrate (Ca-HMB) on muscle protein metabolism, both invitro and invivo. Methods: Studies were conducted in mice bearing the cachexia-inducing murine adenocarcinoma 16 tumor, and in murine C2 C12 myotubes exposed to proteolysis-inducing factor, lipopolysaccharide, and angiotensin II. Results: Both leucine and HMB were found to attenuate the increase in protein degradation and the decrease in protein synthesis in murine myotubes induced by proteolysis-inducing factor, lipopolysaccharide, and angiotensin II. However, HMB was more potent than leucine, because HMB at 50 μM produced essentially the same effect as leucine at 1 mM. Both leucine and HMB reduced the activity of the ubiquitin-proteasome pathway as measured by the functional (chymotrypsin-like) enzyme activity of the proteasome in muscle lysates, as well as Western blot quantitation of protein levels of the structural/enzymatic proteasome subunits (20 S and 19 S) and the ubiquitin ligases (MuRF1 and MAFbx). Invivo studies in mice bearing the murine adenocarcinoma 16 tumor showed a low dose of Ca-HMB (0.25 g/kg) tobe 60% more effective than leucine (1 g/kg) in attenuating loss of body weight over a 4-d period. Conclusion: These results favor the clinical feasibility of using Ca-HMB over high doses of leucine for the treatment of cancer cachexia. © 2014 Elsevier Inc.

Relevância:

100.00% 100.00%

Publicador:

Resumo:

During the civil war between Caesar and Pompey, the military oath which binds the soldier to his army is often openly violated. Yet despite this offense, commanders of armed struggle require recursively the oath to their men. Admittedly, this ritual act seems ineffective given the many desertions and mutinies identified, but military leaders use its symbolic and sacred meaning to legitimize one hand their “anti-republican” actions, on the other armies fighting in a context deemed impius.

Relevância:

100.00% 100.00%

Publicador:

Resumo:

En el presente artículo analizamos los desplazamientos de cultos indígenas hispanos desde distintas áreas de la Península Ibrica hacia los principales lugares de inmigración en Hispania: las áreas mineras y las ciudades. Proponemos que estos grupos de emigrantes rendían culto en su nueva residencia a las deidades que veneraban en sus regiones de procedencia como un medio de preservar su cohesión social y su identidad cultural. La dureza de la vida laboral en las áreas mineras reforzaba la necesidad de fortalecer los lazos culturales.