Effects of Patterned Substrate on Thin Films Simulated by Family Model

Patterned substrate growth has been a subject of much interest. In this work, characteristics of some statistical properties of a film grown on triangular and vicinal substrates using the Family model are studied. Substrate size and tilt angle are varied. It is found that the interface width and the correlation function increase as the roughness of the pattern is increased. The new scaling exponents are calculated and anomalous scaling is obtained. The transient persistence probability does not show a power law relation when the initial surface is sufficiently rough. The initial rough surface also causes multifractal behavior in the model.

Na2.44Mn1.79(SO4)(3): a new member of the alluaudite family of insertion compounds for sodium ion batteries

Sodium-ion batteries have been extensively pursued as economic alternatives to lithium-ion batteries. Investigating the polyanion chemistry, alluaudite structured Na2Fe2II(SO4)(3) has been recently discovered as a 3.8 V positive electrode material (Barpanda et al., Nature Commun., 5: 4358, 2014). Registering the highest ever Fe-III/Fe-II redox potential (vs. Na/Na+) and formidable energy density, it has opened up a new polyanion family for sodium batteries. Exploring the alluaudite family, here we report isotypical Na2+2xMn2-xII(SO4)(3) (x = 0.22) as a novel high-voltage cathode material for the first time. Following low-temperature (ca. 350 degrees C) solid-state synthesis, the structure of this new alluaudite compound has been solved adopting a monoclinic framework (s.g. C2/c) showing antiferromagnetic ordering at 3.4 K. Synergising experimental and ab initio DFT investigation, Na2+2xMn2-xII(SO4)(3) has been found to be a potential high-voltage (ca. 4.4 V) cathode material for sodium batteries.

Robust Glyoxalase activity of Hsp31, a ThiJ/DJ-1/PfpI Family Member Protein, Is Critical for Oxidative Stress Resistance in Saccharomyces cerevisiae

Methylglyoxal (MG) is a reactive metabolic intermediate generated during various cellular biochemical reactions, including glycolysis. The accumulation of MG indiscriminately modifies proteins, including important cellular antioxidant machinery, leading to severe oxidative stress, which is implicated in multiple neurodegenerative disorders, aging, and cardiac disorders. Although cells possess efficient glyoxalase systems for detoxification, their functions are largely dependent on the glutathione cofactor, the availability of which is self-limiting under oxidative stress. Thus, higher organisms require alternate modes of reducing the MG-mediated toxicity and maintaining redox balance. In this report, we demonstrate that Hsp31 protein, a member of the ThiJ/DJ-1/PfpI family in Saccharomyces cerevisiae, plays an indispensable role in regulating redox homeostasis. Our results show that Hsp31 possesses robust glutathione-independent methylglyoxalase activity and suppresses MG-mediated toxicity and ROS levels as compared with another paralog, Hsp34. On the other hand, glyoxalase-defective mutants of Hsp31 were found highly compromised in regulating the ROS levels. Additionally, Hsp31 maintains cellular glutathione and NADPH levels, thus conferring protection against oxidative stress, and Hsp31 relocalizes to mitochondria to provide cytoprotection to the organelle under oxidative stress conditions. Importantly, human DJ-1, which is implicated in the familial form of Parkinson disease, complements the function of Hsp31 by suppressing methylglyoxal and oxidative stress, thus signifying the importance of these proteins in the maintenance of ROS homeostasis across phylogeny.

Cyclic Cationic Peptides Containing Sugar Amino Acids Selectively Distinguishes and Inhibits Maturation of Pre-miRNAs of the Same Family

The discovery of microRNAs (miRNAs) has added a new dimension to the gene regulatory networks, making aberrantly expressed miRNAs as therapeutically important targets. Small molecules that can selectively target and modulate miRNA levels can thus serve as lead structures. Cationic cyclic peptides containing sugar amino acids represent a new class of small molecules that can target miRNA selectively. Upon treatment of these small molecules in breast cancer cell line, we profiled 96 therapeutically important miRNAs associated with cancer and observed that these peptides can selectively target paralogous miRNAs of the same seed family. This selective inhibition is of prime significance in cases when miRNAs of the same family have tissue-specific expression and perform different functions. During these conditions, targeting an entire miRNA family could lead to undesired adverse effects. The selective targeting is attributable to the difference in the three-dimensional structures of precursor miRNAs. Hence, the core structure of these peptides can be used as a scaffold for designing more potent inhibitors of miRNA maturation and hence function.

A family of interesting exact solutions of the sine-Gordon equation

By using AKNS [Phys. Rev. Lett. 31 (1973) 125] system and introducing the wave function, a family of interesting exact solutions of the sine-Gordon equation are constructed. These solutions seem to be some soliton, kink, and anti-kink ones respectively for the different choice of the spectrum, whereas due to the interaction between two traveling-waves they have some properties different from usual soliton, kink, and anti-kink solutions.

De la inconmensurabilidad a la multimodalidad, un camino sin cisuras

Resumen: Una característica frecuente de algunos problemas de decisión económicos es que presentan múltiples objetivos que no pueden medirse en una misma unidad común. En esos casos no hay una función de utilidad que mida en forma similar objetivos de diferente naturaleza y los problemas no son posibles de resolver completamente por puras herramientas matemáticas, ya que su solución implica la introducción de factores subjetivos y condicionantes de todo tipo: religiosos, éticos, jurídicos, institucionales, biológicos, físicos, etcétera. La tendencia hacia el estudio de la complejidad de las decisiones en general –y las económicas en particular- y la necesidad de poder representar esta complejidad, es una característica distintiva de los procesos de decisión contemporáneos. Ampliando la perspectiva de la inconmensurabilidad, pero recurriendo a la experiencia que ella aporta, el pensamiento multimodal ofrece la posibilidad de colaborar con estos procesos de decisión complejos. En el presente trabajo comenzamos por una revisión de los procesos de decisión con múltiples objetivos inconmensurables y avanzamos hacia el pensamiento multimodal como una alternativa para abordar procesos complejos de decisión.

Apuntes para una teología de la ciudad : en el camino hacia una reflexión interdisciplinaria

Una teología de la ciudad no es un planteo nuevo en el contexto latinoamericano, pero sí un tema no suficientemente profundizado. En un marco de creciente urbanización y de profundos desafíos afrontados por el cristianismo, la ciudad vuelve a reclamar la atención de la pastoral de las iglesias y de la teología. El presente ensayo inicia una reflexión a partir de algunos aportes significativos sobre teología y pastoral urbana en el ámbito de Inglaterra y EE.UU. Asimismo, ofrece algunos senderos teológicos programáticos para una investigación interdisciplinaria, junto a algunas consideraciones relativas al método.

El Concilio de Constanza y el fin del Cisma : el rol del reino de Castilla en el camino hacia la unidad

Resumen: El Concilio de Constanza (1414-1418) fue la instancia definitiva de solución del Cisma de Occidente. Sus decisiones condujeron

La aventura no cumplida : el camino hacia el ocaso del caballero andante

Resumen: Los movimientos del héroe hacia su gloria implican una serie de acontecimientos, en los cuales la magia y la maravilla se unen para prodigar este derrotero de auxilios y obstáculos que fortifican el carácter del caballero y ayudan a este a alcanzar su ethos caballeresco. Batallas, encuentros fabulosos y apariciones extrañas se engarzan como cuentas en un collar para conducirlo a su plena realización. De forma similar, las aventuras no cumplidas indican al héroe que la hora del reposo ha llegado, que su andar, si bien en algunas oportunidades continúa, será menos intenso, y que debe dejar el lugar para su heredero. El universo mágico interviene igualmente en esta especie de ocaso del protagonismo para señalarle que la aventura no puede ser llevada a cabo por él, sino por su hijo. En este trabajo se pretende examinar cómo el elemento mágico interviene en este “estado de reposo” del caballero andante, que implica frecuentemente su entronización como gobernante de un reino o imperio, y el nacimiento del nuevo futuro caballero.

Deseo y satisfacción, el camino orteguiano hacia los Estados Unidos de Europa, 1910-1949

Resumen: Se presentan en este artículo de modo sintético las tres etapas principales en el pensamiento del fi lósofo español José Ortega y Gasset sobre su idea de Europa como regeneración de España a través de la europeización de la patria.

Education and the dynamics of family decisions

This paper investigates the extent to which a biased transmission of educational endowments affects fertility. To this end, we devise a version of Becker’s family decision model that takes preference change into account. Specifically, we model education as an instrument that increases the autonomy (to prefer), and autonomy as an instrument of preference-change for household-structures. The empirical validity of the proposed model is examined for the European setting using the European Community Household Panel. In the context of the model, empirical findings imply the following. On the one hand, both preference for quantity and preference for bequest for each offspring (quality) increases with education, while preference for current consumption decreases. On the other hand, education is found to be negatively correlated with fertility, at a decreasing rate. Therefore, the paper provides a useful additional toolkit for public policy evaluation. It explains how public policies oriented toward the guarantee of personal freedoms, such as the expansion of education and autonomy, are likely to guarantee the same freedoms for subsequent generations.

Gestión del riesgo operativo en las entidades de crédito: un camino sin retorno

[ES] Este trabajo presenta la problemática de la gestión del riesgo operativo en las entidades de crédito en el ámbito europeo. Aprobado el texto definitivo del denominado Comité de Supervisión Bancaria (Basilea II), con especial y novedosa regulación del riesgo operativo, amanece como inminente su integración e la regulación bancaria de la UE, y, por tanto, su pronta implantación y supervisión por las autoridades monetarias y financieras. Esta nueva normativa, de carácter flexible y profesional, introduce en el seno del gobierno corporativo de las entidades de crédito nuevos elementos que afectarán a su cultura interna (cultura de gestión de los riesgos), afectando a las decisiones estratégicas y a la organización de las entidades, incentivando a la mejora de la calidad de sus procesos, servicios y operaciones. Todo lo cual supone una acicate para perseguir la eficiencia continua a nivel individual y a nivel del sistema financiero, con visos de adquirir dimensión estratégica. De esta manera, se abre un espacio para la investigación y creatividad en la aplicación y desarrollo de los postulados científicos de la Economía de la Empresa, con posibilidades de incorporarlos a otros sectores empresariales de similar afectación por los riesgos operativos.

Antioxidant defense system and family environment in adolescents with family history of psychosis

[EN] Our objective was to determine antioxidant defence activity in healthy controls (HC) and healthy unaffected second-degree relatives of patients with early onset psychosis (HC-FHP),and to assess its relationship with familiar environment measured using the Family Environment Scale (FES). Methods: We included 82 HC and 14 HC-FHP aged between 9 and 17 years. Total antioxidant status,lipid peroxidation, antioxidant enzyme activities and glutathione levels were determined in blood samples. Results:There was a significant decrease in the total antioxidant level in the HC-FHP group compared with the HC group (OR = 2.94; p = 0.009), but no between-group differences in the Global Assessment of Functioning (GAF) scale scores. For the FES, the HC-FHP group had significantly higher scores in the cohesion (p = 0.007) and intellectual-cultural dimensions (p=0.025). After adjusting for these two FES dimensions, total antioxidant status remained significantly different between groups (OR = 10.86, p = 0.009).