Antioxidant defense system and family environment in adolescents with family history of psychosis
Data(s) |
20/05/2013
20/05/2013
16/11/2012
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Resumo |
[EN] Our objective was to determine antioxidant defence activity in healthy controls (HC) and healthy unaffected second-degree relatives of patients with early onset psychosis (HC-FHP),and to assess its relationship with familiar environment measured using the Family Environment Scale (FES). Methods: We included 82 HC and 14 HC-FHP aged between 9 and 17 years. Total antioxidant status,lipid peroxidation, antioxidant enzyme activities and glutathione levels were determined in blood samples. Results:There was a significant decrease in the total antioxidant level in the HC-FHP group compared with the HC group (OR = 2.94; p = 0.009), but no between-group differences in the Global Assessment of Functioning (GAF) scale scores. For the FES, the HC-FHP group had significantly higher scores in the cohesion (p = 0.007) and intellectual-cultural dimensions (p=0.025). After adjusting for these two FES dimensions, total antioxidant status remained significantly different between groups (OR = 10.86, p = 0.009). |
Identificador |
BMC Psychiatry 12(200) : (2012) 1471-244X http://hdl.handle.net/10810/10136 doi:10.1186/1471-244X-12-200 |
Idioma(s) |
eng |
Publicador |
BioMed Central |
Relação |
http://www.biomedcentral.com/1471-244X/12/200 |
Direitos |
© 2012 Gonzalez-Pinto et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. info:eu-repo/semantics/openAccess |
Palavras-Chave | #oxidative stress #family environment #psychosis #schizophrenia #antioxidant enzymes |
Tipo |
info:eu-repo/semantics/article |