Monsieur Bossu's Treatise of the epick poem: : containing many curious reflexions, very useful and necessary for the right understanding and judging of the excellencies of Homer and Virgil. /

"An essay upon satyr, written by the famous Monsieur Dacier" (caption title): p. 267-276; "Of pastorals. By Monsieur De Fontenell, Englished by Mr. Motteux" (caption title): p. 277-295.

The Ruba'iyat of Omar Khayyām : being a facsimile of the manuscript in the Bodleian Library at Oxford, with a transcript into modern Persian characters, translated, with and introd. and notes, and a bibliography, and some sidelights upon Edward Fitzgerald's poem /

Mode of access: Internet.

History of Manchester, formerly Derryfield, in New-Hampshire : including that of ancient Amoskeag, or the middle Merrimack Valley, together with the address, poem, and other proceedings of the centennial celebration of the incorporation of Derryfield at Manchester, October 22, 1851 /

Includes bibliographical references.

Mount Everest : the Newdigate prize poem, 1922 /

Mode of access: Internet.

Morte Arthure : an alliterative poem of the 14th century, from the Lincoln ms. written by Robert of Thornton /

Includes index.

The great white wall, a poem,

Marginal illustrations.

Easter eve, or, The "New Hagodoh shel Pesach." A metrical family-feast service, consisting of a prologue and one character poem; including the old traditions, legends and melodies, with supplement illustration from Oppenheim's celebrated painting, "The Passover feast."

Hebrew text interspersed.

The revolt of Islam : a poem in twelve cantos /

Originally published in 1818 as "Laon and Cythna," subsequently withdrawn and altered, and reissued, under title "The revolt of Islam," with a new t.-p. and 26 cancel leaves. Cf. T. J. Wise's "A Shelley library".

An ancient neurotrophin code in zebrafish; the Runx/Cbfβ complex specifies the fate switch from TrkB+ to TrkC+ nociceptors and sensory receptor expression

Thesis (Ph.D.)--University of Washington, 2016-06

The Art of the Contemporary Anti-Racist American Poem: ‘In-Between Spaces,’ Exploding Conventions, and Listening as Form

Thesis (Master's)--University of Washington, 2016-06

Inflammation suppressor genes: please switch out all the lights

An effective immune system requires rapid and appropriate activation of inflammatory mechanisms but equally rapid and effective resolution of the inflammatory state. A review of the canonical host response to gram-negative bacteria, the lipopolysaccharide-Toll-like receptor 4 signaling cascade, highlights the induction of repressors that act at each step of the activation process. These inflammation suppressor genes are characterized by their induction in response to pathogen, typically late in the macrophage activation program, and include an expanding class of dominant-negative proteins derived from alternate splicing of common signaling components. Despite the expanse of anti-inflammatory mechanisms available to an activated macrophage, the frailty of this system is apparent in the large numbers of genes implicated in chronic inflammatory diseases. This apparent lack of redundancy between inflammation suppressor genes is discussed with regard to evolutionary benefits in generating a heterogeneous population of immune cells and consequential robustness in defense against new and evolving pathogens.

Stochastic models for regulatory networks of the genetic toggle switch

Bistability arises within a wide range of biological systems from the A phage switch in bacteria to cellular signal transduction pathways in mammalian cells. Changes in regulatory mechanisms may result in genetic switching in a bistable system. Recently, more and more experimental evidence in the form of bimodal population distributions indicates that noise plays a very important role in the switching of bistable systems. Although deterministic models have been used for studying the existence of bistability properties under various system conditions, these models cannot realize cell-to-cell fluctuations in genetic switching. However, there is a lag in the development of stochastic models for studying the impact of noise in bistable systems because of the lack of detailed knowledge of biochemical reactions, kinetic rates, and molecular numbers. in this work, we develop a previously undescribed general technique for developing quantitative stochastic models for large-scale genetic regulatory networks by introducing Poisson random variables into deterministic models described by ordinary differential equations. Two stochastic models have been proposed for the genetic toggle switch interfaced with either the SOS signaling pathway or a quorum-sensing signaling pathway, and we have successfully realized experimental results showing bimodal population distributions. Because the introduced stochastic models are based on widely used ordinary differential equation models, the success of this work suggests that this approach is a very promising one for studying noise in large-scale genetic regulatory networks.

The C-terminus of Raf-1 acts as a 14-3-3-dependent activation switch

The Raf-1 protein kinase is a major activator of the ERK MAPK pathway, which links signaling by a variety of cell surface receptors to the regulation of cell proliferation, survival, differentiation and migration. Signaling by Raf-1 is regulated by a complex and poorly understood interplay between phosphorylation events and protein-protein interactions. One important mode of Raf-1 regulation involves the phosphorylation-dependent binding of 14-3-3 proteins. Here, we have examined the mechanism whereby the C-terminal 14-3-3 binding site of Raf-1, S621, controls the activation of MEK-ERK signaling. We show that phosphorylation of S621 turns over rapidly and is enriched in the activated pool of endogenous Raf-1. The phosphorylation on this site can be mediated by Raf-1 itself but also by other kinase(s). Mutations that prevent the binding of 14-3-3 proteins to S621 render Raf-1 inactive by specifically disrupting its capacity to bind to ATP, and not by gross conformational alteration as indicated by intact MEK binding. Phosphorylation of S621 correlates with the inhibition of Raf-1 catalytic activity in vitro, but 14-3-3 proteins can completely reverse this inhibition. Our findings suggest that 14-3-3 proteins function as critical cofactors in Raf-1 activation, which induce and maintain the protein in a state that is competent for both ATP binding and MEK phosphorylation.

The conceptus induces a switch in protein expression and activities of superoxide dismutase 1 and 2 in the sheep endometrium during early pregnancy

Acknowledgements We thank Philippe Bolifraud (INRA, France), Krawiec Angele, Sandra Grange, Laurence Puillet-Anselme (CHU Grenoble, France) and Margaret Fraser (Aberdeen, UK) for their expert technical assistance. The authors also thank the staff of the sheep sheds of Jouy-en-Josas (INRA, France). The authors would also like to thank the anonymous reviewers for their close examination of this article and their useful comments.