Inflammation suppressor genes: please switch out all the lights


Autoria(s): Wells, C. A.; Ravasi, T.; Hume, D. A.
Data(s)

01/01/2005

Resumo

An effective immune system requires rapid and appropriate activation of inflammatory mechanisms but equally rapid and effective resolution of the inflammatory state. A review of the canonical host response to gram-negative bacteria, the lipopolysaccharide-Toll-like receptor 4 signaling cascade, highlights the induction of repressors that act at each step of the activation process. These inflammation suppressor genes are characterized by their induction in response to pathogen, typically late in the macrophage activation program, and include an expanding class of dominant-negative proteins derived from alternate splicing of common signaling components. Despite the expanse of anti-inflammatory mechanisms available to an activated macrophage, the frailty of this system is apparent in the large numbers of genes implicated in chronic inflammatory diseases. This apparent lack of redundancy between inflammation suppressor genes is discussed with regard to evolutionary benefits in generating a heterogeneous population of immune cells and consequential robustness in defense against new and evolving pathogens.

Identificador

http://espace.library.uq.edu.au/view/UQ:75829

Idioma(s)

eng

Publicador

Federation Amer Soc Exp Biol

Palavras-Chave #Toll-like Receptor-lipopolysaccharide-macrophage #Cell Biology #Hematology #Immunology #Inhibitory Receptors #Negative Regulator #Crohns-disease #Lipopolysaccharide #Macrophages #Activation #Expression #Nod2 #Arthritis #Responses #C1 #320202 Cellular Immunology #730102 Immune system and allergy
Tipo

Journal Article