Melhoria e normalização de ferramentas de apoio à produção aplicando ferramentas Lean

Dissertação de mestrado integrado em Engenharia e Gestão Industrial

Two-particle Bose–Einstein correlations in pp collisions at s√= 0.9 and 7 TeV measured with the ATLAS detector

The paper presents studies of Bose--Einstein Correlations (BEC) for pairs of like-sign charged particles measured in the kinematic range pT> 100 MeV and |η|< 2.5 in proton--proton collisions at centre-of-mass energies of 0.9 and 7 TeV with the ATLAS detector at the CERN Large Hadron Collider. The integrated luminosities are approximately 7 μb−1, 190 μb−1 and 12.4 nb−1 for 0.9 TeV, 7 TeV minimum-bias and 7 TeV high-multiplicity data samples, respectively. The multiplicity dependence of the BEC parameters characterizing the correlation strength and the correlation source size are investigated for charged-particle multiplicities of up to 240. A saturation effect in the multiplicity dependence of the correlation source size is observed using the high-multiplicity 7 TeV data sample. The dependence of the BEC parameters on the average transverse momentum of the particle pair is also investigated.

Modelling tyre-road noise with data mining techniques

The research aimed to establish tyre-road noise models by using a Data Mining approach that allowed to build a predictive model and assess the importance of the tested input variables. The data modelling took into account three learning algorithms and three metrics to define the best predictive model. The variables tested included basic properties of pavement surfaces, macrotexture, megatexture, and uneven- ness and, for the first time, damping. Also, the importance of those variables was measured by using a sensitivity analysis procedure. Two types of models were set: one with basic variables and another with complex variables, such as megatexture and damping, all as a function of vehicles speed. More detailed models were additionally set by the speed level. As a result, several models with very good tyre-road noise predictive capacity were achieved. The most relevant variables were Speed, Temperature, Aggregate size, Mean Profile Depth, and Damping, which had the highest importance, even though influenced by speed. Megatexture and IRI had the lowest importance. The applicability of the models developed in this work is relevant for trucks tyre-noise prediction, represented by the AVON V4 test tyre, at the early stage of road pavements use. Therefore, the obtained models are highly useful for the design of pavements and for noise prediction by road authorities and contractors.

Sistema de apoio à decisão clínica: quality of life system

Dissertação de mestrado integrado em Engenharia e Gestão de Sistemas de Informação

Racionalização e redução de custos das TIC na Administração Pública: o caso da PSP

Dissertação de mestrado integrado em Engenharia e Gestão de Sistemas de Informação

Exploração de dados para soluções de retalho em business intelligence

Dissertação de mestrado integrado em Engenharia de Gestão e Sistemas de Informação

Metabolic engineering with multi-objective optimization of kinetic models

Kinetic models have a great potential for metabolic engineering applications. They can be used for testing which genetic and regulatory modifications can increase the production of metabolites of interest, while simultaneously monitoring other key functions of the host organism. This work presents a methodology for increasing productivity in biotechnological processes exploiting dynamic models. It uses multi-objective dynamic optimization to identify the combination of targets (enzymatic modifications) and the degree of up- or down-regulation that must be performed in order to optimize a set of pre-defined performance metrics subject to process constraints. The capabilities of the approach are demonstrated on a realistic and computationally challenging application: a large-scale metabolic model of Chinese Hamster Ovary cells (CHO), which are used for antibody production in a fed-batch process. The proposed methodology manages to provide a sustained and robust growth in CHO cells, increasing productivity while simultaneously increasing biomass production, product titer, and keeping the concentrations of lactate and ammonia at low values. The approach presented here can be used for optimizing metabolic models by finding the best combination of targets and their optimal level of up/down-regulation. Furthermore, it can accommodate additional trade-offs and constraints with great flexibility.

A importância do profissional de relações públicas no e-commerce em Portugal

Relatório de estágio de mestrado em Ciências da Comunicação (área de especialização em Publicidade e Relações Públicas)

Behavior of inflammatory markers of myocardial injury in cardiac surgery: laboratory correlation with the clinical picture of postpericardiotomy syndrome

OBJECTIVE: To verify the association of serum markers of myocardial injury, such as troponin I, creatinine kinase, and creatinine kinase isoenzyme MB, and inflammatory markers, such as tumor necrosis factor alpha (TNF-alpha), C-reactive protein, and the erythrocyte sedimentation rate in the perioperative period of cardiac surgery, with the occurrence of possible postpericardiotomy syndrome. METHODS: This was a cohort study with 96 patients undergoing cardiac surgery assessed at the following 4 different time periods: the day before surgery (D0); the 3rd postoperative day (D3); between the 7th and 10th postoperative days (D7-10); and the 30th postoperative day (D30). During each period, we evaluated demographic variables (sex and age), surgical variables (type and duration , extracorporeal circulation), and serum dosages of the markers of myocardial injury and inflammatory response. RESULTS: Of all patients, 12 (12.5%) met the clinical criteria for a diagnosis of postpericardiotomy syndrome, and their mean age was 10.3 years lower than the age of the others (P=0.02). The results of the serum markers for tissue injury and inflammatory response were not significantly different between the 2 assessed groups. No significant difference existed regarding either surgery duration or extracorporeal circulation. CONCLUSION: The patients who met the clinical criteria for postpericardiotomy syndrome were significantly younger than the others were. Serum markers for tissue injury and inflammatory response were not different in the clinically affected group, and did not correlate with the different types and duration of surgery or with extracorporeal circulation.

Köhler's Medizinal-Pflanzen in naturgetreuen Abbildungen mit kurz erläuterndem Texte : Atlas zur Pharmacopoea germanica, austriaca, belgica, danica, helvetica, hungarica, rossica, suecica, Neerlandica, British pharmacopoeia, zum Codex medicamentarius, sowie zur Pharmacopoeia of the United States of America /

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Köhler's Medizinal-Pflanzen in naturgetreuen Abbildungen mit kurz erläuterndem Texte : Atlas zur Pharmacopoea germanica, austriaca, belgica, danica, helvetica, hungarica, rossica, suecica, Neerlandica, British pharmacopoeia, zum Codex medicamentarius, sowie zur Pharmacopoeia of the United States of America /

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Köhler's Medizinal-Pflanzen in naturgetreuen Abbildungen mit kurz erläuterndem Texte : Atlas zur Pharmacopoea germanica, austriaca, belgica, danica, helvetica, hungarica, rossica, suecica, Neerlandica, British pharmacopoeia, zum Codex medicamentarius, sowie zur Pharmacopoeia of the United States of America /

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Sistemas aislados gravitacionales

El problema general que nos interesa es el de cuerpos compactos aislados que interaccionan gravitatoriamente. La teoría adecuada para estudiar estos sistemas es la Relatividad General. En esta teoría los sistemas aislados son descriptos por espaciotiempos asintóticamente planos; es así que estudiamos en detalle las propiedades asintóticas de sistemas aislados en relatividad general. Algunos de los puntos específicos a ser investigados son: Proseguiremos con los cálculos para estimar la radiación gravitatoria total emitida en procesos de choque de dos agujeros negros, estudiando el caso de dos masas distintas y con momento angular. Se completarán estudios de sistemas de gravedad linearizada con fuentes distribucionales. Se extenderán los cálculos de soluciones exactas en términos de datos en el infinito nulo futuro al caso de sistemas con carga eléctrica y momento magnético. Se continuará el estudio sobre posibles generalizaciones de la noción de "nice section"; concluyendo el tratamiento de otras nociones de supermomento y el estudio de ecuaciones intrínsecas para justificar variaciones de las ecuaciones de "nice section". Se pretende dar una caracterización general de estructura multipolar para espaciotiempos asintóticamente planos. Se estudiarán propiedades asintóticas del modelo que hemos construido anteriormente para el caso de un sistema binario. Se desea construir un modelo más realista, basado en una solución parcial de las ecuaciones de Einstein aplicables a sistemas binarios. Se pretende implementar un programa de cálculo numérico y representación gráfica que nos permita visualizar por lapsos de tiempos dinámicos extendidos un sistema de ecuaciones de movimiento relativistas. (...) Se formulará un método general de aproximación en el infinito nulo usando como parámetro de pequeñez a la intensidad de radiación máxima emitida por el sistema.

Aplicaciones de la teoría de PDE a la relatividad general

Este plan de trabajo contempla diversas aplicaciones de la teoría de las Ecuaciones en Derivadas Parciales en el contexto de la Relatividad General. (...) Estas aplicaciones tiene como una de las intenciones últimas la de ser empleadas en simulaciones numéricas. Entre ellas destacamos las siguientes: * Fluidos viscosos relativistas y sus límites parabólicos. * Modelado numérico de las ecuaciones del primer punto. * Existencia global de sistemas disipativos. * Teoremas no-hair cosmológicos. * Límite Newtoniano de la relatividad general, resultados rigurosos. * Condiciones de contorno para las ecuaciones de Einstein.

Köhler's Medizinal-Pflanzen in naturgetreuen Abbildungen mit kurz erläuterndem Texte : Atlas zur Pharmacopoea germanica, austriaca, belgica, danica, helvetica, hungarica, rossica, suecica, Neerlandica, British pharmacopoeia, zum Codex medicamentarius, sowie zur Pharmacopoeia of the United States of America /

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