862 resultados para Hepatite C - Aspectos genéticos


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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

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As alterações que afetam as hemoglobinas estão relacionadas à síntese estrutural ou quantitativa dos aminoácidos que compõem as diferentes cadeias globínicas (α/β). Existem inúmeras causas que podem resultar nessas alterações, dentre elas as mutações. A talassemia é um dos distúrbios genéticos mais frequentes do homem e mais difundidos no mundo. Fatos históricos, como imigração e colonização populacionais de diferentes partes do mundo, contribuíram para a difusão da patologia em outras localidades, incluindo o Brasil. A forma de manifestação clínica e laboratorial da talassemia do tipo beta menor (BTT), foi objeto de estudo nesta revisão bibliográfica, pois embora seja uma patologia que não mostra claramente manifestações sintomáticas, seus aspectos clínicos e laboratoriais são muito relevantes. A importância do diagnóstico laboratorial das anemias microcíticas e hipocrômicas presentes, tanto em indivíduos portadores de deficiência de ferro como em beta talassêmicos menor, é um ponto chave quando nos referimos a esses parâmetros, pois os índices HCM e VCM apresentam-se com valores extremamente reduzidos (<24 pg e <70 fL) e a quantidade de glóbulos vermelhos muito aumentados (> 5,0 milhões/μL), na beta talassemia menor em comparação à deficiência de ferro. Portanto os valores contidos no hemograma bem como a presença da inclusão citoplasmática ponteado basófilo e morfologia das hemácias observadas em análise de extensões sanguíneas coradas, é de grande valia na suspeita da beta talassemia menor, tornando-se ponto importante na sugestão da realização de eletroforese de hemoglobina para confirmação do diagnóstico da beta talassemia menor, devido ao aumento quantitativo da Hb A2.

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Pós-graduação em História - FCHS

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Pós-graduação em Agronomia (Proteção de Plantas) - FCA

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Pós-graduação em Pesquisa e Desenvolvimento (Biotecnologia Médica) - FMB

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Species of colonial green algae from 10 Conservation Units from the Southern Brazil were surveyed. The samplings were carried out in 105 stream reaches, consisting of 10 m length transects. In addition to biological data, some environmental variables were measured: depth, current velocity, water temperature, turbidity, specific conductance, pH, dissolved oxygen and nutrients (total nitrogen and orthophosphate). Three species of colonial green algae [Bohlin Ecballocystis pulvinata var. pulvinata, Tetraspora gelatinosa (Vaucher) Desvaux and T. lubrica (Roth) C Agard] were recorded and these species were described and illustrated. Based on the environmental data, it was observed some patterns of ecological distribution, including the occurrence of E. pulvinata var. pulvinata in environments with higher water temperature and current velocity values, while Tetraspora species typically occurred in environments with lower total nitrogen, orthophosphate and specific conductance values.

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Pós-graduação em Direito - FCHS

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In the seeds of pioneer plants, the application of treatments for breaking dormancy, and selection by colour and size, are strategies for obtaining seeds of less dormancy and better germination performance. The aim of this study was to evaluate the effect of the physical and physiological aspects of seeds of the tall fringe-rush (Fimbristylis dichotoma) on germination and dormancy. To do this, the seeds were submitted to the following treatments in three studies: (i) control, immersion in H2SO4 (98%, 36N) for 1 minute, immersion in KNO3 (1, 2 and 3%) for 15 minutes, seeding on a substrate moistened with KNO3 (0.2%) and exposure for 5 and 10 hours in a forced air circulation oven at 40 and 70 degrees C; (ii) classification of the seeds by colour (light and dark) and application of the following treatments: control, immersion of the seeds in H2SO4 (98%, 36N) for 1 and 2 minutes, immersion in KNO3 (5% and 10%) for 15 and 30 minutes and seeding on a substrate moistened with KNO3 (0.2%); (iii) classification by size (0.60, 0.50 and 0.40 mm) and germination on a substrate moistened with KNO3 (0.2%) or distilled H2O. The seeds were evaluated by germination test, first count and germination speed index. Moistening the substrate with KNO3 (0.2%), and heat treatment at 40 degrees C for 10 hours improve performance in seeds of the tall fringe-rush. Light-coloured seeds do not display dormancy. Medium-sized seeds of the tall fringe-rush show better performance in terms of percentage and speed of germination.

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

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The authors present data obtained from the analysis of a questionnaire regarding sexuality among 1,437 adolescent students in the Botucatu municipal district. The student's age varied from 15 to 19 years. The results demonstrate the evolving characteristics of the student's sexuality and suggest that sexual orientation and guidance should be part of the child and adolescent educational process. The authors pointed out that the members of Health care team should stimulate the discussion of sexuality while providing medical advice.

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Pós-graduação em Engenharia Mecânica - FEG

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The extraocular muscle fibres of the South-American opossum were determined according to their metabolic profiles using NADH-diaforase, and myofibrilar ATPase after pre-incubation in both acid (pH 4.3) and alkaline (pH 10.4) media. Three muscles were selected to study the arrangement of the fibres (obliquous dorsalis, rectus dorsalis and rectus lateralis muscles). It was demonstrated that they are organized in two layers: the orbital layer composed by small diameter fibres and the global layer with three-times thicker fibres than the former. The global layer has three fibre types: white, red and intermediate; while the orbital layer presents two fibre types, which react differently to the ATPase.

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)