Environmental context of a compilation about the distribution of large protists from the Infrakingdom Rhizaria in the global ocean

The present data set provides environmental context to a worldwide compilation from 11 oceanographic expeditions during which an underwater vision profiler (UVP) was deployed in situ to determine the vertical distribution plankton larger than 600 µm, belonging to the Infrakingdom Rhizaria.

Geochemistry of surface sediment samples from the equatorial Atlantic south of the Azores

In order to recognize the distribution of hydrothermal tracers south of the Azores, a series of cores has been sampled during the GEOFAR cruise. The distribution of the Mn concentrations shows that the hydrothermal influence is maximum within and to the north-west of the Lucky Strike segment. North of the East-Azores Fracture Zone the sediments are enriched in Ba which could be derived from different sources. The chemical composition of the interstitial water shows that water advection is limited. Mn, Cu, Ni fluxes evaluated in one site have increased during isotopic stages 4 and 2 and the deglaciation.

Dual control of LIF expression and LIF receptor function regulate Stat3 activation at the onset of uterine receptivity and embryo implantation

Leukemia inhibitory factor (LIF) expression in the uterus is essential for embryo implantation in mice. Here we describe the spatial and temporal regulation of LIF signaling in vivo by using tissues isolated from uteri on different days over the implantation period. During this time, LIF receptors are expressed predominantly in the luminal epithelium (LE) of the uterus. Isolated epithelium responds to LIF by phosphorylation and nuclear translocation of signal transducer and activator of transcription (Stat) 3, but not by an increase in mitogen-activated protein kinase levels. The related cytokines Il-6, ciliary neurotrophic factor, as well as epidermal growth factor, do not activate Stat3, although epidermal growth factor stimulates mitogen-activated protein kinase. In vivo Stat3 activation is induced by LIF alone, resulting in the localization of Stat3 specifically to the nuclei of the LE coinciding with the onset of uterine receptivity. The responsiveness of the LE to LIF is regulated temporally, with Stat activation being restricted to day 4 of pregnancy despite the presence of constant levels of LIF receptor throughout the preimplantation period. Uterine receptivity is therefore under dual control and is regulated by both the onset of LIF expression in the endometrial glands and the release from inhibition of receptor function in the LE.

Characterization of a unique variant of bat rabies virus responsible for newly emerging human cases in North America.

The silver-haired bat variant of rabies virus (SHBRV) has been identified as the etiological agent of a number of recent human rabies cases in the United States that are unusual in not having been associated with any known history of conventional exposure. Comparison of the different biological and biochemical properties of isolates of this virus with those of a coyote street rabies virus (COSRV) revealed that there are unique features associated with SHBRV. In vitro studies showed that, while the susceptibility of neuroblastoma cells to infection by both viruses was similar, the infectivity of SHBRV was much higher than that of COSRV in fibroblasts (BHK-21) and epithelial cells (MA-104), particularly when these cells were kept at 34 degrees C. At this temperature, low pH-dependent fusion and cell-to-cell spread of virus is seen in BHK-21 cells infected with SHBRV but not with COSRV. It appears that SHBRV may possess an unique cellular tropism and the ability to replicate at lower temperature, allowing a more effective local replication in the dermis. This hypothesis is supported by in vivo results which showed that while SHBRV is less neurovirulent than COSRV when administered via the intramuscular or intranasal routes, both viruses are equally neuroinvasive if injected intracranially or intradermally. Consistent with the above findings, the amino acid sequences of the glycoproteins of SHBRV and COSRV were found to have substantial differences, particularly in the region that contains the putative toxic loop, which are reflected in marked differences in their antigenic composition. Nevertheless, an experimental rabies vaccine based on the Pittman Moore vaccine strain protected mice equally well from lethal doses of SHBRV and COSRV, suggesting that currently used vaccines should be effective in the postexposure prophylaxis of rabies due to SHBRV.

Els plànols de l’església nova i el plànol geomètric de Santa Pola

La recerca històrica i geogràfi ca a vegades dóna resultats sorprenents. Aquest és el cas de la troballa del Proyecto de Iglesia Parroquial para el pueblo de Santa Pola, en què s’inclou, a més dels plànols originals de la coneguda com a «església rota» (l’actual mercat central), un «Plano Topográfi co de Santa Pola» de gran transcendència per a conéixer els inicis de l’evolució urbana de la localitat, tots signats per Francisco Morell y Gómez el 1863. Primer, tractem el projecte de l’església, analitzem les dades del projecte i els plànols. Després, el més interessant és el plànol topogràfi c inèdit esmentat. Fem una comparació amb el signat el 1863 pel també arquitecte José Ramon Mas y Font. Són iguals? Tenen diferències? Quines són i quina importància tenen? El plànol esdevé un instrument de recerca de primer ordre per a donar resposta a aquestes preguntes.

Student essay attributed to William Ellery Channing, 1797 June 5

Three-page handwritten essay composed in English and attributed to Harvard undergraduate William Ellery Channing. The verso of the last page is inscribed "Channing 5 June 97." A quotation from Edward Young appears at the top of the first page: "A Competence is vital to content / Much wealth is corpulence, if not disease" and discusses the topic of affluence. The document includes edits and struck-through words.

Student notebook of Marston Cabot, ca. 1720-1735

This leather-bound volume contains excerpts copied by Marston Cabot from books he read while he was a student at Harvard in 1723. The volume includes extracts from Charles Morton's 1687 Compendium Physicae (titled "of Phisicks" by Cabot), Dr. Adriani Heereboord (Adrianus Heereboord), Philosophia Naturalis and Johanne-Henrico Alstedio’s (John Henry Alsted) geometry text Compendium Geometria. The excerpts from Compendium Geometria include both figures and text, primarily in Latin with some Greek. The volume also includes “Theses quaedam extractae potissimum ex Enchiridio Metaphysico Domini Johannis Clerici" a précis of Jean Le Clerc's Ontologia et Pneumatologia made by Jonathan Remington, a Harvard Tutor from 1703 to 1711, to serve in place of printed textbooks. The names Jonathan Jackson and Edward Jackson are written on the inside cover, suggesting the book may have been handed down to Edward Jackson (Class of 1726) and his son Jonathan Jackson (Class of 1761). The text of the volume is in Marston Cabot's hand.