Optimizing the nipple-areola sparing mastectomy with double concentric periareolar incision and biodimensional expander-implant reconstruction: Aesthetic and technical refinements

Although the biodimensional anatomical expander-implant system (BEIS) is a reliable technique, little information has been available regarding outcome following nipple-areola sparing mastectomy (NSM). To perform the resection of glandular tissue, while improving the surgical access and maintaining the nipple-areola vascularization we have developed a new approach for NSM based on the double concentric periareolar incision (DCPI). The purpose of this study is to analyze the feasibility, surgical planning and its outcome following NSM. 18 patients underwent NSM reconstructions. Mean time of follow-up was 29 months. The technique was indicated in patients with small/moderate volume breasts. Flap complications were evaluated and information on aesthetic results and patient satisfaction were collected. 83.3% had tumors measuring 2 cm or less (T1) and 72.1% were stage 0 and 1. All patients presented peripherally tumors located (at least 5 cm from the nipple). Skin complications occurred in 11.1%. One patient (5.5%) presented small skin necrosis and a wound dehiscence was observed in one patient (5.5%). The aesthetic result was good/very good in 94.4 percent and the majority of patients were very satisfied/satisfied. No local recurrences were observed. All complications except one were treated by a conservative approach. DCPI-BEIS is a simple and reliable technique for NSM reconstruction. The success depends on patient selection, coordinated planning with the oncologic surgeon and careful intra-operative and post-operative management. (C) 2009 Elsevier Ltd. All rights reserved.

Ca(2+)-activated transbilayer movement of plasma membrane phospholipids in Leishmania donovani during ionomycin or thapsigargin stimulation

The protozoan parasite Leishmania causes serious infections in humans all over the world. After being inoculated into the skin through the bite of an infected sandfly, Leishmania promastigotes must gain entry into macrophages to initiate a successful infection. Specific, surface exposed phospholipids have been implicated in Leishmania-macrophage interaction but the mechanisms controlling and regulating the plasma membrane lipid distribution remains to be elucidated. Here, we provide evidence for Ca(2+)-induced phospholipid scrambling in the plasma membrane of Leishmania donovani. Stimulation of parasites with ionomycin increases intracellular Ca(2+) levels and triggers exposure of phosphatidylethanolamine at the cell surface. We found that increasing intracellular Ca(2+) levels with ionomycin or thapsigargin induces rapid transbilayer movement of NBD-labelled phospholipids in the parasite plasma membrane that is bidirectional, independent of cellular ATP and not specific to the polar lipid head group. The findings suggest the presence of a Ca(2+)-dependent lipid scramblase activity in Leishmania parasites. Our studies further show that lipid scrambling is not activated by rapid exposure of promastigotes to higher physiological temperature that increases intracellular Ca(2+) levels. (C) 2011 Elsevier B.V. All rights reserved.

FT-IR spectroscopy assessment of aesthetic dental materials irradiated with low-dose therapeutic ionizing radiation

The aim of the present study was to evaluate the effects of low-dose therapeutic ionizing radiation on different aesthetic dental materials. Forty five specimens (n = 45) of three different aesthetic restorative materials were prepared and randomly divided into five groups: G1 (control group); G2, G3, G4, G5 experimental groups irradiated respectively with 0.25, 0.50, 0.75, and 1.00 Gy of gamma radiation by the (60)Co teletherapy machine. Chemical analyses were performed using a FT-IR Nicolet 520 spectrophotometer with reflectance diffuse technique. Even a minimal exposition at ionizing radiation in therapeutic doses can provide chemical changes on light-cured composite resins. The three studied restorative materials showed changes after exposure at gamma radiation, however the increase of the radiation dose did not contribute to an increase in this effect.

Speak Good English Movement in Singapore : Reactions in Social and Traditional Media

The first Speak Good English Movement, SGEM, took place in 2000, and has been organized annually ever since. Speaking a “standard” form of English is considered to bring increased personal power. However, the SGEM wants the Singaporeans to use “standard” English in their private life as well. A decade after the beginning of the campaign, a Speak Good Singlish Movement was started. Based on studies of language and identity, it is understandable why some Singaporeans might feel the SGEM threatens their identity. However, the reactions towards the campaign are mainly positive. For the purposes of this analysis, Twitter messages, Facebook pages, and newspaper articles from The Straits Times were collected. The SGEM has hailed both direct and indirect praise and criticism in both social and traditional media: Five newspaper articles praise the campaign while five criticize it; the results are nine and seven respectively for social media. This thesis looks at reactions towards the SGEM in both social and traditional media, analyzes how these reactions might relate to the ideas of the power of language, its variety and the relation of language and identity.

Wind farm construction impacts reindeer migration and movement corridors

Over the last decade, we have seen a massive increase in the construction of wind farms in northern Fennoscandia. Wind farms comprising hundreds of wind turbines are being built, with little knowledge of the possible cumulative adverse effects on the habitat use and migration of semi-domesticated free-ranging reindeer. We assessed how reindeer responded to wind farm construction in an already fragmented landscape, with specific reference to the effects on use of movement corridors and reindeer habitat selection. We used GPS-data from reindeer during calving and post-calving in the MalAyen reindeer herding community in Sweden. We analysed data from the pre-development years compared to the construction years of two relatively small wind farms. During construction of the wind farms, use of original migration routes and movement corridors within 2 km of development declined by 76 %. This decline in use corresponded to an increase in activity of the reindeer measured by increased step lengths within 0-5 km. The step length was highest nearest the development and declining with distance, as animals moved towards migration corridors and turned around or were observed in holding patterns while not crossing. During construction, reindeer avoided the wind farms at both regional and landscape scale of selection. The combined construction activities associated with even a few wind turbines combined with power lines and roads in or close to central movement corridors caused a reduction in the use of such corridors and grazing habitat and increased the fragmentation of the reindeer calving ranges.

The Movement of the Gastrop Littorina Littorea in the Intertidal Zone during the Onset of Winter

The movement of the snail Littorina littoreaon the North Atlantic coast is poorly understood. Most research has concentrated on the vertical distribution of the snail, and suggests that it prefers the low intertidal zone where its food source is most plentiful. In the winter, this distribution is reinforced by a documented seaward migration of snails from the high intertidal zone in response to falling temperatures. From October 14, 2006 to January 22, 2007, I examined the individual movements and recovery of snails in response to the onset of winter. I proposed that falling water and air temperatures drive the majority of snail movement within the intertidal zone, and that water temperature had the greater effect. I also examined the possibility that, in addition to a seaward migration, winter weather patterns in the Gulf of Maine and their effect on the ocean may encourage the wintertime vertical distribution of snails. Finally, I examined the possibility that populations of snails in the comparatively inhospitable high intertidal zone may endure the winter if given access to proper resources.

Oxford movement: its themes and their significance

In retrospective, the Oxford movement of nineteenth century England provides one with an interesting study of the struggles between the spiritual and secular worlds. However, repeated abstraction in an interpretation of its significance has tended to distort accurate understanding of its historical development. Often this also has resulted n a misinterpretation of the nature of its major themes and their significance to the world. For these reasons, this study has attempted to describe the origin, maturity, and dissolution of the series of events which strictly speaking may be considered to be the Oxford movement. In conclusion, liberty has been taken to comment on the nature of the Movement's themes and their significance in their own age and to man today.

In search of academic identity : physical education, sport science and the field of human movement studies

This thesis addresses the problem of the academic identity of the area traditionally referred to as physical education. The study is a critical examination of the argu ments for the justi cation of this area as an autonomous branch of knowledge. The investigation concentrates on a selected number of arguments. The data collection comprised articles books and proceedings of conferences. The preliminary assessment of these materials resulted in a classi cation of the arguments into three groups. The rst group comprises the arguments in favour of physical education as an academic discipline. The second includes the arguments supporting a science of sport. The third consists of the arguments in favour of to a eld of human movement study. The examination of these arguments produced the following results. (a) The area of physical education does not satisfy the conditions presupposed by the de nition of academic discipline. This is so because the area does not form an integrated system of scienti c theories. (b) The same di culty emerges from the examination of the ar guments for sport science. There is no science of sport because there is no integrated system of scienti c theories related to sport. (c) The arguments in favour of a eld of study yielded more productive results. However di culties arise from the de nition of human movement. The analysis of this concept showed that its limits are not well demarcated. This makes it problematic to take human movement as the focus of a eld of studies. These aspects led to the conclusion that such things as an academic discipline of physical education sport science and eld of human movement studies do not exist. At least there are not such things in the sense of autonomous branches of knowledge. This does not imply that a more integrated inquiry based on several disciplines is not possible and desirable. This would enable someone entering phys ical education to nd a more organised structure of knowledge with some generally accepted problem situations procedures and theories on which to base professional practice.

Uma análise das fugas para piano de Bruno Kiefer : uma busca por padrões estilísticos na sua escrita contrapontística

Este trabalho oferece um estudo dos padrões estilísticos definidos através da análise dos processos contrapontísticos encontrados no terceiro movimento da Sonata nº I, Fuga e Toccata e do movimento final de Duas peças Sérias da obra para piano de Bruno Kiefer. A fuga, uma das técnicas de composição linear mais estabelecidas na escrita musical, reflete as transformações estilísticas na música ocidental. Considerando a diversidade de possibilidades estéticas na música do século XX, faz-se mister investigar como Kiefer tratou uma técnica composicional consagrada, preservando de modo singular e consistente o estilo inovador atribuído às suas obras. O referencial teórico adotado para este estudo é Twentieth Century Fugue – A Handbook (1962) de William Graves, Jr.. A partir da análise dos padrões recorrentes nas fugas de Bruno Kiefer, verificou-se o distanciamento entre os parâmetros da fuga tradicional e o estilo da escrita contrapontística do compositor.

Racial discrimination in Brazil: interviews with leaders of the black movement

Racism in Brazil has some specificities when compared to other countries, for, differently from, for instance, South Africa and the United States, Brazilian Constitutions, ever since the Independence (1822), have never distinguished the citizens according to race or color. Furthermore, since the mid-1900s, Afro-Brazilian cultural manifestations, such as, for example, samba and capoeira, started to be valued as a part of our “national identity”. These specificities make race relations in Brazilian society a much more complex issue. This paper is focused on selected parts of interviews that deal with the nature of racial discrimination in Brazil, extracted from interviews with leaders of the black movement produced within the scope of the project “The History of Black Movement in Brazil: organization of a collection of Oral History Interviews”, developed by CPDOC, Getulio Vargas Foundation (Rio de Janeiro). These “histories within history”, as told by our interviewees, may be transformed into images that will be able to condense a given reality, thus allowing us to evaluate the gains obtained by oral history methodology.

Imagens do Brasil: o Cinema Novo e as metamorfoses da identidade nacional

Este trabalho tem como objetivo a análise da política cultural de cinema e sua relação com a identidade nacional, que se desenvolveu entre o final dos anos cinquenta e o início dos anos oitenta. Os principais agentes desse processo são os cineastas vinculados ao Cinema Novo e o Estado autoritário, implantado a partir de 1964, tendo como pano de fundo o intenso processo de modernização sofrido pela sociedade brasileira no período. Dentre as fontes utilizadas, destaca-se a produção cinematográfica do período, importante para compreender as ideias formuladas sobre a identidade nacional e as contradições inerentes a esse processo. No primeiro capítulo, analisamos a gênese do Cinema Novo, reconhecendo-o como movimento político e cultural, estabelecendo suas redes de sociabilidade e caracterizando seus aspectos estéticos e políticos comuns aos cineastas que dele faziam parte. Esta análise considerou três momentos distintos: o primeiro, entre 1955 e 1964, quando ocorreu a gênese do Cinema Novo; o segundo, entre 1964 e 1968, quando o Cinema Novo conheceu seu apogeu e se consolidou como proposta política e cultural; e o terceiro, entre 1969 e 1973, quando a proposta estética se esgotou, dando espaço às articulações políticas e às propostas individuais que caracterizaram esse movimento cultural até o início dos anos oitenta. No segundo capítulo, o objeto principal da análise é a ação do Estado autoritário, estabelecido a partir de 1964, no campo da cultura. Realizamos um retrospecto das intervenções do Estado brasileiro nesse campo até 1964, discorremos sobre a postura do Estado autoritário em relação à produção cultural e destacamos a Política Nacional de Cultura, proposta no final de 1975, a principal referência para se compreender o processo de construção da identidade nacional em tempos de transição. No terceiro capítulo, analisaremos especificamente a política cultural cinematográfica a partir de 1974, seus pontos em comum com a Política Nacional de Cultura e suas contradições em relação à ação do Estado autoritário na área cultural e ao processo de modernização pelo qual passou a sociedade brasileira. Por meio dessa análise, procuramos entender a forma como cinemanovistas e representantes dos órgãos oficiais da área cultural perceberam a gestação de uma política cultural de cinema que contemplasse as necessidades desses tempos de transição e fornecesse os elementos para a construção da identidade nacional. No quarto capítulo, analisamos a trajetória de Joaquim Pedro de Andrade, como intelectual cinemanovista, profundamente influenciado pelos ideais modernistas dos anos vinte e trinta, e crítico do processo de modernização autoritária posto em prática a partir de 1964. Consideramos a trajetória e a obra desse cineasta como paradigmáticas, tanto no que se refere às complexas relações políticas e culturais desenvolvidas pelo Cinema Novo, quanto às profundas transformações vividas pela sociedade brasileira no período. Entre 1955 e 1982, desenvolveram-se várias propostas políticas para a área cultural, destacando-se duas: aquela formulada e apresentada pelo Cinema Novo e aquela referente à intervenção do Estado autoritário nessa área. A atuação dos intelectuais cinemanovistas e o diálogo estabelecido entre estes e seus interlocutores, representantes do Estado autoritário no campo da cultura, possibilitaram a construção de uma identidade nacional em tempos de transição, corroborando o processo de redemocratização e construindo novas formas de se ver, analisar e compreender a sociedade brasileira.