989 resultados para Teste de tolerância à glicose


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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

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Introduction: The stair-climbing test (SCT) is considered a submaximal test of simple implementation and easy access, which assesses the individual’s functional capacity. Although widely used in surgical patients, there is no standardization regarding the height of the stair and verbal stimulus. Objectives: It was determine if verbal stimulus changes the stair-climbing time (SCt) in individuals over 50 years-old. We compared oxygenation, blood pressure, pulse, respiratory rate and Borg scale between SCT performed with and without stimulation. Methods: We evaluated individuals with ages greater than 50 years-old that performed two STC (with and without verbal stimulation), in the stair with 44 steps, achieving 7.04 m in height and recording the time to climb the stair. The systolic blood pressure (SBP) and the diastolic blood pressure (DBP), respiratory rate (RR), pulse, oxygen saturation (SpO2 ) and Borg scale were evaluated before and after the tests. The time in the SCT with and without stimulation were compared using the Student test-t and the other variables were compared using the ANOVA test (p<0.05). Results: The average age was 59.75±6,40 years old in the 21 evaluated individuals. The time in the SCT without stimulus was significantly higher than the one with stimulus. The SBP, pulse, RR and Borg scale were significantly increased when compared to the SCT with and without stimulus. Oxygenation and DBP didn´t have significant differences at any time of the study. Conclusions: The time in the SCT was lower when performed with verbal stimulus. The SBP, pulse, RR and Borg scale changed significantly after the SCT with and without stimulus, remarking that this change was greater in the SCT with stimulus.

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The effort test can be used to assess functional capacity, clinical hemodynamic and metabolic response at the effort, the risk of postoperative pulmonary complications and to assess the response of patients with lung diseases submitted to physiotherapy treatment. Among the stress tests we highlight the Six Minute Test Walk (6 MWT) and Stair Climbing Test (SCT), because they are easy to use and low cost. Especially the SCT is widely used in patients preoperatively. Objective: To compare the effects of six minute walk test and stair climbing test under the hemodynamic and oxygenation in healthy adults. Methods: We conducted a study with healthy subjects above 50 years. The fi rst performed was 6 MWT in quick step with encouragement, in a plan corridor of 30 meters, where the shade was determined the distance walked in 6 minutes, after 6 MWT was performed de SCT with encouragement, on a ladder in shade, consists of 44 steps, with 4 bids and bid by 11 steps, each step measured 16 cm in a total of 7.04 m of height, where the rise time was clocked. Before and after the two tests were measured respiratory rate, pulse, blood pressure and oxygen saturation. Results: We evaluated 21 patients with age 59.6 ± 5.4 years, 5 men and 16 women. The average distance covered on the 6MWT was 496.4 ± 102.2 meters and the average time in SCT 22.6 ± 5.4 seconds. The variables pulse, respiratory rate, systolic blood pressure and Borg scale presented a signifi - cant increase after the tests, however the variables oxygen saturation and diastolic blood pressure did not change signifi cantly. Conclusion: The variables pulse, respiratory rate, systolic blood pressure and Borg scale tests increased after six-minute walk test and stair climbing test but with greater signifi cance after the stair climbing test. Oxygen saturation and diastolic blood pressure did not change signifi cantly after the tests.

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The six-minute walking test can be affected by several variables, among them, the respiratory and peripheral muscle strength. The objective of this study was to correlate the respiratory muscle strength (maximum inspiratory pressure – MIP; and maximum expiratory pressure – MEP) and the hand grip test (HGT)with the six minute walking test distance in institutionalized elderly. It was included in this study 9 institutionalized elderly with age over 70 years old, both gender, evaluated by means of manometer, dynamometry and six minute walking test. The data were correlated by using the Pearson’s correlation test and the Spearman correlation test. From the evaluated elderly, it was four men and five women, with mean age: 78.8±7.3 years old, MIP: 75.7±33.6 cmH2O, MEP: 62.4±25.0 cmH2O, HGT: 20.4±6.2 kgf (right member) and 20.7±6.8 kgf (left member) and the distance on six minute walking test: 238.5±99.0 meters. There was correlation between expiratory strength and hand grip of both members with the distance on the six minute walking test. It is possible to conclude that there are correlation between expiratory muscle strength with the hand grip test and the functional capacity in institucionalized elderly.

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The six-minute walking test can be affected by several variables, among them, the respiratory and peripheral muscle strength. The objective of this study was to correlate the respiratory muscle strength (maximum inspiratory pressure – MIP; and maximum expiratory pressure – MEP) and the hand grip test (HGT)with the six minute walking test distance in institutionalized elderly. It was included in this study 9 institutionalized elderly with age over 70 years old, both gender, evaluated by means of manometer, dynamometry and six minute walking test. The data were correlated by using the Pearson’s correlation test and the Spearman correlation test. From the evaluated elderly, it was four men and five women, with mean age: 78.8±7.3 years old, MIP: 75.7±33.6 cmH2O, MEP: 62.4±25.0 cmH2O, HGT: 20.4±6.2 kgf (right member) and 20.7±6.8 kgf (left member) and the distance on six minute walking test: 238.5±99.0 meters. There was correlation between expiratory strength and hand grip of both members with the distance on the six minute walking test. It is possible to conclude that there are correlation between expiratory muscle strength with the hand grip test and the functional capacity in institucionalized elderly.

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Pós-graduação em Agronomia (Genética e Melhoramento de Plantas) - FCAV

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Pós-graduação em Ciência e Tecnologia Animal - FEIS

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Flavonoides são constituintes fenólicos de plantas que possuem diversas atividades terapêuticas, dentre elas, a atividade antimutagênica. Eles são caracterizados por um esqueleto carbônico C6-C3-C6, em que os componentes C6 são anéis aromáticos e o C3 um anel heterocíclico. Diferenças nessa estrutura podem alterar a atividade e o seu potencial antimutagênico. Para melhor compreensão da atividade antimutagênica exercida pelos flavonoides, neste estudo, os compostos quercetina, kaempferol, luteolina, fisetina, galangina, crisina, flavona, 3-hidroxiflavona, 5-hidroxiflavona e 7-hidroxiflavona, flavonoides que apresentam diferenças no padrão de hidroxilação, foram analisados pelo teste de Ames. Para realização dos ensaios foram utilizadas as cepas TA98, TA100 e TA102 de Salmonella typhimurium em testes com e sem ativação metabólica. Os mutágenos utilizados para comparação do efeito protetor dos flavonoides foram 4-nitro-o-fenilenodiamina (NPD), azida sódica (AZS), mitomicina C (MMC), benzo[a]pireno (B[a]P), aflatoxina B1 (AFB1) e 2-aminoantraceno (2-AA). No ensaio contra o NPD sem ativação metabólica, todos os flavonoides apresentaram efeito antimutagênico, com exceção da fisetina. No ensaio com ativação metabólica contra o B[a]P, todos os flavonoides demonstraram forte efeito antimutagênico, com exceção da quercetina que potencializou o efeito mutagênico do mutágeno. No ensaio contra a AZS sem ativação metabólica, os flavonoides luteolina, crisina, 3-hidroxiflavona e 7-hidroxiflavona reduziram a resposta mutagênica do mutágeno. No ensaio contra a AFB1 com ativação metabólica, os flavonoides kaempferol, luteolina, crisina e galangina (em concentrações mais elevadas) exibiram efeito antimutagênico ...

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The brake system of a Formula SAE car has determinant character in the quality of the project. Any flaw in the design of the brakes, the vehicle is rejected for the competition. The project well done, and its smooth operation, depends on some variables that should be studied and linked to the brake components, as needed by the vehicle. After the calculations, the components were defined according to commercial availability. So it is interesting simulation of braking when the vehicle will be submitted before the implementation of the brake system, saving time and cost. This project also enable the comparison between components from different brands. This work shows the study of a method that would allow simulate and test the brake system in an upcoming project for a bench test