935 resultados para Proteostasis Deficiencies


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The primary health care has been recognized as one of the key components of an effective health system. In its most developed form, the primary health care is the first contact with the health system and the site responsible for the organization of health care over time: individuals, their families and the general population; seeks to provide balance between the two goals of a national health system, which are improving the health of the population and provide equitable distribution of resources. Hospitalizations for primary care sensitive conditions (HPCSC) may be associated with deficiencies of service coverage primary health care or its effectiveness. Hospitalization rates can and should represent a warning sign, triggering mechanisms for analysis and search for explanations for these problems. The use of hospitalization data for HPCSC can serve as indicators of inequality in the health system, contributing to the evaluation of the deployment and implementation of health policies.

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

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Objectives: evaluating the level of information about the examination of uterine cervical cancer and its association with sociodemographic variables in women of a health care unit in the city of Bauru, São Paulo, Brazil. Methods: we conducted a cross-sectional descriptive study with 370 women aged 25 to 59, through structured interviews in their own homes; we used descriptive statistics and the χ2 test. Results: 40.5% of the women had not undergone the Papanicolaou test at the recommended frequency; 58.2% incorrectly defined the test, and 69.5% did not know about the risk factors for the development of cervical cancer; the knowledge about the test showed statistically significant association with schooling and family income of the studied population. Conclusions: women present deficiencies on the proper practice of the Papanicolaou test, on knowledge about the test, risk factors and prevention methods. Therefore, it is necessary to develop primary health actions for the most vulnerable population.

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

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This study takes the old myth of objectivity in media discourse to one of the most important but unrecognized actors in the process of its construction: the mass media information scientist or documentalist. Accepting the subjective presence of the documentalist in his/her productions, this article opts for the recognition and explicit statement of this role, recommending two actions. First, we suggest that public higher education institutions combine the technical training of mass media documentalists with training in critical thinking skills. Our study analysed the subjects covered in course syllabi to detect the deficiencies to be addressed in meeting this objective. Second, we propose alternative lines of training that can contribute to cross-training of mass media documentalists in those degree programs to ensure that they acquire the needed skills in critical analysis.

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The objective was to evaluate the effect of the omission of macronutrient and micronutrient boron in dry matter production, the characterization of the symptoms of nutritional deficiencies and mineral composition in plants of ipeca, an experiment was conducted in greenhouse conditions by the technique the missing element and visual diagnosis. A randomized block experimental design with four repetitions and the treatments were: complete and omissions of N, P, K, Ca, Mg, S and B. The analytical results demonstrated that the production of dry matter was affected in all of the treatments with omission of nutrients and that the ipeca plants presented characteristic symptoms of nutritional deficiencies due to the omissions of N, P, K, Ca, Mg, S and B and the concentrations of the macronutrients and of the micronutrient boron in the different parts of the ipeca plant varied when a certain nutrient was omitted in the solution.

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In 2010 two retailers signed an association agreement to gain an advantage in the market, however this association has promoted many changes within the companies. So this study had the objective to analyze the organizational climate, in the integration of companies context, in order to early detect deficiencies that could pose risks to the process of integration. The results collected from the questionnaires revealed the perceptions and expectations of employees regarding the integration of companies and their level of satisfaction with the organization, in addition, the data obtained from interviews allowed us to understand and to find some causes to the level of satisfaction presented by employees. The results made possible to identify strengths as the company‟s image, points of failure in communication and training and dissatisfaction with the workload, then some actions were suggested with the intention to achieve greater engagement and commitment of employees and consequently contribute to the success of the Integration Program. The conclusion of this study is that the changes promoted by the integration of companies impacted in the organizational climate and increased employees dissatisfaction

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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

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The paper provides a close lecture of the arguments and methods of legal construction, employed in the extensive individual opinions written by the Justices of the Brazilian Supreme Court in the case which authorized the same sex civil union. After tracing an outline of the legal problem and his possible solutions, we analyze the individual opinions, showing their methodological syncretism, the use of legal methods and arguments in a contradictory way as well the deficiencies in the reasoning. The Justices use legal arguments, but do not meet the requirements of rationality in the decision-making. We have a rhetorical attempt that aims to satisfy the public opinion than to offer a comprehensive and coherent solution according the normative elements of the Brazilian Federal Constitution of 1988.

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Children learn very early which groups are stigmatized and how they should be treated. They learn formally and informally, by listening and watching people and the world around them. The construction of children's representations about disabilities starts with access to information on the subject, which may come from their caregivers, media, school etc. This work is part of a monograph that examined the effects of an educational program involving strategies for non-disabled children on conceptions and attitudes concerning mental disability. This paper refers to the initial characterization of these children and their access to information on disability, and to identifying previous access, source and memory of such information. The study included 40 children from two classrooms of the first grade of a public school in Marília, SP. The children were interviewed using an individual semi structured questionnaire. Many children said they did not have access to information on the subject. Among those who had previous access to the information, the television was the most frequent source of information, and characteristics of the deficiencies, relations with diseases and encouragement of solidarity were among the contents reminded by them. The data emphasize the need for the media to expand concerns with the content presented to the public, for parents and teachers to become more involved with the issue, seeking to be informed and revise their own conceptions, in order to transform the subject into something that is part of daily school and family environment.

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Osteodistraction is a clinical reality, available in the last decades for the resolution of large bone deficiencies, in cases that there are pre-existing, but misplaced implants and teeth. The aims of thearticle is to present a case report in which a new possibility for bone distraction, based on tooth-implant bone distractors, made from standard orthodontic expansion-screws, was used in an area where there was an extensive need of alveolar bone and aesthetical recovery, allied to teeth and dental implant misplacement. This technique presented good clinical results, associated to effective simplicity and low cost, becoming viable clinical solution for bone tissue augmentation and aesthetical optimization. In resume, it is possible to say that the suggested technique achieved its objectives, improving the hard and soft tissue profile, whilst allowing completion of oral rehabilitation.

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The aim of this double-blind clinical trial was to assess the longevity of repairs to localized clinical defects in composite resin restorations that were initially planned to be treated with a restoration replacement. Methods Twenty-eight patients aged 18–80 years old with 50 composite resin restorations (CR) were recruited. The restorations with localized, marginal, anatomical deficiencies and/or secondary caries adjacent to CR that were “clinically judged” to be suitable for repair or replacement according to the USPHS criteria were randomly assigned to Repair (n = 25) or Replacement (n = 25) groups, and the quality of the restorations was scored according to the modified USPHS criteria. The restorations were blind and two examiners scored them at baseline (Cohen Kappa agreement score 0.74) and at ten years (Cohen Kappa agreement score 0.87) restorations. Wilcoxon tests were performed for comparisons within the same group (95% CI), and Friedman tests were utilized for multiple comparisons between the different years within each group. Results Over the decade, the two groups behaved similarly on the parameters of marginal adaptation (MA) (p > 0.05), secondary caries (SC) (p > 0.05), anatomy (A) (p < 0.05), and colour (C) (p > 0.05). Conclusions Given that the MA, SC, A and C parameters behaved similarly in both groups, the repair of composite resins should be elected when clinically indicated, because it is a minimally invasive treatment that can consistently increase the longevity of restorations. Clinical significance The repair of defective composite resins as an alternative treatment to increase their longevity proved to be a safe and effective treatment in the long term.