Social Experience Is Sufficient to Modulate Sleep Need of Drosophila without Increasing Wakefulness

Organisms quickly learn about their surroundings and display synaptic plasticity which is thought to be critical for their survival. For example, fruit flies Drosophila melanogaster exposed to highly enriched social environment are found to show increased synaptic connections and a corresponding increase in sleep. Here we asked if social environment comprising a pair of same-sex individuals could enhance sleep in the participating individuals. To study this, we maintained individuals of D. melanogaster in same-sex pairs for a period of 1 to 4 days, and after separation, monitored sleep of the previously socialized and solitary individuals under similar conditions. Males maintained in pairs for 3 or more days were found to sleep significantly more during daytime and showed a tendency to fall asleep sooner as compared to solitary controls (both measures together are henceforth referred to as ``sleep-enhancement''). This sleep phenotype is not strain-specific as it is observed in males from three different ``wild type'' strains of D. melanogaster. Previous studies on social interaction mediated sleep-enhancement presumed `waking experience' during the interaction to be the primary underlying cause; however, we found sleep-enhancement to occur without any significant increase in wakefulness. Furthermore, while sleep-enhancement due to group-wise social interaction requires Pigment Dispersing Factor (PDF) positive neurons; PDF positive and CRYPTOCHROME (CRY) positive circadian clock neurons and the core circadian clock genes are not required for sleep-enhancement to occur when males interact in pairs. Pair-wise social interaction mediated sleep-enhancement requires dopamine and olfactory signaling, while visual and gustatory signaling systems seem to be dispensable. These results suggest that socialization alone (without any change in wakefulness) is sufficient to cause sleep-enhancement in fruit fly D. melanogaster males, and that its neuronal control is context-specific.

Maintaining local displacive disorders in Na0.5Bi0.5TiO3 piezoceramics by K0.5Bi0.5TiO3 substitution

A comprehensive global and local structural characterization using X-ray and neutron diffraction, and EXAFS have been performed to investigate the effect of electrical poling on the structure of (1-x)Na0.5Bi0.5TiO3-(x)K0.5Bi0.5TiO3 compositions. While the annealed samples showed definite indication of presence of local displacive disorders in all the compositions studied (0 tendency of electric field to reduce the local displacive disorder decreased with increasing K0.5Bi0.5TiO3 content in the samples. (C) 2016 Elsevier Ltd. All rights reserved.

An analysis on overall crack-number-density of short-fatigue-cracks

The evolution of dispersed short-fatigue-cracks is analysed based on the equilibrium of crack-number-density (CND). By separating the mean value and the stochastic fluctuation of local CND, the equilibrium equation of overall CND is derived. Comparing with the mean-field equilibrium equation, the equilibrium equation of overall CND has different forms in the expression of crack-nucleation-rate or crack-growth-rate. The simulation results are compared with experimental measurements showing the stochastic analyses provide consistent tendency with experiments. The discrepancy in simulation results between overall CND and mean-field CND is discussed.

Deficits in sensory prediction are related to delusional ideation in healthy individuals.

Motor control strongly relies on neural processes that predict the sensory consequences of self-generated actions. Previous research has demonstrated deficits in such sensory-predictive processes in schizophrenic patients and these low-level deficits are thought to contribute to the emergence of delusions of control. Here, we examined the extent to which individual differences in sensory prediction are associated with a tendency towards delusional ideation in healthy participants. We used a force-matching task to quantify sensory-predictive processes, and administered questionnaires to assess schizotypy and delusion-like thinking. Individuals with higher levels of delusional ideation showed more accurate force matching suggesting that such thinking is associated with a reduced tendency to predict and attenuate the sensory consequences of self-generated actions. These results suggest that deficits in sensory prediction in schizophrenia are not simply consequences of the deluded state and are not related to neuroleptic medication. Rather they appear to be stable, trait-like characteristics of an individual, a finding that has important implications for our understanding of the neurocognitive basis of delusions.

A key role for similarity in vicarious reward.

Humans appear to have an inherent prosocial tendency toward one another in that we often take pleasure in seeing others succeed. This fact is almost certainly exploited by game shows, yet why watching others win elicits a pleasurable vicarious rewarding feeling in the absence of personal economic gain is unclear. One explanation is that game shows use contestants who have similarities to the viewing population, thereby kindling kin-motivated responses (for example, prosocial behavior). Using a game show-inspired paradigm, we show that the interactions between the ventral striatum and anterior cingulate cortex subserve the modulation of vicarious reward by similarity, respectively. Our results support studies showing that similarity acts as a proximate neurobiological mechanism where prosocial behavior extends to unrelated strangers.

美国西部地区加卸载响应比的时空扫描及其地震趋势研究

加卸载响应比理论是近年来提出的地震预报新方法,在中国大陆地区的实际地震预测中取得了较好的效果.为了研究加卸载响应比理论是否适用于不同地质条件的地震,是否具有普适性,选择了典型的美国圣安德烈斯断层带及其周围地区的地震作为研究对象,计算分析了美国西部地区加卸载响应比的变化情况,并对该地区未来的地震趋势进行了研究.

El Conde de Portugal D. Henrique : ambición y lealtad

Resumen: La presente investigación reivindica la persona de D. Henrique de Borgoña, padre del primer rey de Portugal, como inspirador de la política separatista que hizo del condado portugalense un reino reconocido de la Europa cristiana. Igualmente se pone de relieve la importancia del parentesco y relaciones familiares para conseguir ese éxito diplomático.

Quantitative approaches for characterising fibrillar protein nanostructures

Polypeptide sequences have an inherent tendency to self-assemble into filamentous nanostructures commonly known as amyloid fibrils. Such self-assembly is used in nature to generate a variety of functional materials ranging from protective coatings in bacteria to catalytic scaffolds in mammals. The aberrant self-assembly of misfolded peptides and proteins is also, however, implicated in a range of disease states including neurodegenerative conditions such as Alzheimer's and Parkinson's diseases. It is increasingly evident that the intrinsic material properties of these structures are crucial for understanding the thermodynamics and kinetics of the pathological deposition of proteins, particularly as the mechanical fragmentation of aggregates enhances the rate of protein deposition by exposing new fibril ends which can promote further growth. We discuss here recent advances in physical techniques that are able to characterise the hierarchical self-assembly of misfolded protein molecnles and define their properties. © 2010 Materials Research Society.

Los universitarios y sus concepciones políticas a la luz del neotomismo argentino al filo de los siglos XIX y XX

Resumen: Los avances del liberalismo conmovieron, en buena medida, a la filosofía cristiana. Efectivamente él consagró el valor de la libertad como aspiración máxima y, en su nombre, se intentó sacudir el yugo de la autoridad y la Iglesia no quedó al margen, por lo que los católicos se replantearon muchas de sus posiciones, a fin de poder brindar las respuestas sociales que la sociedad estaba reclamando. Fue así que apareció la tercera escolástica, concebida como un movimiento de renovación contra el liberalismo que lo había invadido todo. Los propulsores de esta corriente decidieron restaurar en las escuelas y universidades la filosofía de Santo Tomás. La Argentina sufrió también las embestidas del liberalismo, lo que impulsó a los católicos a prepararse para plasmar soluciones en las más diversas áreas, con la idea de fondo de imponer el catolicismo como el principio organizador del medio social, argumentando que esa había sido la tendencia histórica en el país. Así fue como la tercera renovación escolástica, o neotomismo, penetró en la Argentina a fines del siglo XIX y en el XX, y se impuso tanto entre los seminaristas como en la Universidad de Córdoba y particularmente en su Facultad de Derecho y Ciencias Sociales. Durante los últimos años del otoño decimonónico la neoescolástica estuvo presente en muchas de las tesis presentadas en la Facultad de Derecho, siguiendo, en este aspecto, una tradición de la universidad cordobesa, la que predominaba también entre ciertos profesores. En este trabajo rastreamos los fundamentos del poder político que se encuentran en esos trabajos, refiriéndonos, por un lado, a la visión del grupo sobre el orden, a la igualdad y el progreso y, por otro, a los derechos del hombre.

169 GHz repetition rate passively harmonically mode-locked VECSEL emitting 265 fs pulses

High repetition rate passively mode-locked sources are of significant interest due to their potential for applications including optical clocking, optical sampling, communications and others. Due to their short excited state lifetimes mode-locked VECSELs are ideally suited to high repetition rate operation, however fundamentally mode-locked quantum well-based VECSELs have not achieved repetition rates above 10 GHz due to the limitations placed on the cavity geometry by the requirement that the saturable absorber saturates more quickly than the gain. This issue has been overcome by the use of quantum dot-based saturable absorbers with lower saturation fluences leading to repetition rates up to 50 GHz, but sub-picosecond pulses have not been achieved at these repetition rates. We present a passively harmonically mode-locked VECSEL emitting pulses of 265 fs duration at a repetition rate of 169 GHz with an output power of 20 mW. The laser is based around an antiresonant 6 quantum well gain sample and is mode-locked using a semiconductor saturable absorber mirror. Harmonic modelocking is achieved by using an intracavity sapphire etalon. The sapphire then acts as a coupled cavity, setting the repetition rate of the laser while still allowing a tight focus on the saturable absorber. RF spectra of the laser output show no peaks at harmonics of the fundamental repetition rate up to 26 GHz, indicating stable harmonic modelocking. Autocorrelations reveal groups of pulses circulating in the cavity as a result of an increased tendency towards Q-switched modelocking due to the low pulse energies.

Los economistas como filósofos mundanos

Resumen: Mientras que las principales figuras de la historia de la economía la concibieron como una ciencia inseparable de la filosofía y de otras ciencias humanas, en las últimas décadas se ha producido un movimiento hacia la transformación de la economía en una disciplina esencialmente técnica, con áreas de investigación estrechamente especializadas. Si bien es cierto que la especialización ha permitido realizar un gran progreso en la ciencia económica, los hechos que han ocurrido en los últimos años relacionados con la crisis financiera, sustentan los argumentos de quienes plantean la necesidad de desarrollar foros de interacción interdisciplinaria y aspirar a una visión más amplia de la economía como ciencia.

Model for solidification cracking in low alloy steel weld metals

Data on the occurrence of solidification cracking in low alloy steel welds have been analysed using a classification neural network based on a Bayesian framework. It has thereby been possible to express quantitatively the effect of variables such as the chemical composition, welding conditions, and weld geometry, on the tendency for solidification cracking during solidification. The ability of the network to express the relationship in a suitably non-linear form is shown to be vital in reproducing known experimental phenomena. © 1996 The Institute of Materials.

El acto de ser en la distinción hombre y persona de Santo Tomás de Aquino

Resumen: Santo Tomás obtuvo la distinción de hombre y persona de la evidencia del mal humano, cuyas manifestaciones más importantes son los padecimientos corporales y espirituales, que culminan en la muerte, la debilidad de la razón y la carencia de armonía y de orden en sus facultades. Para la comprensión adecuada del hombre, lo sitúa en la escala de los entes según los grados de perfección. Desde ella, se advierte que el hombre tiene un único ser, aunque esté compuesto de cuerpo y espíritu, que le anima. Es el acto de ser de un espíritu, que unifica todos los constitutivos humanos y que proporciona una mayor individualidad que la que poseen los otros entes. La individualidad o incomunicabilidad única del hombre se expresa con el término «persona», que tiene un estatuto lógico y gramatical especial. La persona expresa directamente al ser, sin la mediación de la esencia y los trascendentales, que explican su gran perfección.

Desde las fragmentaciones sociales hasta las vulnerabilidades individuales : perspectivas para la psicología del mañana

Resumen: Esta conferencia propone una puesta en perspectiva sociohistórica del simposio “Riesgos, desigualdades y fragmentaciones sociales vinculados al trabajo”. Eso recuerda primero que los fenómenos de fragmentación social y de vulnerabilidad adulta estuvieron, desde 1895, en el origen y la gestación de las principales corrientes de la psicología. Posteriormente se cambia a la lógica “fragmentación-vulnerabilidad” a través de los conceptos de precariedad y de vulnerabilidad psicológica. Finalmente se sugiere que, distinguiendo la fragilidad humana de la vulnerabilidad adulta, la psicología puede por un lado entender mejor la actual obsesión de prevención de los riesgos y por otra parte la oscilación adulta entre fragmentación “vulnerabilizante” y conciliación fatigante

The art of human rights : enriching the life of the law school through drawings and other visual resource

In the life of the Law School, focus on the “visual” can operate at three different levels: learning, teaching, and examining (legal concepts). My main interest in this paper is to explore the latter level, “examining”, broadly considered so as to encompass evaluation in general. Furthermore, that interest is pinned down here to the area of constitutional rights and human rights in general, even though the conclusions reached can (and should) likely be extrapolated to other areas of the law... In effect, the first logical step regarding the relevance of the visual approach has to do with using it yourself when you study —assuming that you came to the conclusion that you are a “visual learner”. As you know, VARK theorists propose a quadripartite classification of learners. The acronym VARK stands for Visual, Aural, Read/write, and Kinesthetic sensory modalities that are used for learning information. This model was designed in the late 80s by Neil Fleming and it has received some acceptance and a lot of attention...