Mortalidade de idosos em município do Sudeste brasileiro de 2006 a 2011

O objetivo foi descrever a mortalidade entre idosos em Araraquara (SP), no período de 2006 a 2011. Estudo epidemiológico descritivo, tendo como fontes de dados o Sistema de Informações sobre Mortalidade e a Fundação Sistema Estadual de Análise de Dados. Foi calculada razão entre coeficientes de mortalidade por ponto (R) e por intervalo de 95% de confiança (IC95%). Observou-se mais de 60% dos idosos com nível baixo de escolaridade, sendo que 76% faleceram em hospitais. Entre 2006 e 2008, as diferenças foram estatisticamente significantes entre homens e mulheres, predominando as doenças circulatórias com R = 1,41 (IC95%:1,24-1,58), respiratórias com R = 1,49 (IC95%:1,22-1,76) e neoplasias com R = 1,79 (IC95%: 1,40-2,18). Entre 2009 e 2011, obteve-se, para as causas circulatórias R = 1,18 (IC95%:1,03-1,33), sendo significativas as diferenças para as respiratórias com R = 1,33 (IC95%:1,11-1,55) e câncer sendo R = 1,94 (IC95%:1,53-2,35). O diabetes mellitus e as causas externas apareceram, respectivamente, como quarta e quinta causas de mortes mais frequentes na população idosa. O padrão de mortalidade encontrado ressalta a importância de ações voltadas à redução das principais causas de morte, como o incremento da cobertura da vacina contra a influenza e o controle da hipertensão arterial e do diabetes mellitus.

Caracterização funcional da proteína MxA: estudo do seu envolvimento com a mauinaria de SUMOilação

Pós-graduação em Biotecnologia - IQ

Avaliação da qualidade microbiológica de um composto produzido a partir de resíduos animais e vegetais

Pós-graduação em Microbiologia Agropecuária - FCAV

O gênero masculino e a arte de cuidar de si mesmo

Vários estudos comparativos entre os sexos masculino e feminino comprovaram o fato de que o primeiro é mais vulnerável às doenças, sobretudo às enfermidades graves e crônicas e que morre mais precocemente. A despeito da maior vulnerabilidade e das altas taxas de morbimortalidade, os homens não buscam, como as mulheres, os serviços de atenção básica. O presente estudo buscou compreender como os homens freqüentadores de uma Unidade Básica de Saúde (UBS) se comportam em relação aos cuidados com a sua saúde. Foi realizado em um Centro de Saúde Escola (CSE), Unidade Auxiliar de uma Universidade de uma cidade do interior do Estado de São Paulo, inserido na rede Municipal de Saúde do município. Trata-se de uma pesquisa descritiva, qualitativa e quantitativa. A organização dos dados qualitativos foi baseada na Análise de Discurso do Sujeito Coletivo (DSC), sendo que a obtenção dos discursos ocorreu através de uma entrevista semi-estruturada. Na parte qualitativa, a constituição da amostra foi por conveniência e foram selecionados 15 sujeitos do gênero masculino, maiores de 18 anos, que compareceram na UBS para um atendimento eventual ou para um atendimento pré-agendado. Na parte quantitativa, a constituição da amostra foi ao acaso, sendo sorteados 459 prontuários de usuários do sexo masculino, com 18 anos ou mais, que foram atendidos no período de Janeiro a Dezembro de 2009 para serem analisados através da estatística descritiva. Além disso, foram utilizadas as planilhas referentes às campanhas de vacinação contra a Gripe Pandêmica (H1N1) e Gripe Sazonal (Influenza) para a obtenção do número dos usuários do sexo masculino, de 20 anos ou mais, que participaram dessas campanhas no período de Janeiro a Julho de 2010. Em relação aos dados de caracterização dos indivíduos da amostra selecionada observamos que a faixa etária foi de 50 a 59 ano... (Resumo completo, clicar acesso eletrônico abaixo)

MxA interacts with and is modified by the SUMOylation machinery

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Clinical and laboratory description of a series of cases of acute viral myositis

Describe the clinical and laboratory profile, follow-up, and outcome of a series of cases of acute viral myositis. A retrospective analysis of suspected cases under observation in the emergency department was performed, including outpatient follow-up with the recording of respiratory infection and musculoskeletal symptoms, measurement of muscle enzymes, creatine phosphokinase (CPK), lactate dehydrogenase (LDH), transaminases (AST and ALT), blood count, C-reactive protein, and erythrocyte sedimentation rate in the acute phase and during follow-up until normalization. Between 2000 and 2009, 42 suspected cases were identified and 35 (27 boys) were included. The median age was 7 years and the diagnosis was reported in 89% in the first emergency visit. The observed respiratory symptoms were cough (31%), rhinorrhea (23%), and fever (63%), with a mean duration of 4.3 days. Musculoskeletal symptoms were localized pain in the calves (80%), limited ambulation (57%), gait abnormality (40%), and muscle weakness in the lower limbs (71%), with a mean duration of 3.6 days. There was significant increase in CPK enzymes (5507±9180U/L), LDH (827±598U/L), and AST (199±245U/L), with a tendency to leukopenia (4590±1420) leukocytes/mm(3). The complete recovery of laboratory parameters was observed in 30 days (median), and laboratory and clinical recurrence was documented in one case after 10 months. Typical symptoms with increased muscle enzymes after diagnosis of influenza and self-limited course of the disease were the clues to the diagnosis. The increase in muscle enzymes indicate transient myotropic activity related to seasonal influenza, which should be considered, regardless of the viral identification, possibly associated with influenza virus or other respiratory viruses.

Ecos da memória: a re-construção da identidade em A misteriosa chama da rainha Loana, de Umberto Eco

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

La Casa Nel Vicolo: um romance de Maria Messina à moda do “feuilleton”

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

SCWDS Briefs: Volume 23, Number 1 (April 2007)

Table of Contents: SCWDS History Continued: The Domestic Animal Connection WNV Still With Us: Other Arboviruses May Follow Avian Influenza Update – Spring 2007 Scholarship in Memory of Ed Couvillion Chronic Lead Poisoning in Raptors Unusual Deer Tumor Kevin Keel Receives Award New Edition of Wild Bird Diseases Book

Seeking a Second Opinion: Uncertainty in Disease Ecology

Analytical methods accounting for imperfect detection are often used to facilitate reliable inference in population and community ecology. We contend that similar approaches are needed in disease ecology because these complicated systems are inherently difficult to observe without error. For example, wildlife disease studies often designate individuals, populations, or spatial units to states (e.g., susceptible, infected, post-infected), but the uncertainty associated with these state assignments remains largely ignored or unaccounted for. We demonstrate how recent developments incorporating observation error through repeated sampling extend quite naturally to hierarchical spatial models of disease effects, prevalence, and dynamics in natural systems. A highly pathogenic strain of avian influenza virus in migratory waterfowl and a pathogenic fungus recently implicated in the global loss of amphibian biodiversity are used as motivating examples. Both show that relatively simple modifications to study designs can greatly improve our understanding of complex spatio-temporal disease dynamics by rigorously accounting for uncertainty at each level of the hierarchy.

SCWDS BRIEFS: Volume 21, Number 3 (October 2005)

H5N1 Influenza Virus in Wild Birds: A Fact Sheet Highly Pathogenic Avian Influenza Virus H5N1 and Wild Birds What are avian influenza viruses? What is a Highly Pathogenic Avian Influenza virus? What is “Bird Flu” and what is “HPAI H5N1”? What do we know about avian influenza viruses in wild birds? Do we have HPAI H5N1 in North America? Is there currently a public health risk associated with HPAI H5N1 in wild birds? Is there a domestic animal health risk associated with HPAI in wild birds? What is the possibility of HPAI H5N1 entering North America via migratory wild birds? What is the possibility of this virus being maintained in wild bird populations? Do we have surveillance for HPAI H5N1 in the United States? Additional information on HPAI can be found at these websites: The recognized geographic and species distribution of chronic wasting disease (CWD) has expanded since early September 2005 to include Hampshire County in the eastern panhandle of West Virginia National Fish and Wildlife Health Initiative Guiding Principles Eastern Equine Encephalitis (EEE) virus was isolated from seven white-tailed deer in southwestern Michigan during September 2005 During the past summer, more than 500 head of livestock in North Dakota and South Dakota were lost to one of the largest recorded anthrax outbreaks in U.S. history. Most of the losses were in cattle, but horses, bison, and farm-reared elk also were affected. Dr. John Fischer, Director of SCWDS, has received this year’s Special Recognition Award from the International Association of Fish and Wildlife Agencies (IAFWA). Dr. William Randolph Davidson is retiring in November 2005.

First-year experience of a Brazilian tertiary medical center in supporting severely ill patients using extracorporeal membrane oxygenation

OBJECTIVES: The aim of this manuscript is to describe the first year of our experience using extracorporeal membrane oxygenation support. METHODS: Ten patients with severe refractory hypoxemia, two with associated severe cardiovascular failure, were supported using venous-venous extracorporeal membrane oxygenation (eight patients) or veno-arterial extracorporeal membrane oxygenation (two patients). RESULTS: The median age of the patients was 31 yr (range 14-71 yr). Their median simplified acute physiological score three (SAPS3) was 94 (range 84-118), and they had a median expected mortality of 95% (range 87-99%). Community-acquired pneumonia was the most common diagnosis (50%), followed by P. jiroveci pneumonia in two patients with AIDS (20%). Six patients were transferred from other ICUs during extracorporeal membrane oxygenation support, three of whom were transferred between ICUs within the hospital (30%), two by ambulance (20%) and one by helicopter (10%). Only one patient (10%) was anticoagulated with heparin throughout extracorporeal membrane oxygenation support. Eighty percent of patients required continuous venous-venous hemofiltration. Three patients (30%) developed persistent hypoxemia, which was corrected using higher positive end-expiratory pressure, higher inspired oxygen fractions, recruitment maneuvers, and nitric oxide. The median time on extracorporeal membrane oxygenation support was five (range 3-32) days. The median length of the hospital stay was 31 (range 3-97) days. Four patients (40%) survived to 60 days, and they were free from renal replacement therapy and oxygen support. CONCLUSIONS: The use of extracorporeal membrane oxygenation support in severely ill patients is possible in the presence of a structured team. Efforts must be made to recognize the necessity of extracorporeal respiratory support at an early stage and to prompt activation of the extracorporeal membrane oxygenation team.

Extracorporeal membrane oxygenation in severe hypoxemia: time for reappraisal?

in 2009, during the influenza A (H1N1) epidemic, there were many reported cases of pulmonary infection with severe hypoxemia that was refractory to the ventilatory strategies and rescue therapies commonly used to treat patients with severe acute respiratory distress syndrome. Many of those cases were treated with extracorporeal membrane oxygenation (ECMO), which renewed international interest in the technique. The Extracorporeal Support Study Group was created in order to practice ECMO and to employ it in the treatment of patients with severe hypoxemia. In this article, we discuss the indications for using ECMO and report the case of a patient with refractory hypoxemia who was successfully treated with ECMO.

Comparison of fast-track diagnostics respiratory pathogens multiplex real-time RT-PCR assay with in-house singleplex assays for comprehensive detection of human respiratory viruses

Fast-track Diagnostics respiratory pathogens (FTDRP) multiplex real-time RT-PCR assay was compared with in-house singleplex real-time RT-PCR assays for detection of 16 common respiratory viruses. The FTDRP assay correctly identified 26 diverse respiratory virus strains, 35 of 41 (85%) external quality assessment samples spiked with cultured virus and 232 of 263 (88%) archived respiratory specimens that tested positive for respiratory viruses by in-house assays. Of 308 prospectively tested respiratory specimens selected from children hospitalized with acute respiratory illness, 270 (87.7%) and 265 (86%) were positive by FTDRP and in-house assays for one or more viruses, respectively, with combined test results showing good concordance (K=0.812, 95% CI = 0.786-0.838). Individual FTDRP assays for adenovirus, respiratory syncytial virus and rhinovirus showed the lowest comparative sensitivities with in-house assays, with most discrepancies occurring with specimens containing low virus loads and failed to detect some rhinovirus strains, even when abundant. The FTDRP enterovirus and human bocavirus assays appeared to be more sensitive than the in-house assays with some specimens. With the exceptions noted above, most FTDRP assays performed comparably with in-house assays for most viruses while offering enhanced throughput and easy integration by laboratories using conventional real-time PCR instrumentation. Published by Elsevier B.V.