Valoració del primer curs d'implantació de l'assignatura TFG al grau de Farmàcia (UB)

En el curso 2011-12 la Facultad de Farmacia de la Universidad de Barcelona ha iniciado la asignatura de "Trabajo Fin de Grado" (TFG) en los estudios de Farmacia. Esta asignatura consiste en la elaboración de un trabajo de integración que da lugar a una memoria escrita y a su exposición y defensa ante una comisión. En este primer año han cursado la asignatura un total de 159 alumnos. Los estudiantes se preinscriben a través de una plataforma digital y manifiestan sus preferencias en relación a los proyectos que ofrecen los diferentes Departamentos. Este proceso tiene como finalidad que cada estudiante quede asignado a un Departamento concreto para hacer el TFG

Body mass index and risk of head and neck cancer in a pooled analysis of case-control studies in the International Head and Neck Cancer Epidemiology (INHANCE) Consortium.

BACKGROUND: Head and neck cancer (HNC) risk is elevated among lean people and reduced among overweight or obese people in some studies; however, it is unknown whether these associations differ for certain subgroups or are influenced by residual confounding from the effects of alcohol and tobacco use or by other sources of biases. METHODS: We pooled data from 17 case-control studies including 12 716 cases and the 17 438 controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated for associations between body mass index (BMI) at different ages and HNC risk, adjusted for age, sex, centre, race, education, tobacco smoking and alcohol consumption. RESULTS: Adjusted ORs (95% CIs) were elevated for people with BMI at reference (date of diagnosis for cases and date of selection for controls) 25.0-30.0 kg/m(2) (0.52, 0.44-0.60) and BMI >/=30 kg/m(2) (0.43, 0.33-0.57), compared with BMI >18.5-25.0 kg/m(2). These associations did not differ by age, sex, tumour site or control source. Although the increased risk among people with BMI 25 kg/m(2) was present only in smokers and drinkers. CONCLUSIONS: In our large pooled analysis, leanness was associated with increased HNC risk regardless of smoking and drinking status, although reverse causality cannot be excluded. The reduced risk among overweight or obese people may indicate body size is a modifier of the risk associated with smoking and drinking. Further clarification may be provided by analyses of prospective cohort and mechanistic studies.

Valoració del primer curs d'implantació de l'assignatura TFG al grau de Farmàcia (UB)

En el curso 2011-12 la Facultad de Farmacia de la Universidad de Barcelona ha iniciado la asignatura de "Trabajo Fin de Grado" (TFG) en los estudios de Farmacia. Esta asignatura consiste en la elaboración de un trabajo de integración que da lugar a una memoria escrita y a su exposición y defensa ante una comisión. En este primer año han cursado la asignatura un total de 159 alumnos. Los estudiantes se preinscriben a través de una plataforma digital y manifiestan sus preferencias en relación a los proyectos que ofrecen los diferentes Departamentos. Este proceso tiene como finalidad que cada estudiante quede asignado a un Departamento concreto para hacer el TFG

Valoració del primer curs d'implantació de l'assignatura TFG al grau de Farmàcia (UB)

En el curso 2011-12 la Facultad de Farmacia de la Universidad de Barcelona ha iniciado la asignatura de "Trabajo Fin de Grado" (TFG) en los estudios de Farmacia. Esta asignatura consiste en la elaboración de un trabajo de integración que da lugar a una memoria escrita y a su exposición y defensa ante una comisión. En este primer año han cursado la asignatura un total de 159 alumnos. Los estudiantes se preinscriben a través de una plataforma digital y manifiestan sus preferencias en relación a los proyectos que ofrecen los diferentes Departamentos. Este proceso tiene como finalidad que cada estudiante quede asignado a un Departamento concreto para hacer el TFG

Valoració del primer curs d'implantació de l'assignatura TFG al grau de Farmàcia (UB)

En el curso 2011-12 la Facultad de Farmacia de la Universidad de Barcelona ha iniciado la asignatura de "Trabajo Fin de Grado" (TFG) en los estudios de Farmacia. Esta asignatura consiste en la elaboración de un trabajo de integración que da lugar a una memoria escrita y a su exposición y defensa ante una comisión. En este primer año han cursado la asignatura un total de 159 alumnos. Los estudiantes se preinscriben a través de una plataforma digital y manifiestan sus preferencias en relación a los proyectos que ofrecen los diferentes Departamentos. Este proceso tiene como finalidad que cada estudiante quede asignado a un Departamento concreto para hacer el TFG

Grup d'Innovació Docent en Farmacologia (GIDOF)

Podeu consultar la Setena trobada de professorat de Ciències de la Salut completa a: http://hdl.handle.net/2445/43352

Implantació de l'assignatura d'Introducció a la Clínica Podològica en el Grau de Podologia

La Diplomatura de Podologia es caracteritzava perquè els alumnes passaven directament de realitzar pràctiques de laboratori preclíniques en el primer semestre del segon any a dur a terme pràctica assistencial sense un coneixement i experiència suficient en el funcionament de la clínica.Amb la posada en marxa del grau, es va implantar l’assignatura d’Introducció a la Clínica Podològica [ICP], amb la finalitat de fer de pont entre les pràctiques de laboratori preclíniques i la incorporació assistencial. Això s’aconsegueix amb la incorporació d’un alumne d’ICP en un grup de pràctiques d’alumnes d’un curs superior (Practicum II).

Interrogating eleven fast-evolving genes for signatures of recent positive selection in worldwide human populations

Different signatures of natural selection persist over varying time scales in our genome, revealing possible episodes of adaptative evolution during human history. Here, we identify genes showing signatures of ancestral positive selection in the human lineage and investigate whether some of those genes have been evolving adaptatively in extant human populations. Specifically, we compared more than 11,000 human genes with their orthologs inchimpanzee, mouse, rat and dog and applied a branch-site likelihood method to test for positive selection on the human lineage. Among the significant cases, a robust set of 11 genes were then further explored for signatures of recent positive selection using SNP data. We genotyped 223 SNPs in 39 worldwide populations from the HGDP Diversity panel and supplemented this information with available genotypes for up to 4,814 SNPs distributed along 2 Mb centered on each gene. After exploring the allele frequency spectrum, population differentiation and the maintainance of long unbroken haplotypes, we found signals of recent adaptative phenomena in only one of the 11 candidate gene regions. However, the signal ofrecent selection in this region may come from a different, neighbouring gene (CD5) ratherthan from the candidate gene itself (VPS37C). For this set of positively-selected genes in thehuman lineage, we find no indication that these genes maintained their rapid evolutionarypace among human populations. Based on these data, it therefore appears that adaptation forhuman-specific and for population-specific traits may have involved different genes.

Early Jurassic to Early late Cretaceous radiolarians from the Santa Rosa accretionary complex (Northwestern Costa Rica)

In the circum-Pacific ophiolitic belts, when no other biogenic constituents are found, radiolarians have the potential to provide significant biostratigraph- ic information. The Santa Rosa Accretionary Complex, which crops out in several half-windows (Carrizal, Sitio Santa Rosa, Bahia Nancite, Playa Naranjo) along the south shores of the Santa Elena Peninsula in northwestern Costa Rica, is one of these little-known ophiolitic mélanges. It contains various oceanic assemblages of alkaline basalt, radiolarite and polymictic breccias. The radiolarian biochronology presented in this work is mainly based by correlation on the biozonations of Carter et al. (2010), Baumgartner et al. (1995b), and O'Dogherty (1994) and indicate an Early Jurassic to early Late Cretaceous (early Pliensbachian to earliest Turonian) age for the sediments associated with oceanic basalts or recovered from blocks in breccias or megabreccias. The 19 illus- trated assemblages from the Carrizal tectonic window and Sitio Santa Rosa contain in total 162 species belonging to 65 genera. The nomenclature of tecton- ic units is the one presented by (Baumgartner and Denyer, 2006). This study brings to light the Early Jurassic age of a succession of radiolarite, which was previously thought to be of Cretaceous age, intruded by alkaline basalts sills (Unit 3). The presence of Early Jurassic large reworked blocks in a polymictic megabreccia, firstly reported by De Wever et al. (1985) is confirmed (Unit 4). Therefore, the alkaline basalt associated with the radiolarites of these two units (and maybe also Units 5 and 8) could be of Jurassic age. In the Carrizal tectonic window, Middle to early Late Jurassic radiolarian chert blocks associ- ated with massive tholeitic basalts and Early Cretaceous brick-red ribbon cherts overlying pillow basalts are interpreted as fragments of a Middle Jurassic oceanic basement accreted to an Early Cretaceous oceanic Plate, in an intra-oceanic subduction context. Whereas, the knobby radiolarites and black shales of Playa Carrizal are indicative of a shallower middle Cretaceous paleoenvironment. Other remnants of this oceanic basin are found in Units 2, 6, and 7, which documented the rapid approach of the depocentre to a subduction trench during the late Early Cretaceous (Albian-Cenomanian), to possibly early Late Cretaceous (Turonian).

Mephedrone pharmacokinetics after intravenous and oral administration in rats: relation to pharmacodynamics

Rationale Mephedrone (4-methylmethcathinone) is a still poorly known drug of abuse, alternative to ecstasy or cocaine. Objective The major aims were to investigate the pharmacokineticsa and locomotor activity of mephedrone in rats and provide a pharmacokinetic/pharmacodynamic model. Methods Mephedrone was administered to male SpragueDawley rats intravenously (10 mg/kg) and orally (30 and 60 mg/kg). Plasma concentrations and metabolites were characterized using LC/MS and LC-MS/MS fragmentation patterns. Locomotor activity was monitored for 180240 min. Results Mephedrone plasma concentrations after i.v. administration fit a two-compartment model (α=10.23 h−1, β=1.86 h−1). After oral administration, peak mephedrone concentrations were achieved between 0.5 and 1 h and declined to undetectable levels at 9 h. The absolute bioavailability of mephedrone was about 10 % and the percentage of mephedrone protein binding was 21.59±3.67%. We have identified five phase I metabolites in rat blood after oral administration. The relationship between brain levels and free plasma concentration was 1.85±0.08. Mephedrone induced a dose-dependent increase in locomotor activity, which lasted up to 2 h. The pharmacokineticpharmacodynamic model successfully describes the relationship between mephedrone plasma concentrations and its psychostimulant effect. Conclusions We suggest a very important first-pass effect for mephedrone after oral administration and an easy access to the central nervous system. The model described might be useful in the estimation and prediction of the onset, magnitude,and time course of mephedrone pharmacodynamics as well as to design new animal models of mephedrone addiction and toxicity.

LMS y web 2.0 una relación simbiótica en las aulas universitarias Diseño e integración de actividades pedagógicas 2.0 en una plataforma Blackboard

Peer-reviewed

Creativity in Collaborative Learning across the Life Span

Peer-reviewed

Time in e-Learning Research: A Qualitative Review of the Empirical Consideration of Time in Research into e-Learning

Peer-reviewed