Osakkeiden hintojen muutokset makrotalouden muuttujia ennakoivina tekijöinä 2001-2011: BRIC-maat , euroalue, Japani ja USA.

The aim of this thesis is to examine stock returns as predictive indicators to macroeconomic variables in BRIC-countries, Japan, USA and euro area. We picked to represent macroeconomic variables interest rate, inflation, currency, gross domestic product and industrial production. For the beginning we examined previous studies and theory about the subject. Hypothesis of this thesis were derived from the previous studies. To conduct the results we used tests such augmented Dickey-Fuller, Engle-Granger co-integration, Granger causality and lagged distribution model. According to results stock returns do predictive macroeconomic variables and specifically changes of GDP and industrial production. There were few evidences of stock returns predictive power of inflation.

Ultralujien terästen pienahitsien staattinen lujuus

Kandidaatintyön tarkoituksena oli selvittää hitsausliitosten mitoitusohjeita ultralujille teräksille. Työhön kuului laboratoriotestauksia, joiden avulla tarkasteltiin laskujen soveltuvuutta ultralujille teräksille. Laskuissa verrattiin erityisesti kimmoteorian ja plastisuusteorian toimivuutta. Työn tuloksena tuotettiin mitoitusohjeet otsapienahitseille, eli mitoitusvoimaan nähden poikittaisille hitseille. Myös kylkipienahitseille, eli mitoitusvoimaan nähden yhdensuuntaisille hitseille saatiin alustavia tuloksia.

Paperitehtaan sähkötasehallinta ja sähkön kysyntäjousto energiakustannusten hallinnassa

Paperiteollisuus on energiaintensiivistä teollisuutta, jossa on tehty pitkään työtä tuotantoprosessien energiatehokkuuden parantamiseksi. Paperitehtaan energiakustannuksiin voidaan kuitenkin vaikuttaa myös sähkötaseen hallinnalla ja sähkön kysyntäjouston avulla. Tehtaan seuraavan vuorokauden sähkön kulutus pyritään ennustamaan mahdollisimman tarkasti, mutta esimerkiksi paperitehtaan häiriötilanteissa sähkötase poikkeaa ennustetusta. Tällöin sähkötasetta voidaan korjata ensisijaisesti sähkön jälkimarkkinoiden eli Elbas- kaupankäynnin avulla. Ellei tasetta saada korjattua sähkön jälkimarkkinoilla tase-ero korjataan tasesähköllä, jonka hinta muodostuu säätösähkömarkkinoilla. Tasesähkön hinta saattaa poiketa Elspot- markkinahinnasta voimakkaasti, jolloin tase-erosta joko hyödytään tai hävitään kustannusmielessä. Tämän työn tarkoituksena on selvittää sähkötasehallinnan parantamisen ja sähkön kysyntäjouston vaikutukset paperitehtaan energiakustannuksiin. Työssä tutkittiin tehtaan sähkö-tasehallinnan nykytilannetta ja selvitettiin tase-erojen kustannusvaikuttavuutta. Lisäksi työssä luotiin ajomalleja sähkön kysyntäjouston toteuttamiselle massatehtaan eri tuotantoprosesseille, sekä määritettiin rajahintoja seuraavan vuorokauden energiaennusteeseen. Onnistunut energiaennuste perustuu paperitehtaan käynnin tarkkoihin ja ajankohtaisiin lähtötietoihin. Sähkötaseen poikkeamiin voidaan puolestaan varautua paremmin, kun informaatio tehtaan prosessien alasajosta tulee voimalaitoksen tietoon mahdollisimman aikaisin. Sähkötaseen poikkeamien hallinta voidaan tehdä, joko Elbas- kaupan tai tasesähkön avulla. Ajankohdasta ja tasepoikkeaman volyymista riippuen täytyy tehdä valinta, kumpi vaihtoehdoista on kustannusmielessä kannattavampi. Paperitehtaan eri prosesseille luoduilla ajomalleilla saatiin esiin huomattava säästöpotentiaali. Ajomallien noudattaminen vaatii suunnitelmallista tuotannon hallintaa ja sähkön Elspot- hinnan käyttäytymisen säännöllistä seurantaa. Seuraavan vuorokauden rajahintatietojen määrittämisen pohjalta voidaan arvioida, millä Elspot- hinnalla sähkön myynti muuttuu paperin tuotantoa kannattavammaksi.

Etäluentamittareiden tuomat tuotteistamismahdollisuudet sähkönmyyjille

Diplomityön tavoitteena oli selvittää etäluentamittareiden mahdollistamia tuotteita ja palveluita sekä niiden toteutettavuutta Mäntsälän Sähkö Oy:ssä. Työssä perehdytään yksityisasiakkaille suunnattuihin palveluihin, joita mittaritekniikka mahdollistaa. Mittarit tulee olla asennettuna 80%:lle verkkoyhtiön sähkönkäyttöpaikoista vuoteen 2014 mennessä. Mäntsälän Sähköllä mittareiden vaihtoprojektin alkamisen vuoksi haluttiin selvittää mahdollisten uusien tuotteiden toteutettavuutta. Työssä esitellään Mäntsälän Sähkö Oy:lle tulevan mittarijärjestelmän. Mittarijärjestelmä käyttää eri tietoliikennetapoja, jotka ovat GPRS, RS485 ja radio. Työ sisältää internet-paneelina suoritetun asiakaskyselyn, jossa selvitettiin asiakkaiden tarpeita ja mielipiteitä mahdollisten uusien tuotteiden osalta. Työssä käsiteltäviä tuotteita ovat kuormanohjaus, kysynnän hintajousto, spot-hinnoittelu, laskutus sekä raportointipalvelu. Kulutuksen hintajousto, kuormanohjaus ja spot-hinnoittelu toimivat toisiaan tukevina tuotteina. Tasasuuruista laskutusta voisi tarjota toteutuneen kulutuksen mukaisen laskutuksen ohessa lisäpalveluna. Raportointipalvelu internetissä on hyvä tapa toimittaa asiakkaalle lain velvoittamat tiedot.

Application of a Pid+fuzzy controller on the motion control system in machine tools

This work deals with an hybrid PID+fuzzy logic controller applied to control the machine tool biaxial table motions. The non-linear model includes backlash and the axis elasticity. Two PID controllers do the primary table control. A third PID+fuzzy controller has a cross coupled structure whose function is to minimise the trajectory contour errors. Once with the three PID controllers tuned, the system is simulated with and without the third controller. The responses results are plotted and compared to analyse the effectiveness of this hybrid controller over the system. They show that the proposed methodology reduces the contour error in a proportion of 70:1.

Instability of a square sheet under symmetric biaxial loading

An early experiment found that a square rubber sheet under symmetric biaxial loading may not remain square. This curious result has been one of the most instructive examples in finite elasticity. Here thermodynamic considerations are used to analyze this instability.

Unidirectional fiber-reinforced composite as an oral implant abutment material: Experimental studies of E-glass fiber/BisGMA-TEGDMA polymer in vitro

Fiber-reinforced composites (FRCs) are a new group of non-metallic biomaterials showing a growing popularity in many dental and medical applications. As an oral implant material, FRC is biocompatible in bone tissue environment. Soft tissue integration to FRC polymer material is unclear. This series of in vitro studies aimed at evaluating unidirectional E-glass FRC polymer in terms of mechanical, chemical, and biological properties in an attempt to develop a new non-metallic oral implant abutment alternative. Two different types of substrates were investigated: (a) Plain polymer (BisGMA 50%–TEGDMA 50%) and (b) Unidirectional FRC. The mechanical behavior of high fiber-density FRCs was assessed using a three-point bending test. Surface characterization was performed using scanning electron and spinning disk confocal microscopes. The surface wettability/energy was determined using sessile drop method. The blood response, including blood-clotting ability and platelet morphology was evaluated. Human gingival fibroblast cell responses - adhesion kinetics, adhesion strength, and proliferation activity - were studied in cell culture environment using routine test conditions. A novel tissue culture method was developed and used to evaluate porcine gingival tissue graft attachment and growth on the experimental composite implants. The analysis of the mechanical properties showed that there is a direct proportionality in the relationship between E-glass fiber volume fraction and toughness, modulus of elasticity, and load bearing capacity; however, flexural strength did not show significant improvement when high fiber-density FRC is used. FRCs showed moderate hydrophilic properties owing to the presence of exposed glass fibers on the polymer surface. Blood-clotting time was shorter on FRC substrates than on plain polymer. The FRC substrates also showed higher platelet activation state than plain polymer substrates. Fibroblast cell adhesion strength and proliferation rate were highly pronounced on FRCs. A tissue culture study revealed that gingival epithelium and connective tissue established an immediate close contact with both plain polymer and FRC implants. However, FRC seemed to guide epithelial migration outwards from the tissue/implant interface. Due to the anisotropic and hydrophilic nature of FRC, it can be concluded that this material enhances biological events related with soft tissue integration on oral implant surface.

Productizing professional marketing services through service blueprinting

The goal of this research is to study how knowledge-intensive business services can be productized by using the service blueprinting tool. As services provide the majority of jobs, GDP and productivity growth in Europe, their continuous development is needed for Europe to retain its global competitiveness. As services are turning more complex, their development becomes more difficult. The theoretical part of this study is based on researching productization in the context of knowledge-intensive business services. The empirical part is carried out as a case study in a KIBS company, and utilizes qualitative interviews and case materials. The final outcome of this study is an updated productization framework, designed for KIBS companies, and recommendations for the case company. As the results of this study indicate, productization expanded with service blueprinting can be a useful tool for KIBS companies to develop their services. The updated productization framework is provided for future reference.

Public and private sector cooperative opportunities in the Finnish healthcare internationalization : views from the public sector’s perspective

Traditionally mostly publicly provided Finnish healthcare services are confronted today by the evident challenge of rising healthcare costs as the expenditure on health and social case has exceeded Finland’s national GDP growth significantly since the new millennium. While the opening of the traditional barriers through the EU’s new patient directive resulting in increasing international competition and the free flow of patients within the EU present opportunities for the Finnish healthcare services industry there are also several challenges for the existing healthcare system as proposed by the Ministry of Employment and the Economy in 2011. Due to the structure and nature of the current Finnish healthcare service system the greatest potential for internationalization is seen from a joint cooperation of the public and private sectors in an internationalization network for Finnish healthcare services. As its formation has recently also taken as a strategic initiative to be completed by the Ministry of Employment and the Economy and no earlier research exists on how this is seen in practice by the network actors, the purpose of this study is to examine the proposed solution of forming an internationalization network between the public and private sector actors in Finland in practice from the viewpoint of public sector actors. The research relied heavily on the reports by the Finnish Ministries in understanding the current situation of the Finnish healthcare services internationalization and its potential. Suitable theories were also used to build a more comprehensive view of the matter. The study applied a qualitative research approach on the explorative research problem. The data collection was achieved through expert interviews in two of the largest Finnish public healthcare service providers; the Turku and Helsinki Central University Hospitals. Expert interviews were considered as the most suitable method for data collection in order to create an in-depth understanding of the topic within the limitations of this thesis. In turn, two different public healthcare service providers were chosen to give a broader view of the field instead of focusing on a specific unit and also to allow a possible comparison between the two different organizations. The latter however was shown not to be suitable for the purposes of this study as the opinions of the respondents varied largely also within their own organizations. The conclusion is that while the actors agree on the evident internationalization of Finnish healthcare services, there are several large-scale structural challenges effectively preventing such activities while at the same time the opportunities within Finland vary, as there are several niches but no real large-scale advantages in the highly competitive industry. Interest towards cooperation between the sectors are seen especially in exploiting the advantages offered by the private sector in commercialization and marketization, yet however no clear views exist on how these activities should be governed or structured in the short-term as a larger reform of the entire Finnish healthcare service sector is needed in the long-term.

Water relations of tree species growing on a rock outcrop in the "Parque Estadual de Itapuã", RS

Water relations of the tree species Myrsine umbellata Mart. ex A. DC., Dodonaea viscosa Jacq. and Erythroxylum argentinum O. E. Schulz, growing on a rock outcrop in the "Parque Estadual de Itapuã" (RS), were studied. Environmental (precipitation, temperature, soil water) and plant (water potential, vapor pressure deficit, stomatal conductance, transpiration, leaf specific hydraulic conductance, osmotic potential and cell wall elasticity) parameters were collected in five periods and pooled into two sets of data: wet and dry periods. Myrsine umbellata showed great stability of the plant parameters, including the maintenance of high pre-dawn (psiwpd) and mid-day (psiwmd) water potentials in the dry period (-0.48 and -1.12 MPa, respectively), suggesting the presence of a deep root system. Dodonaea viscosa and E. argentinum reached lower psiwpd (-1.41 and -1.97 MPa, respectively) and a greater degree of stomatal closure in the dry period, suggesting a shallower root system. Differential exposure to soil drought was also corroborated by differential drought effects on the whole-plant leaf specific hydraulic conductance (Gt). Correlation analysis pointed to weak correlations between psiwpd and g s. Erythroxylum argentinum was the only species to show osmotic adjustment in response to drought. It is suggested that M. umbellata has low tolerance to water deficits, adopting an avoidance behavior. The much lower values of psiw reached by D. viscosa and E. argentinum suggest a greater tolerance to drought by these species.

Heart rate variability in young adults - Reference values and associations with cardiometabolic risk factors and vascular properties. The Cardiovascular Risk in Young Finns Study.

Background: The function of the autonomic nervous system (ANS) can be evaluated with heart rate variability (HRV). Decreased HRV is associated with aging, the male sex, increased heart rate, and overall increased cardiometabolic risk. It has been hypothesized that early atherosclerotic vascular changes and ANS function are related. Aims: The aims were to assess reference values on HRV in young adults, and examine associations with HRV and cardiometabolic risk factors and metabolic syndrome (MetS) and to study relations between HRV and ultrasonographically measured vascular properties. Participants and methods: The present thesis is part of the Cardiovascular Risk in Young Finns Study. The thesis is based on the follow-up study in 2001, when the study individuals were 24-39 years of age. HRV data were available on 1 956 individuals. Results: HRV was inversely associated with age and heart rate (for all p<0.001). Highfrequency HRV (HF) was higher, and low-frequency HRV (LF) lower in women than men (p<0.0001 for both). MetS was associated with 11% decreased HF and 12% increased LF/HF-ratio in women, and 8% decreased HF and 4% increased LF/HF-ratio in men. Carotid artery distensibility was independently associated with HF and total HRV (for both p<0.05). Conclusions: The reference values in young adults were generated. Decreased HRV was associated with age, the male sex and increased heart rate. Women had higher HF and lower LF variability than men. MetS was related to decrease in HRV. The observed associations between carotid elasticity and HRV, supports the hypothesis that reduction in carotid elasticity may lead to decrease in autonomic cardiac control.

Chronic hypertension alters the expression of Cx43 in cardiovascular muscle cells

Connexin43 (Cx43), the predominant gap junction protein of muscle cells in vessels and heart, is involved in the control of cell-to-cell communication and is thought to modulate the contractility of the vascular wall and the electrical coupling of cardiac myocytes. We have investigated the effects of arterial hypertension on the expression of Cx43 in aorta and heart in three different models of experimental hypertension. Rats were made hypertensive either by clipping one renal artery (two kidney, one-clip renal (2K,1C) model) by administration of deoxycorticosterone and salt (DOCA-salt model) or by inhibiting nitric oxide synthase with NG-nitro-L-arginine methyl ester (L-NAME model). After 4 weeks, rats of the three models showed a similar increase in intra-arterial mean blood pressure and in the thickness of the walls of both aorta and heart. Analysis of heart mRNA demonstrated no change in Cx43 expression in the three models compared to their respective controls. The same 2K,1C and DOCA-salt hypertensive animals expressed twice more Cx43 in aorta, and the 2K,1C rats showed an increase in arterial distensibility. In contrast, the aortae of L-NAME hypertensive rats were characterized by a 50% decrease in Cx43 and the carotid arteries did not show increased distensibility. Western blot analysis indicated that Cx43 was more phosphorylated in the aortae of 2K,1C rats than in those of L-NAME or control rats, indicating a differential regulation of aortic Cx43 in different models of hypertension. The data suggest that localized mechanical forces induced by hypertension affect Cx43 expression and that the cell-to-cell communication mediated by Cx43 channels may contribute to regulating the elasticity of the vascular wall.

Effect of ultrastructural features on mechanical properties of softwood fiber

The main objective of this study was to develop mathematical model capable to describe the effect of ultrastructural features on the longitudinal modulus of elasticity of softwood fiber. Another objective was to identify, based on ultrastructural features, a potential explanatory factor for the mechanical difference between Norway spruce and Scots pine fibers and to demonstrate its influence utilizing developed modelling tools. According to the literature, the main difference between the pine and spruce fibers is the pit structure, which is clearly different in these fibers. The spruce fiber contains a lot of tiny pits, whereas the pits of the pine fiber are larger and the total number of them is smaller. The effect of the pits on the longitudinal modulus of elasticity of fiber is studied with both the analytical and the numerical model. The results show that, although the spruce fiber seems to contain clearly more pits, larger pits appearing in the pine fiber turn out to have a stronger influence on the longitudinal modulus of elasticity of the fiber. The effect of local variation of microfibril angle which occurs near the pits seems to be minor. Moreover, the results suggest that spruce fibers may have higher ultimate strength due to the more uniform straining behavior.

Food restriction induces in vivo ventricular dysfunction in spontaneously hypertensive rats without impairment of in vitro myocardial contractility

Cardiac structures, function, and myocardial contractility are affected by food restriction (FR). There are few experiments associating undernutrition with hypertension. The aim of the present study was to analyze the effects of FR on the cardiac response to hypertension in a genetic model of hypertension, the spontaneously hypertensive rat (SHR). Five-month-old SHR were fed a control or a calorie-restricted diet for 90 days. Global left ventricle (LV) systolic function was evaluated in vivo by transthoracic echocardiogram and myocardial contractility and diastolic function were assessed in vitro in an isovolumetrically beating isolated heart (Langendorff preparation). FR reduced LV systolic function (control (mean ± SD): 58.9 ± 8.2; FR: 50.8 ± 4.8%, N = 14, P < 0.05). Myocardial contractility was preserved when assessed by the +dP/dt (control: 3493 ± 379; FR: 3555 ± 211 mmHg/s, P > 0.05), and developed pressure (in vitro) at diastolic pressure of zero (control: 152 ± 16; FR: 149 ± 15 mmHg, N = 9, P > 0.05) and 25 mmHg (control: 155 ± 9; FR: 150 ± 10 mmHg, N = 9, P > 0.05). FR also induced eccentric ventricular remodeling, and reduced myocardial elasticity (control: 10.9 ± 1.6; FR: 9.2 ± 0.9%, N = 9, P < 0.05) and LV compliance (control: 82.6 ± 16.5; FR: 68.2 ± 9.1%, N = 9, P < 0.05). We conclude that FR causes systolic ventricular dysfunction without in vitro change in myocardial contractility and diastolic dysfunction probably due to a reduction in myocardial elasticity.

From Unspecific Quenching to Specific Signaling: Functional GTPase Assays Utilizing Quenching Resonance Energy Transfer (QRET) Technology

The aim of the work presented in this study was to demonstrate the wide applicability of a single-label quenching resonance energy transfer (QRET) assay based on time-resolved lanthanide luminescence. QRET technology is proximity dependent method utilizing weak and unspecific interaction between soluble quencher molecule and lanthanide chelate. The interaction between quencher and chelate is lost when the ligand binds to its target molecule. The properties of QRET technology are especially useful in high throughput screening (HTS) assays. At the beginning of this study, only end-point type QRET technology was available. To enable efficient study of enzymatic reactions, the QRET technology was further developed to enable measurement of reaction kinetics. This was performed using proteindeoxyribonuclei acid (DNA) interaction as a first tool to monitor reaction kinetics. Later, the QRET was used to study nucleotide exchange reaction kinetics and mutation induced effects to the small GTPase activity. Small GTPases act as a molecular switch shifting between active GTP bound and inactive GDP bound conformation. The possibility of monitoring reaction kinetics using the QRET technology was evaluated using two homogeneous assays: a direct growth factor detection assay and a nucleotide exchange monitoring assay with small GTPases. To complete the list, a heterogeneous assay for monitoring GTP hydrolysis using small GTPases, was developed. All these small GTPase assays could be performed using nanomolar protein concentrations without GTPase pretreatment. The results from these studies demonstrated that QRET technology can be used to monitor reaction kinetics and further enable the possibility to use the same method for screening.